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13 p, 2.1 MB Peptide Assembly on the Membrane Determines the HIV-1 Inhibitory Activity of Dual-Targeting Fusion Inhibitor Peptides / Gómara Elena, María José (Institut de Química avançada de Catalunya (IQAC-CSIC)) ; Pérez, Yolanda (Institut de Química avançada de Catalunya (IQAC-CSIC)) ; Martinez, Javier P. (Universitat Pompeu Fabra) ; Barnadas Rodríguez, Ramon (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Schultz, Anke (Fraunhofer Institute for Biomedical Engineering (Sulzbach, Alemanya)) ; von Briesen, Hagen (Fraunhofer Institute for Biomedical Engineering (Sulzbach, Alemanya)) ; Perálvarez Marín, Alejandro (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Meyerhans, Andreas (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ; Haro, Isabel (Institut de Química avançada de Catalunya (IQAC-CSIC))
Novel strategies in the design of HIV-I fusion/entry inhibitors are based on the construction of dual- targeting fusion proteins and peptides with synergistic antiviral effects. In this work we describe the design of dual -targeting peptides composed of peptide domains of E2 and El envelope proteins from Human Pegivirus with the aim of targeting both the loop region and the fusion peptide domains of HIV-I gp41. [...]
2019 - 10.1038/s41598-019-40125-4
Scientific reports, Vol. 9 (2019) , art. 3257  

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