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20 p, 3.7 MB |
A Review of Fifteen Years Developing Computational Tools to Study Protein Aggregation
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Pintado-Grima, Carlos (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Bárcenas, Oriol (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Bartolomé-Nafría, Andrea (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Fornt-Suñé, Marc (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Iglesias, Valentin (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Garcia-Pardo, Javier (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Ventura, Salvador (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Universitat Autònoma de Barcelona
The presence of insoluble protein deposits in tissues and organs is a hallmark of many human pathologies. In addition, the formation of protein aggregates is considered one of the main bottlenecks to producing protein-based therapeutics. [...]
2023 - 10.3390/biophysica3010001
Biophysica, Vol. 3 Núm. 1 (January 2023)
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10 p, 1.9 MB |
A3DyDB : exploring structural aggregation propensities in the yeast proteome
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Garcia-Pardo, Javier (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Badaczewska-Dawid, Aleksandra E. (Iowa State University) ;
Pintado-Grima, Carlos (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Iglesias, Valentin (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Kuriata, Aleksander (University of Warsaw) ;
Kmiecik, Sebastian (University of Warsaw) ;
Ventura, Salvador (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Background: The budding yeast Saccharomyces cerevisiae (S. cerevisiae) is a well-established model system for studying protein aggregation due to the conservation of essential cellular structures and pathways found across eukaryotes. [...]
2023 - 10.1186/s12934-023-02182-3
Microbial cell factories, Vol. 22, Issue 1 (September 2023) , art. 186
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16 p, 1.8 MB |
Development of Fortified Breads Enriched with Plant-Based Bioactive Peptides Derived from the Chia (Salvia hispanica L.) Expeller
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Ozón, Brenda (Universidad Nacional de La Plata. Departamento de Ciencias Biológicas) ;
Cotabarren, Juliana (Universidad Nacional de La Plata. Departamento de Ciencias Biológicas) ;
Geier, Florencia R. (Universidad Nacional de La Plata. Departamento de Ciencias Biológicas) ;
Kise, M. Paula (Universidad Nacional de Luján. Departamento de Ciencias Básicas) ;
Garcia-Pardo, Javier (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Parisi, Mónica G. (Universidad Nacional de Luján. Departamento de Ciencias Básicas) ;
Obregón, W. David (Universidad Nacional de La Plata. Departamento de Ciencias Biológicas)
By-products from the industrialization of oilseeds, particularly chia, can be sustainably used for the development of new functional products. In this work, wheat breads supplemented with up to 10 mg of chia expeller hydrolysate/g of flour were prepared, obtaining fortified breads with acceptability for consumption, according to a preliminary consumer research study based on an affective test employing a five-point hedonic scale of global acceptance. [...]
2023 - 10.3390/foods12183382
Foods, Vol. 12, Issue 18 (September 2023) , art. 3382
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13 p, 2.0 MB |
A Multifunctional Trypsin Protease Inhibitor from Yellow Bell Pepper Seeds : Uncovering Its Dual Antifungal and Hypoglycemic Properties
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Cotabarren, Juliana (Universidad Nacional de la Plata. Centro de Investigación de Proteínas Vegetales) ;
Ozón, Brenda (Universidad Nacional de la Plata. Centro de Investigación de Proteínas Vegetales) ;
Claver, Santiago (Universidad Nacional de la Plata. Centro de Investigación de Proteínas Vegetales) ;
Geier, Florencia (Universidad Nacional de la Plata. Centro de Investigación de Proteínas Vegetales) ;
Rossotti, Martina (Universidad Nacional de la Plata. Centro de Investigación de Proteínas Vegetales) ;
Garcia-Pardo, Javier (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Obregón, Walter David (Universidad Nacional de la Plata. Centro de Investigación de Proteínas Vegetales) ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular
Fungal infections are a growing public health concern worldwide and the emergence of antifungal resistance has limited the number of therapeutic options. Therefore, developing novel strategies for identifying and developing new antifungal compounds is an active area of research in the pharmaceutical industry. [...]
2023 - 10.3390/pharmaceutics15030781
Pharmaceutics, Vol. 15, Issue 3 (March 2023) , art. 781
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12 p, 2.9 MB |
Cryo-EM structure of hnRNPDL-2 fibrils, a functional amyloid associated with limb-girdle muscular dystrophy D3
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Garcia-Pardo, Javier (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Bartolomé-Nafría, Andrea (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Chaves-Sanjuan, Antonio (Università degli Studi di Milano. Dipartimento di Bioscienze) ;
Gil-Garcia, Marcos (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Visentin, Cristina (Università degli Studi di Milano. Dipartimento di Bioscienze) ;
Bolognesi, Martino (Università degli Studi di Milano. CRC Fondazione Romeo e Enrica Invernizzi and NOLIMITS) ;
Ricagno, Stefano (Policlinico San Donato. Institute of Molecular and Translational Cardiology, I.R.C.C.S.) ;
Ventura, Salvador (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
hnRNPDL is a ribonucleoprotein (RNP) involved in transcription and RNA-processing that hosts missense mutations causing limb-girdle muscular dystrophy D3 (LGMD D3). Mammalian-specific alternative splicing (AS) renders three natural isoforms, hnRNPDL-2 being predominant in humans. [...]
2023 - 10.1038/s41467-023-35854-0
Nature communications, Vol. 14 (January 2023) , art. 239
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14 p, 2.0 MB |
Enhanced Production of ECM Proteins for Pharmaceutical Applications Using Mammalian Cells and Sodium Heparin Supplementation
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Garcia-Pardo, Javier (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Montané, Sergi (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Avilés, Francesc X. (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Tanco, Sebastián Martín (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Lorenzo Rivera, Julia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
The yields of soluble ECM proteins recombinantly produced with mammalian cells can be significantly enhanced by exploiting the stabilizing properties of heparin. Here, we propose a simple and straightforward scalable protocol for the mammalian cell production of ECM proteins with affinity for heparin, using heparin as a supplement. [...]
2022 - 10.3390/pharmaceutics14102138
Pharmaceutics, Vol. 14, Núm. 10 (October 2022) , art. 2138
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