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12 p, 3.5 MB Activation of lysophosphatidic acid receptor type 1 (LPA1) contributes to pathophysiology of spinal cord injury / Santos Nogueira, Eva (Universitat Autònoma de Barcelona. Institut de Neurociències) ; López-Serrano, Clara (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Hernández Martín, Joaquim (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Lago, Natalia (Institut Pasteur de Montevideo. Laboratorio de Neuroinflamación y Terapia Génica) ; Astudillo, Alma M. (Consejo Superior de Investigaciones Científicas (Espanya). Instituto de Biología y Genética Molecular) ; Balsinde, Jesús (Consejo Superior de Investigaciones Científicas (Espanya). Instituto de Biología y Genética Molecular) ; Estivill-Torrus, Guillermo (Instituto de Investigación Biomédica de Málaga) ; Rodríguez de Fonseca, Fernando (Instituto de Investigación Biomédica de Málaga) ; Chun, Jerold (Scripps Research Institute. Dorris Neuroscience Center) ; López Vales, Rubén (Universitat Autònoma de Barcelona. Institut de Neurociències)
Lysophosphatidic acid (LPA) is an extracellular lipid mediator involved in many physiological functions that signals through six known G-protein-coupled receptors (LPA1-LPA6). A wide range of LPA effects have been identified in the CNS, including neural progenitor cell physiology, astrocyte and microglia activation, neuronal cell death, axonal retraction, and development of neuropathic pain. [...]
2015 - 10.1523/JNEUROSCI.4703-14.2015
The Journal of neuroscience, Vol. 35, Num. 28 (2015) , p. 10224-10235  

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