Dalton, James A R - Resultats de la cerca - Dipòsit Digital de Documents de la UAB

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Resultats globals: 17 registres trobats en 0.02 segons.
Articles, 15 registres trobats Documents de recerca, 2 registres trobats

Articles	15 registres trobats 1 - 10 anar al registre:

19 p, 1.2 MB

Allosteric control of an asymmetric transduction in a G protein-coupled receptor heterodimer / Liu, Junke (University of Science and Technology, Wuhan, China) ; Zhang, Zongyong (University of Science and Technology, Wuhan, China) ; Moreno-Delgado, David (Université de Montpellier, France) ; Dalton, James A. R (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Rovira, Xavier (Université de Montpellier, France) ; Trapero, Ana (Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Barcelona) ; Goudet, Cyril (Université de Montpellier, France) ; Llebaria, Amadeu (Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Barcelona) ; Giraldo, Jesús (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Yuan, Qilin (University of Science and Technology, Wuhan, China) ; Rondard, Philippe (Université de Montpellier, France) ; Huang, Siluo (University of Science and Technology, Wuhan, China) ; Liu, Jianfeng (University of Science and Technology, Wuhan, China) ; Pin, Jean-Philippe (Université de Montpellier, France) ; Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i de Medicina Preventiva i Salut Pública
GPCRs play critical roles in cell communication. Although GPCRs can form heteromers, their role in signaling remains elusive. Here we used rat metabotropic glutamate (mGlu) receptors as prototypical dimers to study the functional interaction between each subunit. [...]
2017 - DOI (Digital Object Identifier)

10.7554/eLife.26985
eLife, Vol. 6 (august 2017)

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14 p, 3.1 MB

Analysis of positive and negative allosteric modulation in metabotropic glutamate receptors 4 and 5 with a dual ligand / Dalton, James A. R. (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Pin, Jean-Philippe (Université de Montpellier) ; Giraldo, Jesús (Universitat Autònoma de Barcelona. Institut de Neurociències)
As class C GPCRs and regulators of synaptic activity, human metabotropic glutamate receptors (mGluRs) 4 and 5 are prime targets for allosteric modulation, with mGlu5 inhibition or mGlu4 stimulation potentially treating conditions like chronic pain and Parkinson's disease. [...]
2017 - DOI (Digital Object Identifier)

10.1038/s41598-017-05095-5
Scientific reports, Vol. 7 (july 2017)

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12 p, 2.3 MB

Angiotensin II type 1/adenosine A receptor oligomers : a novel target for tardive dyskinesia / Oliveira, Paulo A. de (Universidade Federal de Santa Catarina, Trindade) ; Dalton, James A. R (Universitat Autònoma de Barcelona. Institut de Neurociències) ; López-Cano, Marc (Universitat de Barcelona. Institut de Neurociències) ; Ricarte, Adrià (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Morató, Xavier (Universitat de Barcelona. Institut de Neurociències) ; Matheus, Filipe C. (Universidade Federal de Santa Catarina, Trindade) ; Cunha, Andréia S. (Universidade Federal de Santa Catarina, Trindade) ; Müller, Christa E. (University of Bonn, Germany) ; Takahashi, Reinaldo N. (Universidade Federal de Santa Catarina, Trindade) ; Fernández-Dueñas, Víctor (Universitat de Barcelona. Institut de Neurociències) ; Giraldo, Jesús (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Prediger, Rui D. (Universidade Federal de Santa Catarina, Trindade) ; Ciruela, Francisco (Universitat de Barcelona. Institut de Neurociències)
Tardive dyskinesia (TD) is a serious motor side effect that may appear after long-term treatment with neuroleptics and mostly mediated by dopamine D receptors (DRs). Striatal DR functioning may be finely regulated by either adenosine A receptor (AR) or angiotensin receptor type 1 (ATR) through putative receptor heteromers. [...]
2017 - DOI (Digital Object Identifier)

10.1038/s41598-017-02037-z
Scientific reports, Vol. 7 (may 2017)

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9 p, 5.8 MB

Statistics for the analysis of molecular dynamics simulations : providing P values for agonist-dependent GPCR activation / Bruzzese, Agustín (Centro de Investigación Biomédica en Red de Salud Mental) ; Dalton, James A. R. (Centro de Investigación Biomédica en Red de Salud Mental) ; Giraldo, Jesús (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública)
Molecular dynamics (MD) is the common computational technique for assessing efficacy of GPCR-bound ligands. Agonist efficacy measures the capability of the ligand-bound receptor of reaching the active state in comparison with the free receptor. [...]
2020 - DOI (Digital Object Identifier)

10.1038/s41598-020-77072-4
Scientific reports, Vol. 10 (november 2020)

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24 p, 14.0 MB

Structural Assessment of Agonist Efficacy in the μ-Opioid Receptor : Morphine and Fentanyl Elicit Different Activation Patterns / Ricarte, Adrián (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Dalton, James A. R.. (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ; Giraldo, Jesús (Universitat Autònoma de Barcelona. Institut de Neurociències)
Over the past two decades, the opioid epidemic in the United States and Canada has evidenced the need for a better understanding of the molecular mechanisms of medications used to fight pain. Morphine and fentanyl are widely used in opiate-mediated analgesia for the treatment of chronic pain. [...]
2021 - DOI (Digital Object Identifier)

10.1021/acs.jcim.0c00890
Journal of Chemical Information and Modeling, Vol. 61 Núm. 3 (22 2021) , p. 1251-1274

2 documents

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39 p, 7.8 MB

Insights into adenosine A receptor activation through cooperative modulation of agonist and allosteric lipid interactions / Bruzzese, Agustín (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Dalton, James A. R.. (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Giraldo, Jesús (Universitat Autònoma de Barcelona. Institut de Neurociències)
UDTAULÍ.
The activation process of G protein-coupled receptors (GPCRs) has been extensively studied, both experimentally and computationally. In particular, Molecular Dynamics (MD) simulations have proven useful in exploring GPCR conformational space. [...]
2020 - DOI (Digital Object Identifier)

10.1371/journal.pcbi.1007818
PLoS computational biology, Vol. 16 (april 2020)

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11 p, 711.6 KB

Exploring the Activation Mechanism of the mGlu5 Transmembrane Domain / Lans, Isaias (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Díaz Sanzo, Óscar (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ; Dalton, James A. R.. (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ; Giraldo, Jesús (Universitat Autònoma de Barcelona. Institut de Neurociències)
UDTAULÍ.
As a class C GPCR and regulator of synaptic activity, mGlu5 is an attractive drug target, potentially offering treatment for several neurologic and psychiatric disorders. As little is known about the activation mechanism of mGlu5 at a structural level, potential of mean force calculations linked to molecular dynamics simulations were performed on the mGlu5 transmembrane domain crystal structure to explore various internal mechanisms responsible for its activation. [...]
2020 - DOI (Digital Object Identifier)

10.3389/fmolb.2020.00038
Frontiers in Molecular Biosciences, Vol. 7 (march 2020)

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25 p, 3.0 MB

Distinct dopamine D2 receptor antagonists differentially impact D2 receptor oligomerization / Wouters, Elise (Laboratory of Toxicology. Department of Bioanalysis. Faculty of Pharmaceutical Sciences. Ghent University) ; Ricarte Marín, Adrián (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Dalton, James A. R.. (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Giraldo, Jesús (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Stove, Christophe. (Laboratory of Toxicology. Department of Bioanalysis. Faculty of Pharmaceutical Sciences. Ghent University)
Dopamine D receptors (DR) are known to form transient homodimer complexes, of which the increased formation has already been associated with development of schizophrenia. Pharmacological targeting and modulation of the equilibrium of these receptor homodimers might lead to a better understanding of the critical role played by these complexes in physiological and pathological conditions. [...]
2019 - DOI (Digital Object Identifier)

10.3390/ijms20071686
International journal of molecular sciences, Vol. 20 Núm. 7 (january 2019) , p. 1686

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3 p, 404.9 KB

Descrit el possible mecanisme d'activació del receptor cannabinoide 1 / Díaz Sanzo, Óscar (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Dalton, James A. R.. (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Giraldo, Jesús (Universitat Autònoma de Barcelona. Institut de Neurociències)
Un estudi, publicat a la revista Journal of Medicinal Chemistry pels investigadors Óscar Díaz, James Dalton i Jesús Giraldo de l'Institut de Neurociències, descriu el possible mecanisme d'activació del receptor cannabinoide 1 (CB1). [...]
Un estudio, publicado en la revista Journal of Medicinal Chemistry por los investigadores Óscar Díaz, James Dalton y Jesús Giraldo del Instituto de Neurociencias, describe el posible mecanismo de activación del receptor cannabinoide 1 (CB1). [...]
A study published in the Journal of Medicinal Chemistry by the Neuroscience Institute researchers Óscar Díaz, James Dalton and Jesús Giraldo, describes the potential activation mechanism of cannabinoid receptor 1 (CB1). [...]
2019
UAB divulga, Octubre 2019, p. 1-3

3 documents

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10.

14 p, 7.0 MB

Structural insights into positive and negative allosteric regulation of a G protein-coupled receptor through protein-lipid interactions / Bruzzese, Agustín (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Gil, Carles (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Dalton, James A. R.. (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Giraldo, Jesús (Universitat Autònoma de Barcelona. Institut de Neurociències)
Lipids are becoming known as essential allosteric modulators of G protein-coupled receptor (GPCRs). However, how they exert their efects on GPCR conformation at the atomic level is still unclear. In light of recent experimental data, we have performed several long-timescale molecular dynamics (MD) simulations, totalling 24 μs, to rigorously map allosteric modulation and conformational changes in the β2 adrenergic receptor (β2AR) that occur as a result of interactions with three diferent phospholipids. [...]
2018 - DOI (Digital Object Identifier)

10.1038/s41598-018-22735-6
Scientific reports, Vol. 8 (2018) , art. 4456

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Documents de recerca	2 registres trobats

158 p, 24.3 MB

G protein-coupled receptors : providing mechanistic explanations to ligand-receptor and receptor-receptor interactions through in silico studies / Ricarte Marín, Adrián ; Giraldo, Jesús, dir. ; Dalton, James A. R, dir.
Els receptors acoblats a proteïnes G (GPCR) constitueixen la família més gran de proteïnes de membrana del genoma humà. Aquestes proteïnes de membrana estan formades per set hèlixs transmembrana connectades per bucles intracel·lulars i extracel·lulars. [...]
Los receptores acoplados a proteínas G (GPCR) constituyen la familia más grande de proteínas de membrana en el genoma humano. Estas proteínas de membrana están formadas por siete hélices transmembrana conectadas por bucles intracelulares y extracelulares. [...]
G protein-coupled receptors (GPCRs) constitute the largest family of membrane proteins in the human genome. These membrane proteins are made up of seven transmembrane helices connected by intracellular and extracellular loops. [...]
2022

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161 p, 13.6 MB

Investigation of the influence of the membrane lipid environment on g protein-coupled receptor activation by molecular dynamics simulations / Bruzzese Novoa, Agustín Alberto ; Giraldo, Jesús, dir. ; Dalton, James A. R..
Els receptors acoblats a proteïnes G (GPCRs) són importants dianes terapèutiques per a nombroses malalties. Si bé els GPCRs s'han estudiat àmpliament en les últimes dècades, els mecanismes moleculars que determinen la seva activació així com la seva modulació al·lostèrica per lípids de membrana no han estat elucidats íntegrament. [...]
Los receptores acoplados a proteínas G (GPCRs) son importantes dianas terapéuticas para numerosas enfermedades. Si bien los GPCRs se han estudiado ampliamente en las últimas décadas, los mecanismos moleculares que determinan su activación así como su modulación alostérica por lípidos de membrana no han sido elucidados en su totalidad. [...]
G-protein-coupled receptors (GPCRs) are important therapeutic targets for numerous diseases. Although GPCRs have been extensively studied in recent decades, the molecular mechanisms that determine their activation as well as their allosteric modulation by membrane lipids have not been fully elucidated. [...]
2021

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