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Articles, 4 records found

Articles	4 records found

15 p, 1.2 MB

GRP78 at the centre of the stage in cancer and neuroprotection / Casas Louzao, Caty (Universitat Autònoma de Barcelona. Institut de Neurociències)
The 78-kDa glucose-regulated protein GRP78, also known as BiP and HSP5a, is a multifunctional protein with activities far beyond its well-known role in the unfolded protein response (UPR) which is activated after endoplasmic reticulum (ER) stress in the cells. [...]
2017 - DOI (Digital Object Identifier)

10.3389/fnins.2017.00177
Frontiers in Neuroscience, Vol. 11, (May 2017) , p. 177

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13 p, 475.3 KB

Reciprocal Effects of Antiretroviral Drugs Used To Treat HIV Infection on the Fibroblast Growth Factor 21/β-Klotho System / Moure, Ricardo (Universitat de Barcelona. Institut de Biomedicina) ; Domingo, Pere (Domingo Pedrol) (Institut d'Investigació Biomèdica Sant Pau) ; Villarroya, Joan (Institut d'Investigació Biomèdica Sant Pau) ; Gasa, Laura (Universitat de Barcelona. Institut de Biomedicina) ; Gallego-Escuredo, José Miguel (Institut de Recerca Biomèdica de Lleida) ; Quesada-López, Tania (Universitat de Barcelona. Institut de Biomedicina) ; Morón-Ros, Samantha (Universitat de Barcelona. Institut de Biomedicina) ; Maroto, Alberto F. (Universitat de Barcelona. Institut de Biomedicina) ; Mateo, Gracia M. (Institut d'Investigació Biomèdica Sant Pau) ; Domingo, Joan Carles (Universitat de Barcelona. Institut de Biomedicina) ; Villarroya, Francesc (Universitat de Barcelona. Institut de Biomedicina) ; Girlat, Marta (Universitat de Barcelona. Institut de Biomedicina) ; Universitat Autònoma de Barcelona
Following antiretroviral therapy, HIV-infected patients show increased circulating levels of the antidiabetic hormone fibroblast growth factor 21 (FGF21). In contrast, the expression of the FGF21-obligatory coreceptor β-Klotho (KLB) is reduced in target tissues. [...]
2018 - DOI (Digital Object Identifier)

10.1128/AAC.00029-18
Antimicrobial Agents and Chemotherapy, Vol. 62 (may 2018)

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15 p, 4.6 MB

Hepatic regulation of VLDL receptor by PPARβ/δ and FGF21 modulates non-alcoholic fatty liver disease / Zarei, Mohammad (Universitat de Barcelona. Departament de Farmacologia, Toxicologia i Química Terapèutica) ; Barroso, Emma (Universitat de Barcelona. Departament de Farmacologia, Toxicologia i Química Terapèutica) ; Palomer, Xavier (Universitat de Barcelona. Departament de Farmacologia, Toxicologia i Química Terapèutica) ; Dai, Jianli (University of the Chinese Academy of Sciences. Institute for Nutritional Sciences. Key Laboratory of Nutrition and Metabolism) ; Rada, Patricia (Instituto de Salud Carlos III. Centro de Investigación Biomédica en Red) ; Quesada-López, Tania (Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular) ; Escolà-Gil, Joan Carles (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Cedó, Lídia (Institut d'Investigació Biomèdica Sant Pau) ; Zali, Mohammad Reza (Shahid Beheshti University of Medical Sciences. Research Institute for Gastroenterology and Liver Diseases) ; Molaei, Mahsa (Shahid Beheshti University of Medical Sciences. Research Institute for Gastroenterology and Liver Diseases) ; Dabiri, Reza (Semnan University of Medical Sciences. lnternal Medicine Department) ; Vázquez, Santiago (Universitat de Barcelona. Departament de Farmacologia, Toxicologia i Química Terapèutica) ; Pujol Bech, Eugenia (Universitat de Barcelona. Departament de Farmacologia, Toxicologia i Química Terapèutica) ; Valverde, Ángela M. (Instituto de Investigaciones Biomédicas "Alberto Sols") ; Villarroya, Francesc (Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular) ; Liu, Yong (Wuhan University. Institute for Advanced Studies) ; Wahli, Walter (Nanyang Technological University. Lee Kong Chian School of Medicine) ; Vázquez-Carrera, Manuel (Universitat de Barcelona. Departament de Farmacologia, Toxicologia i Química Terapèutica) ; Universitat Autònoma de Barcelona
The very low-density lipoprotein receptor (VLDLR) plays an important role in the development of hepatic steatosis. In this study, we investigated the role of Peroxisome Proliferator-Activated Receptor (PPAR)β/δ and fibroblast growth factor 21 (FGF21) in hepatic VLDLR regulation. [...]
2018 - DOI (Digital Object Identifier)

10.1016/j.molmet.2017.12.008
Molecular metabolism, Vol. 8 (Feb. 2018) , p. 117-131

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19 p, 8.9 MB

Tauroursodeoxycholic bile acid arrests axonal degeneration by inhibiting the unfolded protein response in X-linked adrenoleukodystrophy / Launay, Nathalie (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Ruiz, Montserrat (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Grau-López, Laia (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Ortega, Francisco J. (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Ilieva, Ekaterina V. (Global data, London, UK) ; Martínez, Juan José (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Galea, Elena (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Ferrer, Isidro (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Knecht, Erwin (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Pujol, Aurora 1968- (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Fourcade, Stéphane (Centro de Investigación Biomédica en Red de Enfermedades Raras)
The online version of this article (doi:10. 1007/s00401-016-1655-9) contains supplementary material, which is available to authorized users.
2016 - DOI (Digital Object Identifier)

10.1007/s00401-016-1655-9
Acta Neuropathologica, Vol. 133 (december 2016) , p. 283-301

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