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1.
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19 p, 1.4 MB |
Novel, in-natural-infection subdominant HIV-1 CD8 + T-cell epitopes revealed in human recipients of conserved-region T-cell vaccines
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Borthwick, Nicola (The Jenner Institute, University of Oxford) ;
Lin, Zhansong (Kumamoto University, Japan) ;
Akahoshi, Tomohiro (Kumamoto University, Japan) ;
Llano Montero, Anuska (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Silva-Arrieta, Sandra (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ahmed, Tina (University of Oxford) ;
Dorrell, Lucy (University of Oxford) ;
Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Murakoshi, Hayato (Kumamoto University, Japan) ;
Takiguchi, Masafumi (Kumamoto University, Japan) ;
Hanke, Tomáš (University of Oxford)
Fine definition of targeted CD8 + T-cell epitopes and their human leucocyte antigen (HLA) class I restriction informs iterative improvements of HIV-1 T-cell vaccine designs and may predict early vaccine success or failure. [...]
2017 -  10.1371/journal.pone.0176418
PloS one, Vol. 12 (april 2017)
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2.
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16 p, 2.9 MB |
Therapeutic Vaccination Refocuses T-cell Responses Towards Conserved Regions of HIV-1 in Early Treated Individuals (BCN 01 study)
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Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Manzardo, Christian (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Sánchez-Bernabeu, Álvaro (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Coll, Pep (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Moron-Lopez, Sara (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Puertas, Maria C. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Rosás-Umbert, Miriam (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Cobarsi, Patricia (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Escrig, Roser (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Pérez-Álvarez, Núria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ruiz, Irene (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Rovira, Cristina (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Meulbroek, Michael (Projecte del Noms, BCN Checkpoint, Barcelona, Spain) ;
Crook, Alison (The Jenner Institute, University of Oxford, Oxford, UK) ;
Borthwick, Nicola (The Jenner Institute, University of Oxford, Oxford, UK) ;
Wee, Edmund G. (The Jenner Institute, University of Oxford, Oxford, UK) ;
Yang, Hongbing (University of Oxford. Nuffield Department of Medicine) ;
Miró, José M (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Dorrell, Lucy (University of Oxford. Nuffield Department of Medicine) ;
Pérez-Álvarez, Núria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Hanke, Tomáš (International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan) ;
Universitat Autònoma de Barcelona
Strong and broad antiviral T-cell responses targeting vulnerable sites of HIV-1 will likely be a critical component for any effective cure strategy. BCN01 trial was a phase I, open-label, non-randomized, multicenter study in HIV-1-positive individuals diagnosed and treated during early HIV-1 infection to evaluate two vaccination regimen arms, which differed in the time (8 versus 24 week) between the ChAdV63. [...]
2019 - 10.1016/j.eclinm.2019.05.009
EClinicalMedicine, Vol. 11 (june 2019) , p. 65-80
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3.
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1 p, 240.0 KB |
Corrigendum to 'Therapeutic vaccination refocuses T-cell responses towards conserved regions of HIV-1 in early treated individuals (BCN 01 study)' EClinicalMedicine 11 (2019) 65-80
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Mothe, Beatriz (Universitat de Vic - Universitat Central de Catalunya) ;
Manzardo, Christian (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Sanchez-Bernabeu, Alvaro (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Coll, Pep (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Moron-Lopez, Sara (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Puertas, Maria C.. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Rosás-Umbert, Miriam (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Cobarsi, Patricia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Escrig, Roser (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pérez-Álvarez, Núria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ruiz, Irene (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Rovira, Cristina (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Meulbroek, Michael (Projecte del Noms, BCN Checkpoint, Barcelona, Spain) ;
Crook, Alison (The Jenner Institute, University of Oxford, Oxford, UK) ;
Borthwick, Nicola (The Jenner Institute, University of Oxford, Oxford, UK) ;
Wee, Edmund G. (The Jenner Institute, University of Oxford, Oxford, UK) ;
Yang, Hongbing (University of Oxford. Nuffield Department of Medicine) ;
Miró, José M (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Dorrell, Lucy (University of Oxford. Nuffield Department of Medicine) ;
Pérez-Álvarez, Núria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Hanke, Tomáš (International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan) ;
Universitat Autònoma de Barcelona
2020 - 10.1016/j.eclinm.2019.100250
EClinicalMedicine, Vol. 18 (january 2020)
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4.
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15 p, 676.0 KB |
Mechanisms of abrupt loss of virus control in a cohort of previous HIV controllers
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Rosás Umbert, Miriam (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Llano Montero, Anuska (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Bellido, Rocío (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Olvera, Alex (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ruiz-Riol, Marta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Rocafort, Muntsa (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Fernández, Marco A. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Cobarsi, Patricia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Crespo Casal, Manuel (Complexo Hospitalario Universitario de Vigo) ;
Dorrell, Lucy (Nuffield Department of Medicine, University of Oxford) ;
Del Romero, Jorge (Centro Sanitario Sandoval, Madrid) ;
Alcami, Jose (Instituto de Salud Carlos III) ;
Paredes, Roger (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
A few individuals can control HIV infection without the need for antiretroviral treatment and are referred to as HIV controllers. We have studied HIV controllers who suddenly lose this ability and present with high in vivo viral replication and decays in their CD4 + T-cell counts to identify potential immune and virological factors that were responsible for initial virus control. [...]
2019 - 10.1128/JVI.01436-18
Journal of Virology, Vol. 93 (february 2019)
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5.
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11 p, 1018.7 KB |
Evaluation of the immunogenicity and impact on the latent HIV-1 reservoir of a conserved region vaccine, MVA.HIVconsv, in antiretroviral therapy-treated subjects
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Hancock, Gemma ;
Moron-Lopez, Sara (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Kopycinski, Jakub ;
Puertas, Maria C.. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Giannoulatou, Eleni (University of New South Wales) ;
Rose, Annie ;
Salgado, Maria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Hayton, Emma-Jo ;
Crook, Alison ;
Morgan, Catharine ;
Angus, Brian ;
Chen, Fabian ;
Yang, Hongbing ;
Martinez-Picado, Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Hanke, Tomáš ;
Dorrell, Lucy ;
Universitat Autònoma de Barcelona
Introduction : Vaccines may be key components of a curative strategy for HIV-1. We investigated whether a novel immunogen, HIVconsv, designed to re-direct T cell responses to conserved viral epitopes, could impact the HIV-1 reservoir in chronic antiretroviral therapy (ART)-treated subjects when delivered by modified vaccinia virus Ankara (MVA). [...]
2017 - 10.7448/IAS.20.1.21171
Journal of the International AIDS Society, Vol. 20 (may 2017)
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6.
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10 p, 868.0 KB |
Defining the HLA class I-associated viral antigen repertoire from HIV-1-infected human cells
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Ternette, Nicola (University of Oxford. The Jenner Institute, Nuffield Department of Medicine) ;
Yang, Hongbing (University of Oxford. Nuffield Department of Medicine) ;
Partridge, Thomas (University of Oxford. Nuffield Department of Medicine) ;
Llano Montero, Anuska (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Cedeño, Samandhy (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Fischer, Roman (University of Oxford. Nuffield Department of Medicine) ;
Charles, Philip D. (University of Oxford. Nuffield Department of Medicine) ;
Dudek, Nadine L. (Monash University. Department of Biochemistry and Molecular Biology) ;
Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Crespo Casal, Manuel (Hospital Universitari Vall d'Hebron) ;
Fischer, William M. (Los Alamos National Laboratory. Group T-6, Theoretical Biology) ;
Korber, Bette T. M. (Los Alamos National Laboratory. Group T-6, Theoretical Biology) ;
Nielsen, Morten (Technical University of Denmark. Center for Biological Sequence Analysis) ;
Borrow, Persephone (University of Oxford. Nuffield Department of Medicine) ;
Purcell, Anthony W. (Monash University. Department of Biochemistry and Molecular Biology) ;
Brander, Christian (Institució Catalana de Recerca i Estudis Avançats) ;
Dorrell, Lucy (University of Oxford. The Jenner Institute, Nuffield Department of Medicine) ;
Kessler, Benedikt M. (University of Oxford. Nuffield Department of Medicine) ;
Hanke, Tomáš (University of Oxford. The Jenner Institute, Nuffield Department of Medicine) ;
Universitat Autònoma de Barcelona
Recognition and eradication of infected cells by cytotoxic T lymphocytes is a key defense mechanism against intracellular pathogens. High-throughput definition of HLA class I-associated immunopeptidomes by mass spectrometry is an increasingly important analytical tool to advance our understanding of the induction of T-cell responses against pathogens such as HIV-1. [...]
2015 - 10.1002/eji.201545890
European Journal of Immunology, Vol. 46 (november 2015) , p. 60-69
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7.
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22 p, 877.6 KB |
Identification of effective subdominant anti-HIV-1 CD8+ T cells within entire post-infection and post-vaccination immune responses
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Hancock, Gemma (University of Oxford) ;
Yang, Hongbing (University of Oxford) ;
Yorke, Elisabeth (University of Toronto) ;
Wainwright, Emma (Royal Berkshire NHS Foundation Trust (Reading, Gran Bretanya)) ;
Bourne, Victoria (University of Oxford) ;
Frisbee, Alyse (Duke University (Durham, Estats Units d'Amèrica)) ;
Payne, Tamika L. (Duke University (Durham, Estats Units d'Amèrica)) ;
Berrong, Mark (Duke University (Durham, Estats Units d'Amèrica)) ;
Ferrari, Guido (Duke University (Durham, Estats Units d'Amèrica)) ;
Chopera, Denis (University of Cape Town) ;
Hanke, Tomáš (University of Oxford) ;
Mothe, Beatriz (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Brander, Christian (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
McElrath, M. Juliana (Fred Hutchinson Cancer Research Center (Seattle, Estats Units d'Amèrica)) ;
McMichael, Andrew (University of Oxford) ;
Goonetilleke, Nilu (University of North Carolina School of Medicine) ;
Tomaras, Georgia D. (Duke University (North Carolina, Estats Units d'Amèrica)) ;
Frahm, Nicole (Fred Hutchinson Cancer Research Center (Seattle, Estats Units d'Amèrica)) ;
Dorrell, Lucy (University of Oxford)
Abstract. Defining the components of an HIV immunogen that could induce effective CD8+ T cell responses is critical to vaccine development. We addressed this question by investigating the viral targets of CD8+ T cells that potently inhibit HIV replication in vitro, as this is highly predictive of virus control in vivo. [...]
2015 - 10.1371/journal.ppat.1004658
PLOS pathogens, Vol. 11 Núm. 2 (february 2015)
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8.
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23 p, 3.3 MB |
A human immune data-informed vaccine concept elicits strong and broad T-cell specificities associated with HIV-1 control in mice and macaques
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Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Hu, Xintao (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ;
Llano Montero, Anuska (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Rosati, Margherita (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ;
Olvera, Alex (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Kulkarni, Viraj (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ;
Valentin, Antonio (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ;
Alicea, Cándido (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ;
Pilkington, Guy R. (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ;
Sardesai, Niranjan Y. (Inovio Pharmaceuticals) ;
Rocafort, Muntsa (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Crespo Casal, Manuel (Hospital Universitari Vall d'Hebron) ;
Carrillo, Jorge (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Marco, Andrés (Centre Penitenciari d'Homes (Barcelona, Catalunya)) ;
Mullins, James I. (University of Washington (Estats Units d'Amèrica)) ;
Dorrell, Lucy (John Radcliffe Hospital (Oxford, Regne Unit)) ;
Hanke, Tomáš (University of Oxford (Regne Unit)) ;
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Pavlakis, George N. (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ;
Felber, Barbara K. (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ;
Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Universitat Autònoma de Barcelona
BACKGROUND: None of the HIV T-cell vaccine candidates that have reached advanced clinical testing have been able to induce protective T cell immunity. A major reason for these failures may have been suboptimal T cell immunogen designs. [...]
2015 - 10.1186/s12967-015-0392-5
Journal of translational medicine, Vol. 13 Núm. 60 (february 2015)
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