Resultados globales: 83 registros encontrados en 0.02 segundos.
Artículos, Encontrados 62 registros
Documentos de investigación, Encontrados 21 registros
Artículos Encontrados 62 registros  1 - 10siguientefinal  ir al registro:
1.
15 p, 4.7 MB Epigenetic inactivation of the 5-methylcytosine RNA methyltransferase NSUN7 is associated with clinical outcome and therapeutic vulnerability in liver cancer / Ortiz-Barahona, Vanessa (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Soler, Marta (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Davalos, Veronica (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; García-Prieto, Carlos A. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Janin, Maxime (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Setien, Fernando (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Fernández-Rebollo, Irene (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Bech-Serra, Joan J. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; De La Torre, Carolina (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Guil, Sonia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Villanueva, Alberto (Institut d'Investigació Biomèdica de Bellvitge) ; Zhang, Pei Hong (Fudan University, Shanghai, China) ; Yang, Li (Fudan University, Shanghai, China) ; Guarnacci, Marco (Australian National University, Canberra, Australia) ; Schumann, Ulrike (Australian National University, Canberra, Australia) ; Preiss, Thomas (Australian National University, Canberra, Australia) ; Balaseviciute, Ugne (Hospital Clínic i Provincial de Barcelona) ; Montal, Robert (Universitat de Lleida) ; Llovet, Josep M. (Hospital Clínic i Provincial de Barcelona) ; Esteller, Manel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Background: RNA modifications are important regulators of transcript activity and an increasingly emerging body of data suggests that the epitranscriptome and its associated enzymes are altered in human tumors. [...]
2023 - 10.1186/s12943-023-01785-z
Molecular cancer, Vol. 22 Núm. 1 (may 2023)  
2.
29 p, 401.7 KB Epigenetic targets in B- and T-cell lymphomas : latest developments / Ribeiro, Marcelo L. (Sao Francisco University Medical School) ; Sánchez Vinces, Salvador (Sao Francisco University Medical School) ; Mondragón, Laura (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Roué, Gaël (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Non-Hodgkin's lymphomas (NHLs) comprise a diverse group of diseases, either of mature B-cell or of T-cell derivation, characterized by heterogeneous molecular features and clinical manifestations. While most of the patients are responsive to standard chemotherapy, immunotherapy, radiation and/or stem cell transplantation, relapsed and/or refractory cases still have a dismal outcome. [...]
2023 - 10.1177/20406207231173485
Therapeutic Advances in Hematology, Vol. 14 (1-12 2023)  
3.
9 p, 1.5 MB Validation of a DNA methylation microarray for 285,000 CpG sites in the mouse genome / García-Prieto, Carlos A (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Álvarez-Errico, Damiana (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Musulen, Eva (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Bueno-Costa, Alberto (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Vazquez Prat, Berta Nieves (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Vaquero, Alejandro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Mouse has been extensively used as a model organism in many studies to characterize biological pathways and drug effects and to mimic human diseases. Similar DNA sequences between both species facilitate these types of experiments. [...]
2022 - 10.1080/15592294.2022.2053816
Epigenetics, Vol. 17 Núm. 12 (december 2022) , p. 1677-1685  
4.
13 p, 6.3 MB Validation of the new EPIC DNA methylation microarray (900K EPIC v2) for high-throughput profiling of the human DNA methylome / Noguera-Castells, Aleix (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; García-Prieto, Carlos A. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Álvarez-Errico, Damiana (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
DNA methylation, one of the best characterized epigenetic marks in the human genome, plays a pivotal role in gene transcription regulation and other biological processes in humans. On top of that, the DNA methylome undergoes profound changes in cancer and other disorders. [...]
2023 - 10.1080/15592294.2023.2185742
Epigenetics, Vol. 18 Núm. 1 (december 2023)  
5.
49 p, 3.2 MB Cancer epigenetics in clinical practice / Davalos, Veronica (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Cancer development is driven by the accumulation of alterations affecting the structure and function of the genome. Whereas genetic changes disrupt the DNA sequence, epigenetic alterations contribute to the acquisition of hallmark tumor capabilities by regulating gene expression programs that promote tumorigenesis. [...]
2023 - 10.3322/caac.21765
CA Cancer Journal for Clinicians, Vol. 73 Núm. 4 (2023) , p. 376-424  
6.
14 p, 8.9 MB Epigenetic activation of antiviral sensors and effectors of interferon response pathways during SARS-CoV-2 infection / Bińkowski, Jan (Institució Catalana de Recerca i Estudis Avançats) ; Taryma-Leśniak, Olga (Institució Catalana de Recerca i Estudis Avançats) ; Łuczkowska, Karolina (Pomeranian Medical University in Szczecin, Poland) ; Niedzwiedź, Anna (Independent Public Regional Hospital in Szczecin, Poland) ; Lechowicz, Kacper (Pomeranian Medical University in Szczecin, Poland) ; Strapagiel, Dominik (University of Lodz, Poland) ; Jarczak, Justyna (University of Lodz, Poland) ; Davalos, Veronica (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Pujol, Aurora 1968- (Institut d'Investigació Biomèdica de Bellvitge) ; Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Kotfis, Katarzyna (Pomeranian Medical University in Szczecin, Poland) ; Machaliński, Boguslaw (Pomeranian Medical University in Szczecin, Poland) ; Parczewski, Milosz (Pomeranian Medical University in Szczecin, Poland) ; Wojdacz, Tomasz K. (Aarhus University, Denmark)
Recent studies have shown that methylation changes identified in blood cells of COVID-19 patients have a potential to be used as biomarkers of SARS-CoV-2 infection outcomes. However, different studies have reported different subsets of epigenetic lesions that stratify patients according to the severity of infection symptoms, and more importantly, the significance of those epigenetic changes in the pathology of the infection is still not clear. [...]
2022 - 10.1016/j.biopha.2022.113396
Biomedicine & pharmacotherapy, Vol. 153 (september 2022)  
7.
22 p, 8.7 MB Synthetic Epigenetic Reprogramming of Mesenchymal to Epithelial States Using the CRISPR/dCas9 Platform in Triple Negative Breast Cancer / Waryah, Charlene (University of Western Australia) ; Cursons, Joseph (Monash University, Australia) ; Foroutan, Momeneh (Department of Biochemistry and Molecular Biology. Monash University, Australia) ; Pflueger, Christian (University of Western Australia) ; Wang, Edina (University of Western Australia) ; Molania, Ramyar (University of Melbourne, Australia) ; Woodward, Eleanor (Harry Perkins Institute of Medical Research, Australia) ; Sorolla, Anabel (University of Western Australia) ; Wallis, Christopher (University of Western Australia) ; Moses, Colette (University of Amsterdam, The Netherlands) ; Glas, Irina (Harry Perkins Institute of Medical Research, Australia) ; Magalhães, Leandro (University of Pará, Brazil) ; Thompson, Erik W. (Queensland University of Technology, Brisbane, Australia) ; Fearnley, Liam G. (University of Melbourne, Australia) ; Chaffer, Christine L. (St Vincent's Clinical School. UNSW Medicine, Australia) ; Davis, Melissa (University of Melbourne, Australia) ; Papenfuss, Anthony T. (University of Melbourne, Australia) ; Redfern, Andrew (University of Western Australia) ; Lister, Ryan (The University of Western Australia) ; Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Blancafort, Pilar (University of Western Australia)
Epithelial-mesenchymal transition (EMT) is a reversible transcriptional program invoked by cancer cells to drive cancer progression. Transcription factor ZEB1 is a master regulator of EMT, driving disease recurrence in poor-outcome triple negative breast cancers (TNBCs). [...]
2023 - 10.1002/advs.202301802
Advanced science, Vol. 10 Núm. 22 (august 2023)  
8.
33 p, 1.2 MB Metabotropic Glutamate Receptor 2 and Dopamine Receptor 2 Gene Expression Predict Sensorimotor Gating Response in the Genetically Heterogeneous NIH-HS Rat Strain / Østerbøg, Tina Becher (Research Laboratory for Stereology and Neuroscience. Bispebjerg and Frederiksberg Hospitals. Copenhagen) ; On, Doan Minh (Department of Physiology and Biophysics. Virginia Commonwealth University School of Medicine) ; Oliveras, Ignasi (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ; Río-Álamos, Cristobal (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ; Sánchez González, Ana (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ; Tapias-Espinosa, Carles (Departamento de Psiquiatría y Medicina Legal.) ; Tobeña, Adolf 1950- (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ; Gonzalez-Maeso, Javier (Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine) ; Fernández-Teruel, Alberto (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ; Aznar, Susana (Bispebjerg and Frederiksberg Hospitals (Copenhagen, Dinamarca))
Disruption of sensorimotor gating causes "flooding" of irrelevant sensory input and is considered a congenital trait in several neurodevelopmental disorders. Prepulse inhibition of acoustic startle response (PPI) is the operational measurement and has a high translational validity. [...]
2020 - 10.1007/s12035-019-01829-w
Molecular neurobiology, Vol. 57 Núm. 3 (March 2020) , p. 1516-1528  
9.
10 p, 2.1 MB Structure-Based Virtual Screening and in vitro and in vivo Analyses Revealed Potent Methyltransferase G9a Inhibitors as Prospective Anti-Alzheimer's Agents / Bellver-Sanchis, Aina (Universitat de Barcelona) ; Singh Choudhary, Bhanwar (Ganpat University) ; Companys-Alemany, Júlia (Universitat de Barcelona) ; Sukanya, None (Central University of Rajasthan) ; Ávila-López, Pedro A. (Northwestern University) ; Martínez Rodríguez, Antón Leandro (Universidade de Santiago de Compostela) ; Brea Floriani, Jose Manuel (Universidade de Santiago de Compostela) ; Malik, Ruchi (Central University of Rajasthan) ; Pallàs, Mercè (Universitat de Barcelona) ; Pérez, Belén (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ; Griñán-Ferré, Christian (Universitat de Barcelona)
G9a is a lysine methyltransferase able to di-methylate lysine 9 of histone H3, promoting the repression of genes involved in learning and memory. Novel strategies based on synthesizing epigenetic drugs could regulate gene expression through histone post-translational modifications and effectively treat neurodegenerative diseases, like Alzheimer's disease (AD). [...]
2022 - 10.1002/cmdc.202200002
ChemMedChem, Vol. 17 (may 2022)  
10.
21 p, 3.0 MB An Integrative Analysis of DNA Methylation Pattern in Myotonic Dystrophy Type 1 Samples Reveals a Distinct DNA Methylation Profile between Tissues and a Novel Muscle-Associated Epigenetic Dysregulation / Koehorst, Emma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Odria, Renato (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Capó, Júlia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Núñez-Manchón, Judit (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Arbex, Andrea (Institut Germans Trias i Pujol) ; Almendrote, Míriam (Institut Germans Trias i Pujol) ; Linares-Pardo, Ian (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Natera de Benito, Daniel. (Institut de Recerca Pediàtrica Hospital Sant Joan de Déu. Neuromuscular Unit. Neuropediatric Department) ; Saez, Verónica (Institut de Recerca Pediàtrica Hospital Sant Joan de Déu. Neuromuscular Unit. Neuropediatric Department) ; Nascimento, Andrés (Institut de Recerca Pediàtrica Hospital Sant Joan de Déu. Neuromuscular Unit. Neuropediatric Department) ; Ortez González, Carlos Ignacio (Institut de Recerca Pediàtrica Hospital Sant Joan de Déu. Neuromuscular Unit. Neuropediatric Department) ; Rubio, Miguel Ángel (Hospital del Mar (Barcelona, Catalunya)) ; Diaz-Manera, Jordi (Institut d'Investigació Biomèdica Sant Pau) ; Alonso-Pérez, Jorge (Institut d'Investigació Biomèdica Sant Pau) ; Lucente, Giuseppe (Institut Germans Trias i Pujol) ; Rodriguez-Palmero, Agustín (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Ramos-Fransi, Alba (Institut Germans Trias i Pujol) ; Martínez-Piñeiro, Alicia (Institut Germans Trias i Pujol) ; Nogales-Gadea, Gisela (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Suelves, Mònica (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Universitat Autònoma de Barcelona
Myotonic dystrophy type 1 (DM1) is a progressive, non-treatable, multi-systemic disorder. To investigate the contribution of epigenetics to the complexity of DM1, we compared DNA methy-lation profiles of four annotated CpG islands (CpGis) in the DMPK locus and neighbouring genes, in distinct DM1 tissues and derived cells, representing six DM1 subtypes, by bisulphite sequencing. [...]
2022 - 10.3390/biomedicines10061372
Biomedicines, Vol. 10 Núm. 6 (june 2022) , p. 1372  

Artículos : Encontrados 62 registros   1 - 10siguientefinal  ir al registro:
Documentos de investigación Encontrados 21 registros  1 - 10siguientefinal  ir al registro:
1.
Impacte dels mecanismes epigenètics en la migranya. Identificació i validació de patrons d'expressió diferencials de microARNs en pacients amb migranya / Gallardo López, Víctor José ; Pozo Rosich, Patricia, dir. ; Álvarez-Sabin, José, dir.
Diversos estudis pilot han estudiat el rol dels microARNs (miARNs) en la migranya. No obstant això, els estudis són poc comparables i reproduïbles degut a l'alt grau d'heterogeneïtat que existeix entre els grups. [...]
Varios estudios piloto han estudiado el rol de los microARNs (miARNs) en la migraña. Sin embargo, los estudios son poco comparables y reproducibles debido al alto grado de heterogeneidad que existe entre los grupos. [...]
Several studies have described the potential role of microRNA (miRNAs) in migraine but studies are scarcely reproducible primarily due to the heterogeneous variability of participants. Hence, the main objective of this project is to identify and validate differentially expressed miRNAs (DE miRNAs) in peripheral blood mononuclear cells (PBMCs) of patients with migraine compared to healthy controls (HC) in a well-controlled homogeneous cohort of participants using a three-step methodology: (a) exploratory study, (b) main study and (c) validation study. [...]

2023  
2.
261 p, 23.6 MB Systems Biology for the identification of epigenetic biomarkers and host factors associated with HIV-1 control / Oriol Tordera, Bruna ; Brander, Christian, dir. ; Ruiz-Riol, Marta, dir.
La cura del VIH-1 és un dels majors reptes científics i l'únic tractament és l'administració de fàrmacs antiretrovirals per mantenir una càrrega viral indetectable, i bloquejar el progrés de la malaltia associada a la infecció. [...]
La cura del VIH-1 es uno de los mayores retos científicos y el único tratamiento son los fármacos antirretrovirales que mantienen una carga viral indetectable y bloquean el progreso de la enfermedad asociada a la infección. [...]
An effective HIV-1 cure is still one of the major scientific challenges, and a global solution is not yet available beyond the administration of antiretroviral drugs, which maintain undetectable viral load and pause the progression of HIV associated disease. [...]

2022  
3.
294 p, 12.3 MB Chromatin remodeling in neuroblastoma : BAF complex links epigenetics to metastasis / Jiménez Jiménez, Carlos G. ; Segura Ginard, Miguel F., dir.
La programació epigenètica de les cèl·lules durant el desenvolupament embrionari és essencial per a la determinació i manteniment dels diferents llinatges cel·lulars i la homeòstasi tissular. [...]
La programación epigenética de las células durante el desarrollo embrionario es esencial para la determinación y mantenimiento de los diferentes linajes celulares y la homeóstasis tisular. Los tumores embrionarios se originan a partir de alteraciones moleculares durante etapas del desarrollo que resultan en programas transcripcionales aberrantes controlados por perfiles epigenéticos alterados. [...]
Epigenetic programming of cells during development is essential for the determination and maintenance of cell lineages and for tissue homeostasis. Embryonal tumors are originated by molecular alterations during developmental steps that result in aberrant transcriptional programs controlled by altered epigenetic landscapes. [...]

2022  
4.
157 p, 8.4 MB Auxin Response Factors : integrating auxin signalling with DNA recognition and epigenetics / Crespo, Isidro ; Boer, Roeland D., 1972-, dir. ; Weijers, Dolf, dir.
Les auxines són les principals fitohormones que governen el creixement i desenvolupament de les plantes, principalment a través de la via nuclear de l'auxina, NAP. Els efectors finals en NAP són els factors de resposta d'auxina (ARF). [...]
Las auxinas son las principales fitohormonas que gobiernan el crecimiento y desarrollo de las plantas, principalmente a través de la vía de las auxinas nucleares, NAP. Los efectores finales en NAP son los factores de respuesta de auxina (ARF). [...]
Auxins are the main phytohormones governing plant growth and development mainly through the Nuclear Auxin Pathway, NAP. The final effectors on NAP are the Auxin Response Factors (ARFs). ARFs has been linked to auxin and gene expression for decades, but the recent crystallographic structures of the DNA Binding Domain (ARF-DBD) of two divergent Arabidopsis thaliana ARFs revealed an exceptionally high conservation of the DNA contact points, so this point was unlikely to determine specificity of gene selection. [...]

2021  
5.
215 p, 4.1 MB Cambios genéticos y epigenéticos en un modelo animal post cirugía bariátrica / Cremades Pérez, Manel ; Fernández-Llamazares Rodríguez, Jaume, dir. ; Balibrea Del Castillo, José María, dir.
L'obesitat és un problema de salut de primer ordre que es troba en augment, amb una etiologia multifactorial i associada a un gran nombre de comorbiditats. El seu tractament requereix un enfocament multimodal, ja que cap dels existents, per si sol, manté bons resultats a llarg termini. [...]
La obesidad es un problema de salud de primer orden que se encuentra en aumento, con una etiología multifactorial y asociada a un gran número de comorbilidades. Su tratamiento requiere un enfoque multimodal, ya que ninguno de los existentes, por si solo, mantiene buenos resultados a largo plazo. [...]
Obesity is a major health problem, with a multifactorial etiology and associated with a large number of comorbidities. Its treatment requires a multimodal approach, since none of the existing ones, maintains good long-term results. [...]

2020  
6.
1 p, 585.4 KB Epigenetics of an imprinting disorder : Beckwith-Wiedemann syndrome / Castellet Farrús, Helena ; Roque Cordova, Alicia, dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Universitat Autònoma de Barcelona. Facultat de Biociències
Beckwith-Wiedemann syndrome (BWS) is an imprinting disorder and an overgrowth syndrome. The majority of cases are due to epigenetic alterations hence the epigenetic regulation will be the focus of this work. [...]
2019-05-31
Grau en Bioquímica [814]  
7.
1 p, 1.1 MB Factors involved in mitochondrial epigenetics / Justicia Lucas, Ainoa ; Universitat Autònoma de Barcelona. Facultat de Biociències
2018
Grau en Biologia [812]  
8.
1 p, 2.4 MB Novel improvement in iPSCs generation protocols through mouse gametogenesis epigenetic erasure mechanisms / Díaz Pedrosa, Núria ; Ibáñez, Elena, dir. (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Universitat Autònoma de Barcelona. Facultat de Biociències
The main goal of this review is to describe gametogenesis epigenetic erasure mechanisms and to propose candidate molecules which can erase remaining epigenetic marks that enhace re-differentiation of cultured induced pluripotent stem cells (iPSCs) into their tissue of origin. [...]
2016
Grau en Genètica [833]  
9.
1 p, 7.8 MB On the role that epigenetics may play in evolution / Riera Bellés, Meritxell ; Rodríguez-Trelles, Francisco, dir. (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Universitat Autònoma de Barcelona. Facultat de Biociències
2016
Grau en Biologia [812]  
10.
1 p, 418.9 KB Epigenetics of lncRNAs : HOTAIR and its relationship with cancer / Urtizberea Merino, Marta ; Gomez, Nestor, dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Universitat Autònoma de Barcelona. Facultat de Biociències
2015
Grau en Bioquímica [814]  

Documentos de investigación : Encontrados 21 registros   1 - 10siguientefinal  ir al registro:
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