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Research literature, 1 records found
Research literature 1 records found  
1.
206 p, 2.9 MB Gout as an autoinflammatory disease: from cellular to genetic mechanisms / García Melchor, Emma ; Juan Otero, Manel, dir. ; Guma, Monica, 1971-, dir. ; Sabriá-Leal, M. (Miquel) ; Universitat Autònoma de Barcelona. Departament de Medicina
La gota ha estat classificada com a malaltia autoinflamatòria pel seu caràcter autolimitat i la participació del sistema immune innat i IL-1β en la seva patogènia. Durant els últims anys, l'evidència que els cristalls d'urat monosòdic (UMS) activen l'inflamasoma NLRP3, juntament amb l'eficàcia del tractament bloquejant de IL-1 en pacients gotosos, han reafirmat el concepte de gota com a malaltia autoinflamatòria. [...]
Gout has been classified as an autoinflammatory disease because of its self-remitting course and the involvement of the innate immune system and IL-1β in its pathogenesis. During the last years, the evidence of NLRP3 inflammasome activation by monosodium urate (MSU) crystals and the beneficial effect of IL-1 blockade for the treatment of patients with gout, have reaffirmed the concept of gout as an autoinflammatory disease. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2014  

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