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35 p, 1.9 MB |
Neutron-irradiated antibody-functionalised carbon nanocapsules for targeted cancer radiotherapy
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Wang, Julie T. W. (King's College London. Institute of Pharmaceutical Science) ;
Spinato, Cinzia (Centre National de la Recherche Scientifique (França)) ;
Klippstein, Rebecca (King's College London. Institute of Pharmaceutical Science) ;
Costa, Pedro M. (King's College London. Institute of Pharmaceutical Science) ;
Martincic, Markus (Institut de Ciència de Materials de Barcelona) ;
Pach, Elzbieta (Institut Català de Nanociència i Nanotecnologia) ;
Pérez Ruiz De Garibay, Aritz (Centre National de la Recherche Scientifique (França)) ;
Ménard-Moyon, Cécilia (Centre National de la Recherche Scientifique (França)) ;
Feldman, Robert (Cis Bio International Ion Beam Applications SA) ;
Michel, Yves (Cis Bio International Ion Beam Applications SA) ;
Šefl, Martin (University of Ioannina Medical School) ;
Kyriakou, Ioanna (University of Ioannina Medical School) ;
Emfietzoglou, Dimitris (University of Ioannina Medical School) ;
Saccavini, Jean-Claude (Cis Bio International Ion Beam Applications SA) ;
Ballesteros, Belén (Institut Català de Nanociència i Nanotecnologia) ;
Tobias, Gerard (Institut de Ciència de Materials de Barcelona) ;
Bianco, Alberto (Centre National de la Recherche Scientifique (França)) ;
Al-Jamal, Khuloud T. (King's College London. Institute of Pharmaceutical Science)
Radiotherapy is a cancer treatment utilising high doses of ionizing radiation to destroy cancer cells. Our team has pioneered neutron activation of Sm, filled and sealed into single-walled (SWCNTs) and multi-walled carbon nanotubes (MWCNTs), to create stable and high-dose radioactive carbon nanocapsules for cancer radiotherapy. [...]
2020 -  10.1016/j.carbon.2020.02.060
Carbon, Vol. 162 (June 2020) , p. 410-422
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59 p, 2.2 MB |
Neutron Activated 153Sm Sealed in Carbon Nanocapsules for in Vivo Imaging and Tumor Radiotherapy
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Wang, Julie T. W. (King's College London. Institute of Pharmaceutical Science) ;
Klippstein, Rebecca (King's College London. Institute of Pharmaceutical Science) ;
Martincic, Markus (Institut de Ciència de Materials de Barcelona) ;
Pach, Elzbieta (Institut Català de Nanociència i Nanotecnologia) ;
Feldman, Robert (Cis Bio International Ion Beam Applications SA) ;
Šefl, Martin (Czech Technical University in Prague) ;
Michel, Yves (Cis Bio International Ion Beam Applications SA) ;
Asker, Daniel (King's College London. Institute of Pharmaceutical Science) ;
Sosabowski, Jane K. (Queen Mary University of London) ;
Kalbáč, Martin (J. Heyrovsky Institute of the Physical Chemistry) ;
Da Ros, Tatiana (University of Trieste. Department of Chemical and Pharmaceutical Sciences) ;
Ménard-Moyon, Cécilia (Centre National de la Recherche Scientifique (França)) ;
Bianco, Alberto (Centre National de la Recherche Scientifique (França)) ;
Kyriakou, Ioanna (University of Ioannina Medical School) ;
Emfietzoglou, Dimitris (University of Ioannina Medical School) ;
Saccavini, Jean-Claude (Cis Bio International Ion Beam Applications SA) ;
Ballesteros, Belén (Institut Català de Nanociència i Nanotecnologia) ;
Al-Jamal, Khuloud T. (King's College London. Institute of Pharmaceutical Science) ;
Tobias, Gerard (Institut de Ciència de Materials de Barcelona)
Radiation therapy along with chemotherapy and surgery remain the main cancer treatments. Radiotherapy can be applied to patients externally (external beam radiotherapy) or internally (brachytherapy and radioisotope therapy). [...]
2020 - 10.1021/acsnano.9b04898
ACS nano, Vol. 14, Issue 1 (January 2020) , p. 129-141
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43 p, 1.6 MB |
Non-cytotoxic carbon nanocapsules synthesized via one-pot filling and end-closing of multi-walled carbon nanotubes
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Martincic, Markus (Institut de Ciència de Materials de Barcelona) ;
Vranic, Sandra (The University of Manchester) ;
Pach, Elzbieta (Institut Català de Nanociència i Nanotecnologia) ;
Sandoval, Stefania (Institut de Ciència de Materials de Barcelona) ;
Ballesteros, Belén (Institut Català de Nanociència i Nanotecnologia) ;
Kostarelos, Kostas (The University of Manchester) ;
Tobias, Gerard (Institut de Ciència de Materials de Barcelona)
Filled carbon nanotubes (CNTs) find application in a variety of fields that expand from sensors to supercapacitors going through targeted therapies. Bulk filling of CNTs in general results in samples that contain a large amount of non-encapsulated material external to the CNTs. [...]
2019 - 10.1016/j.carbon.2018.10.006
Carbon, Vol. 141 (January 2019) , p. 782-793
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12 p, 1.4 MB |
Evaluation of the immunological profile of antibody-functionalized metal-filled single-walled carbon nanocapsules for targeted radiotherapy
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Pérez Ruiz De Garibay, Aritz (Centre National de la Recherche Scientifique (França)) ;
Spinato, Cinzia (Centre National de la Recherche Scientifique (França)) ;
Klippstein, Rebecca (King's College London. Institute of Pharmaceutical Science) ;
Bourgognon, Maxime (King's College London. Institute of Pharmaceutical Science) ;
Martincic, Markus (Institut de Ciència de Materials de Barcelona) ;
Pach, Elzbieta (Institut Català de Nanociència i Nanotecnologia) ;
Ballesteros, Belén (Institut Català de Nanociència i Nanotecnologia) ;
Ménard-Moyon, Cécilia (Centre National de la Recherche Scientifique (França)) ;
Al-Jamal, Khuloud T. (King's College London. Institute of Pharmaceutical Science) ;
Tobias, Gerard (Institut de Ciència de Materials de Barcelona) ;
Bianco, Alberto (Centre National de la Recherche Scientifique (França))
This study investigates the immune responses induced by metal-filled single-walled carbon nanotubes (SWCNT) under in vitro, ex vivo and in vivo settings. Either empty amino-functionalized CNTs [SWCNT-NH 2 (1)] or samarium chloride-filled amino-functionalized CNTs with [SmCl 3 @SWCNT-mAb (3)] or without [SmCl 3 @SWCNT-NH 2 (2)] Cetuximab functionalization were tested. [...]
2017 - 10.1038/srep42605
Scientific reports, Vol. 7 (February 2017) , art. 42605
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19 p, 868.7 KB |
Design of antibody-functionalized carbon nanotubes filled with radioactivable metals towards a targeted anticancer therapy
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Spinato, Cinzia (Centre national de la recherche scientifique (França). Institut de Biologie Moléculaire et Cellulaire) ;
Pérez Ruiz De Garibay, Aritz (Centre national de la recherche scientifique (França). Institut de Biologie Moléculaire et Cellulaire) ;
Kierkowicz, Magdalena (Institut de Ciència de Materials de Barcelona) ;
Pach, Elzbieta (Institut Català de Nanociència i Nanotecnologia) ;
Martincic, Markus (Institut de Ciència de Materials de Barcelona) ;
Klippstein, Rebecca (King's College London. Institute of Pharmaceutical Science) ;
Bourgognon, Maxime (King's College London. Institute of Pharmaceutical Science) ;
Wang, Julie Tzu-Wen (King's College London. Institute of Pharmaceutical Science) ;
Ménard-Moyon, Cécilia (Centre national de la recherche scientifique (França). Institut de Biologie Moléculaire et Cellulaire) ;
Al-Jamal, Khuloud T. (King's College London. Institute of Pharmaceutical Science) ;
Ballesteros, Belén (Institut Català de Nanociència i Nanotecnologia) ;
Tobias, Gerard (Institut de Ciència de Materials de Barcelona) ;
Bianco, Alberto (Centre national de la recherche scientifique (França). Institut de Biologie Moléculaire et Cellulaire)
In the present work we have devised the synthesis of a novel promising carbon nanotube carrier for the targeted delivery of radioactivity, through a combination of endohedral and exohedral functionalization. [...]
2016 - 10.1039/c5nr07923c
Nanoscale, Vol. 8, issue 25 (2016) , p. 12626-12638
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10 p, 1.6 MB |
Carbon nanotubes allow capture of krypton, barium and lead for multichannel biological X-ray fluorescence imaging
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Serpell, Christopher J. (University of Kent) ;
Rutte, Reida N. (University of Oxford) ;
Geraki, Kalotina (Harwell Science and Innovation Campus) ;
Pach, Elzbieta (Institut Català de Nanociència i Nanotecnologia) ;
Martincic, Markus (Institut de Ciència de Materials de Barcelona) ;
Kierkowicz, Magdalena (Institut de Ciència de Materials de Barcelona) ;
De Munari, Sonia (University of Oxford) ;
Wals, Kim (University of Oxford) ;
Raj, Ritu (University of Oxford) ;
Ballesteros, Belén (Institut Català de Nanociència i Nanotecnologia) ;
Tobias, Gerard (Institut de Ciència de Materials de Barcelona) ;
Anthony, Daniel C. (University of Oxford) ;
Davis, Benjamin G. (University of Oxford)
The desire to study biology in situ has been aided by many imaging techniques. Among these, X-ray fluorescence (XRF) mapping permits observation of elemental distributions in a multichannel manner. However, XRF imaging is underused, in part, because of the difficulty in interpreting maps without an underlying cellular 'blueprint'; this could be supplied using contrast agents. [...]
2016 - 10.1038/ncomms13118
Nature communications, Vol. 7 (October 2016) , art. 13118
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11 p, 2.8 MB |
Epoxidation of carbon nanocapsules : decoration of single-walled carbon nanotubes filled with metal halides
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D'Accolti, Lucia (University of Bari "A. Moro". Department of Chemistry) ;
Gajewska, Agnieszka (University of Trieste. Department of Chemical and Pharmaceutical Sciences) ;
Kierkowicz, Magdalena (Institut de Ciència de Materials de Barcelona) ;
Martincic, Markus (Institut de Ciència de Materials de Barcelona) ;
Nacci, Angelo (University of Bari "A. Moro". Department of Chemistry) ;
Sandoval, Stefania (Institut de Ciència de Materials de Barcelona) ;
Ballesteros, Belén (Institut Català de Nanociència i Nanotecnologia) ;
Tobias, Gerard (Institut de Ciència de Materials de Barcelona) ;
Da Ros, Tatiana (University of Trieste. Department of Chemical and Pharmaceutical Sciences) ;
Fusco, Caterina (University of Bari. Department of Chemistry)
Methyl(trifluoromethyl)dioxirane (TFDO) can be used for the oxyfunctionalization of SWCNTs filled with NaI and LuCl under mild conditions. The chosen metal halides are of interest for theranostics, both for imaging and therapy when in their radioactive form. [...]
2018 - 10.3390/nano8030137
Nanomaterials, Vol. 8, issue 3 (March 2018)
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