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Interim Results from the IMPACT Study : Evidence for Prostate-specific Antigen Screening in BRCA2 Mutation Carriers
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Page, Elizabeth C. (Institute of Cancer Research) ;
Bancroft, Elizabeth K. (Royal Marsden NHS Foundation Trust) ;
Brook, Mark N. (Institute of Cancer Research) ;
Assel, Melissa (Memorial Sloan Kettering Cancer Center) ;
Hassan Al Battat, Mona (Lund University) ;
Thomas, Sarah (Royal Marsden NHS Foundation Trust) ;
Taylor, Natalie (Royal Marsden NHS Foundation Trust) ;
Chamberlain, Anthony (Institute of Cancer Research) ;
Pope, Jennifer (Institute of Cancer Research) ;
Raghallaigh, Holly Ni (Institute of Cancer Research) ;
Evans, D.Gareth (Central Manchester University Hospitals NHS Foundation Trust) ;
Rothwell, Jeanette (Central Manchester University Hospitals NHS Foundation Trust) ;
Maehle, Lovise (Oslo University Hospital (Oslo, Noruega)) ;
Grindedal, Eli Marie (Oslo University Hospital (Oslo, Noruega)) ;
James, Paul (The Royal Melbourne Hospital) ;
Mascarenhas, Lyon (Peter MacCallum Cancer Centre) ;
McKinley, Joanne (Peter MacCallum Cancer Centre) ;
Side, Lucy (Princess Anne Hospital) ;
Thomas, Tessy (Princess Anne Hospital) ;
van Asperen, Christi (Leiden University Medical Center) ;
Vasen, Hans (The Foundation for the Detection of Hereditary Cancer) ;
Kiemeney, Lambertus A. (Radboud University Medical Center) ;
Ringelberg, Janneke (The Foundation for the Detection of Hereditary Cancer) ;
Jensen, Thomas Dyrso. (Vejle Hospital) ;
Osther, Palle J.S. (Vejle Hospital) ;
Helfand, Brian T. (NorthShore University HealthSystem) ;
Genova, Elena (NorthShore University HealthSystem) ;
Oldenburg, Rogier A. (Erasmus University Medical Center) ;
Cybulski, Cezary (Pomeranian Medical University in Szczecin) ;
Wokolorczyk, Dominika (Pomeranian Medical University in Szczecin) ;
Ong, Kai-Ren (Birmingham Women's Hospital) ;
Huber, Camilla (Birmingham Women's Hospital) ;
Lam, Jimmy (Bedford Park) ;
Taylor, Louise (Daw Park) ;
Salinas, Monica (Hospital Universitari de Bellvitge) ;
Feliubadaló, Lidia (Hospital Universitari de Bellvitge) ;
Oosterwijk, Jan C. (University of Groningen) ;
van Zelst-Stams, Wendy (Radboud University Medical Center) ;
Cook, Jackie (Sheffield Children's Hospital (Sheffield, Regne Unit)) ;
Rosario, Derek J. (Royal Hallamshire Hospital) ;
Domchek, Susan (Basser Research Center. University of Pennsylvania) ;
Powers, Jacquelyn (University of Pennsylvania) ;
Buys, Saundra (University of Utah) ;
O'Toole, Karen (University of Utah) ;
Ausems, Margreet G. E. M (University Medical Centre) ;
Schmutzler, Rita K. (University Hospital Cologne) ;
Rhiem, Kerstin (University Hospital Cologne) ;
Izatt, Louise (Guy's and St Thomas' NHS Foundation Trust) ;
Tripathi, Vishakha (Guy's and St Thomas' NHS Foundation Trust) ;
Teixeira, Manuel R. (Porto University) ;
Cardoso, Marta (Portuguese Oncology Institute (IPO Porto)) ;
Foulkes, William D. (McGill University, Departments of Human Genetics and Oncology) ;
Aprikian, Armen (Research Institute of McGill University Health Centre) ;
van Randeraad, Heleen (The Foundation for the Detection of Hereditary Cancer) ;
Davidson, Rosemarie (Queen Elizabeth University Hospital) ;
Longmuir, Mark (Queen Elizabeth University Hospital) ;
Ruijs, Marielle W.G. (The Netherlands Cancer Institute (Amsterdam, Països Baixos)) ;
Helderman van den Enden, Apollonia T.J.M. (Maastricht University Medical Center) ;
Adank, Muriel (Amsterdam UMC) ;
Williams, Rachel (Prince of Wales Hospital (Australia)) ;
Andrews, Lesley (Prince of Wales Hospital (Australia)) ;
Murphy, Declan G. (Peter MacCallum Cancer Centre) ;
Halliday, Dorothy (Oxford Centre for Genomic Medicine) ;
Walker, Lisa (Oxford Centre for Genomic Medicine) ;
Liljegren, Annelie (Karolinska University Hospital and Karolinska Institutet (Suecia)) ;
Carlsson, Stefan (Karolinska University Hospital and Karolinska Institutet (Suecia)) ;
Azzabi, Ashraf (Newcastle upon Tyne Hospitals) ;
Jobson, Irene (Newcastle upon Tyne Hospitals) ;
Morton, Catherine (The Royal Melbourne Hospital) ;
Shackleton, Kylie (The Royal Melbourne Hospital) ;
Snape, Katie (St George's Hospital) ;
Hanson, Helen (St George's Hospital) ;
Harris, Marion (Monash Health) ;
Tischkowitz, Marc (University of Cambridge) ;
Taylor, Amy (Cambridge University Hospitals NHS Trust) ;
Kirk, Judy (Sydney Medical School) ;
Susman, Rachel (Royal Brisbane & Women's Hospital) ;
Chen-Shtoyerman, Rakefet (Kaplan Medical Center) ;
Spigelman, Allan (The Kinghorn Cancer Centre. St Vincent's Hospital) ;
Pachter, Nicholas (University of Western Australia) ;
Ahmed, Munaza (NE Thames Regional Genetics Service) ;
Ramon y Cajal, Teresa (Institut d'Investigació Biomèdica Sant Pau) ;
Zgajnar, Janez (Institute of Oncology) ;
Brewer, Carole (Royal Devon and Exeter Hospital) ;
Gadea, Neus (Hospital Universitari Vall d'Hebron) ;
Brady, Angela F. (London North West University Healthcare NHS Trust) ;
van Os, Theo (Academic Medical Center) ;
Gallagher, David (St James's Hospital) ;
Johannsson, Oskar (Landspitali University Hospital (Reykjavík, Islàndia)) ;
Donaldson, Alan (St Michael's Hospital) ;
Barwell, Julian (University Hospitals Leicester) ;
Nicolai, Nicola (Istituto Nazionale dei Tumori (Milà, Itàlia)) ;
Friedman, Eitan (Chaim Shema Medical Center) ;
Obeid, Elias (Fox Chase Cancer Center) ;
Greenhalgh, Lynn (Liverpool Women's Hospital) ;
Murthy, Vedana (Tata Memorial Centre) ;
Copakova, Lucia (National Cancer Institute) ;
Saya, Sibel (Institute of Cancer Research) ;
McGrath, John (University of Exeter Medical School) ;
Cooke, Peter (New Cross Hospital) ;
Rønlund, Karina (Vejle Hospital) ;
Richardson, Kate (Peter MacCallum Cancer Centre) ;
Henderson, Alex (West Cumberland Infirmary) ;
Teo, Soo H. (Subang Jaya Medical Centre) ;
Arun, Banu (The University of Texas) ;
Kast, Karin (Technische Universität Dresden) ;
Dias, Alexander (Instituto Nacional de Cancer Jose de Alencar Gomes da Silva (INCA)) ;
Aaronson, Neil K (The Netherlands Cancer Institute (Amsterdam, Països Baixos)) ;
Ardern-Jones, Audrey (Royal Marsden NHS Foundation Trust) ;
Bangma, Chris H. (Erasmus University Medical Center) ;
Castro, Elena (Centro Nacional de Investigaciones Oncológicas) ;
Dearnaley, David (The Institute of Cancer Research. Royal Marsden NHS Foundation Trust (Londres, Regne Unit)) ;
Eccles, Diana M. (The University of Southampton Medical School) ;
Tricker, Karen (Central Manchester University Hospitals NHS Foundation Trust) ;
Eyfjord, Jorunn (University of Iceland) ;
Falconer, Alison (Imperial College Healthcare NHS Trust) ;
Foster, Christopher (HCA Pathology Laboratories) ;
Gronberg, Henrik (University Hospital) ;
Hamdy, Freddie C. (University of Oxford) ;
Stefansdottir, Vigdis (Landspitali University Hospital (Reykjavík, Islàndia)) ;
Khoo, Vincent (The University of Melbourne) ;
Lindeman, Geoffrey J. (The Walter and Eliza Hall Institute of Medical Research) ;
Lubinski, Jan (Pomeranian Medical University in Szczecin) ;
Axcrona, Karol (Akershus University Hospital) ;
Mikropoulos, Christos (Medway Hospital) ;
Mitra, Anita (University College London Hospitals NHS Foundation Trust) ;
Moynihan, Clare (Institute of Cancer Research) ;
Rennert, Gadi (Carmel Medical Center) ;
Suri, Mohnish (Nottingham City Hospital) ;
Wilson, Penny (Innovate UK. Polaris House) ;
Dudderidge, Tim (University Hospital Southampton) ;
Offman, Judith (King's College London) ;
Kote-Jarai, Zsofia (Institute of Cancer Research) ;
Vickers, Andrew (Memorial Sloan Kettering Cancer Center) ;
Lilja, Hans (Memorial Sloan-Kettering Cancer Center (Nova York, Estats Units d'Amèrica)) ;
Eeles, Rosalind A. (Royal Marsden NHS Foundation Trust) ;
Universitat Autònoma de Barcelona
Mutations in BRCA2 cause a higher risk of early-onset aggressive prostate cancer (PrCa). The IMPACT study is evaluating targeted PrCa screening using prostate-specific-antigen (PSA) in men with germline BRCA1/2 mutations. [...]
2019 -  10.1016/j.eururo.2019.08.019
European Urology, Vol. 76 Núm. 6 (december 2019) , p. 831-842
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12 p, 1.7 MB |
Role of POLE and POLD1 in familial cancer
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Mur, Pilar (Centro de Investigación Biomédica en Red de Cáncer) ;
García-Mulero, Sandra (Hospital Universitari de Bellvitge) ;
del Valle, Jesús (Centro de Investigación Biomédica en Red de Cáncer) ;
Magraner-Pardo, Lorena (Spanish National Cancer Research Center (CNIO)) ;
Vidal, August (Hospital Universitari de Bellvitge) ;
Pineda, Marta (Centro de Investigación Biomédica en Red de Cáncer) ;
Cinnirella, Giacomo (Hospital Universitari de Bellvitge) ;
Martín-Ramos, Edgar (Universitat de Barcelona) ;
Pons, Tirso (Consell Superior d'Investigacions Científiques) ;
López-Doriga, Adriana (Centro de Investigación Biomédica en Red de Epidemiologia y Salud Pública (CIBERESP)) ;
Belhadj, Sami (Hospital Universitari de Bellvitge) ;
Feliubadaló, Lidia (Centro de Investigación Biomédica en Red de Cáncer) ;
Munoz-Torres, Pau M. (Hospital Universitari de Bellvitge) ;
Navarro, Matilde (Centro de Investigación Biomédica en Red de Cáncer) ;
Grau, Elia (Hospital Universitari de Bellvitge) ;
Darder, Esther (Institut Català d'Oncologia) ;
Llort, Gemma (Consorci Sanitari de Terrassa) ;
Sanz, Judit (Althaia Xarxa Assistencial Universitària de Manresa) ;
Ramon y Cajal, Teresa (Institut d'Investigació Biomèdica Sant Pau) ;
Balmaña Gelpí, Judith (Hospital Universitari Vall d'Hebron) ;
Brunet, Joan (Institut Català d'Oncologia) ;
Moreno, Víctor (Universitat de Barcelona) ;
Piulats, Josep M. (Hospital Universitari de Bellvitge) ;
Matías-Guiu, Xavier (Hospital Universitari de Bellvitge) ;
Sanz-Pamplona, Rebeca (Centro de Investigación Biomédica en Red de Epidemiologia y Salud Pública (CIBERESP)) ;
Aligué, Rosa (Universitat de Barcelona) ;
Capellá, G. (Gabriel) (Centro de Investigación Biomédica en Red de Cáncer) ;
Lázaro, Conxi (Centro de Investigación Biomédica en Red de Cáncer) ;
Valle, Laura (Centro de Investigación Biomédica en Red de Cáncer) ;
Universitat Autònoma de Barcelona
Germline pathogenic variants in the exonuclease domain (ED) of polymerases POLE and POLD1 predispose to adenomatous polyps, colorectal cancer (CRC), endometrial tumors, and other malignancies, and exhibit increased mutation rate and highly specific associated mutational signatures. [...]
2020 - 10.1038/s41436-020-0922-2
Genetics in medicine, Vol. 22 Núm. 12 (december 2020) , p. 2089-2100
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18 p, 1.0 MB |
Assessing Associations between the AURKA-HMMR-TPX2-TUBG1 Functional Module and Breast Cancer Risk in BRCA1/2 Mutation Carriers
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Blanco Guillermo, Ignacio (Institut d'Investigació Biomèdica de Bellvitge) ;
Kuchenbaecker, Karoline (University of Cambridge) ;
Cuadras, Daniel (Institut d'Investigació Biomèdica de Bellvitge) ;
Wang, Xianshu (Mayo Clinic, Rochester, United States of America) ;
Barrowdale, Daniel (University of Cambridge) ;
de Garibay, Gorka Ruiz (Institut d'Investigació Biomèdica de Bellvitge) ;
Librado, Pablo (Universitat de Barcelona) ;
Sánchez-Gracia, Alejandro (Universitat de Barcelona) ;
Rozas, Julio (Universitat de Barcelona) ;
Bonifaci, Núria (Institut d'Investigació Biomèdica de Bellvitge) ;
McGuffog, Lesley (University of Cambridge) ;
Pankratz, Vernon S. (Mayo Clinic, Rochester, Minnesota) ;
Islam, Abul (University of Dhaka) ;
Mateo, Francesca (Institut d'Investigació Biomèdica de Bellvitge) ;
Berenguer-Llergo, Antoni (Institut d'Investigació Biomèdica de Bellvitge) ;
Petit Montserrat, Anna (Institut d'Investigació Biomèdica de Bellvitge) ;
Català, Isabel (Institut d'Investigació Biomèdica de Bellvitge) ;
Brunet, Joan (Institut d'Investigació Biomèdica de Girona) ;
Feliubadaló, Lidia (Institut d'Investigació Biomèdica de Bellvitge) ;
Tornero, Eva (Institut d'Investigació Biomèdica de Bellvitge) ;
Benitez, Javier (Centro Nacional de Investigaciones Oncológicas) ;
Osorio, Ana (Centro Nacional de Investigaciones Oncológicas) ;
Ramon y Cajal, Teresa (Institut d'Investigació Biomèdica Sant Pau) ;
Aittomäki, Kristiina (Helsinki University Central Hospital) ;
Arun, Banu K. (University of Texas) ;
Toland, Amanda E. (The Ohio State University, Columbus) ;
Karlan, Beth Y. (Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Los Angeles) ;
Walsh, Christine (Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Los Angeles) ;
Lester, Jenny (Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Los Angeles) ;
Greene, Mark H. (National Cancer Institute, Maryland, Rockville) ;
Mai, Phuong L. (National Cancer Institute, Maryland, Rockville) ;
Nussbaum, Robert L. (University of California San Francisco, San Francisco) ;
Andrulis, Irene L. (Samuel Lunenfeld Research Institute, Mount Sinai Hospital, and Departments of Molecular Genetics and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada) ;
Domchek, Susan M. (The University of Pennsylvania School of Medicine, Philadelphia) ;
Nathanson, Katherine L. (The University of Pennsylvania School of Medicine, Philadelphia) ;
Rebbeck, Timothy R. (Abramson Cancer Center and Center for Clinical Epidemiology and Biostatistics, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America) ;
Barkardottir, Rosa B. (Landspitali University Hospital (Reykjavík, Islàndia)) ;
Jakubowska, Anna (Pomeranian Medical University, Szczecin) ;
Lubinski, Jan (Pomeranian Medical University, Szczecin) ;
Durda, Katarzyna (Pomeranian Medical University, Szczecin) ;
Jaworska-Bieniek, Katarzyna (Pomeranian Medical University, Szczecin) ;
Claes, Kathleen (Ghent University, Ghent) ;
Van Maerken, Tom (Ghent University, Ghent) ;
Diez, Orland (Vall d'Hebron Institut d'Oncologia) ;
Hansen, Thomas V. (Copenhagen University Hospital) ;
Jønson, Lars (Copenhagen University Hospital) ;
Gerdes, Anne-Marie (Copenhagen University Hospital) ;
Ejlertsen, Bent (Copenhagen University Hospital) ;
De la Hoya, Miguel (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
Caldes, Trinidad (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
Dunning, Alison M. (University of Cambridge) ;
Oliver, Clare (University of Cambridge) ;
Fineberg, Elena (University of Cambridge) ;
Cook, Margaret (University of Cambridge) ;
Peock, Susan (University of Cambridge) ;
McCann, Emma (Glan Clwyd Hospital, Rhyl) ;
Murray, Alex (Singleton Hospital, Swansea) ;
Jacobs, Chris (Guy's and St. Thomas' National Health Service, London) ;
Pichert, Gabriella (Guy's and St. Thomas' National Health Service, London) ;
Lalloo, Fiona (Central Manchester University Hospitals National Health Service, Manchester) ;
Chu, Carol (Yorkshire Regional Genetics Service, Leeds) ;
Dorkins, Huw (Kennedy-Galton Centre, Harrow) ;
Paterson, Joan (Addenbrookes Hospital (Cambridge, Regne Unit)) ;
Ong, Kai-Ren (Birmingham Women's Hospital) ;
Teixeira, Manuel R. (Universidade do Porto) ;
Hogervorst, Frans B. L. (The Netherlands Cancer Institute (Amsterdam, Països Baixos)) ;
van der Hout, Annemarie H. (University of Groningen) ;
Seynaeve, Caroline (Erasmus University Medical Center, Rotterdam) ;
van der Luijt, Rob B. (University Medical Center Utrecht, Utrecht) ;
Ligtenberg, Marjolijn J. L. (Radboud university medical center, Nijmegen) ;
Devilee, Peter (Leiden University Medical Center, Leiden) ;
Wijnen, Juul T. (Leiden University Medical Center, Leiden) ;
Rookus, Matti A. (The Netherlands Cancer Institute (Amsterdam, Països Baixos)) ;
Meijers-Heijboer, Hanne E. J. (Vrije Universiteit, Amsterdam) ;
Blok, Marinus J. (Maastricht University Medical Center) ;
van den Ouweland, Ans M. W. (Erasmus University Medical Center, Rotterdam) ;
Aalfs, Cora M. (Department of Clinical Genetics, Amsterdam) ;
Rodriguez, Gustavo C. (University of Chicago) ;
Phillips, Kelly-Anne A. (Peter MacCallum Cancer Centre, East Melbourne) ;
Piedmonte, Marion (Roswell Park Cancer Institute, Buffalo, New York) ;
Nerenstone, Stacy R. (Hartford Hospital/Helen and Harry Gray Cancer Center) ;
Bae-Jump, Victoria L. (University of North Carolina) ;
O'Malley, David M. (Ohio State University, Hilliard) ;
Ratner, Elena S. (Yale University School of Medicine) ;
Schmutzler, Rita K. (Uniklinik Köln (Colònia, Alemanya)) ;
Wappenschmidt, Barbara (Uniklinik Köln (Colònia, Alemanya)) ;
Rhiem, Kerstin (University Hospital of Cologne, Cologne, Germany) ;
Engel, Christoph (University of Leipzig) ;
Meindl, Alfons (Technical University Munich) ;
Ditsch, Nina (Ludwig-Maximilian University Munich) ;
Arnold, Norbert (Kiel University Medical Center Schleswig-Holstein) ;
Plendl, Hansjoerg J. (Kiel University Medical Center Schleswig-Holstein) ;
Niederacher, Dieter (University Hospital of Düsseldorf (Alemanya)) ;
Sutter, Christian (Heidelberg University Hospital (Alemanya)) ;
Wang-Gohrke, Shan (University Hospital of Ulm (Alemanya)) ;
Steinemann, Doris (Institute of Cell and Molecular Pathology, Hannover) ;
Preisler-Adams, Sabine (University of Münster) ;
Kast, Karin (Technical University Dresden) ;
Varon-Mateeva, Raymonda (Institute of Human Genetics, Campus Virchov Klinikum, Charite Berlin) ;
Gehrig, Andrea (Centre of Familial Breast and Ovarian Cancer, Institute of Human Genetics, University Würzburg, Würzburg, Germany) ;
Bojesen, Anders (Vejle Hospital, Vejle) ;
Pedersen, Inge Sokilde (Aalborg University Hospital (Dinamarca)) ;
Sunde, Lone (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Jensen, Uffe Birk (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Thomassen, Mads (Odense University Hospital (Dinamarca)) ;
Kruse, Torben A. (Odense University Hospital (Dinamarca)) ;
Foretova, Lenka (Masaryk Memorial Cancer Institute (Brno, República Txeca)) ;
Peterlongo, Paolo (Fondazione Istituto di Oncologia MolecolarE, Milan) ;
Bernard, Loris (Istituto Europeo di Oncologia, Milan) ;
Peissel, Bernard (Fondazione Istituto Nazionale Tumori, Milan) ;
Scuvera, Giulietta (Fondazione Istituto Nazionale Tumori, Milan) ;
Manoukian, Siranoush (Fondazione Istituto Nazionale Tumori, Milan) ;
Radice, Paolo (Fondazione Istituto Nazionale Tumori, Milan) ;
Ottini, Laura ("Sapienza" University, Rome) ;
Montagna, Marco (Istituto Oncologico Veneto, Padua) ;
Agata, Simona (Istituto Oncologico Veneto, Padua) ;
Maugard, Christine (Hopitaux Universitaire de Strasbourg) ;
Simard, Jacques (Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec City) ;
Soucy, Penny (Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec City) ;
Berger, Andreas (Medical University of Vienna) ;
Fink-Retter, Anneliese (Medical University of Vienna) ;
Singer, Christian F. (Medical University of Vienna) ;
Rappaport, Christine (Medical University of Vienna) ;
Geschwantler-Kaulich, Daphne (Medical University of Vienna) ;
Tea, Muy-Kheng (Medical University of Vienna) ;
Pfeiler, Georg (Medical University of Vienna) ;
John, Esther M. (Cancer Prevention Institute of California) ;
Miron, Alex (Dana-Farber Cancer Institute, Boston, Massachusetts) ;
Neuhausen, Susan L. (Beckman Research Institute of City of Hope (Duarte, Estats Units d'Amèrica)) ;
Terry, Mary Beth (Columbia University) ;
Chung, Wendy (Columbia University) ;
Daly, Mary B. (Fox Chase Cancer Center, Philadelphia, Pennsylvania) ;
Goldgar, David E. (University of Utah School of Medicine, Salt Lake City) ;
Janavicius, Ramunas (Vilnius University Hospital Santariskiu Clinics) ;
Dorfling, Cecilia M. (University of Pretoria, Arcadia) ;
van Rensburg, Elisabeth J. (University of Pretoria, Arcadia) ;
Fostira, Florentia (National Centre for Scientific Research Demokritos, Athens) ;
Konstantopoulou, Irene (National Centre for Scientific Research Demokritos, Athens) ;
Garber, Judy (Harvard Medical School, Boston) ;
Godwin, Andrew K. (University of Kansas Medical Center, Kansas City) ;
Olah, Edith (National Institute of Oncology, Budapest) ;
Narod, Steven A. (University of Toronto) ;
Rennert, Gad (Clalit National Israeli Cancer Control Center) ;
Paluch, Shani Shimon (Chaim Sheba Medical Center, Ramat Gan) ;
Laitman, Yael (Institute of Human Genetics, Ramat Gan) ;
Friedman, Eitan (Tel Aviv University, Ramat Aviv) ;
Liljegren, Annelie (Karolinska University Hospital and Karolinska Institutet (Suècia)) ;
Rantala, Johanna (Karolinska University Hospital and Karolinska Institutet (Suècia)) ;
Stenmark-Askmalm, Marie (Linköping University, Sweeden) ;
Loman, Niklas (Lund University Hospital, Sweeden) ;
Imyanitov, Evgeny N. (N.N. Petrov Institute of Oncology, St.-Petersburg) ;
Hamann, Ute (German Cancer Research Center (DKFZ), Heidelberg) ;
Spurdle, Amanda B. (Queensland Institute of Medical Research (QIMR) Berghofer Medical Research Institute, Brisbane) ;
Healey, Sue (Queensland Institute of Medical Research (QIMR) Berghofer Medical Research Institute, Brisbane) ;
Weitzel, Jeffrey N. (Clinical Cancer Genetics, City of Hope, Duarte, California) ;
Herzog, Josef (Clinical Cancer Genetics, City of Hope, Duarte, California) ;
Margileth, David (St. Joseph Hospital of Orange, Duarte, California) ;
Gorrini, Chiara (University Health Network, Toronto) ;
Esteller, M (Institució Catalana de Recerca i Estudis Avançats) ;
Gómez Moruno, Antonio (Institut d'Investigació Biomèdica de Bellvitge) ;
Sayols, Sergi (Institut d'Investigació Biomèdica de Bellvitge) ;
Vidal, Enrique (Institut d'Investigació Biomèdica de Bellvitge) ;
Heyn, Holger (Institut d'Investigació Biomèdica de Bellvitge) ;
Stoppa-Lyonnet, Dominique (Université Paris Descartes, Sorbonne Paris Cité, Paris, France) ;
Léoné, Melanie (Hospices Civils de Lyon-Centre Léon Bérard, Lyon) ;
Barjhoux, Laure (Université Lyon 1) ;
Fassy-Colcombet, Marion (Institut Curie, Paris) ;
De Pauw, Antoine (Institut Curie, Paris) ;
Lasset, Christine (Université Lyon 1) ;
Ferrer, Sandra Fert (Hôtel Dieu Centre Hospitalier, Chambéry) ;
Castera, Laurent (Department of Tumour Biology, Institut Curie, Paris) ;
Berthet, Pascaline (Centre François Baclesse, Caen, France) ;
Cornelis, François (Genetic Unit, Avicenne Hospital, Clermont-Ferrand) ;
Bignon, Yves-Jean (Université de Clermont-Ferrand) ;
Damiola, Francesca (Centre de Recherche en Cancérologie de Lyon) ;
Mazoyer, Sylvie (Centre de Recherche en Cancérologie de Lyon) ;
Sinilnikova, Olga M. (Centre de Recherche en Cancérologie de Lyon) ;
Maxwell, Christopher A. (University of British Columbia, Vancouver) ;
Vijai, Joseph (Memorial Sloan-Kettering Cancer Center, New York) ;
Robson, Mark (Memorial Sloan-Kettering Cancer Center, New York) ;
Kauff, Noah (Memorial Sloan-Kettering Cancer Center, New York) ;
Corines, Marina (Memorial Sloan-Kettering Cancer Center, New York) ;
Villano, Danylko (Memorial Sloan-Kettering Cancer Center, New York) ;
Cunningham, Julie M. (Mayo Clinic, Rochester, Minnesota, United States of America) ;
Lee, Adam (Mayo Clinic, Rochester, Minnesota) ;
Lindor, Noralane (Mayo Clinic, Scottsdale, Arizona) ;
Lázaro, Conxi (Institut d'Investigació Biomèdica de Bellvitge) ;
Easton, Douglas F. (University of Cambridge) ;
Offit, Kenneth (Memorial Sloan-Kettering Cancer Center, New York) ;
Chenevix-Trench, Georgia (Queensland Institute of Medical Research, Brisbane, Australia) ;
Couch, Fergus J. (Mayo Clinic, Rochester, Minnesota) ;
Antoniou, Antonis C. (University of Cambridge) ;
Pujana, Miguel Angel (Institut d'Investigació Biomèdica de Bellvitge)
While interplay between BRCA1 and AURKA-RHAMM-TPX2-TUBG1 regulates mammary epithelial polarization, common genetic variation in HMMR (gene product RHAMM) may be associated with risk of breast cancer in BRCA1 mutation carriers. [...]
2015 - 10.1371/journal.pone.0120020
PloS one, Vol. 10 (april 2015)
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22 p, 1.6 MB |
Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus
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Lawrenson, Kate (Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center) ;
Kar, Siddhartha (Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge) ;
McCue, Karen (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia)) ;
Kuchenbaeker, Karoline (Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge) ;
Michailidou, Kyriaki (Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge) ;
Tyrer, Jonathan (Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge) ;
Beesley, Jonathan (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia)) ;
Ramus, Susan J. (Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center) ;
Li, Qiyuan (Department of Medical Oncology, The Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute) ;
Delgado, Melissa K. (Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center) ;
Lee, Janet M. (Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center) ;
Aittomäki, Kristiina (Helsinki University Hospital (Finlàndia)) ;
Andrulis, Irene L. (Department of Molecular Genetics, University of Toronto) ;
Anton-Culver, Hoda (Department of Epidemiology, Genetic Epidemiology Research Institute, School of Medicine, University of California Irvine) ;
Arndt, Volker (Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)) ;
Arun, Banu K. (University of Texas MD Anderson Cancer Center) ;
Arver, Brita (Karolinska University Hospital and Karolinska Institutet (Suècia)) ;
Bandera, Elisa V. (Cancer Prevention and Control, Rutgers Cancer Institute of New Jersey) ;
Barile, Monica (Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia) ;
Barkardottir, Rosa B. (Department of Pathology, Landspitali University Hospital and BMC (Biomedical Centre), Faculty of Medicine, University of Iceland) ;
Barrowdale, Daniel (Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge) ;
Beckmann, Matthias W. (University Hospital Erlangen, Department of Gynecology and Obstetrics, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN) ;
Benitez, Javier (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Berchuck, Andrew (Department of Obstetrics and Gynecology, Duke University Medical Center) ;
Bisogna, Maria (Gynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center) ;
Bjorge, Line (Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen) ;
Blomqvist, Carl (Helsinki University Hospital (Finlàndia)) ;
Blot, William (International Epidemiology Institute) ;
Bogdanova, Natalia (Gynaecology Research Unit, Hannover Medical School) ;
Bojesen, Anders (Department of Clinical Genetics, Vejle Hospital) ;
Bojesen, Stig E. (Copenhagen University Hospital) ;
Bolla, Manjeet K. (Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge) ;
Bonanni, Bernardo (Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia) ;
Børresen-Dale, Anne-Lise (K.G. Jebsen Center for Breast Cancer Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo) ;
Brauch, Hiltrud (German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ)) ;
Brennan, Paul (International Agency for Research on Cancer) ;
Brenner, Hermann (Division of Preventive Oncology, German Cancer Research Center (DKFZ)) ;
Bruinsma, Fiona (Cancer Epidemiology Centre (Melbourne, Austràlia)) ;
Brunet, Joan (Institut d'Investigació Biomèdica de Girona) ;
Buhari, Shaik Ahmad (Department of Surgery, National University Health System) ;
Burwinkel, Barbara (Department of Obstetrics and Gynecology, University of Heidelberg) ;
Butzow, Ralf (Department of Pathology, Helsinki University Central Hospital) ;
Buys, Saundra (Department of Medicine, Huntsman Cancer Institute, University of Utah School of Medicine) ;
Cai, Qiuyin (Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine) ;
Caldes, Trinidad (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
Campbell, Ian (Cancer Genetics Laboratory, Peter MacCallum Cancer Centre) ;
Canniotto, Rikki (Cancer Pathology & Prevention, Division of Cancer Prevention and Population Sciences, Roswell Park Cancer Institute) ;
Chang-Claude, Jenny (University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf) ;
Chiquette, Jocelyne (Unité de recherche en santé des populations, Centre des maladies du sein Deschênes-Fabia, Centre de recherche FRSQ du Centre hospitalier affilié universitaire de Québec) ;
Choi, Ji-Yeob (Department of Biomedical Sciences, Seoul National University College of Medicine) ;
Claes, Kathleen (Center for Medical Genetics, Ghent University) ;
Cook, Linda S. (Division of Epidemiology and Biostatistics, Department of Internal Medicine, University of New Mexico) ;
Cox, Angela (Sheffield Cancer Research, Department of Oncology, University of Sheffield) ;
Cramer, Daniel W. (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ;
Cross, Simon S. (Academic Unit of Pathology, Department of Neuroscience, University of Sheffield) ;
Cybulski, Cezary (Department of Genetics and Pathology, Pomeranian Medical University) ;
Czene, Kamila (Karolinska Institutet (Estocolm, Suècia). Department of Medical Epidemiology and Biostatistics) ;
Daly, Mary B. (Department of Clinical Genetics, Fox Chase Cancer Center) ;
Damiola, Francesca (INSERM U1052, CNRS UMR5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon) ;
Dansonka-Mieszkowska, Agnieszka (Department of Pathology and Laboratory Diagnostics the Maria Sklodowska Curie Memorial Cancer Center and Institute of Oncology) ;
Darabi, Hatef (Karolinska Institutet (Estocolm, Suècia). Department of Medical Epidemiology and Biostatistics) ;
Dennis, Joe (Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge) ;
Devilee, Peter (Department of Human Genetics, Leiden University Medical Center) ;
Diez, Orland (Vall d'Hebron Institut d'Oncologia) ;
Doherty, Jennifer A. (Department of Community and Family Medicine, Section of Biostatistics & Epidemiology, The Geisel School of Medicine at Dartmouth) ;
Domchek, Susan M. (Department of Medicine, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania) ;
Dorfling, Cecilia M. (Department of Genetics, University of Pretoria) ;
Dörk, Thilo (Gynaecology Research Unit, Hannover Medical School) ;
Dumont, Martine (Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University) ;
Ehrencrona, Hans (Department of Clinical Genetics, Lund University Hospital) ;
Ejlertsen, Bent (Copenhagen University Hospital Rigshospitalet) ;
Ellis, Steve (Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge) ;
Engel, Christoph (Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig) ;
Lee, Eunjung (Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center) ;
Evans, Gareth (Genomic Medicine, Manchester Academic Health Sciences Centre, Institute of Human Development, Manchester University, Central Manchester University Hospitals NHS Foundation Trust) ;
Fasching, Peter A. (University of California at Los Angeles, David Geffen School of Medicine, Department of Medicine, Division of Hematology and Oncology) ;
Feliubadalo, Lidia (Institut d'Investigació Biomèdica de Bellvitge) ;
Figueroa, Jonine (Division of Cancer Epidemiology and Genetics, National Cancer Institute) ;
Flesch-Janys, Dieter (Department of Cancer Epidemiology, Clinical Cancer Registry, University Medical Center Hamburg-Eppendorf) ;
Fletcher, Olivia (Division of Breast Cancer Research, The Institute of Cancer Research) ;
Flyger, Henrik (Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital) ;
Foretova, Lenka (Masaryk Memorial Cancer Institute and Medical Faculty MU) ;
Fostira, Florentia (Molecular Diagnostics Laboratory, (INRASTES) Institute of Nuclear and Radiological Sciences and Technology, National Centre for Scientific Research 'Demokritos', Aghia Paraskevi Attikis) ;
Foulkes, William D. (Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montreal) ;
Fridley, Brooke L. (Biostatistics and Informatics Shared Resource, University of Kansas Medical Center) ;
Friedman, Eitan (Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center) ;
Frost, Debra (Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge) ;
Gambino, Gaetana (University Hospital of Pisa (Pisa, Itàlia)) ;
Ganz, Patricia A. (UCLA Schools of Medicine and Public Health, Division of Cancer Prevention & Control Research, Jonsson Comprehensive Cancer Center) ;
Garber, Judy (Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute) ;
García-Closas, Montserrat (Division of Genetics and Epidemiology, The Institute of Cancer Research) ;
Gentry-Maharaj, Aleksandra (Women's Cancer, UCL EGA Institute for Women's Health) ;
Ghoussaini, Maya (Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge) ;
Giles, Graham G. (Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne) ;
Glasspool, Rosalind (Cancer Research UK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre) ;
Godwin, Andrew K. (Department of Pathology and Laboratory Medicine, University of Kansas Medical Center) ;
Goldberg, Mark S. (Department of Medicine, McGill University) ;
Goldgar, David E. (Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine) ;
González-Neira, Anna (Centro Nacional de Investigaciones Oncológicas) ;
Goode, Ellen L. (Department of Health Sciences Research, Mayo Clinic) ;
Goodman, Marc T. (Cedars Sinai Heart Institute (Los Angeles, Estats Units d'Amèrica)) ;
Greene, Mark H. (Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health) ;
Gronwald, Jacek (Department of Genetics and Pathology, Pomeranian Medical University) ;
Guénel, Pascal (University Paris-Sud) ;
Haiman, Christopher A. (Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center) ;
Hall, Per (Karolinska Institutet (Estocolm, Suècia). Department of Medical Epidemiology and Biostatistics) ;
Hallberg, Emily (Department of Health Sciences Research, Mayo Clinic) ;
Hamann, Ute (Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ)) ;
Hansen, Thomas V. O. (Copenhagen University Hospital Rigshospitalet) ;
Harrington, Patricia A. (Department of Oncology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory) ;
Hartman, Mikael (Saw Swee Hock School of Public Health, National University of Singapore) ;
Hassan, Norhashimah (Cancer Research Initiatives Foundation, Subang Jaya) ;
Healey, Sue (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia)) ;
Heitz, Florian (Department of Gynecology and Gynecologic Oncology, Dr Horst Schmidt Kliniken Wiesbaden) ;
Herzog, Josef (Clinical Cancer Genetics, for the City of Hope Clinical Cancer Genetics Community Research Network) ;
Høgdall, Estrid (Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center) ;
Høgdall, Claus K. (Copenhagen University Hospital Rigshospitalet) ;
Hogervorst, Frans B. L. (The Netherlands Cancer Institute (Amsterdam, Països Baixos)) ;
Hollestelle, Antoinette (Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute) ;
Hopper, John L. (Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne) ;
Hulick, Peter J. (Center for Medical Genetics, NorthShore University Health System) ;
Huzarski, Tomasz (Department of Genetics and Pathology, Pomeranian Medical University) ;
Imyanitov, Evgeny N. (N.N. Petrov Institute of Oncology) ;
Isaacs, Claudine (Lombardi Comprehensive Cancer Center, Georgetown University) ;
Ito, Hidemi (Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute) ;
Jakubowska, Anna (Department of Genetics and Pathology, Pomeranian Medical University) ;
Janavicius, Ramunas (State Research Institute Centre for Innovative Medicine) ;
Jensen, Allan (Copenhagen University Hospital Rigshospitalet) ;
John, Esther M. (Department of Epidemiology, Cancer Prevention Institute of California) ;
Johnson, Nichola (Division of Breast Cancer Research, The Institute of Cancer Research) ;
Kabisch, Maria (Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ)) ;
Kang, Daehee (Department of Preventive Medicine, Seoul National University College of Medicine) ;
Kapuscinski, Miroslav (Centre for Epidemiology and Biostatistics, University of Melbourne) ;
Karlan, Beth Y. (Cedars Sinai Heart Institute (Los Angeles, Estats Units d'Amèrica)) ;
Khan, Sofia (Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital) ;
Kiemeney, Lambertus A. (Radboud University Medical Centre, Radboud Institute for Health Sciences) ;
Kjaer, Susanne Kruger (Copenhagen University Hospital Rigshospitalet) ;
Knight, Julia A. (Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto) ;
Konstantopoulou, Irene (Molecular Diagnostics Laboratory, (INRASTES) Institute of Nuclear and Radiological Sciences and Technology, National Centre for Scientific Research 'Demokritos', Aghia Paraskevi Attikis) ;
Kosma, Veli-Matti (Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland) ;
Kristensen, Vessela (Oslo University Hospital (Oslo, Noruega)) ;
Kupryjanczyk, Jolanta (Department of Pathology and Laboratory Diagnostics the Maria Sklodowska Curie Memorial Cancer Center and Institute of Oncology) ;
Kwong, Ava (Department of Surgery, The University of Hong Kong) ;
De la Hoya, Miguel (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
Laitman, Yael (Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center) ;
Lambrechts, Diether (Laboratory for Translational Genetics, Department of Oncology, University of Leuven) ;
Le, Nhu (Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center) ;
De Leeneer, Kim (Center for Medical Genetics, Ghent University) ;
Lester, Jenny (Cedars Sinai Heart Institute (Los Angeles, Estats Units d'Amèrica)) ;
Levine, Douglas A. (Gynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center) ;
Li, Jingmei (Karolinska Institutet (Estocolm, Suècia). Department of Medical Epidemiology and Biostatistics) ;
Lindblom, Annika (Karolinska Institutet (Estocolm, Suècia). Department of Molecular Medicine and Surgery) ;
Long, Jirong (Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine) ;
Lophatananon, Artitaya (Division of Health Sciences, Warwick Medical School, Warwick University) ;
Loud, Jennifer T. (Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health) ;
Lu, Karen (Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center) ;
Lubinski, Jan (Department of Genetics and Pathology, Pomeranian Medical University) ;
Mannermaa, Arto (Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland) ;
Manoukian, Siranoush (Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT)) ;
Le Marchand, Loic (University of Hawaii Cancer Center) ;
Margolin, Sara (Department of Oncology - Pathology, Karolinska Institutet) ;
Marme, Frederik (National Center for Tumour Diseases, University of Heidelberg) ;
Massuger, Leon F. A. G. (Radboud University Medical Centre. Department of Gynaecology) ;
Matsuo, Keitaro (Department of Preventive Medicine, Kyushu University Faculty of Medical Sciences) ;
Mazoyer, Sylvie (INSERM U1052, CNRS UMR5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon) ;
McGuffog, Lesley (Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge) ;
McLean, Catriona (Anatomical Pathology, The Alfred Hospital) ;
McNeish, Iain (Institute of Cancer Sciences, University of Glasgow, Wolfson Wohl Cancer Research Centre, Beatson Institute for Cancer Research) ;
Meindl, Alfons (Technische Universität München) ;
Menon, Usha (Women's Cancer, UCL EGA Institute for Women's Health) ;
Mensenkamp, Arjen R. (Department of Human Genetics, Radboud University Medical Centre) ;
Milne, Roger L. (Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne) ;
Montagna, Marco (Immunology and Molecular Oncology Unit, Instituto Oncologico Veneto IOV, IRCCS) ;
Moysich, Kirsten B. (Department of Cancer Prevention and Control, Roswell Park Cancer Institute) ;
Muir, Kenneth (Institute of Population Health, University of Manchester) ;
Mulligan, Anna Marie (Department of Laboratory Medicine and Pathobiology, University of Toronto) ;
Nathanson, Katherine L. (Department of Medicine, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania) ;
Ness, Roberta B. (The University of Texas School of Public Health) ;
Neuhausen, Susan L. (Department of Population Sciences, Beckman Research Institute of City of Hope) ;
Nevanlinna, Heli (Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital) ;
Nord, Silje (K.G. Jebsen Center for Breast Cancer Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo) ;
Nussbaum, Robert L. (Department of Medicine and Genetics, University of California) ;
Odunsi, Kunle (Department of Gynecological Oncology, Roswell Park Cancer Institute) ;
Offit, Kenneth (Department of Medicine, Memorial Sloan-Kettering Cancer Center) ;
Olah, Edith (Department of Molecular Genetics, National Institute of Oncology) ;
Olopade, Olufunmilayo I. (Center for Clinical Cancer Genetics and Global Health, University of Chicago Medical Center) ;
Olson, Janet E. (Department of Health Sciences Research, Mayo Clinic) ;
Olswold, Curtis (Department of Health Sciences Research, Mayo Clinic) ;
O'Malley, David (The Ohio State University and the James Cancer Center) ;
Orlow, Irene (Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center) ;
Orr, Nick (Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research) ;
Osorio, Ana (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Park, Sue Kyung (Department of Surgery, Seoul National University College of Medicine) ;
Pearce, Celeste L. (Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center) ;
Pejovic, Tanja (Knight Cancer Institute, Oregon Health and Science University) ;
Peterlongo, Paolo (IFOM, The FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology) ;
Pfeiler, Georg (Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna) ;
Phelan, Catherine M. (Department of Cancer Epidemiology, Moffitt Cancer Center) ;
Poole, Elizabeth M. (Department of Epidemiology, Harvard TH Chan School of Public Health) ;
Pylkäs, Katri (Laboratory of Cancer Genetics and Tumour Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu) ;
Radice, Paolo (Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori (INT)) ;
Rantala, Johanna (Karolinska University Hospital and Karolinska Institutet (Suècia)) ;
Rashid, Muhammad Usman (Department of Basic Sciences, Shaukat Khanum Memorial Cancer Hospital and Research Centre (SKMCH & RC)) ;
Rennert, Gad (Clalit National Israeli Cancer Control Center and Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine) ;
Rhenius, Valerie (Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge) ;
Rhiem, Kerstin (University Hospital of Cologne (Colònia, Alemanya). Centre of Familial Breast and Ovarian Cancer and Centre for Integrated Oncology (CIO)) ;
Risch, Harvey A. (Department of Chronic Disease Epidemiology, Yale School of Public Health) ;
Rodriguez, Gus (Division of Gynecologic Oncology, NorthShore University HealthSystem) ;
Rossing, Mary Anne (Department of Epidemiology, University of Washington) ;
Rudolph, Anja (Division of Cancer Epidemiology, German Cancer Research Center (DKFZ)) ;
Salvesen, Helga B. (Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen) ;
Sangrajrang, Suleeporn (National Cancer Institute) ;
Sawyer, Elinor J. (King's College London) ;
Schildkraut, Joellen M. (Cancer Control and Population Sciences, Duke Cancer Institute) ;
Schmidt, Marjanka K. (Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital) ;
Schmutzler, Rita K. (Center of Familial Breast and Ovarian Cancer, University Hospital of Cologne) ;
Sellers, Thomas A. (Department of Cancer Epidemiology, Moffitt Cancer Center) ;
Seynaeve, Caroline (Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute) ;
Shah, Mitul (Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge) ;
Shen, Chen-Yang (School of Public Health, China Medical University) ;
Shu, Xiao-Ou (Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine) ;
Sieh, Weiva (Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine) ;
Singer, Christian F. (Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna) ;
Sinilnikova, Olga M. (INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon) ;
Slager, Susan (Department of Health Sciences Research, Mayo Clinic) ;
Song, Honglin (Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge) ;
Soucy, Penny (Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University) ;
Southey, Melissa C. (Department of Pathology, University of Melbourne) ;
Stenmark-Askmalm, Marie (Division of Clinical Genetics, Department of Clinical and Experimental Medicine, Linköping University) ;
Stoppa-Lyonnet, Dominique (Université Paris Descartes) ;
Sutter, Christian (Institute of Human Genetics, Department of Human Genetics, University Hospital Heidelberg) ;
Swerdlow, Anthony (Division of Genetics and Epidemiology, The Institute of Cancer Research) ;
Tchatchou, Sandrine (Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital) ;
Teixeira, Manuel R. (Biomedical Sciences Institute (ICBAS), Porto University) ;
Teo, Soo H. (Cancer Research Initiatives Foundation, Subang Jaya) ;
Terry, Kathryn L. (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ;
Terry, Mary Beth (Department of Epidemiology, Mailman School of Public Health, Columbia University) ;
Thomassen, Mads (Odense University Hospital (Dinamarca)) ;
Tibiletti, Maria Grazia (UO Anatomia Patologica, Ospedale di Circolo-Università dell'Insubria) ;
Tihomirova, Laima (Latvian Biomedical Research and Study Centre) ;
Tognazzo, Silvia (Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto IOV - IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico)) ;
Toland, Amanda Ewart (Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University) ;
Tomlinson, Ian (Wellcome Trust Centre for Human Genetics (Oxford, Regne Unit)) ;
Torres, Diana (Institute of Human Genetics, Pontificia Universidad Javeriana, Cra. 7 #40-62) ;
Truong, Thérèse (University Paris-Sud) ;
Tseng, Chiu-chen (Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center) ;
Tung, Nadine (Department of Medical Oncology, Beth Israel Deaconess Medical Center) ;
Tworoger, Shelley S. (Department of Epidemiology, Harvard TH Chan School of Public Health) ;
Vachon, Celine (Department of Health Sciences Research, Mayo Clinic) ;
van den Ouweland, Ans M. W. (Department of Clinical Genetics, Erasmus University Medical Center) ;
van Doorn, Helena C. (Department of Gynecology, Family Cancer Clinic, Erasmus MC Cancer Institute) ;
van Rensburg, Elizabeth J. (Department of Genetics, University of Pretoria) ;
Van't Veer, Laura J. (Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital) ;
Vanderstichele, Adriaan (University Hospitals Leuven (Bèlgica)) ;
Vergote, Ignace (University Hospitals Leuven (Bèlgica)) ;
Vijai, Joseph (Department of Medicine, Memorial Sloan-Kettering Cancer Center) ;
Wang, Qin (Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge) ;
Wang-Gohrke, Shan (University Hospital Ulm, 89069 Ulm) ;
Weitzel, Jeffrey N. (Clinical Cancer Genetics, for the City of Hope Clinical Cancer Genetics Community Research Network) ;
Wentzensen, Nicolas (Division of Cancer Epidemiology and Genetics, National Cancer Institute) ;
Whittemore, Alice S. (Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine) ;
Wildiers, Hans (University Hospitals Leuven (Bèlgica)) ;
Winqvist, Robert (Laboratory of Cancer Genetics and Tumour Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu) ;
Wu, Anna H. (Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center) ;
Yannoukakos, Drakoulis (Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research 'Demokritos') ;
Yoon, Sook-Yee (University Malaya Cancer Research Institute, Faculty of Medicine, University Malaya Medical Centre, University Malaya) ;
Yu, Jyh-Cherng (Department of Surgery, Tri-Service General Hospital, National Defense Medical Center) ;
Zheng, Wei (Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine) ;
Zheng, Ying (Shanghai Center for Disease Control and Prevention) ;
Khanna, Kum Kum (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia)) ;
Simard, Jacques (Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University) ;
Monteiro, Alvaro N. (Cancer Epidemiology Program, Division of Population Sciences, H. Lee Moffitt Cancer Center & Research Institute) ;
French, Juliet D. (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia)) ;
Couch, Fergus J. (Department of Laboratory Medicine and Pathology, Mayo Clinic) ;
Freedman, Matthew L. (Department of Medical Oncology, The Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute) ;
Easton, Douglas F. (Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge) ;
Dunning, Alison M. (Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge) ;
Pharoah, Paul D. (Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge) ;
Edwards, Stacey L. (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia)) ;
Chenevix-Trench, Georgia (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia)) ;
Antoniou, Antonis C. (Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge) ;
Gayther, Simon A. (Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center) ;
Universitat Autònoma de Barcelona
A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify 13 candidate causal SNPs associated with serous OC (P =9. [...]
2016 - 10.1038/ncomms12675
Nature communications, Vol. 7 (09 2016)
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Fine-Scale Mapping at 9p22.2 Identifies Candidate Causal Variants That Modify Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers
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Vigorito, Elena (University of Cambridge. Centre for Cancer Genetic Epidemiology) ;
Kuchenbaecker, Karoline B. (University of Cambridge. Centre for Cancer Genetic Epidemiology) ;
Beesley, Jonathan (Department of Genetics, QIMR Berghofer Medical Research Institute, Herston Road, Brisbane, Australia, 4029) ;
Adlard, Julian (Yorkshire Regional Genetics Service, Chapel Allerton Hospital, Leeds, United Kingdom) ;
Agnarsson, Bjarni A. (Landspitali University Hospital (Reykjavík, Islàndia)) ;
Andrulis, Irene L. (Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada) ;
Arun, Banu K. (Department of Breast Medical Oncology and Clinical Cancer Genetics Program, University Of Texas MD Anderson Cancer Center, 1515 Pressler Street, CBP 5, Houston, TX, United States of America) ;
Barjhoux, Laure (Bâtiment Cheney D, Centre Léon Bérard, 28 rue Laënnec, Lyon, France) ;
Belotti, Muriel (Service de Génétique Oncologique, Institut Curie, 26, rue d'Ulm, Paris Cedex 05, France) ;
Benitez, Javier (Centro Nacional de Investigaciones Oncológicas) ;
Berger, Andreas (Dept of OB/GYN, Medical University of Vienna, Vienna, Austria) ;
Bojesen, Anders (Department of Clinical Genetics, Vejle Hospital, Kabbeltoft 25, Vejle, Denmark) ;
Bonanni, Bernardo (Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), via Ripamonti 435, 20141 Milan, Italy) ;
Brewer, Carole (Royal Devon & Exeter Hospital (Exeter, Regne Unit)) ;
Caldes, Trinidad (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
Caligo, Maria (University Hospital of Pisa (Pisa, Itàlia)) ;
Campbell, Ian (Research Division, Peter MacCallum Cancer Centre, Locked Bag 1, A'Beckett Street, Melbourne, VIC 8006, Australia) ;
Chan, Salina B. (Divisadero Street, C415, San Francisco, CA 94143-1714, United States of America) ;
Claes, Kathleen (Center for Medical Genetics, Ghent University, De Pintelaan 185, 9000 Gent, Belgium) ;
Cohn, David E. (Ohio State University Columbus Cancer Council GYN Oncology, 3651 Ridge Mill Drive, Columbus, OH 43026, United States of America) ;
Cook, Jackie (Sheffield Children's Hospital (Sheffield, Regne Unit)) ;
Daly, Mary B. (Department of Clinical Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA, United States of America) ;
Damiola, Francesca (Bâtiment Cheney D, Centre Léon Bérard, 28 rue Laënnec, Lyon, France) ;
Davidson, Rosemarie (Department of Clinical Genetics, South Glasgow University Hospitals, Glasgow, United Kingdom) ;
De Pauw, Antoine (Service de Génétique Oncologique, Institut Curie, 26, rue d'Ulm, Paris Cedex 05, France) ;
Delnatte, Capucine (Unité d'oncogénétique, ICO-Centre René Gauducheau, Boulevard Jacques Monod, 44805 Nantes Saint Herblain Cedex, France) ;
Diez, Orland (Vall d'Hebron Institut d'Oncologia) ;
Domchek, Susan M. (Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, United States of America) ;
Dumont, Martine (Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, 2705 Laurier Boulevard, Quebec City (Quebec), Canada) ;
Durda, Katarzyna (Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin, Poland) ;
Dworniczak, Bernd (Institute of Human Genetics, University of Münster, Münster, Germany) ;
Easton, Douglas F. (University of Cambridge. Centre for Cancer Genetic Epidemiology) ;
Eccles, Diana M (University Hospital Southampton NHS Foundation Trust (Regne Unit)) ;
Edwinsdotter Ardnor, Christina (Department of Radiation Sciences, Oncology, Umeå University, Umea, Sweden) ;
Eeles, Ros (Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, United Kingdom) ;
Ejlertsen, Bent (Copenhagen University Hospital Rigshospitalet) ;
Ellis, Steve (Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, United Kingdom) ;
Evans, Gareth (Genomic Medicine, Manchester Academic Health Sciences Centre, Institute of Human Development, Manchester University, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom) ;
Feliubadalo, Lidia (Institut d'Investigació Biomèdica de Bellvitge) ;
Fostira, Florentia (Molecular Diagnostics Laboratory, (INRASTES) Institute of Nuclear and Radiological Sciences and Technology, National Centre for Scientific Research "Demokritos", Patriarchou Gregoriou & Neapoleos str., Aghia Paraskevi, Attiki, Athens, Greece) ;
Foulkes, William D. (Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montreal, Quebec, Canada) ;
Friedman, Eitan (The Susanne Levy Gertner Oncogenetics Unit, Institute of Human Genetics, Chaim Sheba Medical Center, Ramat Gan 52621, and Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv 69978, Israel) ;
Frost, Debra (Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, United Kingdom) ;
Gaddam, Pragna (Clinical Cancer Genetics Laboratory, Memorial Sloane Kettering Cancer Center, New York, NY, United States of America) ;
Ganz, Patricia A. (UCLA Schools of Medicine and Public Health, Division of Cancer Prevention & Control Research, Jonsson Comprehensive Cancer Center, 650 Charles Young Drive South, Room A2-125 HS, Los Angeles, CA 90095-6900, United States of America) ;
Garber, Judy (Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, United States of America) ;
García-Barberán, Vanesa (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
Gauthier-Villars, Marion (Service de Génétique Oncologique, Institut Curie, 26, rue d'Ulm, Paris Cedex 05, France) ;
Gehrig, Andrea (Centre of Familial Breast and Ovarian Cancer, Department of Medical Genetics, Institute of Human Genetics, University Würzburg, Würzburg, Germany) ;
Gerdes, Anne-Marie (Copenhagen University Hospital Rigshospitalet) ;
Giraud, Sophie (Service de Génétique Moléculaire et Clinique, Hospices Civils de Lyon, Lyon cedex 04, France) ;
Godwin, Andrew K. (Department of Pathology and Laboratory Medicine, 3901 Rainbow Boulevard, 4019 Wahl Hall East, MS 3040, University of Kansas Medical Center, Kansas City, Kansas, United States of America) ;
Goldgar, David E. (Department of Dermatology, University of Utah School of Medicine, 30 North 1900 East, SOM 4B454, Salt Lake City, UT 84132, United States of America) ;
Hake, Christopher R. (City of Hope Clinical Cancer Genetics Community Research Network, 1500 East Duarte Road, Duarte, CA 91010, United States of America) ;
Hansen, Thomas V. O. (Copenhagen University Hospital Rigshospitalet) ;
Healey, Sue (Department of Genetics, QIMR Berghofer Medical Research Institute, Herston Road, Brisbane, Australia, 4029) ;
Hodgson, Shirley (Medical Genetics Unit, St George's, University of London, London, United Kingdom) ;
Hogervorst, Frans B. L. (Family Cancer Clinic, Netherlands Cancer Institute, P.O. Box 90203, 1000 BE, Amsterdam, The Netherlands) ;
Houdayer, Claude (Service de Génétique Oncologique, Institut Curie, 26, rue d'Ulm, Paris Cedex 05, France) ;
Hulick, Peter J. (Center for Medical Genetics, NorthShore University Health System, University of Chicago Pritzker School of Medicine, 1000 Central Street, Suite 620, Evanston, IL 60201, United States of America) ;
Imyanitov, Evgeny N. (N.N. Petrov Institute of Oncology, St.-Petersburg 197758, Russia) ;
Isaacs, Claudine (Lombardi Comprehensive Cancer Center, Georgetown University, 3800 Reservoir Road NW, Washington, DC, United States of America) ;
Izatt, Louise (Clinical Genetics, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom) ;
Izquierdo, Angel (Institut d'Investigació Biomèdica de Girona) ;
Jacobs, Lauren (Clinical Genetics Research Laboratory, Dept. of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, United States of America) ;
Jakubowska, Anna (Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin, Poland) ;
Janavicius, Ramunas (Vilnius University Hospital Santariskiu Clinics, Hematology, oncology and transfusion medicine center, Dept. of Molecular and Regenerative Medicine, Santariskiu st., State Research Institute Centre for Innovative medicine, Zygymantu st. 9, Vilnius, Lithuania) ;
Jaworska-Bieniek, Katarzyna (Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin, Poland) ;
Jensen, Uffe Birk (Aarhus University Hospital (Aarhus, Dinamarca)) ;
John, Esther M. (Department of Epidemiology, Cancer Prevention Institute of California, 2201 Walnut Avenue, Suite 300, Fremont, CA 94538, United States of America) ;
Vijai, Joseph (Clinical Genetics Research Laboratory, Dept. of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10044, United States of America) ;
Karlan, Beth Y. (Cedars Sinai Heart Institute (Los Angeles, Estats Units d'Amèrica)) ;
Kast, Karin (Department of Gynaecology and Obstetrics, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany) ;
Investigators, KConFab (Kathleen Cuningham Consortium for Research into Familial Breast Cancer, Peter MacCallum Cancer Center, Melbourne, Australia) ;
Khan, Sofia (Helsinki University Hospital (Finlàndia)) ;
Kwong, Ava (The Hong Kong Hereditary Breast Cancer Family Registry, Cancer Genetics Center, Hong Kong Sanatorium and Hospital, Hong Kong China) ;
Laitman, Yael (The Susanne Levy Gertner Oncogenetics Unit, Institute of Human Genetics, Chaim Sheba Medical Center, Ramat Gan 52621, Israel) ;
Lester, Jenny (Cedars Sinai Heart Institute (Los Angeles, Estats Units d'Amèrica)) ;
Lesueur, Fabienne (Genetic Epidemiology of Cancer team, Inserm U900, Institut Curie, Mines ParisTech, 26 rue d'Ulm, 75248 Paris cedex 05, France) ;
Liljegren, Annelie (Karolinska University Hospital and Karolinska Institutet (Suècia)) ;
Lubinski, Jan (Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin, Poland) ;
Mai, Phuong L. (Clinical Genetics Branch, DCEG, NCI, NIH, 9609 Medical Center Drive, Room 6E-454, Bethesda, MD, United States of America) ;
Manoukian, Siranoush (Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), Via Giacomo Venezian 1, 20133 Milan, Italy) ;
Mazoyer, Sylvie (Bâtiment Cheney D, Centre Léon Bérard, 28 rue Laënnec, Lyon, France) ;
Meindl, Alfons (Department of Gynaecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University Munich, Munich, Germany) ;
Mensenkamp, Arjen R. (Radboud University Medical Centre. Department of Human Genetics) ;
Montagna, Marco (Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Via Gattamelata 64, Padua, Italy) ;
Nathanson, Katherine L. (Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, United States of America) ;
Neuhausen, Susan L. (Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, United States of America) ;
Nevanlinna, Heli (Helsinki University Hospital (Finlàndia)) ;
Niederacher, Dieter (University Hospital of Düsseldorf (Alemanya)) ;
Olah, Edith (Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary) ;
Olopade, Olufunmilayo I. (The University of Chicago Medicine, 5841 South Maryland Avenue, MC 2115 Chicago, IL 60637) ;
Ong, Kai-ren (Birmingham Women's Hospital) ;
Osorio, Ana (Centro Nacional de Investigaciones Oncológicas) ;
Park, Sue Kyung (Department of Preventive Medicine, Seoul National University College of Medicine, Department of Biomedical Science, Seoul National University Graduate School, and Cancer Research Institute, Seoul National University, 103 Daehak-ro, Jongno-gu, Seoul 110-799, Korea) ;
Paulsson-Karlsson, Ylva (Department of Immunology, Genetics and Pathology, Uppsala University, SE-751 85 Uppsala, Sweden) ;
Pedersen, Inge Sokilde (Aalborg University Hospital (Dinamarca)) ;
Peissel, Bernard (Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), Via Giacomo Venezian 1, 20133 Milan, Italy) ;
Peterlongo, Paolo (IFOM, The FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, c/o IFOM-IEO campus, via Adamello 16, 20139 Milan, Italy) ;
Pfeiler, Georg (Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria) ;
Phelan, Catherine M. (Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, United States of America) ;
Piedmonte, Marion (NRG Oncology, Statistics and Data Management Center, Roswell Park Cancer Institute, Elm St & Carlton St, Buffalo, NY 14263, United States of America) ;
Poppe, Bruce (Center for Medical Genetics, Ghent University, De Pintelaan 185, 9000 Gent, Belgium) ;
Pujana, Miquel Angel (Institut d'Investigació Biomèdica de Bellvitge) ;
Radice, Paolo (Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predicted Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), c/o Amaedeolab, via GA Amadeo 42, 20133 Milan, Italy) ;
Rennert, Gad (Clalit National Israeli Cancer Control Center and Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine, 7 Michal St., Haifa 34362, Israel) ;
Rodriguez, Gustavo C. (Division of Gynecologic Oncology, NorthShore University HealthSystem, Univ of Chicago, 2650 Ridge Avenue Suite 1507 Walgreens, Evanston, IL 60201, United States of America) ;
Rookus, Matti A. (The Netherlands Cancer Institute (Amsterdam, Països Baixos)) ;
Ross, Eric A. (Biostatistics and Bioinformatics Facility, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, United States of America) ;
Schmutzler, Rita Katharina (Center for Hereditary Breast and Ovarian Cancer, Medical Faculty, University Hospital Cologne, Cologne, Germany) ;
Simard, Jacques (Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, 2705 Laurier Boulevard, Quebec City (Quebec), Canada) ;
Singer, Christian F. (Dept of OB/GYN, Medical University of Vienna, Vienna, Austria, and Waehringer Guertel 18-20, A 1090 Vienna, Austria) ;
Slavin, Thomas P. (Clinical Cancer Genetics, City of Hope, 1500 East Duarte Road, Duarte, California 91010, United States of America) ;
Soucy, Penny (Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, 2705 Laurier Boulevard, Quebec City (Quebec), Canada) ;
Southey, Melissa (Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Parkville, Victoria, Australia) ;
Steinemann, Doris (Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany) ;
Stoppa-Lyonnet, Dominique (Service de Génétique Oncologique, Institut Curie, 26, rue d'Ulm, Paris Cedex 05, France) ;
Sukiennicki, Grzegorz (Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin, Poland) ;
Sutter, Christian (Institute of Human Genetics, Department of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany) ;
Szabo, Csilla I. (National Human Genome Research Institute, National Institutes of Health, Building 50, Room 5312, 50 South Drive, MSC 004, Bethesda, MD 20892-8004, United States of America) ;
Tea, Muy-Kheng (Dept of OB/GYN, Medical University of Vienna, Vienna, Austria, and Waehringer Guertel 18-20, A 1090 Vienna, Austria) ;
Teixeira, Manuel R. (Department of Genetics, Portuguese Oncology Institute, Rua Dr. António Bernardino de Almeida, 4200-072 Porto, Portugal) ;
Teo, Soo-Hwang (Cancer Research Initiatives Foundation, Sime Darby Medical Centre, 1 Jalan SS12/1A, Subang Jaya, 47500 Malaysia) ;
Terry, Mary Beth (Department of Epidemiology, Columbia University, New York, NY, United States of America) ;
Thomassen, Mads (Odense University Hospital (Dinamarca)) ;
Tibiletti, Maria Grazia (UO Anatomia Patologica, Ospedale di Circolo-Università dell'Insubria, Via O.Rossi 9, 21100 Varese, Italy) ;
Tihomirova, Laima (Latvian Biomedical Research and Study Centre, Ratsupites str 1, Riga, Latvia) ;
Tognazzo, Silvia (Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Via Gattamelata 64, Padua, Italy) ;
van Rensburg, Elizabeth J. (Cancer Genetics Laboratory, Department of Genetics, University of Pretoria, Private Bag X323, Arcadia 0007, South Africa) ;
Varesco, Liliana (Unit of Hereditary Cancer, Department of Epidemiology, Prevention and Special Functions, IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) AOU San Martino-IST Istituto Nazionale per la Ricerca sul Cancro, largo Rosanna Benzi 10, 16132 Genoa, Italy) ;
Varon-Mateeva, Raymonda (Institute of Human Genetics, Campus Virchov Klinikum, Charite Berlin, Berlin, Germany) ;
Vratimos, Athanassios (Molecular Diagnostics Laboratory, (INRASTES) Institute of Nuclear and Radiological Sciences and Technology, National Centre for Scientific Research "Demokritos" Patriarchou Gregoriou & Neapoleos str., Aghia Paraskevi, Attiki, Athens, Greece) ;
Weitzel, Jeffrey N. (Clinical Cancer Genetics, City of Hope, 1500 East Duarte Road, Duarte, California 91010, United States of America) ;
McGuffog, Lesley (University of Cambridge. Centre for Cancer Genetic Epidemiology) ;
Kirk, Judy (Westmead Hospital) ;
Toland, Amanda Ewart (Divison of Human Cancer Genetics, Departments of Internal Medicine and Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, 998 Biomedical Research Tower, Columbus, OH, United States of America) ;
Hamann, Ute (Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120 Heidelberg, Germany) ;
Lindor, Noralane (Department of Health Sciences Research, Mayo Clinic, 13400 E. Scottsdale Blvd., Scottsdale, AZ, United States of America) ;
Ramus, Susan J. (Department of Preventive Medicine, Keck School of Medicine, University of Southern California, California, United States of America) ;
Greene, Mark H. (Clinical Genetics Branch, DCEG, NCI, NIH, 9609 Medical Center Drive, Room 6E-454, Bethesda, MD, United States of America) ;
Couch, Fergus J. (Department of Laboratory Medicine and Pathology, and Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, Minnesota, United States of America) ;
Offit, Kenneth (Clinical Genetics Research Laboratory, Dept. of Medicine, Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10044, United States of America) ;
Pharoah, Paul D. P. (Department of Oncology, University of Cambridge, Cambridge, United Kingdom) ;
Chenevix-Trench, Georgia (Department of Genetics, QIMR Berghofer Medical Research Institute, Herston Road, Brisbane, Australia, 4029) ;
Antoniou, Antonis C. (University of Cambridge. Centre for Cancer Genetic Epidemiology) ;
Universitat Autònoma de Barcelona
Population-based genome wide association studies have identified a locus at 9p22. 2 associated with ovarian cancer risk, which also modifies ovarian cancer risk in BRCA1 and BRCA2 mutation carriers. We conducted fine-scale mapping at 9p22. [...]
2016 - 10.1371/journal.pone.0158801
PloS one, Vol. 11 (july 2016)
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11 p, 362.2 KB |
BARD1 Pathogenic Variants Are Associated with Triple-Negative Breast Cancer in a Spanish Hereditary Breast and Ovarian Cancer Cohort
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Rofes, Paula (Centro de Investigación Biomédica en Red de Cáncer) ;
Del Valle, Jesús (Centro de Investigación Biomédica en Red de Cáncer) ;
Torres Esquius, Sara (Vall d'Hebron Institut d'Oncologia) ;
Feliubadaló, Lidia (Centro de Investigación Biomédica en Red de Cáncer) ;
Stradella, Agostina (Institut Català d'Oncologia) ;
Moreno-Cabrera, José Marcos (Centro de Investigación Biomédica en Red de Cáncer) ;
López-Doriga, Adriana (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
Munté, Elisabet (Centro de Investigación Biomédica en Red de Cáncer) ;
de Cid, Rafael (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Campos, Olga (Institut Català d'Oncologia) ;
Cuesta, Raquel (Institut Català d'Oncologia) ;
Teulé, Álex (Institut Català d'Oncologia) ;
Grau, Èlia (Institut Català d'Oncologia) ;
Sanz, Judit (Althaia Xarxa Assistencial Universitària de Manresa) ;
Capellá, G. (Gabriel) (Centro de Investigación Biomédica en Red de Cáncer) ;
Diez, Orland (Vall d'Hebron Institut d'Oncologia) ;
Brunet, Joan (Universitat de Girona) ;
Balmaña Gelpí, Judith (Vall d'Hebron Institut d'Oncologia) ;
Lázaro, Conxi (Centro de Investigación Biomédica en Red de Cáncer) ;
Universitat Autònoma de Barcelona
Only a small fraction of hereditary breast and/or ovarian cancer (HBOC) cases are caused by germline variants in the high-penetrance breast cancer 1 and 2 genes (BRCA1 and BRCA2). BRCA1-associated ring domain 1 (BARD1), nuclear partner of BRCA1, has been suggested as a potential HBOC risk gene, although its prevalence and penetrance are variable according to populations and type of tumor. [...]
2021 - 10.3390/genes12020150
Genes, Vol. 12 (january 2021)
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12 p, 2.3 MB |
A comprehensive custom panel design for routine hereditary cancer testing: preserving control, improving diagnostics and revealing a complex variation landscape
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Castellanos, Elisabeth (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ;
Gel, Bernat (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ;
Rosas, Inma (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ;
Tornero, Eva (Institut Català d'Oncologia) ;
Santín, Sheila (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ;
Pluvinet, Raquel (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ;
Velasco, Juan (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ;
Sumoy, Lauro (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ;
Del Valle, Jesús (Institut Català d'Oncologia) ;
Perucho, Manuel (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ;
Blanco Guillermo, Ignacio (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Navarro, Matilde (Institut Català d'Oncologia) ;
Brunet, Joan (Institut Català d'Oncologia) ;
Pineda, Marta (Institut Català d'Oncologia) ;
Feliubadaló, Lidia (Institut Català d'Oncologia) ;
Capellá, G. (Gabriel) (Institut Català d'Oncologia) ;
Lázaro, Conxi (Institut Català d'Oncologia) ;
Serra, Eduard (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer)
We wanted to implement an NGS strategy to globally analyze hereditary cancer with diagnostic quality while retaining the same degree of understanding and control we had in pre-NGS strategies. To do this, we developed the I2HCP panel, a custom bait library covering 122 hereditary cancer genes. [...]
2017 - 10.1038/srep39348
Scientific reports, 2017, p. 1-12
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11 p, 1.3 MB |
Benchmarking of Whole Exome Sequencing and Ad Hoc Designed Panels for Genetic Testing of Hereditary Cancer
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Feliubadaló, Lidia (Institut Català d'Oncologia) ;
Tonda, Raúl (Centre de Regulació Genòmica) ;
Gausachs, Mireia (Institut Català d'Oncologia) ;
Trotta, Jean-Rémi (Centre de Regulació Genòmica) ;
Castellanos, Elisabeth (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
López-Doriga, Adriana (Institut Català d'Oncologia) ;
Teulé, Àlex (Institut Català d'Oncologia) ;
Tornero, Eva (Institut Català d'Oncologia) ;
Del Valle, Jesús (Institut Català d'Oncologia) ;
Gel, Bernat (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gut, Marta (Centre de Regulació Genòmica) ;
Pineda, Marta (Institut Català d'Oncologia) ;
González, Sara (Institut Català d'Oncologia) ;
Menéndez, Mireia (Institut Català d'Oncologia) ;
Navarro, Matilde (Institut Català d'Oncologia) ;
Capellá, G. (Gabriel) (Institut Català d'Oncologia) ;
Gut, Ivo (Centre de Regulació Genòmica) ;
Serra, Eduard (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Brunet, Joan (Institut Català d'Oncologia) ;
Beltran i Agulló, Sergi (Centre de Regulació Genòmica) ;
Lázaro, Conxi (Institut Català d'Oncologia)
Next generation sequencing panels have been developed for hereditary cancer, although there is some debate about their cost-effectiveness compared to exome sequencing. The performance of two panels is compared to exome sequencing. [...]
2017 - 10.1038/srep37984
Scientific reports, 2017-11
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