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1.
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24 p, 4.0 MB |
Defensive-lipid droplets : Cellular organelles designed for antimicrobial immunity
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Safi, Rémi (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Sánchez-Álvarez, Miguel (Instituto de Investigaciones Biomédicas Alberto Sols (IIB)) ;
Bosch, Marta (Universitat de Barcelona) ;
Demangel, Caroline (Université Paris Cité, France) ;
Parton, Robert G. (University of Queensland, Australia) ;
Pol, Albert (Institució Catalana de Recerca i Estudis Avançats)
Microbes have developed many strategies to subvert host organisms, which, in turn, evolved several innate immune responses. As major lipid storage organelles of eukaryotes, lipid droplets (LDs) are an attractive source of nutrients for invaders. [...]
2023 -  10.1111/imr.13199
Immunological Reviews, Vol. 317 Núm. 1 (august 2023) , p. 113-136
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2.
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14 p, 3.9 MB |
Deletion or Inhibition of NOD1 Favors Plaque Stability and Attenuates Atherothrombosis in Advanced Atherogenesis †
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González-Ramos, S. (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Fernández-García, V. (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Recalde, M. (Instituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM)) ;
Rodríguez, Cristina (Institut d'Investigació Biomèdica Sant Pau) ;
Martínez-González, José (Institut d'Investigació Biomèdica Sant Pau) ;
Andrés, Vicente (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Martín-Sanz, P. (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Boscá, Lisardo (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Universitat Autònoma de Barcelona
Atherothrombosis, the main cause of acute coronary syndromes (ACS), is characterized by the rupture of the atherosclerotic plaque followed by the formation of thrombi. Fatal plaque rupture sites show large necrotic cores combined with high levels of inflammation and thin layers of collagen. [...]
2020 - 10.3390/cells9092067
Cells, Vol. 9 Núm. 9 (october 2020) , p. 632
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3.
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18 p, 6.6 MB |
IRF7 expression correlates with HIV latency reversal upon specific blockade of immune activation
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Ezeonwumelu, I.J (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
García Vidal, Edurne (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Felip, Eudald (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Puertas, Maria C. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Oriol-Tordera, Bruna (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Gutiérrez-Chamorro, Lucía (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Gohr, André (Max Planck Institute of Molecular Cell Biology and Genetics) ;
Ruiz Riol, Marta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Massanella, Marta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Badia, Roger (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Riveira-Muñoz, Eva (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ballana, Ester (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Universitat Autònoma de Barcelona
The persistence of latent HIV reservoirs allows for viral rebound upon antiretroviral therapy interruption, hindering effective HIV-1 cure. Emerging evidence suggests that modulation of innate immune stimulation could impact viral latency and contribute to the clearing of HIV reservoir. [...]
2022 - 10.3389/fimmu.2022.1001068
Frontiers in immunology, Vol. 13 (september 2022)
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4.
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17 p, 9.6 MB |
Gene dysregulation in acute HIV-1 infection - early transcriptomic analysis reveals the crucial biological functions affected
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Parker, Erica (University of Western Australia) ;
Judge, Melinda A. (University of Western Australia) ;
Pastor Palomo, Lucía (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Fuente-Soro, Laura (Hospital Clínic i Provincial de Barcelona) ;
Jairoce, Chenjerai (Centro de Investigação em Saúde da Manhiça (CISM)) ;
Carter, Kim W. (Telethon Kids Institute) ;
Anderson, Denise (Telethon Kids Institute) ;
Mandomando, Inácio (Centro de Investigação em Saúde da Manhiça (CISM)) ;
Clifford, Holly D. (Telethon Kids Institute) ;
Naniche, Denise (Hospital Clínic i Provincial de Barcelona) ;
Le Souëf, Peter Neils (Telethon Kids Institute) ;
Universitat Autònoma de Barcelona
Transcriptomic analyses from early human immunodeficiency virus (HIV) infection have the potential to reveal how HIV causes widespread and lasting damage to biological functions, especially in the immune system. [...]
2023 - 10.3389/fcimb.2023.1074847
Frontiers in cellular and infection microbiology, Vol. 13 (april 2023)
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5.
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15 p, 2.3 MB |
Induction of Innate Memory in Human Monocytes Exposed to Mixtures of Bacterial Agents and Nanoparticles
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Della Camera, Giacomo (European Commission. Joint Research Centre) ;
Liu, Tinghao (China-Italy Joint Laboratory of Pharmacobiotechnology for Medical Immunomodulation) ;
Yang, Wenjie (China-Italy Joint Laboratory of Pharmacobiotechnology for Medical Immunomodulation) ;
Li, Yang (China-Italy Joint Laboratory of Pharmacobiotechnology for Medical Immunomodulation) ;
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia) ;
Gioria, Sabrina (European Commission. Joint Research Centre) ;
Italiani, Paola (China-Italy Joint Laboratory of Pharmacobiotechnology for Medical Immunomodulation) ;
Boraschi, Diana (China-Italy Joint Laboratory of Pharmacobiotechnology for Medical Immunomodulation)
We assessed whether concomitant exposure of human monocytes to bacterial agents and different engineered nanoparticles can affect the induction of protective innate memory, an immune mechanism that affords better resistance to diverse threatening challenges. [...]
2022 - 10.3390/ijms232314655
International journal of molecular sciences, Vol. 23, Issue 23 (November 2022) , art. 14655
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13 p, 7.0 MB |
Innate memory reprogramming by gold nanoparticles depends on the microbial agents that induce memory
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Swartzwelter, Benjamin J. (Paris Lodron University of Salzburg. Department Biosciences) ;
Michelini, Sara (Paris Lodron University of Salzburg. Department Biosciences) ;
Frauenlob, Tobias (Paris Lodron University of Salzburg. Department Biosciences) ;
Barbero, Francesco (Institut Català de Nanociència i Nanotecnologia) ;
Verde, Alessandro (Consiglio Nazionale delle Ricerche (Nàpols, Itàlia). Istituto di Biochimica e Biologia Cellulare) ;
De Luca, Anna Chiara (Consiglio Nazionale delle Ricerche (Nàpols, Itàlia). Istituto di Biochimica e Biologia Cellulare) ;
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia) ;
Duschl, Albert (Paris Lodron University of Salzburg. Department Biosciences) ;
Horejs-Hoeck, Jutta (Paris Lodron University of Salzburg. Department Biosciences) ;
Italiani, Paola (Consiglio Nazionale delle Ricerche (Nàpols, Itàlia). Istituto di Biochimica e Biologia Cellulare) ;
Boraschi, Diana (Stazione Zoologica Anton Dohrn)
Innate immune memory, the ability of innate cells to react in a more protective way to secondary challenges, is induced by exposure to infectious and other exogeous and endogenous agents. Engineered nanoparticles are particulate exogenous agents that, as such, could trigger an inflammatory reaction in monocytes and macrophages and could therefore be also able to induce innate memory. [...]
2021 - 10.3389/fimmu.2021.751683
Frontiers in immunology, Vol. 12 (Nov. 2021) , art. 751683
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8.
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20 p, 1.2 MB |
The interactions between nanoparticles and the innate immune system from a nanotechnologist perspective
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Ernst, Lena M. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Casals, Eudald (Wuyi University. School of Biotechnology and Health Sciences) ;
Italiani, Paola (Institute of Biochemistry and Cell Biology (Nàpols, Itàlia)) ;
Boraschi, Diana (Stazione Zoologica Anton Dohrn) ;
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia)
The immune system contributes to maintaining the body's functional integrity through its two main functions: recognizing and destroying foreign external agents (invading microorganisms) and identifying and eliminating senescent cells and damaged or abnormal endogenous entities (such as cellular debris or misfolded/degraded proteins). [...]
2021 - 10.3390/nano11112991
Nanomaterials, Vol. 11, issue 11 (Nov. 2021) , art. 2991
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9.
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26 p, 2.5 MB |
Addressing nanomaterial immunosafety by evaluating innate immunity across living species
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Boraschi, Diana (Istituto di Biochimica e Biologia Cellulare (Nàpols)) ;
Alijagic, Andi (Istituto per la Ricerca e l'Innovazione Biomedica (Palermo)) ;
Auguste, Manon (Università di Genova. Dipartimento di scienze della terra, dell'ambiente e della vita) ;
Barbero, Francesco (Institut Català de Nanociència i Nanotecnologia) ;
Ferrari, Eleonora (ZMBP Eberhard-Karls University Tübingen. Center for Plant Molecular Biology) ;
Hernadi, Szabolcs (Cardiff University. School of Biosciences) ;
Mayall, Craig (University of Liubljana. Department of Biology) ;
Michelini, Sara (Paris-Lodron-University Salzburg. Department of Biosciences) ;
Navarro Pacheco, Natividad I. (Czech Academy of Sciences. Institute of Microbiology) ;
Prinelli, Alessandra (AvantiCell Science Ltd) ;
Swart, Elmer (UK Centre for Ecology and Hydrology) ;
Swartzwelter, Benjamin J. (Istituto di Biochimica e Biologia Cellulare (Nàpols)) ;
Bastús, Neus G. (Institut Català de Nanociència i Nanotecnologia) ;
Canesi, Laura (Università di Genova. Dipartimento di scienze della terra, dell'ambiente e della vita) ;
Drobne, Damjana (University of Liubljana. Department of Biology) ;
Duschl, Albert (Paris-Lodron-University Salzburg. Department of Biosciences) ;
Ewart, Marie-Ann (AvantiCell Science Ltd) ;
Horejs-Hoeck, Jutta (Paris-Lodron-University Salzburg. Department of Biosciences) ;
Italiani, Paola (Istituto di Biochimica e Biologia Cellulare (Nàpols)) ;
Kemmerling, Birgit (Center for Plant Molecular Biology - ZMBP. Eberhard-Karls University Tübingen) ;
Kille, Peter (Cardiff University. School of Biosciences) ;
Prochazkova, Petra (Czech Academy of Sciences. Institute of Microbiology) ;
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia) ;
Spurgeon, David J. (UK Centre for Ecology and Hydrology) ;
Svendsen, Claus (UK Centre for Ecology and Hydrology) ;
Wilde, Colin J. (AvantiCell Science Ltd) ;
Pinsino, Annalisa (Istituto per la Ricerca e l'Innovazione Biomedica (Palermo))
The interaction of a living organism with external foreign agents is a central issue for its survival and adaptation to the environment. Nanosafety should be considered within this perspective, and it should be examined that how different organisms interact with engineered nanomaterials (NM) by either mounting a defensive response or by physiologically adapting to them. [...]
2020 - 10.1002/smll.202000598
Small, Vol. 16, issue 21 (May 2020) , art. 2000598
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10.
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16 p, 2.6 MB |
The FlagT4G Vaccine Confers a Strong and Regulated Immunity and Early Virological Protection against Classical Swine Fever
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Bohórquez Garzón, José Alejandro (University of Illinois at Urbana-Champaign. Veterinary Diagnostic Laboratory) ;
Wang, Miaomiao (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
Díaz, Ivan (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
Alberch, Mònica (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
Pérez-Simó, Marta (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
Rosell, Rosa (Generalitat de Catalunya. Departament d'Acció Climàtica, Alimentació i Agenda Rural) ;
Gladue, Douglas P. (Plum Island Animal Disease Center) ;
Borca, Manuel V. (Plum Island Animal Disease Center) ;
Ganges, Llilianne (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal)
Control of classical swine fever virus (CSFV) in endemic countries relies on vaccination, mostly using vaccines that do not allow for differentiation of vaccinated from infected animals (DIVA). FlagT4G vaccine is a novel candidate that confers robust immunity and shows DIVA capabilities. [...]
2022 - 10.3390/v14091954
Viruses, Vol. 14 (september 2022)
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