Home > Search Results: Enriquez-Barreto, Lilian
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Articles, 5 records found
Articles 5 records found  
1.
12 p, 995.9 KB The PI3K signaling pathway as a pharmacological target in Autism related disorders and Schizophrenia / Enríquez-Barreto, Lilian (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Morales, Miguel (Universitat Autònoma de Barcelona. Institut de Neurociències)
This review is focused in PI3K's involvement in two widespread mental disorders: Autism and Schizophrenia. A large body of evidence points to synaptic dysfunction as a cause of these diseases, either during the initial phases of brain synaptic circuit's development or later modulating synaptic function and plasticity. [...]
2016 - 10.1186/s40591-016-0047-9
Molecular and Cellular Therapies, Vol. 4 (february 2016)  
Detailed record - Creative Commons
2.
18 p, 3.4 MB Learning improvement after PI3K activation correlates with de novo formation of functional small spines / Enríquez-Barreto, Lilian (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Cuesto, Germán (Centro de Investigación Biomédica (La Rioja)) ; Domínguez Iturza, Nuria (Centro de Investigación Biomédica (La Rioja)) ; Gavilán, Elena (Universidad de Sevilla. Instituto de Biomedicina de Sevilla) ; Ruano, Diego (Universidad de Sevilla. Instituto de Biomedicina de Sevilla) ; Sandi, Carmen (École Polytechnique Fédérale de Lausanne (Suïssa). Brain Mind Institute) ; Fernández-Ruiz, Antonio (Instituto Cajal (Consejo Superior de Investigaciones Científicas)) ; Martín-Vázquez, Gonzalo (Instituto Cajal (Consejo Superior de Investigaciones Científicas)) ; Herreras, Oscar (Instituto Cajal (Consejo Superior de Investigaciones Científicas)) ; Morales, Miguel (Centro de Investigación Biomédica (La Rioja)) ; Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular
PI3K activation promotes the formation of synaptic contacts and dendritic spines, morphological features of glutamatergic synapses that are commonly known to be related to learning processes. In this report, we show that in vivo administration of a peptide that activates the PI3K signaling pathway increases spine density in the rat hippocampus and enhances the animals' cognitive abilities, while in vivo electrophysiological recordings show that PI3K activation results in synaptic enhancement of Schaffer and stratum lacunosum moleculare inputs. [...]
2014 - 10.3389/fnmol.2013.00054
Frontiers in molecular neuroscience, Vol. 6 (January 2014) , art. 54  
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3.
33 p, 2.7 MB CRTC1 function during memory encoding is disrupted in neurodegeneration / Parra-Damas, Arnaldo (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Chen, Meng (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Enríquez-Barreto, Lilian (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Ortega, Laura (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Acosta, Sara (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Camats Perna, Judith (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Fullana, M. Neus (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Aguilera, José (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Rodríguez Álvarez, José (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Saura Antolín, Carlos (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Methods: We evaluated the activation of CRTC1 in the hippocampus of control mice and mice lacking the Alzheimer's disease-linked presenilin genes (presenilin conditional double knockout [PS cDKO]) after one-trial contextual fear conditioning by using biochemical, immunohistochemical, and gene expression analyses. [...]
2016 - 10.1016/j.biopsych.2016.06.025
Biological psychiatry, Vol. 81, Num. 2 (January 2017) , p. 111-123  
Detailed record - Creative Commons
4.
24 p, 5.5 MB GSK3β inhibition promotes synaptogenesis in Drosophila and mammalian neurons / Cuesto, Germán (Centro de Investigación Biomédica de La Rioja (Logronyo)) ; Jordán-Álvarez, Sheila (Instituto Cajal (Consejo Superior de Investigaciones Científicas)) ; Enríquez-Barreto, Lilian (Centro de Investigación Biomédica de La Rioja (Logronyo)) ; Ferrús, Alberto (Instituto Cajal (Consejo Superior de Investigaciones Científicas)) ; Morales, Miguel (Centro de Investigación Biomédica de La Rioja (Logronyo)) ; Acebes, Ángel (Instituto Cajal (Consejo Superior de Investigaciones Científicas))
The PI3K-dependent activation of AKT results in the inhibition of GSK3β in most signaling pathways. These kinases regulate multiple neuronal processes including the control of synapse number as shown for Drosophila and rodents. [...]
2015 - 10.1371/journal.pone.0118475
PloS one, Vol. 10 Núm. 3 (March 2015) , e0118475  
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5.
14 p, 2.8 MB Gene expression parallels synaptic excitability and plasticity changes in Alzheimer's disease / Saura Antolín, Carlos (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Parra-Damas, Arnaldo (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Enríquez-Barreto, Lilian (Universitat Autònoma de Barcelona. Institut de Neurociències)
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by abnormal accumulation of β-amyloid and tau and synapse dysfunction in memory-related neural circuits. Pathological and functional changes in the medial temporal lobe, a region essential for explicit memory encoding, contribute to cognitive decline in AD. [...]
2015 - 10.3389/fncel.2015.00318
Frontiers in cellular neuroscience, Vol. 9 Núm. 318 (2015)  
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