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Results overview: Found 6 records in 0.02 seconds.
Articles, 5 records found
Research literature, 1 records found
Articles 5 records found  
1.
12 p, 2.4 MB δ Opioid receptor agonism preserves the retinal pigmented epithelial cell tight junctions and ameliorates the retinopathy in experimental diabetes / De Faria, J. M. L. (Renal Pathophysiology Laboratory Investigation on Diabetes Complications. Faculty of Medical Sciences. State University of Campinas (UNICAMP)) ; Duarte, D. A. (Renal Pathophysiology Laboratory Investigation on Diabetes Complications. Faculty of Medical Sciences. State University of Campinas (UNICAMP)) ; Simó, R. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Garcia-Ramírez, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Dátilo, M. N. (Renal Pathophysiology Laboratory Investigation on Diabetes Complications. Faculty of Medical Sciences. State University of Campinas (UNICAMP)) ; Pasqualetto, F. C. (Renal Pathophysiology Laboratory Investigation on Diabetes Complications. Faculty of Medical Sciences. State University of Campinas (UNICAMP)) ; De Faria, J. B. L. (Renal Pathophysiology Laboratory Investigation on Diabetes Complications. Faculty of Medical Sciences. State University of Campinas (UNICAMP)) ; Universitat Autònoma de Barcelona
PURPOSE. Outer blood retinal barrier breakdown is a neglected feature of diabetic retinopathy (DR). We demonstrated that the agonism of the δ opioid receptor (DOR) by epicatechin preserves the tight junction proteins in ARPE-19 cells under diabetic conditions. [...]
2019 - 10.1167/iovs.19-26761
Investigative Ophthalmology & Visual Science, Vol. 60 Núm. 12 (january 2019) , p. 3842-3853  
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2.
20 p, 6.5 MB SOCS1-derived peptide administered by eye drops prevents retinal neuroinflammation and vascular leakage in experimental diabetes / Hernández, Cristina (Universitat Autònoma de Barcelona. Departament de Medicina) ; Bogdanov, Patricia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Gómez-Guerrero, Carmen (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ; Sampedro, J. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Solà-Adell, C. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Espejo, Carmen (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Garcia-Ramírez, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Prieto, I. (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ; Egido, Jesús (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ; Simó, R. (Universitat Autònoma de Barcelona. Departament de Medicina)
Current treatments for diabetic retinopathy (DR) target late stages when vision has already been significantly affected. Accumulating evidence suggests that neuroinflammation plays a major role in the pathogenesis of DR, resulting in the disruption of the blood-retinal barrier. [...]
2019 - 10.3390/ijms20153615
International journal of molecular sciences, Vol. 20 Núm. 15 (january 2019) , p. 3615  
Detailed record - Creative Commons
3.
15 p, 3.4 MB Topical Administration of Bosentan Prevents Retinal Neurodegeneration in Experimental Diabetes / Bogdanov, Patricia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Simó-Servat, Olga (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Sampedro, Joel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Solà-Adell, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Garcia-Ramírez, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Ramos, Hugo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Guerrero, Marta (Universitat de Barcelona. Departament de Farmàcia i Tecnologia Farmacèutica, i Fisicoquímica) ; Suñé-Negre, Josep Maria (Universitat de Barcelona. Departament de Farmàcia i Tecnologia Farmacèutica, i Fisicoquímica) ; Ticó, Josep Ramon (Universitat de Barcelona. Departament de Farmàcia i Tecnologia Farmacèutica, i Fisicoquímica) ; Montoro, Bruno (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Durán, Vicente (Medical Mix S.L.U.) ; Arias Barquet, Lluís (Hospital Universitari de Bellvitge) ; Hernández, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Simó Canonge, Rafael (Universitat Autònoma de Barcelona. Departament de Medicina)
Experimental evidence suggests that endothelin 1 (ET-1) is involved in the development of retinal microvascular abnormalities induced by diabetes. The effects of ET-1 are mediated by endothelin A- and B-receptors (ETA and ETB). [...]
2018 - 10.3390/ijms19113578
International journal of molecular sciences, Vol. 19 Núm. 11 (13 2018)  
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4.
7 p, 952.8 KB Overexpression of Hemopexin in the Diabetic Eye / Hernández, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Garcia-Ramírez, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Simó Canonge, Rafael (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Universitat Autònoma de Barcelona
Hemopexin is a well-recognized permeability factor in the kidney, but its potential role in blood-retinal barrier (BRB) breakdown has not been explored. The main aims of this study were as follows: 1) to determine hemopexin expression in the retina and its content in the vitreous fluid from diabetic patients with diabetic macular edema (DME) and nondiabetic patients, 2) to evaluate the effect of hemopexin on BRB permeability, and 3) to determine whether dexamethasone prevents an eventual hemopexin-induced hyperpermeability. [...]
2013 - 10.2337/dc12-2634
Diabetes Care, Vol. 36 (august 2013) , p. 2815-2821  
Detailed record - Creative Commons
5.
10 p, 1.6 MB Topical Administration of Somatostatin Prevents Retinal Neurodegeneration in Experimental Diabetes / Hernández, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Garcia-Ramírez, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Corraliza Márquez, Lidia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Fernández-Carneado, Jimena (BCN Peptides, Barcelona, Spain) ; Farrera-Sinfreu, Josep (BCN Peptides, Barcelona, Spain) ; Ponsati, Berta (BCN Peptides, Barcelona, Spain) ; González-Rodríguez, Águeda (Instituto de Investigaciones Biomédicas "Alberto Sols") ; Valverde, Ángela M. (Instituto de Investigaciones Biomédicas "Alberto Sols") ; Simó Canonge, Rafael (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Universitat Autònoma de Barcelona
Retinal neurodegeneration is an early event in the pathogenesis of diabetic retinopathy (DR). Somatostatin (SST) is an endogenous neuroprotective peptide that is downregulated in the diabetic eye. The aim of the study was to test the usefulness of topical administration of SST in preventing retinal neurodegeneration. [...]
2013 - 10.2337/db12-0926
Diabetes, Vol. 62 (june 2013) , p. 2569-2578  
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Research literature 1 records found  
1.
218 p, 6.2 MB Diabetes mellitus y barrera hematorretiniana. Análisis in vitro de la expresión de proteínas de tight junction y su traducción funcional. Implicaciones terapéuticas / Villarroel Fandos, Marta ; Simó Canonge, Rafael, dir. ; Hernández, Cristina, dir. ; Garcia-Ramírez, Marta, dir. ; Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular
El edema macular diabético (DME) es una de las primeras causas de disminución de la agudeza visual en pacientes con retinopatía diabética (DR). La rotura de la barrera hematorretiniana (BHR) debido a la disrupción de las tight junctions (TJ) es el principal factor causante del DME. [...]
Diabetic macular edema (DME) is one of the primary causes of poor visual acuity in patients with diabetic retinopathy (DR). The breakdown of the blood-retinal barrier (BRB) due to the disruption of tight junctions (TJ) is the main factor accounting for DME. [...]
[Barcelona] : Universitat Autònoma de Barcelona, 2015  
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1 Garcia-Ramírez, Marta,
5 García-Ramírez, Marta
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