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11 p, 330.9 KB |
Asthma control conundrum in clinical practice - Data from a two-stage Delphi survey and literature review
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Canonica, G. Walter (Humanitas University) ;
Spanevello, Antonio (Università degli Studi dell'Insubria) ;
Pérez de Llano, Luis (University Hospital Lucus Augusti (Lugo, Galícia)) ;
Domingo, Christian (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Blakey, John D (Curtin University) ;
Garcia, Gabriel (Hospital R Rossi) ;
Inoue, Hiromasa (Kagoshima University) ;
Dalcolmo, Margareth (Reference Center Hélio Fraga) ;
Yang, Dong (Fudan University) ;
Mokashi, Soniya (GlaxoSmithKline) ;
Kurne, Abhishek (Global Medical Affairs) ;
Butta, Aman Kapil (GSK Asia House) ;
Universitat Autònoma de Barcelona
Definitions and measures of asthma control used in clinical trials and practice often vary, as highlighted in the manuscript, "Is asthma control more than just an absence of symptoms? An expert consensus statement". [...]
2023 -  10.1016/j.dib.2023.109422
Data in brief, Vol. 50 (july 2023)
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9 p, 526.0 KB |
Burden of refractory and unexplained chronic cough on patients' lives : a cohort study
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Puente, Luis (Hospital Universitario Gregorio Marañón) ;
Dávila, Ignacio (Hospital Clínico Universitario (Salamanca)) ;
Quirce Gancedo, Santiago (Hospital Universitario La Paz (Madrid)) ;
Crespo Lessmann, Astrid (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Martínez-Moragón, Eva (Hospital Universitari Doctor Peset (València)) ;
Sola, Javier (Hospital Universitario Ramón y Cajal (Madrid)) ;
Nieto, María Luisa (Hospital Arnau de Vilanova (València)) ;
González-Barcala, Francisco-Javier (Universidad de Santiago de Compostela) ;
Cea-Calvo, Luis (Medical Affairs) ;
Sánchez-Jareño, Marta (Medical Affairs) ;
Rivas-Pardinas, Cristina (Medical Affairs) ;
Domingo, Christian (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Universitat Autònoma de Barcelona
Chronic cough (cough lasting for ≥8 weeks) can lead to significant impairment in quality of life (QoL). Using patient-reported outcomes, this cohort study assessed the perceived impact of chronic cough on QoL and everyday life in patients from outpatient hospital clinics with refractory chronic cough (RCC) or unexplained chronic cough (UCC). [...]
2023 - 10.1183/23120541.00425-2023
ERJ Open Research, Vol. 9 (september 2023)
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13 p, 1.1 MB |
Long-term efficacy of dupilumab in severe asthma by baseline oral corticosteroid dose
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Domingo, Christian (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Rabe, Klaus F. (Observational and Pragmatic Research Institute) ;
Price, David (Universitair Ziekenhuis Gent) ;
Brusselle, Guy (National Jewish Health) ;
Wechsler, Michael E. (Regeneron Pharmaceuticals Inc.) ;
Xia, Changming (Sanofi) ;
Pandit-Abid, Nami (Sanofi) ;
Gall, Rebecca (Regeneron Pharmaceuticals Inc.) ;
Rowe, Paul J. (Sanofi) ;
Deniz, Yamo (Regeneron Pharmaceuticals Inc.) ;
Jacob-Nara, Juby A. (Sanofi) ;
Radwan, Amr (Regeneron Pharmaceuticals Inc.) ;
Universitat Autònoma de Barcelona
Dupilumab has been shown to improve clinical outcomes long term while reducing oral corticosteroid (OCS) dose in patients with severe OCS-dependent asthma. This post hoc analysis assesses the impact of OCS dose at baseline (≤10 or >10 mg·day −1) on long-term outcomes of dupilumab treatment. [...]
2023 - 10.1183/23120541.00056-2023
ERJ Open Research, Vol. 9 (november 2023)
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13 p, 1.7 MB |
Consensus goals and standards for specialist cough clinics : the NEUROCOUGH international Delphi study
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Song, Woo-Jung (University of Ulsan College of Medicine) ;
Dupont, Lieven (University Hospitals Leuven (Bèlgica)) ;
Birring, Surinder S. (King's College London) ;
Chung, Kian Fan (Imperial College London) ;
Dąbrowska, Marta (Medical University of Warsaw) ;
Dicpinigaitis, Peter (Albert Einstein College of Medicine and Montefiore Medical Center) ;
Domingo, Christian (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Fontana, Giovanni (University of Florence) ;
Gibson, Peter G. (University of Newcastle) ;
Guilleminault, Laurent (Hôpital Larrey and Center for Pathophysiology Toulouse Purpan) ;
Hull, James H. (Royal Brompton Hospital (Londres)) ;
Idzko, Marco (Medical University of Vienna) ;
Kardos, Peter (Maingau Clinic of the Red Cross) ;
Kim, Hyun Jung (Korea University College of Medicine) ;
Lai, Kefang (Guangzhou Institute of Respiratory Health) ;
Lavorini, Federico (University of Florence) ;
Millqvist, Eva (University of Gothenburg) ;
Morice, Alyn H. (University of Hull) ;
Niimi, Akio (Nagoya City University) ;
Parker, Sean M. (North Tyneside General Hospital) ;
Satia, Imran (McMaster University (Canadà)) ;
Smith, Jaclyn A. (University of Manchester) ;
van den Berg, Jan Willem (Isala Hospital) ;
McGarvey, Lorcan P. (Queen's University Belfast) ;
Universitat Autònoma de Barcelona
Current guidelines on the management of chronic cough do not provide recommendations for the operation of specialist cough clinics. The objective of the present study was to develop expert consensus on goals and standard procedures for specialist cough clinics. [...]
2023 - 10.1183/23120541.00618-2023
ERJ Open Research, Vol. 9 (november 2023)
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12 p, 3.1 MB |
Remission outcomes in severe eosinophilic asthma with mepolizumab therapy : Analysis of the REDES study
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Pavord, Ian (University of Oxford) ;
Gardiner, Frances (GSK House) ;
Heaney, Liam G. (Queen's University Belfast) ;
Domingo, Christian (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Price, Robert G. (Biostatistics, GSK) ;
Pullan, Alison (Plus-Project Partnership Ltd) ;
Oppenheimer, John (UMDNJ-Rutgers New Jersey Medical School) ;
Brusselle, Guy (Universitair Ziekenhuis Gent) ;
Nagase, Hiroyuki (Teikyo University School of Medicine) ;
Chupp, Geoffrey (Yale Center for Asthma and Airways Disease (YCAAD)) ;
Pizzichini, Emilio (Federal University of Santa Catarina) ;
Bañas-Conejero, David (GSK) ;
Howarth, Peter (GSK House) ;
Universitat Autònoma de Barcelona
Clinical remission as a multicomponent treatment goal in severe asthma is being explored in clinical practice. This post hoc analysis used data from the REDES study to assess the proportion of patients with severe eosinophilic asthma achieving our multicomponent definitions of clinical remission after 1 year of mepolizumab treatment. [...]
2023 - 10.3389/fimmu.2023.1150162
Frontiers in immunology, Vol. 14 (april 2023)
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9 p, 1.4 MB |
Treatment patterns of monoclonal antibodies in patients with severe uncontrolled asthma treated by pulmonologists in Spain
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Casas-Maldonado, Francisco (Hospital Universitario San Cecilio (Granada)) ;
Álvarez Gutiérrez, Francisco Javier (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Blanco-Aparicio, Marina (Complejo Hospitalario Universitario de A Coruña) ;
Domingo, Christian (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Cisneros, Carolina (Hospital Universitario de la Princesa (Madrid)) ;
Soto-Campos, Gregorio (Hospital Universitario de Jerez (Jerez de la Frontera)) ;
Román Bernal, Berta (Hospital Dr. José Molina Orosa, Lanzarote) ;
González-Barcala, Francisco Javier (Hospital Clínico Universitario (Santiago de Compostela, Galícia)) ;
Universitat Autònoma de Barcelona
Introduction and objectives: The use of monoclonal antibody (mAb)-based therapies is becoming the new standard of care for severe uncontrolled asthma (SUA). Even though patients may qualify for one or more of these targeted treatments, based on different clinical criteria, a global vision of mAb prescription management in a large sample of hospitals is not well characterised in Spain. [...]
Introducción y objetivos: El uso de terapias basadas en anticuerpos monoclonales (mAb) se está convirtiendo en el nuevo estándar de atención para el asma grave no controlada (AGNC). A pesar de que los pacientes pueden optar a uno o varios de estos tratamientos dirigidos, con base en diferentes criterios clínicos, en España no se ha caracterizado bien una visión global de la gestión de la prescripción de mAb en una gran muestra de hospitales. [...]
Elsevier España, 2023 - 10.1016/j.opresp.2023.100252
Open Respiratory Archives, Vol. 5 Num. 3 (jul. 2023) , art. 100252
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7 p, 599.5 KB |
Efficacy and Potential Positioning of Tezepelumab in the Treatment of Severe Asthma
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Plaza, Vicente (Institut d'Investigació Biomèdica Sant Pau) ;
Cañete, Conxa (Consorci Sanitari Integral (L'Hospitalet de Llobregat)) ;
Domingo, Christian (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Martinez Rivera, Carlos (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Muñoz Gall, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Los excelentes resultados de los anticuerpos monoclonales en el tratamiento del asma grave no controlada (AGNC) constituyen un hito en el tratamiento actual de los trastornos asmáticos. Sin embargo, aún quedan varios aspectos complementarios susceptibles de mejorar para los que se esperan contribuciones decisivas de los nuevos biofármacos, entre los cuales se encuentra el tezepelumab, un anticuerpo monoclonal que bloquea la linfopoyetina estromal tímica (TSLP). [...]
The excellent results for monoclonal antibodies in the treatment of severe uncontrolled asthma (SUCA) represent a milestone in current treatment of asthmatic disorders. Remaining, however, are several subsidiary areas for improvement in which new biologics are expected to make a decisive contribution. [...]
2023 - 10.1016/j.opresp.2022.100231
Open Respiratory Archives, Vol. 5 Núm. 2 (2023) , p. 100231
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