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9 p, 513.6 KB |
Assessing the rate of non-linkage to care and identifying barriers in individuals living with hepatitis B. Results of the LINK-B study
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Feliu-Prius, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Barreira-Diaz, Ana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rando, Ariadna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vargas-Accarino, Elena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Palom, Adriana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vico-Romero, Judit (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ruiz Cobo, Juan Carlos (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Riveiro Barciela, Mar (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Rodríguez Frías, Francisco (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Esteban, Rafael (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Buti, Maria (Universitat Autònoma de Barcelona. Departament de Medicina)
Background & Aims: Hepatitis B infection is the most frequent cause of chronic hepatitis and liver cancer worldwide. Active searching for individuals with chronic hepatitis B has been proposed as a strategy to achieve the elimination of this virus. [...]
2024 -  10.1111/liv.15814
Liver International, Vol. 44, Num. 3 (march 2024) , p. 706-714
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7 p, 817.8 KB |
Hepatitis B reactivation is a rare event among patients with resolved infection undergoing anti-CD20 antibodies in monotherapy without antiviral prophylaxis : results from the HEBEM study
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Marzo Escartin, Blanca (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Vidal-Jordana, Angela (Hospital Universitari Vall d'Hebron) ;
Castilló, Joaquín (Hospital Universitari Vall d'Hebron) ;
Robles-Sanchez, Miguel-Angel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Otero-Romero, Susana (Hospital Universitari Vall d'Hebron) ;
Tintoré, Mar (Hospital Universitari Vall d'Hebron) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Buti, Maria (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Riveiro Barciela, Mar (Universitat Autònoma de Barcelona. Departament de Medicina)
INTRODUCTION: Prospective data on the risk of hepatitis B reactivation (HBVr) among patients with resolved HBV infection undergoing anti-CD20 antibodies monotherapy is scarce. We aimed to assess the risk of HBVr in patients with resolved HBV infection treated with rituximab or ocrelizumab in monotherapy for multiple sclerosis (MS) or neuromyelitis optica spectrum disorder (NMOSD) without antiviral prophylaxis. [...]
D. Steinkopff-Verlag, 2023 - 10.1007/s00415-023-11973-y
Journal of Neurology, Vol. 271 (2024) p. 134-140
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3.
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16 p, 1.9 MB |
Cross-sectional evaluation of circulating hepatitis B virus RNA and DNA : Different quasispecies?
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García-García, Selene (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Cortese, Maria Francesca (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Tabernero, David (Instituto de Salud Carlos II) ;
Gregori i Font, Josep (Instituto de Salud Carlos II) ;
Vila, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pacín Ruiz, Beatriz (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Quer, Josep 1963- (Instituto de Salud Carlos II) ;
Casillas, Rosario (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Castillo-Ribelles, Laura (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ferrer-Costa, Roser (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rando-Segura, Ariadna (Hospital Universitari Vall d'Hebron) ;
Trejo-Zahínos, Jesús (Hospital Universitari Vall d'Hebron) ;
Pumarola Suñé, Tomàs (Hospital Universitari Vall d'Hebron) ;
Casis-Saez, Ernesto (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Esteban, Rafael (Instituto de Salud Carlos II) ;
Riveiro Barciela, Mar (Instituto de Salud Carlos II) ;
Buti, Maria (Instituto de Salud Carlos II) ;
Rodríguez Frías, Francisco (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Different forms of pregenomic and other hepatitis B virus (HBV) RNA have been detected in patients' sera. These circulating HBV-RNAs may be useful for monitoring covalently closed circular DNA activity, and predicting hepatitis B e-antigen seroconversion or viral rebound after nucleos(t)ide analog cessation. [...]
2021 - 10.3748/wjg.v27.i41.7144
World Journal of Gastroenterology, Vol. 27 (november 2021) , p. 7144-7158
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4.
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12 p, 843.6 KB |
Association of hepatitis B virus infection status with outcomes of non-small cell lung cancer patients undergoing anti-PD-1/PD-L1 therapy
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Zhang, Xuanye (Sun Yat-sen University Cancer Center) ;
Tian, Dan (Guangdong Academy of Medical Sciences) ;
Chen, Yue (The Eighth Affiliated Hospital of Sun Yat-sen University) ;
Chen, Chen (Sun Yat-sen University Cancer Center) ;
He, Li-Na (Sun Yat-sen University Cancer Center) ;
Zhou, Yixin (Sun Yat-sen University Cancer Center) ;
Li, Haifeng (Sun Yat-sen University Cancer Center) ;
Lin, Zuan (Sun Yat-sen University Cancer Center) ;
Chen, Tao (Sun Yat-sen University Cancer Center) ;
Wang, Yuhong (Sun Yat-sen University Cancer Center) ;
Russo, Alessandro (A.O. Papardo) ;
Nadal, Ernest (Hospital Universitari de Bellvitge) ;
Passiglia, Francesco (S. Luigi Gonzaga Hospital) ;
Soo, Ross Andrew (National University Health System) ;
Watanabe, Satoshi (Niigata University Graduate School of Medical and Dental Sciences) ;
Morán, Teresa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Oh, In-Jae (Hwasun Hospital) ;
Fu, Sha (Sun Yat-sen University) ;
Hong, Shaodong (Sun Yat-sen University Cancer Center) ;
Zhang, Li (Sun Yat-sen University Cancer Center) ;
Universitat Autònoma de Barcelona
The aim of this study was to evaluate the safety and survival outcomes of anti-programmed cell death (PD)-1/programmed cell death-ligand 1 (PD-L1) monotherapy in patients with advanced non-small cell lung cancer (NSCLC) and different hepatitis B virus (HBV) infection status. [...]
2021 - 10.21037/tlcr-21-455
Translational Lung Cancer Research, Vol. 10 (july 2021) , p. 3191-3202
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5.
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9 p, 1.4 MB |
ACE Score Identifies HBeAg-negative Inactive Carriers at a Single-point Evaluation, Regardless of HBV Genotype
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Roade, Luisa (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Riveiro Barciela, Mar (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Palom, Adriana (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Rodríguez Frías, Francisco (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bes, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rando-Segura, Ariadna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Salcedo, Maria-Teresa (Hospital Universitari Vall d'Hebron) ;
Casillas, Rosario (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vargas-Accarino, Elena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Tabernero, David (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Sauleda, Silvia (Banc de Sang i Teixits (Barcelona, Catalunya)) ;
Esteban, Rafael (Hospital Universitari Vall d'Hebron) ;
Buti, Maria (Hospital Universitari Vall d'Hebron)
Hepatitis B virus (HBV) biomarkers have been used for a better categorization of patients, even though the lack of simple algorithms and the impact of genotypes limit their application. Our aim was to assess the usefulness of noninvasive markers for the identification of HBV inactive carriers (ICs) in a single-point evaluation and to design a predictive model for their identification. [...]
2022 - 10.14218/JCTH.2022.00068
Journal of Clinical and Translational Hepatology, Vol. 10 (april 2022) , p. 1068-1076
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6.
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18 p, 1.0 MB |
Hepatitis B Virus Variants with Multiple Insertions and/or Deletions in the X Open Reading Frame 3' End : Common Members of Viral Quasispecies in Chronic Hepatitis B Patients
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García-García, Selene (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Caballero, Andrea (Hospital Universitari Vall d'Hebron) ;
Tabernero, David (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Cortese, Maria Francesca (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Gregori i Font, Josep (Hospital Universitari Vall d'Hebron) ;
Rodriguez-Algarra, Francisco (Queen Mary University of London) ;
Quer, Josep 1963- (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Riveiro Barciela, Mar (Hospital Universitari Vall d'Hebron) ;
Homs, Maria (Institut Català de la Salut) ;
Rando-Segura, Ariadna (Hospital Universitari Vall d'Hebron) ;
Pacín Ruiz, Beatriz (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Vila, Marta (Hospital Universitari Vall d'Hebron) ;
Ferrer-Costa, Roser (Hospital Universitari Vall d'Hebron) ;
Pumarola Suñé, Tomàs (Hospital Universitari Vall d'Hebron) ;
Buti, Maria (Hospital Universitari Vall d'Hebron) ;
Rodríguez Frías, Francisco (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Deletions in the 3' end region of the hepatitis B virus (HBV) X open reading frame (HBX) may affect the core promoter (Cp) and have been frequently associated with hepatocellular carcinoma (HCC). The aim of this study was to investigate the presence of variants with deletions and/or insertions (Indels) in this region in the quasispecies of 50 chronic hepatitis B (CHB) patients without HCC. [...]
2022 - 10.3390/biomedicines10051194
Biomedicines, Vol. 10, Issue 5 (May 2022) , art. 1194
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15 p, 3.5 MB |
Quantification of HBsAg to predict low levels and seroclearance in HBeAg-negative patients receiving nucleos(t)ide analogues
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Broquetas, Teresa (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Garcia-Retortillo, M (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Hernandez, Juan José (Laboratori de Referència de Catalunya (El Prat de Llobregat, Catalunya)) ;
Puigvehí, Marc (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Cañete Hidalgo, Nuria (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Coll, Susanna (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Cabrero, Beatriz (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Giménez, Maria Dolors (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Solà, Ricard (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Carrión Rodríguez, José Antonio (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Universitat Autònoma de Barcelona
Background: HBeAg-negative chronic hepatitis B patients require long-term nucleos(t)ide analogues (NAs) because loss of surface antigen (HBsAg) is unusual. Low quantitative HBsAg (qHBsAg) levels can identify patients with higher probability of seroclearance. [...]
2017 - 10.1371/journal.pone.0188303
PloS one, Vol. 12 Núm. 11 (november 2017) , p. e0188303
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8.
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8 p, 251.6 KB |
Chronic hepatitis D associated with worse patient-reported outcomes than chronic hepatitis B
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Buti, Maria (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Stepanova, Maria (Center for Outcomes Research in Liver Disease, Washington, DC, USA) ;
Palom, Adriana (Hospital Universitari Vall d'Hebron) ;
Riveiro Barciela, Mar (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Nader, Fatema (Center for Outcomes Research in Liver Disease, Washington) ;
Roade, Luisa (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Esteban, Rafael (Esteban Mur) (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Younossi, Zobair (Betty and Guy Beatty Center for Integrated Research) ;
Universitat Autònoma de Barcelona
Health-related quality of life (HRQoL) determined by patient-reported outcomes (PROs) is impaired in chronic hepatitis B (CHB) and C patients, but there are no data regarding patients with chronic hepatitis D (CHD). [...]
2021 - 10.1016/j.jhepr.2021.100280
JHEP Reports, Vol. 3 (march 2021)
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9.
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11 p, 1.2 MB |
Viral and immune factors associated with successful treatment withdrawal in HBeAg-negative chronic hepatitis B patients
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García-López, Mireia (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Lens, Sabela (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Pallett, Laura J. (University College London) ;
Testoni, Barbara (University of Lyon) ;
Rodríguez-Tajes, Sergio (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Mariño, Zoe (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Bartres, Concepció (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
García-Pras, Ester (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Leonel, Thais (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Perpiñán, Elena (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Lozano, Juan José (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Rodríguez Frías, Francisco (Hospital Universitari Vall d'Hebron) ;
Koutsoudakis, George (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Zoulim, Fabien (University of Lyon) ;
Maini, Mala K. (University College London) ;
Forns, Xavier (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Pérez-Del-Pulgar, Sofía (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Universitat Autònoma de Barcelona
Factors associated with a successful outcome upon nucleos(t)ide analogue (NA) treatment withdrawal in HBeAg-negative chronic hepatitis B (CHB) patients have yet to be clarified. The objective of this study was to analyse the HBV-specific T cell response, in parallel with peripheral and intrahepatic viral parameters, in patients undergoing NA discontinuation. [...]
2021 - 10.1016/j.jhep.2020.11.043
Journal of Hepatology, Vol. 74 (may 2021) , p. 1064-1074
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10.
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5 p, 217.3 KB |
Current trends in access to treatment for hepatitis B in immigrants vs non-immigrants
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Miquel Planas, Mireia (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Pardo, Albert (Hospital Universitari Joan XXIII de Tarragona) ;
Forné, Montse (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Martínez-Alpin, Gemma (Consorci Sanitari de Terrassa) ;
Rodríguez-Castellano, Adrià (Hospital Universitari Joan XXIII de Tarragona) ;
Casas, Meritxell (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Rosinach, Mercè (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Roget, Mercè (Consorci Sanitari de Terrassa) ;
Dalmau, Blai (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Temiño, Rocío (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Quer, Joan Carlos (Hospital Universitari Joan XXIII de Tarragona) ;
Sánchez-Delgado, Jordi (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Ortiz, Jordi (Consorci Sanitari de Terrassa) ;
Vergara, Mercedes (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Universal vaccination for hepatitis B virus (HBV) and migratory movements have changed the demographic characteristics of this disease in Spain and in Europe. Therefore, we evaluated the characteristics of the disease and the possible differences according to origin (immigrants vs non-immigrants) and access to treatment. [...]
2020 - 10.1093/gastro/goaa010
Gastroenterology Report, Vol. 8 Num. 5 (oct. 2020) , p. 362-366
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