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16 p, 2.1 MB |
Genome-wide multi-trait analysis of irritable bowel syndrome and related mental conditions identifies 38 new independent variants
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Alemany, Sílvia (Hospital Universitari Vall d'Hebron) ;
Soler Artigas, María (Hospital Universitari Vall d'Hebron) ;
Cabana-Domínguez, Judit (Hospital Universitari Vall d'Hebron) ;
Fakhreddine, Dana (Hospital Universitari Vall d'Hebron) ;
Llonga, Natalia (Hospital Universitari Vall d'Hebron) ;
Vilar-Ribó, L (Hospital Universitari Vall d'Hebron) ;
Rodríguez-Urrutia, Amanda (Hospital Universitari Vall d'Hebron) ;
Palacio, Judit (Hospital Universitari Vall d'Hebron) ;
González Castro, Ana Maria (Hospital Universitari Vall d'Hebron) ;
Lobo Álvarez, Beatriz (Hospital Universitari Vall d'Hebron) ;
Alonso Cotoner, Carmen (Hospital Universitari Vall d'Hebron) ;
Simrén, Magnus (University of North Carolina) ;
Santos, Javier (Hospital Universitari Vall d'Hebron) ;
Ramos-Quiroga, Josep Antoni (Hospital Universitari Vall d'Hebron) ;
Ribasés Haro, Marta (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
Irritable bowel syndrome (IBS) is a chronic disorder of gut-brain interaction frequently accompanied by mental conditions, including depression and anxiety. Despite showing substantial heritability and being partly determined by a genetic component, the genetic underpinnings explaining the high rates of comorbidity remain largely unclear and there are no conclusive data on the temporal relationship between them. [...]
2023 -  10.1186/s12967-023-04107-5
Journal of translational medicine, Vol. 21 (april 2023)
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17 p, 2.5 MB |
Acute Stress Regulates Sex-Related Molecular Responses in the Human Jejunal Mucosa : Implications for Irritable Bowel Syndrome
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Rodiño-Janeiro, Bruno K. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pigrau Pastor, Marc (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Salvo-Romero, Eloísa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Nieto Ruiz, Adoración (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Expósito, Elba (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
González Castro, Ana Maria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Galan Soldevilla, Carmen (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
de Torres, Inés (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Pribic, Teodora (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Hernández, Laura (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Lobo Álvarez, Beatriz (Universitat Autònoma de Barcelona. Facultat de Medicina) ;
Fortea, Marina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gallart, Milagros (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pardo-Camacho, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Guagnozzi, Danila (Universitat Autònoma de Barcelona. Facultat de Medicina) ;
Santos, Javier (Universitat Autònoma de Barcelona. Facultat de Medicina) ;
Alonso Cotoner, Carmen (Universitat Autònoma de Barcelona. Facultat de Medicina) ;
Universitat Autònoma de Barcelona
Irritable bowel syndrome (IBS) is a prevalent gastrointestinal disorder linked to intestinal barrier dysfunction and life stress. We have previously reported that female sex per se determines an increased susceptibility to intestinal barrier dysfunction after cold pain stress (CPS). [...]
2023 - 10.3390/cells12030423
Cells, Vol. 12 (january 2023)
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8 p, 1.7 MB |
Blastocystis sp. Carriage and Irritable Bowel Syndrome : Is the Association Already Established?
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Salvador, Fernando (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Lobo Álvarez, Beatriz (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Goterris, Lidia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Alonso Cotoner, Carmen (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Santos, Javier (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Sulleiro Igual, Elena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bailo, Begoña (National Centre of Microbiology, Instituto de Salud Carlos III, 28220 Madrid, Spain; (B.B.); (D.C.); (I.F.)) ;
Carmena, David (National Centre of Microbiology, Instituto de Salud Carlos III, 28220 Madrid, Spain; (B.B.); (D.C.); (I.F.)) ;
Sánchez-Montalvá, Adrián (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bosch-Nicolau, Pau (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Espinosa-Pereiro, Juan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Fuentes, Isabel (National Centre of Microbiology, Instituto de Salud Carlos III, 28220 Madrid, Spain; (B.B.); (D.C.); (I.F.)) ;
Molina Romero, Israel (Hospital Universitari Vall d'Hebron. Institut de Recerca)
The intestinal protist Blastocystis sp. is one of the most common intestinal parasites observed in humans, and has a worldwide distribution, being more prevalent in developing countries. Although this parasite has been described decades ago, the pathogenic potential it is still not understood completely. [...]
2021 - 10.3390/biology10040340
Biology, Vol. 10 (april 2021)
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14 p, 478.1 KB |
Clinical response to linaclotide at week 4 predicts sustained response in irritable bowel syndrome with constipation and improvements in digestive and extra-digestive symptoms
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Serrano-Falcón, Blanca (Hospital Clínico San Carlos (Madrid)) ;
Delgado-Aros, Sílvia (Hospital del Mar (Barcelona, Catalunya)) ;
Mearin, Fermín 1956- (Centro Médico Teknon) ;
Ciriza de los Ríos, Constanza (Hospital Universitario 12 de Octubre (Madrid)) ;
Serra Pueyo, Jordi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Mínguez, Miguel (Universitat de València) ;
Montoro Huguet, Miguel (Hospital San Jorge) ;
Perelló, Antonia (Hospital de Viladecans) ;
Santander, Cecilio (Universidad Autónoma de Madrid) ;
Pérez-Aisa, Ángeles (Agencia Sanitaria Costa del Sol) ;
Bañón-Rodríguez, Inmaculada (Allergan plc) ;
Rey, Enrique (Hospital Clínico San Carlos, Universidad Complutense)
Linaclotide is approved for the treatment of moderate-to-severe irritable bowel syndrome (IBS) with constipation (IBS-C) in adults. This study aimed to assess factors predictive of a clinical response and improvements in non-IBS symptoms with linaclotide treatment in a Spanish patient population. [...]
2019 - 10.1177/1756284819857358
Therapeutic Advances in Gastroenterology, Vol. 12 (august 2019)
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13 p, 1.8 MB |
Overexpression of corticotropin-releasing factor in intestinal mucosal eosinophils is associated with clinical severity in Diarrhea-Predominant Irritable Bowel Syndrome
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Salvo-Romero, Eloísa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martínez Martínez, Cristina (Institut de Recerca Biomèdica de Lleida) ;
Lobo Álvarez, Beatriz (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rodiño-Janeiro, Bruno K. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pigrau Pastor, Marc (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Sánchez-Chardi, Alejandro D. (Universitat Autònoma de Barcelona) ;
González Castro, Ana Maria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Fortea, Marina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pardo-Camacho, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Nieto Ruiz, Adoración (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Expósito, Elba (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Guagnozzi, Danila (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rodríguez-Urrutia, Amanda (Centro de Investigación Biomédica en Red de Salud Mental) ;
de Torres, Inés (Hospital Universitari Vall d'Hebron) ;
Farré, Ricard (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Azpiroz Vidaur, Fernando (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Alonso Cotoner, Carmen (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Santos, Javier (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Vicario, María (Nestlé Research (Suïssa))
Corticotropin-releasing factor (CRF) has been identified in intestinal mucosal eosinophils and associated with psychological stress and gut dysfunction. Irritable bowel syndrome (IBS) is commonly characterized by altered intestinal motility, immune activation, and increased gut barrier permeability along with heightened susceptibility to psychosocial stress. [...]
2020 - 10.1038/s41598-020-77176-x
Scientific reports, Vol. 10 (november 2020)
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35 p, 2.8 MB |
Cannabidiol and Other Non-Psychoactive Cannabinoids for Prevention and Treatment of Gastrointestinal Disorders : Useful Nutraceuticals?
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Martínez Perea, Vicente (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Iriondo De-Hond, Amaia (Instituto de Investigación en Ciencias de la Alimentación) ;
Borrelli, Francesca (University of Naples Federico II) ;
Capasso, Raffaele (University of Naples Federico II) ;
del Castillo, María Dolores (Instituto de Investigación en Ciencias de la Alimentación) ;
Abalo, Raquel (Universidad Rey Juan Carlos)
Cannabis sativa is an aromatic annual flowering plant with several botanical varieties, used for different purposes, like the production of fibers, the production of oil from the seeds, and especially for recreational or medical purposes. [...]
2020 - 10.3390/ijms21093067
International journal of molecular sciences, Vol. 21 (april 2020)
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11 p, 484.9 KB |
Increased Colonic Epithelial Permeability and Mucosal Eosinophilia in Ulcerative Colitis in Remission Compared With Irritable Bowel Syndrome and Health
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Katinios, Georgios (Linköping University) ;
Casado Bedmar, María Teresa (Linköping University) ;
Walter, Susanna A. (Linköping University) ;
Vicario Perez, Maria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
González Castro, Ana Maria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bednarska, Olga (Linköping University) ;
Söderholm, Johan D. (Linköping University) ;
Hjortswang, Henrik (Linköping University) ;
Keita, Åsa V. (Linköping University) ;
Universitat Autònoma de Barcelona
Barrier dysfunction is recognized as a pathogenic factor in ulcerative colitis (UC) and irritable bowel syndrome (IBS), but it is unclear to what extent the factors related to barrier dysfunction are disease-specific. [...]
2020 - 10.1093/ibd/izz328
Inflammatory Bowel Diseases, Vol. 26 (january 2020) , p. 974-984
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22 p, 609.1 KB |
A Review of Microbiota and Irritable Bowel Syndrome : Future in Therapies
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Rodiño-Janeiro, Bruno K. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vicario, María (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Alonso Cotoner, Carmen (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pascua-García, Roberto (Servicio de Atención Primaria de Celanova, Orense, Spain) ;
Santos, Javier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Irritable bowel syndrome (IBS), one of the most frequent digestive disorders, is characterized by chronic and recurrent abdominal pain and altered bowel habit. The origin seems to be multifactorial and is still not well defined for the different subtypes. [...]
2018 - 10.1007/s12325-018-0673-5
Advances in Therapy, Vol. 35 (march 2018) , p. 289-310
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