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20 p, 2.8 MB |
The high mobility group protein HMG20A cooperates with the histone reader PHF14 to modulate TGFβ and Hippo pathways
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Gómez-Marín, Elena (Genome Biology Department. Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER. Consejo Superior de Investigaciones Científicas (CSIC). Universidad de Sevilla (USE). Universidad Pablo de Olavide (UPO)) ;
Posavec-Marjanović, Melanija (Institut Germans Trias i Pujol) ;
Zarzuela, Laura (Cell Dynamics and Signaling Department. Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER. Consejo Superior de Investigaciones Científicas (CSIC). Universidad de Sevilla (USE). Universidad Pablo de Olavide (UPO)) ;
Basurto-Cayuela, Laura (Genome Biology Department. Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER. Consejo Superior de Investigaciones Científicas (CSIC). Universidad de Sevilla (USE). Universidad Pablo de Olavide (UPO)) ;
Guerrero-Martínez, José A. (Genome Biology Department. Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER. Consejo Superior de Investigaciones Científicas (CSIC). Universidad de Sevilla (USE). Universidad Pablo de Olavide (UPO)) ;
Arribas, Gonzalo (Genome Biology Department. Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER. Consejo Superior de Investigaciones Científicas (CSIC). Universidad de Sevilla (USE). Universidad Pablo de Olavide (UPO)) ;
Yerbes, Rosario (Cell Dynamics and Signaling Department. Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER. Consejo Superior de Investigaciones Científicas (CSIC). Universidad de Sevilla (USE). Universidad Pablo de Olavide (UPO)) ;
Ceballos-Chávez, María (Genome Biology Department. Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER. Consejo Superior de Investigaciones Científicas (CSIC). Universidad de Sevilla (USE). Universidad Pablo de Olavide (UPO)) ;
Rodríguez-Paredes, Manuel (Institute of Toxicology. University Medical Center Mainz. Johannes Gutenberg University) ;
Tomé, Mercedes (Cell Dynamics and Signaling Department. Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER. Consejo Superior de Investigaciones Científicas (CSIC). Universidad de Sevilla (USE). Universidad Pablo de Olavide (UPO)) ;
Durán, Raúl V. (Cell Dynamics and Signaling Department. Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER. Consejo Superior de Investigaciones Científicas (CSIC). Universidad de Sevilla (USE). Universidad Pablo de Olavide (UPO)) ;
Buschbeck, Marcus (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Reyes, José C. (Genome Biology Department. Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER. Consejo Superior de Investigaciones Científicas (CSIC). Universidad de Sevilla (USE). Universidad Pablo de Olavide (UPO))
High mobility group (HMG) proteins are chromatin regulators with essential functions in development, cell differentiation and cell proliferation. The protein HMG20A is predicted by the AlphaFold2 software to contain three distinct structural elements, which we have functionally characterized: i) an amino-terminal, intrinsically disordered domain with transactivation activity; ii) an HMG box with higher binding affinity for double-stranded, four-way-junction DNA than for linear DNA; and iii) a long coiled-coil domain. [...]
2022 -  10.1093/nar/gkac766
Nucleic acids research, Vol. 50 Núm. 17 (january 2022) , p. 9838-9857
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13 p, 527.1 KB |
Autonomic response to walk tests is useful for assessing outcome measures in people with multiple sclerosis
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Kontaxis, Spyridon (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Laporta, Estela (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Garcia, Esther (Universitat Autònoma de Barcelona. Departament de Microelectrònica i Sistemes Electrònics) ;
Guerrero, Ana Isabel (Hospital Universitari Vall d'Hebron) ;
Zabalza, Ana (Hospital Universitari Vall d'Hebron) ;
Matteo, Martinis (Vita Salute San Raffaele University) ;
Lucia, Roselli (Vita Salute San Raffaele University) ;
Simblett, Sara (King's College London) ;
Weyer, Janice (RADAR-CNS Patient Advisory Board) ;
Hotopf, Matthew (King's College London) ;
Narayan, Vaibhav A. (Research and Development Information Technology) ;
Rashid, Zulqarnain (King's College London) ;
Folarin, Amos A. (University College London) ;
Dobson, Richard J. B. (University College London) ;
Buron, Mathias Due (Copenhagen University Hospital Rigshospitalet) ;
Leocani, Letizia (Vita Salute San Raffaele University) ;
Cummins, Nicholas (King's College London) ;
Vairavan, Srinivasan (Research and Development Information Technology) ;
Costa, Gloria Dalla (Vita Salute San Raffaele University) ;
Magyari, Melinda (Copenhagen University Hospital Rigshospitalet) ;
Sørensen, Per Soelberg (Copenhagen University Hospital Rigshospitalet) ;
Nos, Carlos (Hospital Universitari Vall d'Hebron) ;
Bailón, Raquel (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Comi, Giancarlo (Casa di Cura del Policlinico (Milà, Itàlia)) ;
the RADAR-CNS Consortium, None (The RADAR-CNS Consortium)
The aim of this study was to evaluate the association between changes in the autonomic control of cardiorespiratory system induced by walk tests and outcome measures in people with Multiple Sclerosis (pwMS). [...]
2023 - 10.3389/fphys.2023.1145818
Frontiers in physiology, Vol. 14 (april 2023)
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11 p, 732.4 KB |
Automatic Assessment of the 2-Minute Walk Distance for Remote Monitoring of People with Multiple Sclerosis
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Kontaxis, Spyridon (Universidad de Zaragoza) ;
Laporta, Estela (Universidad de Zaragoza) ;
Garcia, Esther (Universitat Autònoma de Barcelona. Departament de Microelectrònica i Sistemes Electrònics) ;
Martinis, Matteo (University Vita-Salute and Hospital San Raffaele) ;
Leocani, Letizia (University Vita-Salute and Hospital San Raffaele) ;
Roselli, Lucia (University Vita-Salute and Hospital San Raffaele) ;
Buron, Mathias Due (Copenhagen University Hospital Rigshospitalet) ;
Guerrero, Ana Isabel (Hospital Universitari Vall d'Hebron) ;
Zabalza, Ana (Hospital Universitari Vall d'Hebron) ;
Cummins, Nicholas (King's College London) ;
Vairavan, Srinivasan (Janssen Research and Development) ;
Hotopf, Matthew (King's College London) ;
Dobson, Richard J. B. (University College London) ;
Narayan, Vaibhav A. (Davos Alzheimer's Collaborative) ;
La Porta, Maria Libera (University Vita-Salute and Hospital San Raffaele) ;
Costa, Gloria Dalla (University Vita-Salute and Hospital San Raffaele) ;
Magyari, Melinda (Copenhagen University Hospital Rigshospitalet) ;
Sørensen, Per Soelberg (Copenhagen University Hospital Rigshospitalet) ;
Nos, Carlos (Hospital Universitari Vall d'Hebron) ;
Bailón, Raquel (Universidad de Zaragoza) ;
Comi, Giancarlo (Casa di Cura del Policlinico (Milà, Itàlia))
The aim of this study was to investigate the feasibility of automatically assessing the 2-Minute Walk Distance (2MWD) for monitoring people with multiple sclerosis (pwMS). For 154 pwMS, MS-related clinical outcomes as well as the 2MWDs as evaluated by clinicians and derived from accelerometer data were collected from a total of 323 periodic clinical visits. [...]
2023 - 10.3390/s23136017
Sensors (Basel, Switzerland), Vol. 23 (june 2023)
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18 p, 1.0 MB |
NRN1 Gene as a Potential Marker of Early-Onset Schizophrenia : Evidence from Genetic and Neuroimaging Approaches
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Almodóvar-Payá, Carmen (Instituto de Salud Carlos III) ;
Guardiola-Ripoll, Maria (Instituto de Salud Carlos III) ;
Giralt López, Maria (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Gallego, Carme (Molecular Biology Institute of Barcelona) ;
Salgado-Pineda, Pilar (Centro de Investigación Biomédica en Red de Salud Mental) ;
Miret, Salvador (Hospital Universitari Santa Maria de Lleida) ;
Salvador, Raymond (Centro de Investigación Biomédica en Red de Salud Mental) ;
Muñoz, María J. (Complex Assistencial en Salut Mental Benito Menni (Sant Boi de Llobregat, Catalunya)) ;
Lázaro, Luisa (Hospital Clínic i Provincial de Barcelona) ;
Guerrero-Pedraza, Amalia (Complex Assistencial en Salut Mental Benito Menni (Sant Boi de Llobregat, Catalunya)) ;
Parellada, Mara (Instituto de Investigación Sanitaria del Hospital Gregorio Marañón) ;
Carrión, María I. (Hospital Universitario de Navarra) ;
Cuesta, Manuel J. (Instituto de Investigación Sanitaria de Navarra) ;
Maristany, Teresa (Hospital Sant Joan de Déu Fundació de Recerca) ;
Sarró, Salvador (Centro de Investigación Biomédica en Red de Salud Mental) ;
Fañanás, Lourdes (Universitat de Barcelona. Institut de Biomedicina) ;
Callado, Luis F. (Instituto de Salud Carlos III) ;
Arias, Barbara (Universitat de Barcelona. Institut de Biomedicina) ;
Pomarol-Clotet, Edith (Centro de Investigación Biomédica en Red de Salud Mental) ;
Fatjó-Vilas, Mar (Departament de Biologia Evolutiva, Ecología i Ciències Ambientals, Universitat de Barcelona (UB))
Included in the neurotrophins family, the Neuritin 1 gene (NRN1) has emerged as an attractive candidate gene for schizophrenia (SZ) since it has been associated with the risk for the disorder and general cognitive performance. [...]
2022 - 10.3390/ijms23137456
International journal of molecular sciences, Vol. 23 Num. 13 (july 2022)
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10 p, 6.4 MB |
Imaging of Antiferroelectric Dark Modes in an Inverted Plasmonic Lattice
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Rodríguez-Álvarez, Javier (Universitat de Barcelona) ;
Labarta, Amílcar (Universitat de Barcelona) ;
Idrobo, Juan Carlos (University of Washington) ;
Dell'Anna, Rossana (FBK - Bruno Kessler Foundation) ;
Cian, Alessandro (FBK - Bruno Kessler Foundation) ;
Giubertoni, Damiano (FBK - Bruno Kessler Foundation) ;
Borrisé, Xavier (Institut Català de Nanociència i Nanotecnologia) ;
Guerrero, Albert (Institut de Microelectrònica de Barcelona) ;
Pérez Murano, Francesc (Institut de Microelectrònica de Barcelona) ;
Fraile Rodríguez, Arantxa (Universitat de Barcelona) ;
Batlle, Xavier (Universitat de Barcelona)
Plasmonic lattice nanostructures are of technological interest because of their capacity to manipulate light below the diffraction limit. Here, we present a detailed study of dark and bright modes in the visible and near-infrared energy regime of an inverted plasmonic honeycomb lattice by a combination of Au + focused ion beam lithography with nanometric resolution, optical and electron spectroscopy, and finite-difference time-domain simulations. [...]
2023 - 10.1021/acsnano.2c11016
ACS nano, Vol. 17, Issue 9 (May 2023) , p. 8123-8132
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6 p, 189.8 KB |
Cost-Effectiveness of Robotic vs. Laparoscopic Surgery for Different Surgical Procedures : Protocol for a Prospective, Multicentric Study (ROBOCOSTES)
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Ielpo, Benedetto (Hospital del Mar (Barcelona, Catalunya)) ;
Podda, Mauro (University of Cagliari) ;
Burdío, Fernando (Hospital del Mar (Barcelona, Catalunya)) ;
Sanchez-Velazquez, Patricia (Hospital del Mar (Barcelona, Catalunya)) ;
Guerrero, Maria-Alejandra (Hospital del Mar (Barcelona, Catalunya)) ;
Nuñez, Javier (IVEC) ;
Toledano, Miguel (Hospital Universitario Río Hortega (Valladolid)) ;
Morales Conde, Salvador (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Mayol, Julio (Hospital Clínico San Carlos (Madrid)) ;
López Cano, Manuel (Hospital Universitari Vall d'Hebron) ;
Espin-Basany, Eloy (Hospital Universitari Vall d'Hebron) ;
Pellino, Gianluca (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
The studies which address the impact of costs of robotic vs. laparoscopic approach on quality of life (cost-effectiveness studies) are scares in general surgery. The Spanish national study on cost-effectiveness differences among robotic and laparoscopic surgery (ROBOCOSTES) is designed as a prospective, multicentre, national, observational study. [...]
2022 - 10.3389/fsurg.2022.866041
Frontiers in Surgery, Vol. 9 (may 2022)
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12 p, 682.4 KB |
Peripheral Inflammatory Indexes Neutrophil/Lymphocyte Ratio (NLR) and Red Cell Distribution Width (RDW) as Prognostic Biomarkers in Advanced Solitary Fibrous Tumour (SFT) Treated with Pazopanib
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Hidalgo-Ríos, Samuel (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Carrillo García, Jaime (Hospital Universitario General de Villalba. Servicio de Oncología Médica) ;
Moura, David S. (Hospital Universitario General de Villalba. Servicio de Oncología Médica) ;
Stacchiotti, Silvia (Fondazione IRCCS Istituto Nazionale dei Tumori (Milà, Itàlia)) ;
López Pousa, Antonio (Institut d'Investigació Biomèdica Sant Pau) ;
Redondo, Andrés (Hospital Universitario La Paz. Servicio de Oncología Médica. Instituto de Investigación en Salud (IdiPAZ)) ;
Italiano, Antoine (Institut Bergonié. Department of Oncology) ;
Gutiérrez, Antonio (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Grignani, Giovanni (Candiolo Cancer Institute. FPO - IRCCS) ;
Hindi, Nadia (Hospital Universitario Fundación Jiménez Díaz. Servicio de Oncología Médica) ;
López-Guerrero, J.A (Laboratory of Molecular Biology. Fundación Instituto Valenciano de Oncología) ;
Garcia del Muro, Xavier (Institut d'Investigació Biomèdica de Bellvitge) ;
Martínez-Trufero, Javier (Hospital Universitario Miguel Servet. Servicio de Oncología Médica) ;
Palmerini, Emanuela (IRCCS Istituto Ortopedico Rizzoli (Bologna)) ;
Sebio, Ana (Institut d'Investigació Biomèdica Sant Pau) ;
Bernabeu, Daniel (Hospital Universitario La Paz. Sección de Radiología musculoesquelética) ;
Le Cesne, Axel (Gustave Roussy Cancer Campus. Department of Medical Oncology) ;
Casali, Paolo Giovanni (Fondazione IRCCS Istituto Nazionale dei Tumori. Adult Mesenchymal and Rare Tumor Unit. Department of Cancer Medicine) ;
Blay, Jean-Yves (Department of Medical Oncology. Centre Léon Bérard. Université Claude Bernard Lyon) ;
Cruz-Jurado, Josefina (Hospital Universitario de Canarias. Servicio de Oncología Médica) ;
Martín-Broto, Javier (Hospital Universitario Fundación Jiménez Díaz. Servicio de Oncología Médica)
Pazopanib was assessed prospectively in the GEIS-32 phase II study (NCT02066285) on advanced solitary fibrous tumour (SFT), resulting in a longer progression-free survival (PFS) and overall survival (OS) compared with historical controls treated with chemotherapy. [...]
2022 - 10.3390/cancers14174186
Cancers, Vol. 14 Núm. 17 (september 2022) , p. 4186
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11 p, 1.6 MB |
Combining fMRI and DISC1 gene haplotypes to understand working memory-related brain activity in schizophrenia
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Guardiola-Ripoll, Maria (Centro de Investigación Biomédica en Red de Salud Mental) ;
Sotero-Moreno, Alejandro (FIDMAG Germanes Hospitalàries Research Foundation) ;
Almodóvar-Payá, Carmen (Centro de Investigación Biomédica en Red de Salud Mental) ;
Hostalet, Noemí (FIDMAG Germanes Hospitalàries Research Foundation) ;
Guerrero-Pedraza, Amalia (Benito Menni, Complejo Asistencial en Salud Mental) ;
Ramiro, Núria (Hospital San Rafael (Barcelona, Catalunya)) ;
Ortiz-Gil, Jordi (Hospital General de Granollers. Unitat de Psicologia) ;
Arias, Barbara (Universitat de Barcelona. Departament de Biologia Evolutiva, Ecologia i Ciències Ambientals) ;
Madre Rull, Mercè (Institut d'Investigació Biomèdica Sant Pau) ;
Soler-Vidal, Joan (Benito Menni, Complejo Asistencial en Salud Mental) ;
Salvador, Raymond (Centro de Investigación Biomédica en Red de Salud Mental) ;
McKenna, Peter J. (Centro de Investigación Biomédica en Red de Salud Mental) ;
Pomarol-Clotet, Edith (Centro de Investigación Biomédica en Red de Salud Mental) ;
Fatjó-Vilas, Mar (Universitat de Barcelona. Departament de Biologia Evolutiva, Ecologia i Ciències Ambientals)
The DISC1 gene is one of the most relevant susceptibility genes for psychosis. However, the complex genetic landscape of this locus, which includes protective and risk variants in interaction, may have hindered consistent conclusions on how DISC1 contributes to schizophrenia (SZ) liability. [...]
2022 - 10.1038/s41598-022-10660-8
Scientific reports, Vol. 12 Núm. 1 (december 2022) , p. 7351
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12 p, 405.5 KB |
Mercado Mundial de Competencias Laborales : una aproximación desde la Teoría de Redes
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Guerrero Herrera, Laura Araceli (Universidad Autónoma del Estado de Hidalgo (Mèxic)) ;
Terrones Cordero, Aníbal (Universidad Autónoma del Estado de Hidalgo (Mèxic)) ;
Sánchez Torres, Yolanda (Universidad Autónoma del Estado de Hidalgo (Mèxic))
Las competencias laborales han tomado mayor relevancia en las últimas décadas donde las organizaciones modernas bajo el paradigma de la economía del conocimiento han incrementado la demanda de personal con habilidades que les garanticen niveles significativos de diferenciación y competitividad. [...]
Labor skills have become more relevant in recent decades where modern organizations under the paradigm of the knowledge economy have increased the demand for personnel with skills that guarantee them significant levels of differentiation and competitiveness. [...]
Les compétences de la main-d'œuvre sont devenues plus pertinentes au cours des dernières décennies, où les organisations modernes sous le paradigme de l'économie du savoir ont augmenté la demande de personnel doté de compétences garantissant des niveaux significatifs de différenciation et de compétitivité. [...]
2023 - 10.5565/rev/redes.1001
Redes : revista hispana para el análisis de redes sociales, Vol. 34 Núm. 2 (2023) , p. 254-265 (Articulos)
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