Resultados globales: 35 registros encontrados en 0.03 segundos.
Artículos, Encontrados 31 registros
Documentos de investigación, Encontrados 4 registros
Artículos Encontrados 31 registros  1 - 10siguientefinal  ir al registro:
1.
15 p, 9.2 MB Morphologically different hydroxyapatite nanoparticles exert differential genotoxic effects in Drosophila / Güneş, Merve (Akdeniz University. Department of Biology) ; Yalçın, Burçin (Akdeniz University. Department of Biology) ; Burgazlı, Ayşen Yağmur (Akdeniz University. Department of Biology) ; Tagorti, Ghada (Akdeniz University. Department of Biology) ; Yavuz, Emre (Akdeniz University. Department of Chemistry) ; Akarsu, Esin (Akdeniz University. Department of Chemistry) ; Kaya, Nuray (Akdeniz University. Department of Biology) ; Marcos Dauder, Ricardo (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Kaya, Bülent (Akdeniz University. Department of Biology)
Hydroxyapatite (HAP) occurs naturally in sedimentary and metamorphic rocks and constitutes the hard structures in many organisms. Since synthetic nano-sized HAP (HAP-NPs) are used in orthopedic applications and for heavy metal remediation in aquatic and terrestrial media, both environment and humans are exposed to them. [...]
2023 - 10.1016/j.scitotenv.2023.166556
Science of the total environment, Vol. 904 (December 2023) , art. 166556  
2.
8 p, 573.0 KB A comprehensive analysis of candidate genes in familial pancreatic cancer families reveals a high frequency of potentially pathogenic germline variants / Earl, Julie (Red de Investigación Biomédica en Cáncer (CIBERONC)) ; Galindo-Pumariño, Cristina (Red de Investigación Biomédica en Cáncer (CIBERONC)) ; Encinas, J. (Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS)) ; Barreto, E. (Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS)) ; Castillo, M.E. (Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS)) ; Pachón, V. (Red de Investigación Biomédica en Cáncer (CIBERONC)) ; Ferreiro, R. (Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS)) ; Rodríguez-Garrote, M. (Red de Investigación Biomédica en Cáncer (CIBERONC)) ; González-Martínez, S. (Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS)) ; Ramon y Cajal, Teresa (Institut d'Investigació Biomèdica Sant Pau) ; Diaz, L.R. (Hospital 12 de Octubre (Madrid)) ; Chirivella, Isabel (Hospital Clínic Universitaride València) ; Rodriguez, M. (Hospital Teresa Herrera) ; de Castro, E.M. (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ; García-Seisdedos, D. (Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS)) ; Muñoz, G. (Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS)) ; Rosa, J.M.R. (Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS)) ; Marquez, M. (Centro Nacional de Investigaciones Oncológicas) ; Malats, N. (Centro Nacional de Investigaciones Oncológicas) ; Carrato, A. (Red de Investigación Biomédica en Cáncer (CIBERONC)) ; Universitat Autònoma de Barcelona
The 5-year survival rate of patients with pancreatic ductal adenocarcinoma (PDAC) is around 5% due to the fact that the majority of patients present with advanced disease that is treatment resistant. [...]
2020 - 10.1016/j.ebiom.2020.102675
EBioMedicine, Vol. 53 (march 2020) , p. 102675  
3.
14 p, 2.4 MB Small molecule inhibitor of OGG1 blocks oxidative DNA damage repair at telomeres and potentiates methotrexate anticancer effects / Baquero, Juan Miguel (Centro Nacional de Investigaciones Oncológicas) ; Benítez-Buelga, Carlos (Karolinska Institutet (Estocolm, Suècia)) ; Rajagopal, Varshni (Karolinska Institutet (Estocolm, Suècia)) ; Zhenjun, Zhao (Karolinska Institutet (Estocolm, Suècia)) ; Torres, Raul (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Müller, Sarah (Karolinska Institutet (Estocolm, Suècia)) ; Hanna, Bishoy M. F. (Karolinska Institutet (Estocolm, Suècia)) ; Loseva, Olga (Karolinska Institutet (Estocolm, Suècia)) ; Wallner, Olov (Karolinska Institutet (Estocolm, Suècia)) ; Michel, Maurice (Karolinska Institutet (Estocolm, Suècia)) ; Rodriguez-Perales, Sandra (Grupo de Citogenética Molecular. Programa de Genética del Cáncer Humano. Centro Nacional de Investigaciones Oncológicas de España (Madrid)) ; Gad, Helge (The University of Sheffield) ; Visnes, Torkild (SINTEF Industry (Noruega)) ; Helleday, Thomas (The University of Sheffield) ; Benitez, Javier (Centro Nacional de Investigaciones Oncológicas) ; Osorio, Ana (Centro Nacional de Investigaciones Oncológicas) ; Universitat Autònoma de Barcelona
The most common oxidative DNA lesion is 8-oxoguanine which is mainly recognized and excised by the 8-oxoG DNA glycosylase 1 (OGG1), initiating the base excision repair (BER) pathway. Telomeres are particularly sensitive to oxidative stress (OS) which disrupts telomere homeostasis triggering genome instability. [...]
2021 - 10.1038/s41598-021-82917-7
Scientific reports, Vol. 11 Núm. 1 (december 2021) , p. 3490  
4.
18 p, 5.6 MB Lysine Methyltransferase Inhibitors Impair H4K20me2 and 53BP1 Foci in Response to DNA Damage in Sarcomas, a Synthetic Lethality Strategy / Campillo-Marcos, Ignacio (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Monte-Serrano, Eva (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Navarro-Carrasco, Elena (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; García-González, Raúl (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Lazo, Pedro A. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Background: Chromatin is dynamically remodeled to adapt to all DNA-related processes, including DNA damage responses (DDR). This adaptation requires DNA and histone epigenetic modifications, which are mediated by several types of enzymes; among them are lysine methyltransferases (KMTs). [...]
2021 - 10.3389/fcell.2021.715126
Frontiers in Cell and Developmental Biology, Vol. 9 (september 2021) , p. 715126  
5.
25 p, 6.2 MB Poly(Adp-ribose) binding and macroh2a mediate recruitment and functions of kdm5a at dna lesions / Kumbhar, Ramhari (University of Texas at Austin) ; Sanchez, Anthony (University of Texas at Austin) ; Perren, Jullian (University of Texas at Austin) ; Gong, Fade (Baylor College of Medicine) ; Corujo, David (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Medina, Frank (University of Texas at Austin) ; Devanathan, Sravan K. (University of Texas at Austin) ; Xhemalce, Blerta (University of Texas at Austin) ; Matouschek, Andreas (University of Texas at Austin) ; Buschbeck, Marcus (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Buck-Koehntop, Bethany A. (University of Utah) ; Miller, Kyle M. (University of Texas at Austin) ; Universitat Autònoma de Barcelona
The histone demethylase KDM5A erases histone H3 lysine 4 methylation, which is involved in transcription and DNA damage responses (DDRs). While DDR functions of KDM5A have been identified, how KDM5A recognizes DNA lesion sites within chromatin is unknown. [...]
2021 - 10.1083/jcb.202006149
The journal of cell biology, Vol. 220 Núm. 7 (2021) , p. e202006149  
6.
16 p, 4.3 MB Role of H4K16 acetylation in 53BP1 recruitment to double-strand break sites in in vitro aged cells / González-Bermúdez, Lourdes (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Genescà, Anna (Institut Català d'Oncologia) ; Terradas, Mariona (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Martín Flix, Marta (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Increased frequency of DNA double strand breaks (DSBs) with aging suggests an age-associated decline in DSB repair efficiency, which is also influenced by the epigenetic landscape. H4 acetylation at lysine 16 (H4K16Ac) has been related to DSB repair since deacetylation of this mark is required for efficient 53BP1 recruitment to DSBs. [...]
2022 - 10.1007/s10522-022-09979-6
Biogerontology, Vol. 23, Issue 4 (August 2022) , p. 499-514  
7.
36 p, 800.8 KB Establishment and validation of surface model for biodosimetry based on γ-H2AX foci detection / López Vásquez, Juan Sebastián (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ; Pujol Canadell, Mònica (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ; Puig, Pedro (Universitat Autònoma de Barcelona. Departament de Matemàtiques) ; Ribas, Montserrat (Institut d'Investigació Biomèdica Sant Pau) ; Carrasco de Fez, Pablo (Institut d'Investigació Biomèdica Sant Pau) ; Armengol Rosell, Gemma (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ; Barquinero, Joan Francesc (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia)
Introduction: In the event of a radiation accident detecting γ-H2AX foci is being accepted as fast method for triage and dose assessment. However, due to their disappearance kinetics, published calibrations have been constructed at specific post-irradiation times. [...]
2022 - 10.1080/09553002.2022.1998706
International Journal of Radiation Biology, Vol. 98, Issue 1 (2022) , p. 1-10  
8.
25 p, 318.6 KB ATM and DNA-PKcs make a complementary couple in DNA double strand break repair / Martín Flix, Marta (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Terradas, Mariona (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ; Tusell Padrós, Laura (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Genescà, Anna (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
The interplay between ATM and DNA-PKcs kinases during double strand breaks (DSBs) resolution is still a matter of debate. ATM and DNA-PKcs participate differently in the DNA damage response pathway (DDR), but important common aspects are indeed found: both of them are activated when faced with DSBs, they share common targets in the DDR and the absence of either kinase results in faulty DSB repair. [...]
2012 - 10.1016/j.mrrev.2011.12.006
Mutation Research - Reviews in Mutation Research, Vol. 751, Issue 1 (July-September 2012) , p. 29-35  
9.
20 p, 7.5 MB Towards a New, Endophenotype-Based Strategy for Pathogenicity Prediction in BRCA1 and BRCA2 : In Silico Modeling of the Outcome of HDR/SGE Assays for Missense Variants / Özkan, Selen (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Padilla Sirera, Natàlia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; de la Cruz, Xavier (Institució Catalana de Recerca i Estudis Avançats) ; Universitat Autònoma de Barcelona
The present limitations in the pathogenicity prediction of BRCA1 and BRCA2 (BRCA1/2) missense variants constitute an important problem with negative consequences for the diagnosis of hereditary breast and ovarian cancer. [...]
2021 - 10.3390/ijms22126226
International journal of molecular sciences, Vol. 22 (june 2021)  
10.
26 p, 17.4 MB High-depth African genomes inform human migration and health / Choudhury, Ananyo (University of the Witwatersrand) ; Aron, S. (University of the Witwatersrand) ; Botigué, Laura (Centre de Recerca en Agrigenòmica) ; Sengupta, D. (University of the Witwatersrand) ; Botha, G. (University of Cape Town) ; Bensellak, T. (Abdelmalek Essaadi University) ; Wells, G. (University of the Western Cape) ; Kumuthini, J. (University of the Western Cape) ; Shriner, Daniel (National Institutes of Health (USA)) ; Fakim, Y. J. (University of Mauritius) ; Ghoorah, A. W. (University of Mauritius) ; Dareng, E. (Institute of Human Virology Nigeria) ; Odia, T. (Covenant University) ; Falola, O. (Covenant University) ; Adebiyi, E. (Covenant University) ; Hazelhurst, S. (University of the Witwatersrand) ; Mazandu, G. (University of Cape Town) ; Nyangiri, O. A. (Makerere University) ; Mbiyavanga, M. (University of Cape Town) ; Benkahla, A. (Institute Pasteur of Tunis) ; Kassim, S. K. (Ain Shams University (El Caire, Egipte)) ; Mulder, N. (University of Cape Town) ; Adebamowo, S. N. (University of Maryland Baltimore) ; Chimusa, E. R. (University of Cape Town) ; Muzny, D. (Baylor College of Medicine) ; Metcalf, G. (Baylor College of Medicine) ; Gibbs, R. A. (Baylor College of Medicine) ; Rotimi, C. (National Institutes of Health (USA)) ; Ramsay, M. (University of the Witwatersrand) ; Adeyemo, Adebowale A (National Institutes of Health (USA)) ; Lombard, Z. (University of the Witwatersrand) ; Hanchard, N. A. (Baylor College of Medicine) ; TrypanoGEN Research Group ; H3Africa Consortium
The African continent is regarded as the cradle of modern humans and African genomes contain more genetic variation than those from any other continent, yet only a fraction of the genetic diversity among African individuals has been surveyed. [...]
2020 - 10.1038/s41586-020-2859-7
Nature, Vol. 586 (October 2020) , p. 741-748  

Artículos : Encontrados 31 registros   1 - 10siguientefinal  ir al registro:
Documentos de investigación Encontrados 4 registros  
1.
8.9 MB Dealing with the main challenges of fanconi anemia molecular diagnosis and therapy / Persico, Ilaria ; Bogliolo, Massimo, dir. ; Pio D'Adamo, Adamo, dir. ; Surrallés i Calonge, Jordi, dir.
L'anèmia de Fanconi (FA) és un trastorn genètic rar de la reparació de l'ADN amb àmplia heterogeneïtat genètica, múltiples mutacions privades i alta taxa de mosaïcisme, que encara prejutgen el diagnòstic molecular en el cas de variants de difícil caracterització o de patogenicitat dubtosa. [...]
La anemia de Fanconi (FA) es un trastorno genético raro de la reparación del ADN con amplia heterogeneidad genética, múltiples mutaciones privadas y alta tasa de mosaicismo, que todavía prejuzgan el diagnóstico molecular en el caso de variantes de difícil caracterización o de patogenicidad dudosa. [...]
Fanconi anemia (FA) is a rare genetic DNA repair deficiency with vast genetic heterogeneity, multiple private mutations, and high mosaicism rate, still jeopardizing molecular diagnosis in case of variants with difficult characterization or unclear pathogenicity. [...]

2023  
2.
Discovery of synthetic lethal or viable interactions between DNA repair pathways / Steigerwald, Daniela ; Surrallés i Calonge, Jordi, dir. ; Bogliolo, Massimo, dir.
Les cèl·lules de mamífer han desenvolupat rutes de reparació de l'ADN per protegir el material genètic de mutacions que podrien provocar càncer o mort cel·lular. Cada ruta de reparació de l'ADN respon a un tipus específic de dany. [...]
Las células de mamífero han desarrollado rutas de reparación del ADN para proteger el material genético de mutaciones que podrían provocar cáncer o muerte celular. Cada ruta de reparación del ADN responde a un tipo específico de daño. [...]
Mammalian cells have developed a set of DNA repair pathways to protect the genomic information from mutations that could lead to cancer or cell death. Each DNA repair pathway responds to a specific kind of DNA damage. [...]

2022  
3.
1 p, 1.5 MB Chromatin plasticity in the DNA damage response: a key player in double-strand break repair pathway choice / García Moro, Eva ; Universitat Autònoma de Barcelona. Facultat de Biociències
2018
Grau en Ciències Biomèdiques [832]  
4.
1 p, 1.1 MB Genomic instability as a link between cancer and aging / Sebastián Pérez, Rubén ; Pallarès i Goitiz, Irantzu, dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Universitat Autònoma de Barcelona. Facultat de Biociències
2016
Grau en Bioquímica [814]  

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