Results overview: Found 3 records in 0.02 seconds.
Articles, 1 records found
Research literature, 2 records found
Articles 1 records found  
1.
12 p, 849.5 KB A comprehensive study of the genetic impact of rare variants in SORL1 in European early-onset Alzheimer's disease / Verheijen, Jan (Institute Born-Bunge, University of Antwerp, Antwerp, Belgium) ; Van den Bossche, Tobi (Department of Neurology and Memory Clinic, Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken, Antwerp, Belgium) ; van der Zee, Julie (Institute Born-Bunge, University of Antwerp, Antwerp, Belgium) ; Engelborghs, Sebastiaan (Department of Neurology and Memory Clinic, Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken, Antwerp, Belgium) ; Sánchez Valle, Raquel (Alzheimer's Disease and Other Cognitive Disorders Unit, Neurology Department, Hospital Clínic, Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain) ; Lladó, Albert (Alzheimer's Disease and Other Cognitive Disorders Unit, Neurology Department, Hospital Clínic, Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain) ; Graff, Caroline (Genetics Unit, Department of Geriatric Medicine, Karolinska University Hospital, Stockholm, Sweden) ; Thonberg, Håkan (Genetics Unit, Department of Geriatric Medicine, Karolinska University Hospital, Stockholm, Sweden) ; Pastor, Pau (Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain) ; Ortega-Cubero, Sara (Department of Neurology, Complejo Asistencial Universitario de Palencia, Palencia, Spain) ; Pastor, Maria A. (Department of Neurology, Clínica Universidad de Navarra, University of Navarra School of Medicine, Pamplona, Spain) ; Benussi, Luisa (Molecular Markers Laboratory, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Istituto Centro San Giovanni di Dio-Fatebenefratelli, Brescia, Italy) ; Ghidoni, Roberta (Molecular Markers Laboratory, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Istituto Centro San Giovanni di Dio-Fatebenefratelli, Brescia, Italy) ; Binetti, Giuliano (MAC Memory Center, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Istituto Centro San Giovanni di Dio-Fatebenefratelli, Brescia, Italy) ; Clarimon, Jordi (Institut d'Investigació Biomèdica Sant Pau) ; Lleó Bisa, Alberto (Institut d'Investigació Biomèdica Sant Pau) ; Fortea Ormaechea, Juan (Institut d'Investigació Biomèdica Sant Pau) ; de Mendonça, Alexandre (Faculty of Medicine and Institute of Molecular Medicine, University of Lisbon, Lisbon, Portugal) ; Martins, Madalena (Faculty of Medicine and Institute of Molecular Medicine, University of Lisbon, Lisbon, Portugal) ; Grau-Rivera, Oriol (Neurological Tissue Bank of the Biobanc, Hospital Clinic, Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain) ; Gelpi, Ellen (Neurological Tissue Bank of the Biobanc, Hospital Clinic, Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain) ; Bettens, Karolien (Institute Born-Bunge, University of Antwerp, Antwerp, Belgium) ; Mateiu, Ligia (Bioinformatics Unit, Department of Molecular Genetics, VIB, Antwerp, Belgium) ; Dillen, Lubina (Institute Born-Bunge, University of Antwerp, Antwerp, Belgium) ; Cras, Patrick (Department of Neurology, Antwerp University Hospital, Edegem, Belgium) ; De Deyn, Peter P. (Department of Neurology and Memory Clinic, Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken, Antwerp, Belgium) ; Van Broeckhoven, Christine (Institute Born-Bunge, University of Antwerp, Antwerp, Belgium) ; Sleegers, Kristel (Institute Born-Bunge, University of Antwerp, Antwerp, Belgium)
The sortilin-related receptor 1 (SORL1) gene has been associated with increased risk for Alzheimer's disease (AD). Rare genetic variants in the SORL1 gene have also been implicated in autosomal dominant early-onset AD (EOAD). [...]
2016 - 10.1007/s00401-016-1566-9
Acta Neuropathologica, Vol. 132 (march 2016) , p. 213-224  

Research literature 2 records found  
1.
209 p, 3.4 MB A Biphasic model for cortical structural changes in preclinical AD : a multimodal MRI, CSF and PET study / Vilaplana Martínez, Eduard, autor. ; Lleó Bisa, Alberto, supervisor acadèmic. ; Fortea Ormaechea, Juan, supervisor acadèmic. ; Universitat Autònoma de Barcelona. Institut de Neurociències.
La enfermedad de Alzheimer (EA) se caracteriza neuropatológicamente por la presencia de depósitos extracelulares de ß-amiloide (Aß) y ovillos neurofibrilares intracelulares (proteína tau fosforilada, p-tau) así como fenómenos inflamatorios. [...]
The Alzheimer's disease (AD) neuropathological hallmarks are the presence of extracellular amyloid ß (Aß) deposition and intracellular neurofibrillary tangles (hyperphosphorilated tau protein) as well as inflammation phenomena. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2017.  
2.
126 p, 2.6 MB Sporadic cerebral amyloid angiopathy, beyond lobar intracerebral hemorrhage : multimodal biomarker studies of atypical presentations / Carmona Iragui, María, autor. ; Blesa González, Rafael, supervisor acadèmic. ; Lleó Bisa, Alberto, supervisor acadèmic. ; Fortea Ormaechea, Juan, supervisor acadèmic. ; Universitat Autònoma de Barcelona. Institut de Neurociències.
La angiopatía amiloide cerebral (C17) se define por el depósito de proteína β-amiloide en las capas media y adventicia de arterias y capilares leptomeníngeos y corticales. Es una causa importante de hemorragia intracerebral lobar, episodios neurológicos focales transitorios y contribuye significativamente al deterioro cognitivo y a la demencia en los ancianos. [...]
La angiopatía amiloide cerebral (CAA) se define por el depósito de proteína β-amiloide en las capas media y adventicia de arterias y capilares leptomeníngeos y corticales. Es una causa importante de hemorragia intracerebral lobar, episodios neurológicos focales transitorios y contribuye significativamente al deterioro cognitivo y a la demencia en los ancianos. [...]
Cerebral Amyloid Angiopathy (CAA) is defined by β-amyloid protein deposition in the media and adventitia of leptomeningeal and cortical small arteries and capillaries. CAA is a major cause of lobar intracerebral hemorrhage (ICH), transient focal neurological episodes, and an important contributor to age-related cognitive decline and dementia in the elderly. [...]

[Bellaterra] : Universitat Autònoma de Barcelona, 2017.  

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