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9 p, 325.6 KB |
Nintedanib for the treatment of patients with refractory metastatic colorectal cancer (LUME-Colon 1) : a phase III, international, randomized, placebo-controlled study
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Van Cutsem, E. (University Hospitals Gasthuisberg (Leuven, Bélgica)) ;
Yoshino, Takayuki (Department of Gastrointestinal Oncology, National Cancer Center Hospital East, Chiba, Japan) ;
Lenz, H. J. (Division of Medical Oncology, Norris Comprehensive Cancer Center, Los Angeles, USA) ;
Lonardi, Sara (Medical Oncology Unit 1, Department of Clinical and Experimental Oncology, Istituto Oncologico Veneto - IRCCS, Padua) ;
Falcone, Alfredo (Department of Translational Research on New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy) ;
Limón, M. L. (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Saunders, M. (Department of Clinical Oncology, The Christie NHS Foundation Trust, Manchester, UK) ;
Sobrero, A. (Department of Medical Oncology, Azienda Ospedaliera San Martino, Genoa, Italy) ;
Park, Y S. (Department of Hematology and Oncology, Samsung Medical Center, Seoul, South Korea) ;
Ferreiro, R. (Hospital Universitario Ramón y Cajal (Madrid)) ;
Hong, Y S. (Department of Oncology, Asan Medical Center, Seoul, South Korea) ;
Tomasek, J. (Masaryk Memorial Cancer Institute (Brno, República Txeca)) ;
Taniguchi, H. (Aichi Cancer Center Hospital) ;
Ciardiello, Fortunato (Oncologia Medica, Seconda Università deli Studi di Napoli, Naples, Italy) ;
Stoehr, J. (Boehringer Ingelheim, Pharma GmbH & Co. KG, Biberach, Germany) ;
Oum'Hamed, Z. (Boehringer Ingelheim France S.A.S, Reims, France) ;
Vlassak, S. (SCS Boehringer Ingelheim Comm.V, Brussels, Belgium) ;
Studeny, M. (Division of Medicine/Clinical Development Department, Boehringer Ingelheim, Vienna, Austria) ;
Argiles, G.. (Vall d'Hebron Institut d'Oncologia) ;
Universitat Autònoma de Barcelona
Angiogenesis is critical to colorectal cancer (CRC) growth and metastasis. Phase I/II studies have demonstrated the efficacy of nintedanib, a triple angiokinase inhibitor, in patients with metastatic CRC. [...]
2018 -  10.1093/annonc/mdy241
Annals of oncology, Vol. 29 (july 2018) , p. 1955-1963
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16 p, 1.5 MB |
Health-related Quality of Life in the Phase III LUME-Colon 1 Study : Comparison and Interpretation of Results From EORTC QLQ-C30 Analyses
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Lenz, Heinz Joseph (Division of Medical Oncology. USC Norris Comprehensive Cancer Center) ;
Argilés Martínez, Guillem (Vall d'Hebron Institut d'Oncologia) ;
Yoshino, Takayuki (Department of Gastroenterology and Gastrointestinal Oncology. National Cancer Center Hospital East) ;
Lonardi, Sara (Phase 1 Trial Unit and Medical Oncology Unit 1. Istituto Oncologico Veneto IRCCS) ;
Falcone, Alfredo (Department of Oncology. University of Pisa) ;
Limón, María Luisa (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Sobrero, Alberto (Ospedale Policlinico San Martino IRCCS) ;
Hastedt, Claudia (Boehringer Ingelheim International GmbH) ;
Peil, Barbara (Boehringer Ingelheim Pharma GmbH & Co. KG) ;
Voss, Florian (Boehringer Ingelheim Pharma GmbH & Co. KG) ;
Griebsch, Ingolf (Boehringer Ingelheim International GmbH) ;
Van Cutsem, Eric (University Hospitals Leuven (Bèlgica)) ;
Universitat Autònoma de Barcelona
Based on European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) outputs from the LUME-Colon 1 study, we compared and discussed different statistical methods for evaluating health-related quality of life data in oncology clinical trials. [...]
2019 - 10.1016/j.clcc.2019.08.005
Clinical Colorectal Cancer, Vol. 18 Núm. 4 (december 2019) , p. 269-279.e5
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7 p, 770.6 KB |
Proxies of quality of life in metastatic colorectal cancer : analyses in the RECOURSE trial
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Van Cutsem, Eric (University Hospitals Leuven (Bèlgica)) ;
Falcone, Alfredo (Azienda Ospedaliero-Universitaria Pisana) ;
García Carbonero, Rocio (Hospital Universitario 12 de Octubre (Madrid)) ;
Komatsu, Yoshito (Hokkaido University Hospital) ;
Pastorino, Alessandro (IRCCS AOU San Martino IST) ;
Peeters, Marc (University Hospital Antwerp (Bèlgica)) ;
Shimada, Yasuhiro (National Cancer Center Hospital) ;
Yamazaki, Kentaro (Shizuoka Cancer Center) ;
Yoshino, Takayuki (National Cancer Center Hospital East) ;
Zaniboni, Alberto (Fondazione Poliambulanza) ;
Amellal, Nadia (Institut de Recherches Servier) ;
Kanehisa, Akira (Institut de Recherches Servier) ;
Winkler, Robert (Taiho Oncology) ;
Makris, Lukas (Taiho Oncology) ;
Mayer, Robert J. (Dana-Farber Cancer Institute (Boston, Estats Units d'Amèrica)) ;
Ohtsu, Atsushi (National Cancer Center Hospital East) ;
Tabernero, Josep (Universitat Autònoma de Barcelona. Departament de Medicina)
In the pivotal phase III, randomised, double-blind, placebo-controlled RECOURSE study, treatment with trifluridine/tipiracil was well tolerated and associated with prolonged progression-free and overall survival in patients with metastatic colorectal cancer (mCRC). [...]
2017 - 10.1136/esmoopen-2017-000261
ESMO open, Vol. 2 (november 2017)
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