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11 p, 1.3 MB |
Metabolites related to purine catabolism and risk of type 2 diabetes incidence; modifying effects of the TCF7L2-rs7903146 polymorphism
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Papandreou, Christopher (Institut d'Investigació Sanitària Pere Virgili) ;
Li, Jun (Harvard T.H. Chan School of Public Health (Boston, Estats Units d'Amèrica)) ;
Liang, Liming (Harvard T.H. Chan School of Public Health (Boston, Estats Units d'Amèrica)) ;
Bulló, Mònica (Institut d'Investigació Sanitària Pere Virgili) ;
Zheng, Yan (Harvard T.H. Chan School of Public Health (Boston, Estats Units d'Amèrica)) ;
Ruiz-Canela, Miguel (Universidad de Navarra) ;
Yu, Edward (Harvard T.H. Chan School of Public Health (Boston, Estats Units d'Amèrica)) ;
Guasch-Ferré, Marta (Institut d'Investigació Sanitària Pere Virgili) ;
Razquin, Cristina (Universidad de Navarra) ;
Clish, Clary (Massachusetts Institute of Technology) ;
Corella, Dolores (Universitat de València) ;
Estruch, Ramón (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Ros, Emilio (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Fitó, Montserrat (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Arós, Fernando (Arabako Unibertsitate Ospitalea) ;
Serra-Majem, Lluís (Universidad de Las Palmas de Gran Canaria) ;
Rosique, Nuria (Institut d'Investigació Sanitària Pere Virgili) ;
Martínez-González, Miguel A. (Harvard T.H. Chan School of Public Health (Boston, Estats Units d'Amèrica)) ;
Hu, Frank B. (Harvard Medical School) ;
Salas-Salvadó, Jordi (Institut d'Investigació Sanitària Pere Virgili) ;
Universitat Autònoma de Barcelona
Studies examining associations between purine metabolites and type 2 diabetes (T2D) are limited. We prospectively examined associations between plasma levels of purine metabolites with T2D risk and the modifying effects of transcription factor-7-like-2 (TCF7L2) rs7903146 polymorphism on these associations. [...]
2019 -  10.1038/s41598-019-39441-6
Scientific reports, Vol. 9 Núm. 1 (january 2019) , p. 2892
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Rare coding variants and X-linked loci associated with age at menarche
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Lunetta, Kathryn L. (Boston University School of Public Health (Estats Units d'Amèrica)) ;
Day, Felix R. (University of Cambridge. School of Clinical Medicine (Gran Bretanya)) ;
Sulem, Patrick (deCODE Genetics (Reykjavík, Islàndia)) ;
Ruth, Katherine S. (University of Exeter. Medical School (Gran Bretanya)) ;
Tung, Joyce Y. (23andMe (California, Estats Units d'Amèrica)) ;
Hinds, David A. (23andMe (California, Estats Units d'Amèrica)) ;
Esko, Tõnu (University of Tartu. Estonian Genome Center (Estònia)) ;
Elks, Cathy E. (University of Cambridge. School of Clinical Medicine (Gran Bretanya)) ;
Altmaier, Elisabeth (Helmholtz Zentrum München (Alemanya)) ;
He, Chunyan (Fairbanks School of Public Health (Indianapolis, Estats Units d'Amèrica)) ;
Huffman, Jennifer E. (University of Edinburgh. Institute of Genetics and Molecular Medicine (Gran Bretanya)) ;
Mihailov, Evelin (University of Tartu. Estonian Genome Center (Estònia)) ;
Porcu, Eleonora (Institute of Genetics and Biomedical Research (Sardinia, Itàlia)) ;
Robino, Antonietta (Institute for Maternal and Child Health (Trieste, Itàlia)) ;
Rose, Lynda M. (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ;
Schick, Ursula M. (Fred Hutchinson Cancer Research Center (Seattle, Estats Units d'Amèrica)) ;
Stolk, Lisette (Erasmus University Rotterdam) ;
Teumer, Alexander (University Medicine Greifswald (Alemanya)) ;
Thompson, Deborah J. (University of Cambridge. Centre for Cancer Genetic Epidemiology) ;
Traglia, Michela (San Raffaele Scientific Institute (Milà, Itàlia)) ;
Wang, Carol A. (University of Western Australia. School of Women's and Infants' Health (Crawley, Austràlia)) ;
Yerges-Armstrong, Laura M. (University of Maryland School of Medicine (Estats Units d'Amèrica)) ;
Antoniou, Antonis C. (University of Cambridge. Centre for Cancer Genetic Epidemiology) ;
Barbieri, Caterina (San Raffaele Scientific Institute (Milà, Itàlia)) ;
Coviello, Andrea D. (Boston University School of Medicine (Estats Units d'Amèrica)) ;
Cucca, Francesco (Institute of Genetics and Biomedical Research (Sardinia, Itàlia)) ;
Demerath, Ellen W. (University of Minnesota (Minneapolis, Estats Units d'Amèrica)) ;
Dunning, Alison M. (University of Cambridge. Centre for Cancer Genetic Epidemiology) ;
Gandin, Ilaria (Institute for Maternal and Child Health (Trieste, Itàlia)) ;
Grove, Megan L. (University of Texas Health Science Center at Houston (Estats Units d'Amèrica)) ;
Gudbjartsson, Daniel F. (deCODE Genetics (Reykjavík, Islàndia)) ;
Hocking, Lynne J. (University of Aberdeen (Regne Unit)) ;
Hofman, Albert (Erasmus MC (Rotterdam, Paisos Baixos)) ;
Huang, Jinyan (Shanghai Jiao Tong University School of Medicine) ;
Jackson, Rebecca D. (The Ohio State University (Estats Units d'Amèrica)) ;
Karasik, David (Harvard Medical School (Boston, Estats Units d'Amèrica)) ;
Kriebel, Jennifer (Helmholtz Zentrum München (Alemanya)) ;
Lange, Ethan M. (University of North Carolina. Department of Genetics (Estats Units d'Amèrica)) ;
Lange, Leslie A. (University of North Carolina. Department of Genetics (Estats Units d'Amèrica)) ;
Langenberg, Claudia (University of Cambridge. School of Clinical Medicine (Gran Bretanya)) ;
Li, Xin (Harvard T.H. Chan School of Public Health (Boston, Estats Units d'Amèrica)) ;
Luan, Jian'an (University of Cambridge. School of Clinical Medicine (Gran Bretanya)) ;
Mägi, Reedik (University of Tartu. Estonian Genome Center (Estònia)) ;
Morrison, Alanna C. (University of Texas Health Science Center at Houston (Estats Units d'Amèrica)) ;
Padmanabhan, Sandosh (University of Glasgow. Institute of Cardiovascular and Medical Sciences (Gran Bretanya)) ;
Pirie, Ailith (University of Cambridge. Centre for Cancer Genetic Epidemiology) ;
Polasek, Ozren (University of Split. School of Medicine (Croàcia)) ;
Porteous, David (University of Edinburgh.Institute of Genetics and Molecular Medicine (Gran Bretanya)) ;
Reiner, Alex P. (Fred Hutchinson Cancer Research Center (Seattle, Estats Units d'Amèrica)) ;
Rivadeneira, Fernando (Erasmus University Rotterdam) ;
Rudan, Igor (University of Edinburgh. Institute for Population Health Sciences and Informatics (Gran Bretanya)) ;
Sala, Cinzia F. (San Raffaele Scientific Institute (Milà, Itàlia)) ;
Schlessinger, David (National Institute on Aging (Baltimore, Estats Units d'Amèrica)) ;
Scott, Robert A. (University of Cambridge. School of Clinical Medicine (Gran Bretanya)) ;
Stöckl, Doris (German Research Center for Environmental Health (Germany)) ;
Visser, J. (Erasmus University Rotterdam) ;
Völker, Uwe (Greifswald Medical School (Alemanya)) ;
Vozzi, Diego (Institute for Maternal and Child Health (Trieste, Itàlia)) ;
Wilson, James G. (University of Mississippi. Department of Physiology and Biophysics (Estats Units d'Amèrica)) ;
Zygmunt, Marek (Greifswald Medical School (Alemanya)) ;
Boerwinkle, Eric (University of Texas Health Science Center at Houston (Estats Units d'Amèrica)) ;
Buring, Julie (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ;
Crisponi, Laura (Institute of Genetics and Biomedical Research (Sardinia, Itàlia)) ;
Easton, Douglas F. (University of Cambridge. Centre for Cancer Genetic Epidemiology) ;
Hayward, Caroline (University of Edinburgh. Institute of Genetics and Molecular Medicine (Gran Bretanya)) ;
Hu, Frank B. (Harvard Medical School (Boston, Estats Units d'Amèrica)) ;
Liu, Simin (Brown University. Departments of Epidemiology and Medicine (Providence, Estats Units d'Amèrica)) ;
Metspalu, Andres (University of Tartu. Estonian Genome Center (Estònia)) ;
Pennell, Craig E. (University of Western Australia. School of Women's and Infants' Health (Crawley, Austràlia)) ;
Ridker, Paul M. (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ;
Strauch, Konstantin (German Research Center for Environmental Health (Germany)) ;
Streeten, Elizabeth A. (University of Maryland School of Medicine (Estats Units d'Amèrica)) ;
Toniolo, Daniela (San Raffaele Scientific Institute (Milà, Itàlia)) ;
Uitterlinden, André G. (Erasmus University Rotterdam) ;
Ulivi, Sheila (Institute for Maternal and Child Health (Trieste, Itàlia)) ;
Völzke, Henry (University Medicine Greifswald (Alemanya)) ;
Wareham, Nicholas J. (University of Cambridge. School of Clinical Medicine (Gran Bretanya)) ;
Wellons, Melissa (Vanderbilt University Medical Center (Nashville, Estats Units d'Amèrica)) ;
Franceschini, Nora (University of North Carolina (Estats Units d'Amèrica). Department of Epidemiology) ;
Chasman, Daniel I. (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ;
Thorsteinsdottir, Unnur (deCODE Genetics (Reykjavík, Islàndia)) ;
Murray, Anna (University of Exeter. Medical School (Gran Bretanya)) ;
Stefánsson, Kári (deCODE Genetics (Reykjavík, Islàndia)) ;
Murabito, Joanne M. (National Heart, Lung, and Blood Institute (Framingham, Estats Units d'Amèrica)) ;
Ong, Ken K. (University of Cambridge. School of Clinical Medicine (Gran Bretanya)) ;
Perry, John R. B. (University of Cambridge. School of Clinical Medicine (Gran Bretanya))
More than 100 loci have been identified for age at menarche by genome-wide association studies; however, collectively these explain only ∼3% of the trait variance. Here we test two overlooked sources of variation in 192,974 European ancestry women: low-frequency protein-coding variants and X-chromosome variants. [...]
2015 - 10.1038/ncomms8756
Nature communications, Vol. 4 Núm. 6 (august 2015)
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