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19 p, 13.0 MB |
Detection of Sleep-Disordered Breathing in Patients with Spinal Cord Injury Using a Smartphone
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Castillo-Escario, Yolanda (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Kumru, Hatice (Institut Germans Trias i Pujol. Institut Guttmann) ;
Ferrer-Lluis, Ignasi (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Vidal, Joan (Institut Germans Trias i Pujol. Institut Guttmann) ;
Jané, Raimon (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Universitat Autònoma de Barcelona
Patients with spinal cord injury (SCI) have an increased risk of sleep-disordered breathing (SDB), which can lead to serious comorbidities and impact patients' recovery and quality of life. However, sleep tests are rarely performed on SCI patients, given their multiple health needs and the cost and complexity of diagnostic equipment. [...]
2021 -  10.3390/s21217182
Sensors (Basel, Switzerland), Vol. 21 (october 2021)
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17 p, 1.7 MB |
Transcutaneous Cervical Spinal Cord Stimulation Combined with Robotic Exoskeleton Rehabilitation for the Upper Limbs in Subjects with Cervical SCI : Clinical Trial
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García-Alén, Loreto (Institut Germans Trias i Pujol. Institut Guttmann) ;
Kumru, Hatice (Institut Germans Trias i Pujol. Institut Guttmann) ;
Castillo-Escario, Yolanda (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Benito-Penalva, Jesús (Institut Germans Trias i Pujol. Institut Guttmann) ;
Medina-Casanovas, Josep (Institut Germans Trias i Pujol. Institut Guttmann) ;
Gerasimenko, Yury P. (University of Louisville) ;
Edgerton, Victor (Rancho Research Institute) ;
García Alias, Guillermo (Institut Germans Trias i Pujol. Institut Guttmann) ;
Vidal, Joan (Institut Germans Trias i Pujol. Institut Guttmann) ;
Universitat Autònoma de Barcelona
Restoring arm and hand function is a priority for individuals with cervical spinal cord injury (cSCI) for independence and quality of life. Transcutaneous spinal cord stimulation (tSCS) promotes the upper extremity (UE) motor function when applied at the cervical region. [...]
2023 - 10.3390/biomedicines11020589
Biomedicines, Vol. 11 (february 2023)
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3.
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18 p, 30.1 MB |
Preclinical Development of a Therapy for Chronic Traumatic Spinal Cord Injury in Rats Using Human Wharton's Jelly Mesenchymal Stromal Cells : Proof of Concept and Regulatory Compliance
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Vives Armengol, Joaquim (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Hernández, Joaquim (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Mirabel, Clémentine (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Puigdomenech-poch, Maria (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Romeo-Guitart, David (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Marmolejo Martínez-Artesero, Sara (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Cabrera-Pérez, Raquel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Jaramillo, Jessica (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Kumru, Hatice (Universitat Autònoma de Barcelona. Departament de Medicina) ;
García-lópez, Joan (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Vidal-Samsó, Joan (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Navarro, X. (Xavier) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Coll-Bonet, Ruth (Banc de Sang i Teixits)
(1) Background: the use of Mesenchymal Stromal Cells (MSC) in emerging therapies for spinal cord injury (SCI) hold the potential to improve functional recovery. However, the development of cell-based medicines is challenging and preclinical studies addressing quality, safety and efficacy must be conducted prior to clinical testing; (2) Methods: herein we present (i) the characterization of the quality attributes of MSC from the Wharton's jelly (WJ) of the umbilical cord, (ii) safety of intrathecal infusion in a 3-month subchronic toxicity assessment study, and (iii) efficacy in a rat SCI model by controlled impaction (100 kdynes) after single (day 7 post-injury) and repeated dose of 1 × 10 MSC,WJ (days 7 and 14 post-injury) with 70-day monitoring by electrophysiological testing, motor function assessment and histology evaluation; (3) Results: no toxicity associated to MSC,WJ infusion was observed. [...]
2022 - 10.3390/cells11142153
Cells, Vol. 11 Núm. 14 (7-2 2022) , p. 2153
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16 p, 2.2 MB |
Transcutaneous electrical neuromodulation of the cervical spinal cord depends both on the stimulation intensity and the degree of voluntary activity for training. A pilot study
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Kumru, Hatice (Institut Germans Trias i Pujol. Institut Guttmann) ;
Rodríguez-Cañón, María (Institut Germans Trias i Pujol. Institut Guttmann) ;
Edgerton, Victor (Institut Germans Trias i Pujol. Institut Guttmann) ;
García, Loreto (Institut Germans Trias i Pujol. Institut Guttmann) ;
Flores, África (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Soriano Crespo, Ignasi (Institut Germans Trias i Pujol. Institut Guttmann) ;
Opisso, Eloy (Institut Germans Trias i Pujol. Institut Guttmann) ;
Gerasimenko, Yury (University of Louisville) ;
Navarro, X. (Xavier) (Institut Germans Trias i Pujol. Institut Guttmann) ;
García Alias, Guillermo (Institut Germans Trias i Pujol. Institut Guttmann) ;
Vidal, Joan (Institut Germans Trias i Pujol. Institut Guttmann)
Electrical enabling motor control (eEmc) through transcutaneous spinal cord stimulation offers promise in improving hand function. However, it is still unknown which stimulus intensity or which muscle force level could be better for this improvement. [...]
2021 - 10.3390/jcm10153278
Journal of clinical medicine, Vol. 10 Núm. 15 (january 2021) , p. 3278
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13 p, 4.4 MB |
Assessment of trunk flexion in arm reaching tasks with electromyography and smartphone accelerometry in healthy human subjects
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Castillo-Escario, Yolanda (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Kumru, Hatice (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Valls-Solé, Josep (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
García-Alen, Loreto (Institut Germans Trias i Pujol. Institut Guttmann) ;
Vidal, Joan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Jané Campos, Raimon (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina)
Trunk stability is essential to maintain upright posture and support functional movements. In this study, we aimed to characterize the muscle activity and movement patterns of trunk flexion during an arm reaching task in sitting healthy subjects and investigate whether trunk stability is affected by a startling acoustic stimulus (SAS). [...]
2021 - 10.1038/s41598-021-84789-3
Scientific reports, Vol. 11 (march 2021)
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7 p, 319.4 KB |
Risk Taking in Hospitalized Patients with Acute and Severe Traumatic Brain Injury
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Fecteau, Shirley (Harvard Medical School, Boston, Massachusetts, United States of America) ;
Levasseur-Moreau, Jean (Laval University, Quebec city, Canada) ;
García-Molina, Alberto (Institut Germans Trias i Pujol. Institut Guttmann) ;
Kumru, Hatice (Institut Germans Trias i Pujol. Institut Guttmann) ;
Vergara, Raúl Pelayo (Institut Germans Trias i Pujol. Institut Guttmann) ;
Bernabeu Guitart, Montserrat (Institut Germans Trias i Pujol. Institut Guttmann) ;
Roig, Teresa (Institut Germans Trias i Pujol. Institut Guttmann) ;
Pascual Leone, Álvaro (Institut Germans Trias i Pujol. Institut Guttmann) ;
Tormos, José Maria (Institut Germans Trias i Pujol. Institut Guttmann)
Rehabilitation can improve cognitive deficits observed in patients with traumatic brain injury (TBI). However, despite rehabilitation, the ability of making a choice often remains impaired. Risk taking is a daily activity involving numerous cognitive processes subserved by a complex neural network. [...]
2013 - 10.1371/journal.pone.0083598
PloS one, Vol. 8 (december 2013)
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18 p, 4.3 MB |
Cervical Electrical Neuromodulation Effectively Enhances Hand Motor Output in Healthy Subjects by Engaging a Use-Dependent Intervention
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Kumru, Hatice (Institut Germans Trias i Pujol. Institut Guttmann) ;
Flores, África (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Rodríguez-Cañón, María (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Edgerton, Victor (Institut Germans Trias i Pujol. Institut Guttmann) ;
García, Loreto (Institut Germans Trias i Pujol. Institut Guttmann) ;
Benito-Penalva, Jesús (Institut Germans Trias i Pujol. Institut Guttmann) ;
Navarro, X. (Xavier) (Xavier) (Institut Germans Trias i Pujol. Institut Guttmann) ;
Gerasimenko, Yury (Department of Physiology and Biophysics, University of Louisville, Louisville, KY 40292, USA) ;
García Alias, Guillermo (Institut Germans Trias i Pujol. Institut Guttmann) ;
Vidal, Joan (Institut Germans Trias i Pujol. Institut Guttmann)
Electrical enabling motor control (eEmc) through transcutaneous spinal cord stimulation is a non-invasive method that can modify the functional state of the sensory-motor system. We hypothesize that eEmc delivery, together with hand training, improves hand function in healthy subjects more than either intervention alone by inducing plastic changes at spinal and cortical levels. [...]
2021 - 10.3390/jcm10020195
Journal of clinical medicine, Vol. 10 (january 2021)
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8 p, 1.4 MB |
Motor Cortex Plasticity during Unilateral Finger Movement with Mirror Visual Feedback
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Kumru, Hatice (Institut Germans Trias i Pujol. Institut Guttmann) ;
Albu, Sergiu (Texas A&M University, College Station, TX 77843-4235, USA) ;
Pelayo, Raul (Institut Germans Trias i Pujol. Institut Guttmann) ;
Rothwell, John (Institute of Neurology, University College London, London WC1N 3BG, UK) ;
Opisso, Eloy (Institut Germans Trias i Pujol. Institut Guttmann) ;
Leon, Daniel (Institut Germans Trias i Pujol. Institut Guttmann) ;
Soler, Dolor (Institut Germans Trias i Pujol. Institut Guttmann) ;
Tormos, Josep Maria (Institut Germans Trias i Pujol. Institut Guttmann) ;
Universitat Autònoma de Barcelona
Plasticity is one of the most important physiological mechanisms underlying motor recovery from brain lesions. Rehabilitation methods, such as mirror visual feedback therapy, which are based on multisensory integration of motor, cognitive, and perceptual processes, are considered effective methods to induce cortical reorganization. [...]
2015 - 10.1155/2016/6087896
Neural plasticity, Vol. 2016 (december 2015)
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