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1.
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0 p, 2.2 MB |
Impact of tobacco, alcohol, and marijuana on genome-wide DNA methylation and its relationship with hypertension
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Carreras-Gallo, Natàlia (Barcelona Institute for Global Health (ISGlobal)) ;
Dwaraka, Varun B. (TruDiagnostic) ;
Cáceres, Alejandro (Universitat Politècnica de Catalunya) ;
Smith, Ryan (TruDiagnostic) ;
Mendez, Tavis L. (TruDiagnostic) ;
Went, Hannah (TruDiagnostic) ;
González, Juan Ramón (Universitat Autònoma de Barcelona. Departament de Matemàtiques)
Tobacco, alcohol, and marijuana consumption is an important public health problem because of their high use worldwide and their association with the risk of mortality and many health conditions, such as hypertension, which is the commonest risk factor for death throughout the world. [...]
2023 -  10.1080/15592294.2023.2214392
Epigenetics, Vol. 18, Issue 1 (May 2023) , art. 2214392
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2.
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16 p, 1.6 MB |
Epigenome-Wide Association Study in Peripheral Tissues Highlights DNA Methylation Profiles Associated with Episodic Memory Performance in Humans
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Sommerer, Yasmine (University of Lübeck) ;
Dobricic, Valerija (University of Lübeck) ;
Schilling, Marcel (University of Lübeck) ;
Ohlei, Olena (University of Lübeck) ;
Bartrés-Faz, David (Campus Clínic August Pi i Sunyer) ;
Cattaneo, Gabriele (Institut Germans Trias i Pujol. Institut Guttmann) ;
Demuth, Ilja (Charité - Universitätsmedizin Berlin) ;
Düzel, Sandra (Max Planck Institute for Human Development) ;
Franzenburg, Sören (Christian-Albrechts-University of Kiel) ;
Fuß, Janina (Christian-Albrechts-University of Kiel) ;
Lindenberger, Ulman (Max Planck Institute for Human Development) ;
Pascual Leone, Álvaro (Harvard Medical School) ;
Sabet, Sanaz Sedghpour (Christian-Albrechts-University of Kiel) ;
Solé-Padullés, Cristina (Campus Clínic August Pi i Sunyer) ;
Tormos, Josep M. (Institut Germans Trias i Pujol. Institut Guttmann) ;
Vetter, Valentin Max (Charité - Universitätsmedizin Berlin) ;
Wesse, Tanja (Christian-Albrechts-University of Kiel) ;
Franke, Andre (Christian-Albrechts-University of Kiel) ;
Lill, Christina M. (Imperial College London) ;
Bertram, Lars (University of Oslo) ;
Universitat Autònoma de Barcelona
The decline in episodic memory (EM) performance is a hallmark of cognitive aging and an early clinical sign in Alzheimer's disease (AD). In this study, we conducted an epigenome-wide association study (EWAS) using DNA methylation (DNAm) profiles from buccal and blood samples for cross-sectional (n = 1019) and longitudinal changes in EM performance (n = 626; average follow-up time 5. [...]
2022 - 10.3390/biomedicines10112798
Biomedicines, Vol. 10 (november 2022)
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3.
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17 p, 1.3 MB |
Altered methylation pattern in EXOC4 is associated with stroke outcome : an epigenome-wide association study
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Cullell, Natalia (Institut d'Investigació Biomèdica Sant Pau) ;
Soriano Tárraga, Carolina (NeuroGenomics and Informatics. Washington University School of Medicine) ;
Gallego-Fabrega, Cristina (Institut d'Investigació Biomèdica Sant Pau) ;
Cárcel-Márquez, Jara (Institut d'Investigació Biomèdica Sant Pau) ;
Muiño, Elena (Institut d'Investigació Biomèdica Sant Pau) ;
Llucià-Carol, Laia (Institut d'Investigació Biomèdica Sant Pau) ;
Lledós, Miquel (Institut d'Investigació Biomèdica Sant Pau) ;
Esteller, M (Institució Catalana de Recerca i Estudis Avançats) ;
Castro de Moura, Manuel (Programa de Epigenética y Biología del Cáncer (PEBC)) ;
Montaner, Joan (Instituto de Biomedicina de Sevilla) ;
Rosell Novel, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Delgado Martínez, María Pilar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martí-Fàbregas, Joan (Institut d'Investigació Biomèdica Sant Pau) ;
Krupinski, Jerzy (Centre for Bioscience. School of HealthCare Science. Manchester Metropolitan University) ;
Roquer, Jaume (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Jiménez-Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Background and purpose: The neurological course after stroke is highly variable and is determined by demographic, clinical and genetic factors. However, other heritable factors such as epigenetic DNA methylation could play a role in neurological changes after stroke. [...]
2022 - 10.1186/s13148-022-01340-5
Clinical Epigenetics, Vol. 14 Núm. 1 (december 2022) , p. 124
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4.
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17 p, 2.6 MB |
DNA methylation analyses identify an intronic ZDHHC6 locus associated with time to recurrent stroke in the Vitamin Intervention for Stroke Prevention (VISP) clinical trial
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Davis Armstrong, N.M. (East Carolina University. Department of Biology) ;
Chen, Wei-Min (University of Virginia. Department of Public Health Sciences) ;
Hsu, F.C. (Wake Forest School of Medicine) ;
Brewer, M.S. (East Carolina University. Department of Biology) ;
Cullell, Natalia (Fundació per la Recerca Biomèdica i Social Mútua de Terrassa) ;
Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ;
Williams, S.R. (University of Virginia. Department of Neurology) ;
Sale, M.M. (University of Virginia. Department of Public Health Sciences) ;
Worrall, B.B. (University of Virginia. Department of Neurology) ;
Keene, K.L. (East Carolina University. Brody School of Medicine)
Aberrant DNA methylation profiles have been implicated in numerous cardiovascular diseases; however, few studies have investigated how these epigenetic modifications contribute to stroke recurrence. The aim of this study was to identify methylation loci associated with the time to recurrent cerebro- and cardiovascular events in individuals of European and African descent. [...]
2021 - 10.1371/journal.pone.0254562
PloS one, Vol. 16 Núm. 7 July (july 2021) , p. e0254562
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5.
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36 p, 6.3 MB |
Look-alike humans identified by facial recognition algorithms show genetic similarities
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Joshi, Ricky S. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Rigau, M. (Barcelona Supercomputing Center) ;
García-Prieto, Carlos A (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Castro de Moura, Manuel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Piñeyro, David (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Moran, S (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Davalos, Veronica (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Carrión, P. (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ;
Ferrando-Bernal, Manuel (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ;
Olalde, I. (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ;
Lalueza-Fox, Carles (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ;
Navarro, Arcadi 1969- (Institució Catalana de Recerca i Estudis Avançats) ;
Fernández-Tena, C. (Herta Security. S.L.) ;
Aspandi, D. (Universitat Pompeu Fabra. Departament de Tecnologies de la Informació i les Comunicacions) ;
Sukno, F.M. (Universitat Pompeu Fabra. Departament de Tecnologies de la Informació i les Comunicacions) ;
Binefa i Valls, Xavier (Universitat Pompeu Fabra. Departament de Tecnologies de la Informació i les Comunicacions) ;
Valencia, A. (Institució Catalana de Recerca i Estudis Avançats) ;
Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
The human face is one of the most visible features of our unique identity as individuals. Interestingly, monozygotic twins share almost identical facial traits and the same DNA sequence but could exhibit differences in other biometrical parameters. [...]
2022 - 10.1016/j.celrep.2022.111257
Cell reports, Vol. 40 Núm. 8 (23 2022) , p. 111257
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6.
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19 p, 964.7 KB |
DNA methylome combined with chromosome cluster-oriented analysis provides an early signature for cutaneous melanoma aggressiveness
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Carrier, Arnaud (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Desjobert, Cécile (Unité de Service et de Recherche) ;
Ponger, Loic (Sorbone University) ;
Lamant, Laurence (Université Toulouse III Paul Sabatier) ;
Bustos, Matias (Saint John's Cancer Institute) ;
Torres Ferreira, Jorge (Portuguese Oncology Institute of Porto) ;
Henrique, Rui (University of Porto) ;
Jeronimo, Carmen (University of Porto) ;
Lanfrancone, Luisa (Instituto Europeo di Oncologia) ;
Delmas, Audrey (Université Toulouse III Paul Sabatier) ;
Favre, Gilles (Université Toulouse III Paul Sabatier) ;
Daunay, Antoine (Fondation Jean Dausset-CEPH) ;
Busato, Florence (Université Paris-Saclay. Centre National de Recherche en Génomique Humaine) ;
Hoon, Dave S. B. (Saint John's Cancer Institute) ;
Tost, Jorg (Université Paris-Saclay. Centre National de Recherche en Génomique Humaine) ;
Etievant, Chantal (Unité de Service et de Recherche) ;
Riond, Joëlle (Université Toulouse III Paul Sabatier) ;
Arimondo, Paola Barbara (Institut Pasteur)
Aberrant DNA methylation is a well-known feature of tumours and has been associated with metastatic melanoma. However, since melanoma cells are highly heterogeneous, it has been challenging to use affected genes to predict tumour aggressiveness, metastatic evolution, and patients' outcomes. [...]
2022 - 10.7554/eLife.78587
eLife, Vol. 11 (september 2022) , p. e78587
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7.
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15 p, 2.0 MB |
Epigenome-wide three-way interaction study identifies a complex pattern between TRIM27, KIAA0226, and smoking associated with overall survival of early-stage NSCLC
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Ji, Xinyu (Nanjing Medical University) ;
Lin, Lijuan (Nanjing Medical University) ;
Fan, Juanjuan (Nanjing Medical University) ;
Li, Yi (University of Michigan) ;
Wei, Yongyue (Nanjing Medical University) ;
Shen, Sipeng (Nanjing Medical University) ;
Su, Li (Harvard T.H. Chan School of Public Health (Estats Units d'Amèrica)) ;
Shafer, Andrea (Harvard Medical School) ;
Bjaanæs, Maria Moksnes (Oslo University Hospital (Oslo, Noruega)) ;
Karlsson, Anna (Lund University) ;
Planck, Maria (Lund University) ;
Staaf, Johan (Lund University) ;
Helland, Åslaug (University of Oslo) ;
Esteller, M (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Zhang, Ruyang (Nanjing Medical University) ;
Chen, Feng (Nanjing Medical University) ;
Christiani, David C (Harvard Medical School) ;
Universitat Autònoma de Barcelona
The interaction between DNA methylation of tripartite motif containing 27 (cg05293407) and smoking has previously been identified to reveal histologically heterogeneous effects of TRIM27 DNA methylation on early-stage non-small-cell lung cancer (NSCLC) survival. [...]
2022 - 10.1002/1878-0261.13167
Molecular Oncology, Vol. 16 Núm. 3 (february 2022) , p. 717-731
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38 p, 310.7 KB |
The SARS-CoV-2 receptor angiotensin-converting enzyme 2 (ACE2) in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome : analysis of high-throughput epigenetic and gene expression studies
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Malato, João (Universidade de Lisboa) ;
Sotzny, Franziska (Humboldt-Universität zu Berlin) ;
Bauer, Sandra (Charité - Universitätsmedizin Berlin) ;
Freitag, Helma (Charité - Universitätsmedizin Berlin) ;
Fonseca, André (Universidade do Algarve) ;
Grabowska, Anna D. (Medical University of Warsaw) ;
Graça, Luís (Universidade de Lisboa) ;
Cordeiro, Clara (Universidade do Algarve) ;
Nacul, Luís (British Columbia Women's Hospital and Health Centre (Canada)) ;
Lacerda, Eliana (London School of Hygiene & Tropical Medicine) ;
Castro-Marrero, Jesús (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Scheibenbogen, Carmen (Charité - Universitätsmedizin Berlin) ;
Westermeier, Francisco (Universidad Bernardo O'Higgins (Xile)) ;
Sepúlveda, Nuno (London School of Hygiene & Tropical Medicine) ;
Universitat Autònoma de Barcelona
Patients affected by Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) show specific epigenetic and gene expression signatures of the disease. However, it is unknown whether these signatures include abnormal levels of the human angiotensin-converting enzymes, ACE and ACE2, the latter being the main receptor described for the host-cell invasion by SARS-CoV-2. [...]
2021 - 10.1101/2021.03.23.21254175
medRxiv, april 2021
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10.
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15 p, 2.9 MB |
MethCORR modelling of methylomes from formalin-fixed paraffin-embedded tissue enables characterization and prognostication of colorectal cancer
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Mattesen, T. B. (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Rasmussen, M. H. (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Sandoval, J. (Instituto de Investigación Sanitaria La Fe) ;
Ongen, H. (Genetic Medicine and Development. University of Geneva Medical School-CMU) ;
Árnadóttir, S. S. (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Gladov, J. (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Martínez Cardús, Anna (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Castro de Moura, Manuel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Madsen, A. H. (Department of Surgery. Hospitalsenheden Vest) ;
Laurberg, S. (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Dermitzakis, Emmanouil T (University of Geneva Medical School) ;
Esteller, M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Andersen, Claus Lindbjerg (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Bramsen, Jesper Bertram (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Universitat Autònoma de Barcelona
Transcriptional characterization and classification has potential to resolve the inter-tumor heterogeneity of colorectal cancer and improve patient management. Yet, robust transcriptional profiling is difficult using formalin-fixed, paraffin-embedded (FFPE) samples, which complicates testing in clinical and archival material. [...]
2020 - 10.1038/s41467-020-16000-6
Nature communications, Vol. 11 Núm. 1 (january 2020) , p. 2025
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