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Results overview: Found 5 records in 0.01 seconds.
Articles, 4 records found
Research literature, 1 records found
Articles 4 records found  
1.
24 p, 13.5 MB Epigenetic regulation of cell fate reprogramming in aging and disease : A predictive computational model / Folguera Blasco, Núria (Universitat Autònoma de Barcelona. Departament de Matemàtiques) ; Cuyàs, Elisabet (Institut de Recerca Biomèdica de Girona) ; Menéndez, Javier A. (Institut Català d'Oncologia) ; Alarcón Cor, Tomás (Escola Superior de Matemàtiques de Barcelona)
Understanding the control of epigenetic regulation is key to explain and modify the aging process. Because histone-modifying enzymes are sensitive to shifts in availability of cofactors (e. g. metabolites), cellular epigenetic states may be tied to changing conditions associated with cofactor variability. [...]
2018 - 10.1371/journal.pcbi.1006052
PLoS computational biology, Vol. 14, Issue 3 (March 2018) , art. e1006052  
Detailed record - Creative Commons
2.
11 p, 2.0 MB In silico clinical trials for anti-aging therapies / Menendez, Javier A. (Institut d'Investigació Biomèdica de Girona) ; Cuyàs, Elisabet (Institut d'Investigació Biomèdica de Girona) ; Folguera Blasco, Núria (The Francis Crick Institute. Quantitative Cell Biology Lab) ; Verdura, Sara (Institut d'Investigació Biomèdica de Girona) ; Martin-Castillo, Begoña (Institut Català d'Oncologia) ; Joven, Jorge (Institut d'Investigació Sanitària Pere Virgili) ; Alarcón Cor, Tomás (Universitat Autònoma de Barcelona. Departament de Matemàtiques)
Therapeutic strategies targeting the hallmarks of aging can be broadly grouped into four categories, namely systemic (blood) factors, metabolic manipulation (diet regimens and dietary restriction mimetics), suppression of cellular senescence (senolytics), and cellular reprogramming, which likely have common characteristics and mechanisms of action. [...]
2019 - 10.18632/aging.102180
Aging (Albany NY), Vol. 11, Issue 16 (August 2019) , p. 6591-6601  
Detailed record - Creative Commons
3.
27 p, 3.0 MB A multiscale model of epigenetic heterogeneity-driven cell fate decision-making / Folguera Blasco, Núria (Universitat Autònoma de Barcelona. Departament de Matemàtiques) ; Pérez Carrasco, Rubén (University College London. Department of Mathematics) ; Cuyàs, Elisabet (Institut d'Investigació Biomèdica de Girona) ; Menendez, Javier A. (Institut d'Investigació Biomèdica de Girona) ; Alarcón Cor, Tomás (Universitat Autònoma de Barcelona. Departament de Matemàtiques) ; Centre de Recerca Matemàtica
The inherent capacity of somatic cells to switch their phenotypic status in response to damage stimuli in vivo might have a pivotal role in ageing and cancer. However, how the entryexit mechanisms of phenotype reprogramming are established remains poorly understood. [...]
2019 - 10.1371/journal.pcbi.1006592
PLoS computational biology, Vol. 15, Issue 4 (April 2019) , art. e1006592  
Detailed record - Creative Commons
4.
13 p, 3.9 MB Accelerated geroncogenesis in hereditary breast-ovarian cancer syndrome / Menendez, Javier A. (Institut d'Investigació Biomèdica de Girona) ; Folguera Blasco, Núria (Centre de Recerca Matemàtica) ; Cuyàs, Elisabet (Institut d'Investigació Biomèdica de Girona) ; Fernández-Arroyo, Salvador (Hospital Universitari de Sant Joan) ; Joven, Jorge (Hospital Universitari de Sant Joan) ; Alarcón Cor, Tomás (Universitat Autònoma de Barcelona. Departament de Matemàtiques)
The geroncogenesis hypothesis postulates that the decline in metabolic cellular health that occurs naturally with aging drives a "field effect" predisposing normal tissues for cancer development. We propose that mutations in the cancer susceptibility genes BRCA1/2 might trigger "accelerated geroncogenesis" in breast and ovarian epithelia. [...]
2016 - 10.18632/oncotarget.7867
Oncotarget, Vol. 7, issue 11 (March 2016) , p. 11959-11971  
Detailed record - Creative Commons

Research literature 1 records found  
1.
252 p, 4.8 MB Stochastic modelling of epigenetic regulation : analysis of its heterogeneity and its implications in cell plasticity / Folguera Blasco, Núria ; Alarcón Cor, Tomás, dir. ; Menéndez Menéndez, Javier, dir. ; Universitat Autònoma de Barcelona. Departament de Matemàtiques ; Centre de Recerca Matemàtica
En aquesta tesi doctoral, el nostre objectiu principal és entendre la importància de la regulació epigenètica en la determinació del destí cel lular i de les seves possibles tran- sicions cap a altres estats. [...]
In this thesis, we aim at understanding the importance of epigenetic regulation(ER) in cell fate decisions and transitions. In order to address this issue, we first formulate a stochastic model of epigenetic regulation. [...]
[Barcelona] : Universitat Autònoma de Barcelona, 2019.  
Detailed record - Creative Commons

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