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13 p, 3.4 MB Network-based proteomic approaches reveal the neurodegenerative, neuroprotective and pain-related mechanisms involved after retrograde axonal damage / Casas Louzao, Caty (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Isus, Laura (Institut de Recerca Biomèdica) ; Herrando-Grabulosa, Mireia (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Mancuso, Francesco M. (Vall d'Hebron Institut d'Oncologia) ; Borrás, Eva (Universitat Pompeu Fabra. Centre de Regulació Genòmica) ; Sabidó, Eduardo (Universitat Pompeu Fabra. Centre de Regulació Genòmica) ; Forés Vineta, Joaquim (Universitat de Barcelona. Hospital Clínic) ; Aloy, Patrick (Institució Catalana de Recerca i Estudis Avançats (ICREA))
Neurodegenerative processes are preceded by neuronal dysfunction and synaptic disconnection. Disconnection between spinal motoneuron (MN) soma and synaptic target leads either to a retrograde degenerative process or to a regenerative reaction, depending injury proximity among other factors. [...]
2015 - 10.1038/srep09185
Scientific Reports, Vol. 5 (2015) , art. 9185  

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