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32 p, 913.8 KB Alzheimer's disease biomarkers detection in human samples by efficient capturing through porous magnetic microspheres and labelling with electrocatalytic gold nanoparticles / De la Escosura Muñiz, Alfredo (Institut Català de Nanociència i Nanotecnologia) ; Plichta, Zdeněk (Akademie věd České republiky) ; Horák, Daniel (Akademie věd České republiky) ; Merkoçi, Arben (Institut Català de Nanociència i Nanotecnologia)
A nanobiosensor based on the use of porous magnetic microspheres (PMM) as efficient capturing/pre-concentrating platform is presented for detection of Alzheimer's disease (AD) biomarkers. These PMMs prepared by a multistep swelling polymerization combined with iron oxide precipitation afford carboxyl functional groups suitable for immobilization of antibodies on the particle surface allowing an enhanced efficiency in the capturing of AD biomarkers from human serum samples. [...]
2015 - 10.1016/j.bios.2014.07.086
Biosensors and bioelectronics, Vol. 67 (May 2015) , p. 162-169  

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