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Correction to : The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients (Critical Care, (2021), 25, 1, (331), 10.1186/s13054-021-03727-x)
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Torres, Antoni (Hospital Clínic i Provincial de Barcelona) ;
Motos, Ana (Universitat de Barcelona) ;
Riera del Brio, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Fernández-Barat, Laia (Universitat de Barcelona) ;
Ceccato, Adrian (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Pérez-Arnal, Raquel (Barcelona Supercomputing Center) ;
Garcia-Gasulla, Darío (Barcelona Supercomputing Center) ;
Peñuelas, Oscar (Hospital Universitario de Getafe) ;
Lorente, José Angel (Hospital Universitario de Getafe) ;
Rodríguez, Alejandro (Hospital Universitari de Tarragona Joan XXIII) ;
De Gonzalo Calvo, David (Hospital Universitari Arnau de Vilanova) ;
Almansa, Raquel (Instituto de Investigación Biomédica de Salamanca) ;
Gabarrús, Albert (Universitat de Barcelona) ;
Menéndez, Rosario (University and Polytechnic Hospital La Fe) ;
Bermejo-Martin, Jesus F (Instituto de Investigación Biomédica de Salamanca) ;
Ferrer, Ricard (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Amaya-Villar, Rosario (Hospital Universitario Virgen de Rocío) ;
Añón, José M. (Hospital Universitario La Paz) ;
Barberà, Carme (Hospital Santa Maria) ;
Barberán, José (Universidad San Pablo-CEU) ;
Blandino Ortiz, Aaron (Hospital Universitario Ramón y Cajal) ;
Bustamante-Munguira, Elena (Hospital Clínico Universitario Valladolid) ;
Caballero, Jesús (Hospital Arnau de Vilanova (Lleida, Catalunya)) ;
Carbajales, Cristina (Hospital Álvaro Cunqueiro) ;
Carbonell, Nieves (Hospital Clínico y Universitario de Valencia) ;
Catalán-González, Mercedes (Hospital Universitario) ;
Galbán, Cristóbal (Complejo Hospitalario Universitario de Santiago) ;
Gumucio-Sanguino, Víctor D. (Institut d'Investigació Biomèdica de Bellvitge) ;
de la Torre, Maria del Carmen (Hospital de Mataró) ;
Díaz Santos, Emilio (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Estella, Ángel (Universidad de Cádiz) ;
Gallego, Elena (Hospital San Pedro de Alcántara) ;
García Garmendia, José Luis (Hospital San Juan de Dios del Aljarafe) ;
Garnacho-Montero, José (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Gómez, José M. (Hospital General Universitario Gregorio Marañón) ;
Huerta, Arturo (Clínica Sagrada Familia (Barcelona, Catalunya)) ;
Jorge García, Ruth Noemí (Hospital Nuestra Señora de Gracia) ;
Loza-Vázquez, Ana (Hospital Universitario Virgen de Valme) ;
Marin-Corral, Judith (Hospital del Mar (Barcelona, Catalunya)) ;
Martínez de la Gándara, Amalia (Hospital Universitario Infanta Leonor) ;
Martínez Varela, Ignacio (Hospital Universitario Lucus Augusti) ;
López Messa, Juan (Complejo Asistencial Universitario de Palencia) ;
M. Albaiceta, Guillermo (Hospital Universitario Central de Asturias) ;
Novo, Mariana Andrea (Hospital Universitari Son Espases) ;
Peñasco, Yhivian (Hospital Universitario Marqués de Valdecilla) ;
Pozo-Laderas, Juan Carlos (Hospital Universitario Reina Sofia) ;
Ricart, Pilar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Salvador-Adell, Inmaculada (Hospital Verge de La Cinta) ;
Sánchez-Miralles, Angel (Hospital de Sant Joan d'Alacant) ;
Sancho Chinesta, Susana (Hospital Universitario y Politécnico La Fe) ;
Socias, Lorenzo (Hospital Son Llàtzer) ;
Solé-Violan, Jordi (Hospital Universitari de Gran Canària Doctor Negrín) ;
Suares Sipmann, Fernando (Hospital Universitario La Princesa) ;
Tamayo Lomas, Luis (Hospital Universitario Río Hortega de Valladolid) ;
Trenado, José (Hospital Universitari MútuaTerrassa) ;
Barbé, Ferran (Institut de Recerca Biomèdica de Lleida) ;
Adell-Serrano, B. ;
Agrifoglio, A. ;
Aguilar Cabello, M. ;
Aguilera, L. ;
Alcaraz-Serrano, V. ;
Aldecoa, C. ;
Alegre, C. ;
Álvarez, S. ;
Álvarez Ruiz, A. ;
Andrea, R. ;
Ángel, J. ;
Arrieta, M. ;
Ayestarán, J.I. ;
Badia, J.R. ;
Badía, M. ;
Báez Pravia, O. ;
Mariño, A.B. ;
Balsera, B. ;
Barbena, L. ;
Barbeta, E. ;
Bardi, T. ;
Barral Segade, P. ;
Barroso, M. ;
Berezo García, J.Á. ;
Bigas, J. ;
Blancas, R. ;
Blasco Cortés, M.L. ;
Boado, M. ;
Bodi Saera, M. ;
Bofill, N. ;
Bouza Vieiro, M.T. ;
Bueno, L. ;
Bustamante-Munguira, J. ;
Cachafeiro, L. ;
Campi Hermoso, D. ;
Campos Fernández, S. ;
Cano, I. ;
Cantón-Bulnes, M.L. ;
Cardina Fernández, P. ;
Carrión García, L. ;
Carvalho, S. ;
Casacuberta-Barberà, N. ;
Castellà, M. ;
Castellví, A. ;
Castro, P. ;
Cicuendez Ávila, R. ;
Cillóniz, C. ;
Clar, L. ;
Climent, C. ;
Codina, J. ;
Conde, P. ;
Contreras, S. ;
Martin, M.C. ;
de Pablo Sánchez, R. ;
De Mendoza, D. ;
del Busto Martínez, C. ;
Díaz, Y. ;
Rivas Vilas, M.D. ;
Dólera Moreno, C. ;
Dot, I. ;
Enríquez Giraudo, P. ;
Esmorís Arijón, I. ;
Farre Monjo, T. ;
Fernández, J. ;
Ferrando, C. ;
Figueras, A. ;
Forcadell-Ferreres, E. ;
Forcelledo Espina, L. ;
Franco, N. ;
Furro, À. ;
García, F. ;
García, B. ;
García Prieto, E. ;
García Redruello, C. ;
García Sagastume, A. ;
Gascón Castillo, M.L. ;
Gomà, G. ;
Gómez Casal, V. ;
Gómez, S. ;
Gómez Gonzalez, C. ;
González, J. ;
Gordo, F. ;
Gracia, M.P. ;
Herraiz, A. ;
Herrán-Monge, R. ;
Ibarz, M. ;
Iglesias, S. ;
Janer, M.T. ;
Jiménez, G. ;
Juan Díaz, M. ;
Kiarostami, K. ;
Lazo Álvarez, J.I. ;
León, M. ;
López-Gavín, A. ;
López Lago, A. ;
Macias Guerrero, D. ;
Mamolar Herrera, N. ;
Mañez Mendiluce, R. ;
Mantellini, C.L. ;
Marco Naya, G. ;
Marcos, P. ;
Marmol Peis, E. ;
Martín Vicente, P. ;
Martínez, M. ;
Martínez Fernández, C.E. ;
Martínez Juan, M.D. ;
Masa Jimenez, J.F. ;
Masclans, J. R. ;
Maseda, E. ;
Menor Fernández, E.M. ;
Miralbés, M. ;
Monclou, J. ;
Montejo-González, J.C. ;
Montserrat, N. ;
Mora Aznar, M. ;
Moral-Parras, P. ;
Morales, D. ;
Moreno Cano, S.G. ;
Mosquera Rodríguez, D. ;
Muñoz-Bermúdez, R. ;
Nicolás, J.M. ;
Nogue Bou, R. ;
Nogueras Salinas, R. ;
Ocón, M. ;
Ortega, A. ;
Ossa, S. ;
Pagliarani, P. ;
Parera Pous, A. ;
Parrilla, F. ;
Pérez Bastida, L. ;
Pérez, P. ;
Pérez Planelles, G. ;
Rubio, E.P. ;
Pestaña Laguna, D. ;
Piñol-Tena, À. ;
Prados, J. ;
Pujol, A. ;
Ramon Coll, N. ;
Renedo Sanchez-Giron, G. ;
Roche-Campo, F. ;
Rodriguez, L. ;
Rodríguez de Castro, F. ;
Rodríguez, S. ;
Rodríguez Ruiz, C. ;
Rubio, J. ;
Rubio López, A. ;
Ruiz Miralles, M. ;
Ryan Murúa, P. ;
Saborido Paz, E. ;
Salazar Degracia, A. ;
Sanchez, M. ;
Sánchez, A. ;
Santacoloma, B. ;
Sariñena, M.T. ;
Segura Pensado, M. ;
Serra, L. ;
Serra-Fortuny, M. ;
Serrano Lázaro, A. ;
Servià, L. ;
Soliva, L. ;
Speziale, C. ;
Tognetti, D. ;
Tormos, A. ;
Torres, M. ;
Trefler, S. ;
Trujillano, J. ;
Úbeda, A. ;
Urrelo-Cerrón, L. ;
Val, E. ;
Valdivia Ruiz, L. ;
Vallverdú, M. ;
Van der Hofstadt Martin-Montalvo, M. ;
Vara Adrio, S. ;
Vázquez, N. ;
Vengoechea, J. ;
Vidal Cortes, P. ;
Vilà-Vilardel, C. ;
Vilanova, J. ;
Villada Warrington, T. ;
Yang, H. ;
Yang, M. ;
Zapatero, A. ;
Universitat Autònoma de Barcelona
2021 -  10.1186/s13054-021-03849-2
Critical Care, Vol. 25 Núm. 1 (12 2021) , p. 435
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7 p, 1.0 MB |
Genome-Wide Association Study of VKORC1 and CYP2C9 on acenocoumarol dose, stroke recurrence and intracranial haemorrhage in Spain
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Cullell, Natalia (Institut d'Investigació Biomèdica Sant Pau) ;
Carrera, Caty (Hospital Universitari Vall d'Hebron) ;
Muiño, Elena (Institut d'Investigació Biomèdica Sant Pau) ;
Torres-Aguila, Nuria P.. (Institut d'Investigació Biomèdica Sant Pau) ;
Cárcel-Márquez, Jara (Institut d'Investigació Biomèdica Sant Pau) ;
González-Sánchez, J. (Manchester Metropolitan University) ;
Gallego-Fabrega, Cristina (Institut d'Investigació Biomèdica Sant Pau) ;
Molina, J. (Hospital Universitari MútuaTerrassa/Fundacio Docència i Recerca MútuaTerrassa) ;
Besora, S. (Hospital Universitari MútuaTerrassa/Fundacio Docència i Recerca MútuaTerrassa) ;
Sotoca, J. (Hospital Universitari MútuaTerrassa/Fundacio Docència i Recerca MútuaTerrassa) ;
Buongiorno, María Teresa (Hospital Universitari MútuaTerrassa/Fundacio Docència i Recerca MútuaTerrassa) ;
Jiménez-Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Giralt Steinhauer, Eva (Institut Hospital del Mar d'Investigacions Mèdiques) ;
de Torres-Chacón, R. (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Montaner, J. (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Mancha, Fernando (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Cabezas, Juan Antonio (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Martí-Fàbregas, Joan (Institut d'Investigació Biomèdica Sant Pau) ;
Prats-Sánchez, Luis Antonio (Institut d'Investigació Biomèdica Sant Pau) ;
Camps-Renom, Pol (Institut d'Investigació Biomèdica Sant Pau) ;
Purroy, Francisco (Hospital Universitari Arnau de Vilanova) ;
Cambray, S. (Universitat de Lleida) ;
Freijo, M.d.M. (Hospital de Basurto (Bilbao, Biscaia)) ;
Vives-Bauzá, C. (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Tur, S. (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Font, M.À. (Hospital Moisès Broggi) ;
López-Cancio, Elena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Hernández-Pérez, María (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Obach, Víctor (Hospital Clínic i Provincial de Barcelona) ;
Calleja, Ana (Hospital Clínico Universitario de Valladolid) ;
Arenillas, Juan F (Hospital Clínico Universitario de Valladolid) ;
Rodríguez-Yáñez, M. (Fundación Instituto de Investigación Sanitaria de Santiago [IDIS]) ;
Castillo, J. (Fundación Instituto de Investigación Sanitaria de Santiago [IDIS]) ;
Sobrino, T. (Fundación Instituto de Investigación Sanitaria de Santiago [IDIS]) ;
Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ;
Krupinski, J. (Manchester Metropolitan University) ;
Universitat Autònoma de Barcelona
Acenocoumarol is an oral anticoagulant with significant interindividual dose variations. Variants in CYP2C9 and VKORC1 have been associated with acenocoumarol maintenance dose. We analysed whether any of the 49 polymorphisms in CYP2C9 and VKORC1 previously associated with acenocoumarol maintenance dose in a Genome-Wide Association study (GWAs) in Dutch population are associated with stroke recurrence, intracranial haemorrhage (ICH) and acenocoumarol maintenance dose in a Spanish population. [...]
2020 - 10.1038/s41598-020-59641-9
Scientific reports, Vol. 10 Núm. 1 (january 2020) , p. 2806
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11 p, 897.2 KB |
MRI Radiomic Signature of White Matter Hyperintensities Is Associated With Clinical Phenotypes
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Bretzner, Martin (University of Lille) ;
Bonkhoff, Anna K. (Massachusetts General Hospital) ;
Schirmer, Markus D. (Massachusetts General Hospital) ;
Hong, Sungmin (Massachusetts General Hospital) ;
Dalca, Adrian V. (Massachusetts Institute of Technology) ;
Donahue, Kathleen L. (Massachusetts General Hospital) ;
Giese, Anne-Katrin (Massachusetts General Hospital) ;
Etherton, Mark R. (Massachusetts General Hospital) ;
Rist, Pamela M. (Brigham and Women's Hospital) ;
Nardin, Marco (Massachusetts General Hospital) ;
Marinescu, Razvan (Massachusetts Institute of Technology) ;
Wang, Clinton (Massachusetts Institute of Technology) ;
Regenhardt, Robert W. (Massachusetts General Hospital) ;
Leclerc, Xavier (University of Lille) ;
Lopes, Renaud (Institut Pasteur de Lille) ;
Benavente, Oscar R. (Department of Medicine, University of British Columbia) ;
Cole, John W. (Department of Neurology, University of Maryland School of Medicine a) ;
Donatti, Amanda (School of Medical Sciences, University of Campinas (Brasil)) ;
Griessenauer, Christoph J. (Paracelsus Medical University) ;
Heitsch, Laura (Department of Neurology, Washington University School of Medicine) ;
Holmegaard, Lukas (Sahlgrenska Academy at University of Gothenburg) ;
Jood, Katarina (University of Gothenburg) ;
Jimenez-Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Kittner, Steven J. (Department of Neurology, University of Maryland School of Medicine) ;
Lemmens, Robin (University Hospitals Leuven) ;
Levi, Christopher R. (Department of Neurology, John Hunter Hospital) ;
McArdle, Patrick F. (Department of Medicine, University of Maryland School of Medicine) ;
McDonough, Caitrin W. (Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida) ;
Meschia, James F. (Mayo Clinic (Estats Units d'Amèrica)) ;
Phuah, Chia-Ling (Department of Neurology, Washington University School of Medicine) ;
Rolfs, Arndt (Centogene (Alemanya)) ;
Ropele, Stefan (Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz) ;
Rosand, Jonathan (Massachusetts General Hospital) ;
Roquer, Jaume (Department of Neurology, University of Miami) ;
Rundek, Tatjana (Department of Neurology, University of Miami) ;
Sacco, Ralph L. (Department of Neurology University of Miami) ;
Schmidt, Reinhold (Department of Neurology, Medical University of Graz) ;
Sharma, Pankaj (St. Peter's Hospitals (Regne Unit)) ;
Slowik, Agnieszka (Department of Neurology, Jagiellonian University Medical College) ;
Sousa, Alessandro (Department of Neurology, University of Maryland School of Medicine) ;
Stanne, Tara M. (University of Gothenburg) ;
Strbian, Daniel (Department of Neurology, Helsinki University Central Hospital) ;
Tatlisumak, Turgut (Department of Neurology, Sahlgrenska University Hospital) ;
Thijs, Vincent (Florey Institute of Neuroscience and Mental Health, Department of Neurology Austin Health) ;
Vagal, Achala (Department of Radiology, University of Cincinnati College of Medicine) ;
Wasselius, Johan (Skåne University Hospital (Suècia)) ;
Woo, Daniel (Department of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine) ;
Wu, Ona (Massachusetts General Hospital) ;
Zand, Ramin (Department of Neurology, Geisinger) ;
Worrall, Bradford B. (Department of Neurology and Public Health Sciences, University of Virginia) ;
Maguire, Jane M. (University of Technology Sydney) ;
Lindgren, Arne (Department of Clinical Sciences Lund, Lund University) ;
Jern, Christina (Sahlgrenska Academy at University of Gothenburg) ;
Golland, Polina (Massachusetts Institute of Technology) ;
Kuchcinski, Grégory (University of Lille) ;
Rost, Natalia S. (Massachusetts General Hospital) ;
Universitat Autònoma de Barcelona
Neuroimaging measurements of brain structural integrity are thought to be surrogates for brain health, but precise assessments require dedicated advanced image acquisitions. By means of quantitatively describing conventional images, radiomic analyses hold potential for evaluating brain health. [...]
2021 - 10.3389/fnins.2021.691244
Frontiers in Neuroscience, Vol. 15 (july 2021)
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10 p, 678.7 KB |
Excessive White Matter Hyperintensity Increases Susceptibility to Poor Functional Outcomes After Acute Ischemic Stroke
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Hong, Sungmin (Massachusetts General Hospital) ;
Giese, Anne-Katrin (University Medical Center Hamburg-Eppendorf) ;
Schirmer, Markus D. (University Hospital Bonn) ;
Bonkhoff, Anna K. (Massachusetts General Hospital) ;
Bretzner, Martin (Université du Lille) ;
Rist, Pamela (Brigham and Women's Hospital) ;
Dalca, Adrian V. (Department of Radiology, Massachusetts General Hospital) ;
Regenhardt, Robert W. (Massachusetts General Hospital) ;
Etherton, Mark R. (Massachusetts General Hospital) ;
Donahue, Kathleen L. (Massachusetts General Hospital) ;
Nardin, Marco (Harvard Medical School) ;
Mocking, Steven J. T. (Massachusetts General Hospital) ;
McIntosh, Elissa C. (Massachusetts General Hospital) ;
Attia, John (University of Newcastle) ;
Benavente, Oscar R. (University of British Columbia) ;
Cole, John W. (University of Maryland. School of Medicine) ;
Donatti, Amanda (University of Campinas) ;
Griessenauer, Christoph J. (Research Institute of Neurointervention, Paracelsus Medical University) ;
Heitsch, Laura (Washington University School of Medicine) ;
Holmegaard, Lukas (University of Gothenburg) ;
Jood, Katarina (University of Gothenburg) ;
Jimenez-Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Roquer, Jaume (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Kittner, Steven J. (University of Maryland School of Medicine) ;
Lemmens, Robin (University Hospitals Leuven (Bèlgica)) ;
Levi, Christopher R. (John Hunter Hospital) ;
McDonough, Caitrin W. (University of Florida) ;
Meschia, James F. (Mayo Clinic (Estats Units d'Amèrica)) ;
Phuah, Chia-Ling (Department of Neurology, Washington University School of Medicine & Barnes-Jewish Hospital) ;
Rolfs, Arndt (Centogene AG (Alemanya)) ;
Ropele, Stefan (Department of Neurology, Medical University Graz) ;
Rosand, Jonathan (Massachusetts General Hospital) ;
Rundek, Tatjana (Department of Neurology, University of Miami) ;
Sacco, Ralph L. (Department of Neurology , University of Miami) ;
Schmidt, Reinhold (Department of Neurology, Medical University Graz) ;
Enzinger, Christian (Department of Neurology, Medical University Graz) ;
Sharma, Pankaj (St. Peter's and Ashford Hospitals) ;
Slowik, Agnieszka (Jagiellonian University Medical College) ;
Sousa, Alessandro (University of Campinas) ;
Stanne, Tara M. (University of Gothenburg) ;
Strbian, Daniel (University of Helsinki) ;
Tatlisumak, Turgut (Sahlgrenska University Hospital) ;
Thijs, Vincent (Austin Health (Austràlia)) ;
Vagal, Achala (University of Cincinnati College of Medicine) ;
Wasselius, Johan (Skåne University Hospital (Suècia)) ;
Woo, Daniel (University of Cincinnati College of Medicine) ;
Zand, Ramin (Geisinger (Estats Units d'Amèrica)) ;
McArdle, Patrick F. (University of Maryland School of Medicine) ;
Worrall, Bradford B. (University of Virginia) ;
Wu, Ona (Massachusetts General Hospital) ;
Jern, Christina (Department of University of Gothenburg) ;
Lindgren, Arne G. (Lund University. Department of Clinical Sciences) ;
Maguire, Jane (University of Technology Sydney) ;
Tomppo, Liisa (University of Helsinki) ;
Golland, Polina (Massachusetts Institute of Technology) ;
Rost, Natalia S. (Massachusetts General Hospital) ;
Universitat Autònoma de Barcelona
Objective: To personalize the prognostication of post-stroke outcome using MRI-detected cerebrovascular pathology, we sought to investigate the association between the excessive white matter hyperintensity (WMH) burden unaccounted for by the traditional stroke risk profile of individual patients and their long-term functional outcomes after a stroke. [...]
2021 - 10.3389/fneur.2021.700616
Frontiers in neurology, Vol. 12 (september 2021)
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5.
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17 p, 1.3 MB |
Altered methylation pattern in EXOC4 is associated with stroke outcome : an epigenome-wide association study
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Cullell, Natalia (Institut d'Investigació Biomèdica Sant Pau) ;
Soriano Tárraga, Carolina (NeuroGenomics and Informatics. Washington University School of Medicine) ;
Gallego-Fabrega, Cristina (Institut d'Investigació Biomèdica Sant Pau) ;
Cárcel-Márquez, Jara (Institut d'Investigació Biomèdica Sant Pau) ;
Muiño, Elena (Institut d'Investigació Biomèdica Sant Pau) ;
Llucià-Carol, Laia (Institut d'Investigació Biomèdica Sant Pau) ;
Lledós, Miquel (Institut d'Investigació Biomèdica Sant Pau) ;
Esteller, M (Institució Catalana de Recerca i Estudis Avançats) ;
Castro de Moura, Manuel (Programa de Epigenética y Biología del Cáncer (PEBC)) ;
Montaner, Joan (Instituto de Biomedicina de Sevilla) ;
Rosell Novel, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Delgado Martínez, María Pilar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martí-Fàbregas, Joan (Institut d'Investigació Biomèdica Sant Pau) ;
Krupinski, Jerzy (Centre for Bioscience. School of HealthCare Science. Manchester Metropolitan University) ;
Roquer, Jaume (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Jiménez-Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Background and purpose: The neurological course after stroke is highly variable and is determined by demographic, clinical and genetic factors. However, other heritable factors such as epigenetic DNA methylation could play a role in neurological changes after stroke. [...]
2022 - 10.1186/s13148-022-01340-5
Clinical Epigenetics, Vol. 14 Núm. 1 (december 2022) , p. 124
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6.
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12 p, 1.1 MB |
A Polygenic Risk Score Based on a Cardioembolic Stroke Multitrait Analysis Improves a Clinical Prediction Model for This Stroke Subtype
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Cárcel-Márquez, Jara (Institut d'Investigació Biomèdica Sant Pau) ;
Muiño, Elena (Institut d'Investigació Biomèdica Sant Pau) ;
Gallego-Fabrega, Cristina (Institut d'Investigació Biomèdica Sant Pau) ;
Cullell, Natalia (Institut d'Investigació Biomèdica Sant Pau) ;
Lledós, Miquel (Institut d'Investigació Biomèdica Sant Pau) ;
Llucià-Carol, Laia (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Sobrino, Tomás (Hospital Clínico Universitario (Santiago de Compostela, Galícia)) ;
Campos, Francisco (Hospital Clínico Universitario (Santiago de Compostela, Galícia)) ;
Castillo, José (Hospital Clínico Universitario (Santiago de Compostela, Galícia)) ;
Freijo, Marimar (Biocruces-Bizkaia Health Research Institute. Department of Neurology) ;
Arenillas, Juan F (Hospital Universitario de Valladolid) ;
Obach, Víctor (Hospital Clínic i Provincial de Barcelona) ;
Álvarez Sabín, José (Hospital Universitari Vall d'Hebron) ;
Molina, Carlos A. (Hospital Universitari Vall d'Hebron) ;
Ribó, Marc (Hospital Universitari Vall d'Hebron) ;
Jiménez-Conde, Jordi (Hospital del Mar (Barcelona, Catalunya)) ;
Roquer, Jaume (Hospital del Mar (Barcelona, Catalunya)) ;
Muñoz-Narbona, Lucia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
López-Cancio, Elena (Hospital Central de Asturias (HUCA)) ;
Millán, Mònica (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Diaz-Navarro, Rosa (Institut d'Investigació Sanitària Illes Balears) ;
Vives-Bauza, Cristòfol (Institut d'Investigació Sanitària Illes Balears) ;
Serrano-Heras, Gemma (Complejo Hospitalario Universitario de Albacete) ;
Segura, Tomás (Complejo Hospitalario Universitario de Albacete) ;
Ibañez, Laura (Washington University School of Medicine. Department of Psychiatry) ;
Heitsch, Laura (Washington University School of Medicine. Department of Neurology) ;
Delgado, Pilar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Dhar, Rajat (Washington University School of Medicine. Department of Neurology.) ;
Krupinski, Jerzy (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Delgado Mederos, Raquel (Institut d'Investigació Biomèdica Sant Pau) ;
Prats-Sánchez, Luis Antonio (Institut d'Investigació Biomèdica Sant Pau) ;
Camps-Renom, Pol (Institut d'Investigació Biomèdica Sant Pau) ;
Blay, Natalia (Institut Germans Trias i Pujol) ;
Sumoy, Lauro (Institut Germans Trias i Pujol) ;
de Cid, Rafael (Institut Germans Trias i Pujol) ;
Montaner, Joan (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Cruchaga, Carlos (Washington University in St. Louis. Neurogenomics and Informatics Center.) ;
Lee, Jim-Moo (Washington University School of Medicine. Department of Neurology.) ;
Martí-Fàbregas, Joan (Institut d'Investigació Biomèdica Sant Pau) ;
Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Background: Occult atrial fibrillation (AF) is one of the major causes of embolic stroke of undetermined source (ESUS). Knowing the underlying etiology of an ESUS will reduce stroke recurrence and/or unnecessary use of anticoagulants. [...]
2022 - 10.3389/fcvm.2022.940696
Frontiers in Cardiovascular Medicine, Vol. 9 (august 2022) , p. 940696
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7.
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17 p, 693.0 KB |
Contribution of Common Genetic Variants to Risk of Early-Onset Ischemic Stroke
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Jaworek, Thomas ;
Xu, Huichun ;
Gaynor, Brady ;
Cole, John W. ;
Rannikmae, Kristiina ;
Stanne, Tara M. ;
Tomppo, Liisa ;
Abedi, Vida ;
Amouyel, Philippe ;
Armstrong, Nicole D. ;
Attia, John ;
Bell, Steven ;
Benavente, Oscar R. ;
Boncoraglio, Giorgio B. ;
Butterworth, Adam ;
Cárcel-Márquez, Jara (Institut d'Investigació Biomèdica Sant Pau) ;
Chen, Zhengming ;
Chong, Michael ;
Cruchaga, Carlos ;
Cushman, Mary ;
Danesh, John ;
Debette, Stéphanie ;
Duggan, David J. ;
Durda, Jon Peter ;
Engstrom, Gunnar ;
Enzinger, Chris ;
Faul, Jessica D. ;
Fecteau, Natalie S. ;
Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ;
Gieger, Christian ;
Giese, Anne-Katrin ;
Grewal, Raji P. ;
Grittner, Ulrike ;
Havulinna, Aki S. ;
Heitsch, Laura ;
Hochberg, Marc C. ;
Holliday, Elizabeth ;
Hu, Jie ;
Ilinca, Andreea ;
Irvin, Marguerite R. ;
Jackson, Rebecca D. ;
Jacob, Mina A. ;
Rabionet, Raquel ;
Jimenez-Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Johnson, Julie A. ;
Kamatani, Yoichiro ;
Kardia, Sharon L.R. ;
Koido, Masaru ;
Kubo, Michiaki ;
Lange, Leslie ;
Lee, Jin-Moo ;
Lemmens, Robin ;
Levi, Christopher R. ;
Li, Jiang ;
Li, Liming ;
Lin, Kuang ;
Lopez, Haley ;
Luke, Sothear ;
Maguire, Jane ;
McArdle, Patrick F. ;
McDonough, Caitrin W. ;
Meschia, James F. (Mayo Clinic (Jacksonville, Estats Units d'Amèrica)) ;
Metso, Tiina ;
Müller-Nurasyid, Martina ;
Dichgans, Martin ;
O'Donnell, Martin ;
Peddareddygari, Leema R. ;
Pera, Joanna ;
Perry, James A. ;
Peters, Annette ;
Putaala, Jukka ;
Ray, Debashree ;
Rexrode, Kathryn ;
Ribasés Haro, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rosand, Jonathan ;
Rothwell, Peter M. ;
Rundek, Tatjana ;
Ryan, Kathleen A. ;
Sacco, Ralph L. ;
Salomaa, Veikko ;
Sánchez-Mora, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Schmidt, Reinhold ;
Sharma, Pankaj ;
Slowik, Agnieszka ;
Smith, Jennifer A. ;
Smith, Nicholas L. ;
Wassertheil-Smoller, Sylvia ;
Söderholm, Martin ;
Stine, O. Colin ;
Strbian, Daniel ;
Sudlow, Cathie L.M. ;
Tatlisumak, Turgut ;
Terao, Chikashi ;
Thijs, Vincent ;
Torres-Aguila, Nuria P.. ;
Trégouët, David-Alexandre ;
Tuladhar, Anil M. ;
Veldink, Jan ;
Walters, Robin G. ;
Weir, David R. ;
Woo, Daniel ;
Worrall, Bradford B. ;
Hong, Charles C. ;
Ross, Owen A. ;
Zand, Ramin ;
de Leeuw, Frank-Erik ;
Lindgren, Arne G. ;
Paré, Guillaume ;
Anderson, Christopher D. ;
Markus, Hugh S. ;
Jern, Christina ;
Malik, Rainer ;
Dichgans, Martin ;
Mitchell, Braxton D. ;
Kittner, Steven J. ;
Universitat Autònoma de Barcelona
Current genome-wide association studies of ischemic stroke have focused primarily on late-onset disease. As a complement to these studies, we sought to identify the contribution of common genetic variants to risk of early-onset ischemic stroke. [...]
2022 - 10.1212/WNL.0000000000201006
Neurology, Vol. 99 (october 2022) , p. e1738-e1754
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8.
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12 p, 1.9 MB |
Sex-specific lesion pattern of functional outcomes after stroke
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Bonkhoff, Anna K. (J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Harvard Medical School) ;
Bretzner, Martin (Univ. Lille) ;
Hong, Sungmin (Massachusetts General Hospital (Boston)) ;
Schirmer, Markus D. (University Hospital Bonn (Bonn, Alemanya)) ;
Cohen, Alexander (Boston Children's Hospital (Boston, Estats Units d'Amèrica)) ;
Regenhardt, Robert W. (Massachusetts General Hospital (Boston)) ;
Donahue, Kathleen L. (Massachusetts General Hospital (Boston)) ;
Nardin, Marco J. (Massachusetts General Hospital (Boston)) ;
Dalca, Adrian Vasile (Massachusetts General Hospital (Boston)) ;
Giese, Anne-Katrin (University Medical Center Hamburg-Eppendorf) ;
Etherton, Mark R. (Massachusetts General Hospital (Boston)) ;
Hancock, Brandon L. (Massachusetts General Hospital (Boston)) ;
Mocking, Steven J. T. (Massachusetts General Hospital (Boston)) ;
McIntosh, Elissa C. (Massachusetts General Hospital (Boston)) ;
Attia, John (University of Newcastle) ;
Benavente, Oscar R. (University of British Columbia) ;
Bevan, Stephen (University of Lincoln) ;
Cole, John W. (University of Maryland School of Medicine) ;
Donatti, Amanda (University of Campinas) ;
Griessenauer, Christoph J. (Paracelsus Medical University) ;
Heitsch, Laura (Washington University School) ;
Holmegaard, Lukas (Sahlgrenska University Hospital (Suècia)) ;
Jood, Katarina (Sahlgrenska University Hospital (Suècia)) ;
Jimenez-Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Kittner, Steven J. (University of Maryland) ;
Lemmens, Robin (University Hospitals Leuven (Bèlgica)) ;
Levi, Christopher R. (John Hunter Hospital) ;
McDonough, Caitrin W. (University of Florida) ;
Meschia, James F. (Mayo Clinic (Jacksonville, Estats Units d'Amèrica)) ;
Phuah, Chia-Ling (Washington University School of Medicine) ;
Rolfs, Arndt (Centogene AG) ;
Ropele, Stefan (Medical University Graz) ;
Rosand, Jonathan (Massachusetts General Hospital (Boston)) ;
Roquer, Jaume (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Rundek, Tatjana (University of Miami) ;
Sacco, Ralph L. (University of Miami. Miller School of Medicine) ;
Schmidt, Reinhold (Medical University Graz) ;
Sharma, Pankaj (St Peter's and Ashford Hospital) ;
Slowik, Agnieszka (Jagiellonian University Medical College) ;
Söderholm, Martin (Skåne University Hospital (Suècia)) ;
Sousa, Alessandro (University of Campinas) ;
Stanne, Tara M. (University of Gothenburg) ;
Strbian, Daniel (Helsinki University Hospital) ;
Tatlisumak, Turgut (Sahlgrenska Academy at University of Gothenburg) ;
Thijs, Vincent (Austin Health) ;
Vagal, Achala (University of Cincinnati College of Medicine) ;
Wasselius, Johan (Skåne University Hospital (Suècia)) ;
Woo, Daniel (University of Cincinnati College of Medicine) ;
Zand, Ramin (Department of Neurology, Geisinger) ;
McArdle, Patrick F. (University of Maryland School of Medicine) ;
Worrall, Bradford B. (University of Virginia) ;
Jern, Christina (Sahlgrenska University Hospital (Suècia)) ;
Lindgren, Arne G. (Lund University) ;
Maguire, Jane (University of Technology Sydney) ;
Fox, Michael D. (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ;
Bzdok, Danilo (Mila-Quebec Artificial Intelligence Institute) ;
Wu, Ona (Boston Children's Hospital (Boston, Estats Units d'Amèrica)) ;
Rost, Natalia S. (Massachusetts General Hospital (Boston)) ;
Universitat Autònoma de Barcelona
Stroke represents a considerable burden of disease for both men and women. However, a growing body of literature suggests clinically relevant sex differences in the underlying causes, presentations and outcomes of acute ischaemic stroke. [...]
2022 - 10.1093/braincomms/fcac020
Brain Communications, Vol. 4 (february 2022)
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9.
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9 p, 990.5 KB |
International stroke genetics consortium recommendations for studies of genetics of stroke outcome and recovery
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Lindgren, Arne G. (Skåne University Hospital (Suècia)) ;
Braun, Robynne G. (Department of Neurology, University of Maryland) ;
Juhl Majersik, Jennifer (Department of Neurology, University of Utah) ;
Clatworthy, Philip (North Bristol NHS Trust) ;
Mainali, Shraddha (The Ohio State University) ;
Derdeyn, Colin P. (University of Iowa) ;
Maguire, Jane (University of Technology Sydney) ;
Jern, Christina (Sahlgrenska University Hospital (Suècia)) ;
Rosand, Jonathan (Massachusetts General Hospital (Boston)) ;
Cole, John W. (University of Maryland School of Medicine) ;
Lee, Jin-Moo (Washington University School of Medicine, St. Louis) ;
Khatri, Pooja (University of Cincinnati) ;
Nyquist, Paul (Johns Hopkins School of Medicine, Baltimore) ;
Debette, Stéphanie (Bordeaux University Hospital (França)) ;
Keat Wei, Loo (Universiti Tunku Abdul Rahman, Perak) ;
Rundek, Tatjana (University of Miami. Miller School of Medicine) ;
Leifer, Dana (Weill Cornell Medicine, New York) ;
Thijs, Vincent (Florey Institute of Neuroscience and Mental Health, Melbourne) ;
Lemmens, Robin (University Hospitals Leuven (Bèlgica)) ;
Heitsch, Laura (Washington University School of Medicine) ;
Prasad, Kameshwar (Rajendra Institute of Medical Sciences) ;
Jimenez-Conde, Jordi (Hospital del Mar (Barcelona, Catalunya)) ;
Dichgans, Martin (Institute for Stroke and Dementia Research (Munic, Alemanya)) ;
Rost, Natalia S. (Massachusetts General Hospital (Boston)) ;
Cramer, Steven C. (California Rehabilitation Institute) ;
Bernhardt, Julie (Florey Institute of Neuroscience and Mental Health (Melbourne, Austràlia)) ;
Worrall, Bradford B. (University of Virginia) ;
Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Numerous biological mechanisms contribute to outcome after stroke, including brain injury, inflammation, and repair mechanisms. Clinical genetic studies have the potential to discover biological mechanisms affecting stroke recovery in humans and identify intervention targets. [...]
2021 - 10.1177/17474930211007288
International Journal of Stroke, Vol. 17 (april 2021) , p. 260-268
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10.
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14 p, 3.0 MB |
Outcome after acute ischemic stroke is linked to sex-specific lesion patterns
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Bonkhoff, Anna K. (Massachusetts General Hospital (Boston)) ;
Schirmer, Markus D. (University Hospital Bonn (Bonn, Alemanya)) ;
Bretzner, Martin (Univ. Lille) ;
Hong, Sungmin (Massachusetts General Hospital (Boston)) ;
Regenhardt, Robert W. (Massachusetts General Hospital (Boston)) ;
Brudfors, Mikael (School of Biomedical Engineering & Imaging Sciences) ;
Donahue, Kathleen L. (Massachusetts General Hospital (Boston)) ;
Nardin, Marco J. (Massachusetts General Hospital (Boston)) ;
Dalca, Adrian Vasile (Massachusetts General Hospital (Boston)) ;
Giese, Anne-Katrin (University Medical Center Hamburg-Eppendorf) ;
Etherton, Mark R. (Massachusetts General Hospital (Boston)) ;
Hancock, Brandon L. (Massachusetts General Hospital (Boston)) ;
Mocking, Steven J. T. (Massachusetts General Hospital (Boston)) ;
McIntosh, Elissa C. (Massachusetts General Hospital (Boston)) ;
Attia, John (School of Medicine and Public Health) ;
Benavente, Oscar R. (University of British Columbia) ;
Bevan, Stephen (University of Lincoln) ;
Cole, John W. (University of Maryland School of Medicine and Veterans Affairs Maryland Health Care System) ;
Donatti, Amanda (Brazilian Institute of Neuroscience and Neurotechnology (BRAINN)) ;
Griessenauer, Christoph J. (Research Institute of Neurointervention) ;
Heitsch, Laura (Washington University School of Medicine & Barnes-Jewish Hospital) ;
Holmegaard, Lukas (Sahlgrenska University Hospital (Suècia)) ;
Jood, Katarina (Sahlgrenska University Hospital (Suècia)) ;
Jimenez-Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Kittner, Steven J. (University of Maryland School of Medicine and Veterans Affairs Maryland Health Care System) ;
Lemmens, Robin (University Hospitals Leuven (Bèlgica)) ;
Levi, Christopher R. (John Hunter Hospital) ;
McDonough, Caitrin W. (University of Florida) ;
Meschia, James F. (Mayo Clinic (Jacksonville, Estats Units d'Amèrica)) ;
Phuah, Chia-Ling (Washington University School of Medicine) ;
Rolfs, Arndt (Centogene AG) ;
Ropele, Stefan (Medical University Graz) ;
Rosand, Jonathan (Massachusetts General Hospital (Boston)) ;
Roquer, Jaume (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Rundek, Tatjana (University of Miami) ;
Sacco, Ralph L. (University of Miami) ;
Schmidt, Reinhold (Medical University Graz) ;
Sharma, Pankaj (St Peter's and Ashford Hospitals) ;
Slowik, Agnieszka (Jagiellonian University Medical College) ;
Söderholm, Martin (Skåne University Hospital (Suècia)) ;
Sousa, Alessandro (Brazilian Institute of Neuroscience and Neurotechnology (BRAINN)) ;
Stanne, Tara M. (the Sahlgrenska Academy at University of Gothenburg) ;
Strbian, Daniel (Helsinki University Hospital (Finlàndia)) ;
Tatlisumak, Turgut (Sahlgrenska University Hospital (Suècia)) ;
Thijs, Vincent (Austin Health) ;
Vagal, Achala (University of Cincinnati College of Medicine) ;
Wasselius, Johan (Skåne University Hospital (Suècia)) ;
Woo, Daniel (University of Cincinnati College of Medicine) ;
Zand, Ramin (Geisinger) ;
McArdle, Patrick F. (University of Maryland School of Medicine) ;
Worrall, Bradford B. (University of Virginia) ;
Jern, Christina (Sahlgrenska University Hospital (Suècia)) ;
Lindgren, Arne G. (Lund University) ;
Maguire, Jane (University of Technology Sydney) ;
Bzdok, Danilo (Mila - Quebec Artificial Intelligence Institute) ;
Wu, Ona (Massachusetts General Hospital (Boston)) ;
Rost, Natalia S. (Massachusetts General Hospital (Boston)) ;
Universitat Autònoma de Barcelona
Acute ischemic stroke affects men and women differently. In particular, women are often reported to experience higher acute stroke severity than men. We derived a low-dimensional representation of anatomical stroke lesions and designed a Bayesian hierarchical modeling framework tailored to estimate possible sex differences in lesion patterns linked to acute stroke severity (National Institute of Health Stroke Scale). [...]
2021 - 10.1038/s41467-021-23492-3
Nature communications, Vol. 12 (june 2021)
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