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14 p, 1.9 MB |
Molecular and functional profiling identifies therapeutically targetable vulnerabilities in plasmablastic lymphoma
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Frontzek, Fabian (University Hospital of Münster (Alemanya)) ;
Staiger, Annette M. (Robert Bosch Hospital) ;
Zapukhlyak, Myroslav (University Hospital of Münster (Alemanya)) ;
Xu, Wendan (University Hospital of Münster (Alemanya)) ;
Bonzheim, Irina (University Hospital of Tübingen (Alemanya)) ;
Borgmann, Vanessa (University Hospital of Tübingen (Alemanya)) ;
Sander, Philip (University Hospital of Tübingen (Alemanya)) ;
Baptista, Maria Joao (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Heming, Jan-Niklas (University Hospital of Münster (Alemanya)) ;
Berning, Philipp (University Hospital of Münster (Alemanya)) ;
Wullenkord, Ramona (University Hospital of Münster (Alemanya)) ;
Erdmann, Tabea (University Hospital of Münster (Alemanya)) ;
Lutz, Mathias (University Hospital of Münster (Alemanya)) ;
Veratti, Pia (University Hospital Freiburg) ;
Ehrenfeld, Sophia (University of Freiburg) ;
Wienand, Kirsty (University Medical Center Göttingen) ;
Horn, Heike (Robert Bosch Hospital) ;
Goodlad, John R. (Queen Elizabeth University Hospital) ;
Wilson, Matthew R. (Beatson West of Scotland Cancer Centre (Glasgow, Regne Unit)) ;
Anagnostopoulos, Ioannis (Charité - Universitätsmedizin Berlin) ;
Lamping, Mario (Charité - Universitätsmedizin Berlin) ;
González Barca, Eva (Universitat de Barcelona) ;
Climent, Fina (Institut d'Investigació Biomèdica de Bellvitge) ;
Salar, Antonio (Hospital del Mar (Barcelona, Catalunya)) ;
Castellvi, Josep (Hospital Universitari Vall d'Hebron) ;
Abrisqueta, Pau (Hospital Universitari Vall d'Hebron) ;
Menarguez, Javier (Hospital General Universitario Gregorio Marañón) ;
Aldámiz-Echevarría, T (Hospital General Universitario Gregorio Marañón) ;
Richter, Julia (Christian-Albrechts-University) ;
Klapper, Wolfram (Christian-Albrechts-University) ;
Tzankov, Alexander (University Hospital Basel (Basilea, Suïssa)) ;
Dirnhofer, Stefan (University Hospital Basel (Basilea, Suïssa)) ;
Rosenwald, Andreas (University of Würzburg) ;
Mate Sanz, Jose Luís (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Tapia, Gustavo (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Lenz, Peter (Department of Physics. University of Marburg) ;
Miething, C. (German Cancer Research Center) ;
Hartmann, Wolfgang (University Hospital of Münster (Alemanya)) ;
Chapuy, Björn (University Medical Center Göttingen) ;
Fend, Falko (University Hospital of Tübingen (Alemanya)) ;
Ott, Gustav (Department of Clinical Pathology. Robert Bosch Hospital) ;
Navarro, José-Tomás (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Grau, Michael (University Hospital of Münster (Alemanya)) ;
Lenz, Georg (University Hospital of Münster (Alemanya)) ;
Universitat Autònoma de Barcelona
Plasmablastic lymphoma (PBL) represents a rare and aggressive lymphoma subtype frequently associated with immunosuppression. Clinically, patients with PBL are characterized by poor outcome. The current understanding of the molecular pathogenesis is limited. [...]
2021 -  10.1038/s41467-021-25405-w
Nature communications, Vol. 12 Núm. 1 (january 2021) , p. 5183
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10 p, 2.4 MB |
Sarcoma classification by DNA methylation profiling
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Koelsche, Christian (Heidelberg University Hospital (Alemanya)) ;
Schrimpf, Daniel (German Cancer Research Center) ;
Stichel, Damian (German Cancer Research Center) ;
Sill, Martin (German Cancer Research Center) ;
Sahm, Felix (German Cancer Research Center) ;
Reuss, David E. (German Cancer Research Center) ;
Blattner, Mirjam (German Cancer Research Center) ;
Worst, Barbara (Heidelberg University Hospital (Alemanya)) ;
Heilig, Christoph E. (German Cancer Consortium) ;
Beck, Katja (German Cancer Research Center) ;
Horak, Peter (German Cancer Consortium) ;
Kreutzfeldt, Simon (German Cancer Consortium) ;
Paff, Elke (Heidelberg University Hospital (Alemanya)) ;
Stark, Sebastian (Heidelberg University Hospital (Alemanya)) ;
Johann, Pascal (Heidelberg University Hospital (Alemanya)) ;
Selt, Florian (German Cancer Research Center) ;
Ecker, Jonas (German Cancer Research Center) ;
Sturm, Dominik (Heidelberg University Hospital (Alemanya)) ;
Pajtler, Kristian W. (Heidelberg University Hospital (Alemanya)) ;
Reinhardt, Annekathrin (German Cancer Research Center) ;
Wefers, Annika K. (German Cancer Research Center) ;
Sievers, Philipp (German Cancer Research Center) ;
Ebrahimi, Azadeh (German Cancer Research Center) ;
Suwala, Abigail (German Cancer Research Center) ;
Fernández-Klett, Francisco (German Cancer Research Center) ;
Casalini, Belén (German Cancer Research Center) ;
Korshunov, Andrey (German Cancer Research Center) ;
Hovestadt, Volker (Harvard Medical School) ;
Kommoss, Felix K.F. (DHeidelberg University Hospital) ;
Kriegsmann, Mark (Heidelberg University Hospital (Alemanya)) ;
Schick, Matthias (German Cancer Research Center) ;
Bewerunge-Hudler, Melanie (German Cancer Research Center) ;
Milde, Till (German Cancer Research Center) ;
Witt, Olaf (German Cancer Research Center) ;
Kulozik, Andreas E. (eidelberg University Hospital) ;
Kool, Marcel (German Cancer Research Center) ;
Romero-Pérez, Laura (LMU Munich) ;
Grünewald, Thomas G.P. (LMU Munich) ;
Kirchner, Thomas (LMU Munich) ;
Wick, Wolfgang (German Cancer Research Center) ;
Platten, Michael (German Cancer Research Center) ;
Unterberg, Andreas (Heidelberg University Hospital (Alemanya)) ;
Uhl, Matthias (Heidelberg Institute of Radiation Oncology) ;
Abdollahi, Amir (German Cancer Research Center) ;
Debus, Jürgen (German Cancer Research Center) ;
Lehner, Burkhard (Heidelberg University Hospital (Alemanya)) ;
Thomas, Christian (University Hospital of Münster (Alemanya)) ;
Hasselblatt, Martin (University Hospital of Münster (Alemanya)) ;
Paulus, Werner (University Hospital of Münster (Alemanya)) ;
Hartmann, Christian (Hannover Medical School) ;
Staszewski, Ori (University of Freiburg) ;
Prinz, Marco (University of Freiburg) ;
Hench, Jürgen (University Hospital Basel (Basilea, Suïssa)) ;
Frank, Stephan (University Hospital Basel (Basilea, Suïssa)) ;
Versleijen-Jonkers, Yvonne M.H. (Radboud University Medical Center) ;
Weidema, Marije E. (Radboud University Medical Center) ;
Mentzel, Thomas (Dermatopathology Bodensee) ;
Griewank, Klaus (University Duisburg-Essen) ;
De Álava, Enrique (Universidad de Sevilla) ;
Díaz-Martín, Juan (Instituto de Biomedicina de Sevilla) ;
Idoate Gastearena, Miguel A. (Clínica Universidad de Navarra) ;
Chang, Kenneth Tou-En (Department of Pathology and Laboratory Medicine. KK Women's and Children's Hospital) ;
Low, Sharon Yin Yee (National Neuroscience Institute (Singapur)) ;
Cuevas-Bourdier, Adrian (Laboratoire National de Santé (França)) ;
Mittelbronn, Michel (Luxembourg Institute of Health) ;
Mynarek, Martin (University Medical Center Hamburg-Eppendorf) ;
Rutkowski, Stefan (University Medical Center Hamburg-Eppendorf) ;
Schüller, Ulrich (Research Institute Children's Cancer Center Hamburg) ;
Mautner, Viktor F. (University Medical Center Hamburg-Eppendorf) ;
Schittenhelm, Jens (Institute of Pathology and Neuropathology. University Hospital of Tübingen) ;
Serrano, Jonathan (New York University School of Medicine) ;
Snuderl, Matija (New York University School of Medicine) ;
Büttner, Reinhard (Uniklinik Köln (Colònia, Alemanya)) ;
Klingebiel, Thomas (University Children's Hospital) ;
Buslei, Rolf (Sozialstiftung Bamberg. Klinikum am Bruderwald) ;
Gessler, Manfred (Würzburg University) ;
Wesseling, Pieter (Amsterdam University Medical Centers/VUmc) ;
Dinjens, Winand N.M. (Erasmus MC Cancer Institute) ;
Brandner, Sebastian (University College London Hospitals NHS Foundation Trust) ;
Jaunmuktane, Zane (University College London) ;
Lyskjær, Iben (University College London) ;
Schirmacher, Peter (Heidelberg University Hospital (Alemanya)) ;
Stenzinger, Albretch (Heidelberg University Hospital (Alemanya)) ;
Brors, Benedikt (German Cancer Research Center) ;
Glimm, Hanno (German Cancer Consortium) ;
Heining, Christoph (German Cancer Consortium) ;
Tirado, Oscar M. (Institut d'Investigació Biomèdica de Bellvitge) ;
Sáinz-Jaspeado, Miguel (Institut d'Investigació Biomèdica de Bellvitge) ;
Mora, Jaume (Hospital Sant Joan de Déu (Barcelona, Catalunya)) ;
Alonso, Javier (Instituto de Salud Carlos III) ;
Garcia del Muro, Xavier (Institut d'Investigació Biomèdica de Bellvitge) ;
Moran, S (Institut d'Investigació Biomèdica de Bellvitge) ;
Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Benhamida, Jamal K. (Memorial Sloan Kettering Cancer Center) ;
Ladanyi, Marc (Department of Pathology. Memorial Sloan Kettering Cancer Center) ;
Wardelmann, Eva (University Hospital of Münster (Alemanya)) ;
Antonescu, Cristina (Memorial Sloan Kettering Cancer Center) ;
Flanagan, Adrienne (University College London Cancer Institute) ;
Dirksen, Uta (University Duisburg-Essen) ;
Hohenberger, Peter (University of Heidelberg) ;
Baumhoer, Daniel (University Hospital Basel (Basilea, Suïssa)) ;
Hartmann, Wolfgang (University Hospital of Münster (Alemanya)) ;
Vokuhl, Christian (Universitätsklinikum Schleswig-Holstein (Alemanya)) ;
Flucke, Uta (Radboud University Medical Center) ;
Petersen, Iver (Institute of Pathology) ;
Mechtersheimer, Gunhild (Heidelberg University Hospital (Alemanya)) ;
Capper, David (Charité - Universitätsmedizin Berlin) ;
Jones, David T.W. (PGerman Cancer Research Center) ;
Fröhling, Stefan (German Cancer Consortium) ;
Pfister, Stefan M. (Heidelberg University Hospital (Alemanya)) ;
von Deimling, Andreas (German Cancer Research Center)
Sarcomas are malignant soft tissue and bone tumours affecting adults, adolescents and children. They represent a morphologically heterogeneous class of tumours and some entities lack defining histopathological features. [...]
2021 - 10.1038/s41467-020-20603-4
Nature communications, Vol. 12 Núm. 1 (january 2021) , p. 498
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9 p, 2.1 MB |
ROS1 rearrangements in lung adenocarcinoma: prognostic impact, therapeutic options and genetic variability
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Scheffler, Matthias (Center for Integrated Oncology Köln Bonn (Cologne, Alemanya)) ;
Schultheis, Anne M. (Center for Integrated Oncology Köln Bonn (Cologne, Alemanya)) ;
Teixidó, Cristina (Hospital Universitari Quiron Dexeus (Barcelona, Catalunya)) ;
Michels, Sebastian (Center for Integrated Oncology Köln Bonn (Cologne, Alemanya)) ;
Morales Espinosa, Daniela (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Viteri, Santiago (Hospital Universitari Quiron Dexeus (Barcelona, Catalunya)) ;
Hartmann, Wolfgang (University Hospital of Münster (Alemanya)) ;
Merkelbach Bruse, Sabine (Center for Integrated Oncology Köln Bonn (Cologne, Alemanya)) ;
Fischer, Rieke (Center for Integrated Oncology Köln Bonn (Cologne, Alemanya)) ;
Schildhaus, Hans Ulrich (University Medical Center of Göttingen (Alemanya)) ;
Fassunke, Jana (Center for Integrated Oncology Köln Bonn (Cologne, Alemanya)) ;
Sebastian, Martin (University Hospital of Frankfurt (Alemanya)) ;
Serke, Monika (Lung Clinic Hemer (Alemanya)) ;
Kaminsky, Britta (Bethanien Hospital (Solingen, Alemanya)) ;
Randerath, Winfried (Bethanien Hospital (Solingen, Alemanya)) ;
Gerigk, Ulrich (Malteser Hospital Seliger Gerhard Bonn/Rhein-Sieg (Alemanya)) ;
Ko, Yon-Dschun (Johanniter Hospital (Bonn, Alemanya)) ;
Krüger, Stefan (Florence-Nightingale Hospital (Düsseldorf, Alemanya)) ;
Schnell, Roland ;
Rothe, Achim ;
Kropf Sanchen, Cornelia (University Hospital of Ulm (Alemanya)) ;
Heukamp, Lukas (Center for Integrated Oncology Köln Bonn (Cologne, Alemanya)) ;
Rosell, Rafael (Hospital Universitari Quiron Dexeus (Barcelona, Catalunya)) ;
Büttner, Reinhard (Center for Integrated Oncology Köln Bonn (Cologne, Alemanya)) ;
Wolf, Jürgen (Center for Integrated Oncology Köln Bonn (Cologne, Alemanya))
BACKGROUND: While recent data show that crizotinib is highly effective in patients with ROS1 rearrangement, few data is available about the prognostic impact, the predictive value for different treatments, and the genetic heterogeneity of ROS1-positive patients. [...]
2015 - 10.18632/oncotarget.3387
Oncotarget, Vol. 6 Núm. 12 (april 2015)
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