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Results overview: Found 7 records in 0.02 seconds.
Articles, 6 records found
Research literature, 1 records found
Articles 6 records found  
1.
27 p, 369.7 KB Treatment with scFv-h3D6 Prevented Neuronal Loss and Improved Spatial Memory in Young 3xTg-AD Mice by Reducing the Intracellular Amyloid-β Burden / Esquerda-Canals, Gisela (Universitat Autònoma de Barcelona. Disseny de Proteïnes i Immunoteràpia) ; Roda, Alejandro Ramos (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Martí-Clúa, Joaquín (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Montoliu-Gaya, Laia (Universitat Autònoma de Barcelona. Disseny de Proteïnes i Immunoteràpia) ; Rivera-Hernández, Geovanny (Universitat Autònoma de Barcelona. Disseny de Proteïnes i Immunoteràpia) ; Villegas Hernández, Sandra (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
The intracellular deposition of amyloid-beta (A beta) peptides has been described in the brains of both Alzheimer's disease (AD) patients and animal models. A correlation between the intracellular amyloid burden and neurodegeneration has recently been reported in a triple-transgenic AD (3xTg-AD) murine model. [...]
2019 - 10.3233/JAD-190484
Journal of Alzheimer's disease, Vol. 70 Núm. 4 (2019) , p. 1069-1091  
Detailed record -
2.
15 p, 2.2 MB Clinical performance and head-to-head comparison of CSF p-tau235 with p-tau181, p-tau217 and p-tau231 in two memory clinic cohorts / Lantero-Rodríguez, Juan (University of Gothenburg) ; Vrillon, Agathe (Groupe Hospitalo Universitaire Assistance Publique Hôpitaux de Paris Nord Hôpital Lariboisière Fernand-Widal) ; Fernández-Lebrero, Aida (Institut Hospital del Mar d'Investigacions Mèdiques) ; Ortiz-Romero, Paula (Institut Hospital del Mar d'Investigacions Mèdiques) ; Snellman, Anniina (University of Turku) ; Montoliu-Gaya, Laia (the Sahlgrenska Academy at the University of Gothenburg) ; Brum, Wagner S. (Universidade Federal do Rio Grande do Sul (UFRGS)) ; Cognat, Emmanuel (Groupe Hospitalo Universitaire Assistance Publique Hôpitaux de Paris Nord Hôpital Lariboisière Fernand-Widal) ; Dumurgier, Julien (Groupe Hospitalo Universitaire Assistance Publique Hôpitaux de Paris Nord Hôpital Lariboisière Fernand-Widal) ; Puig-Pijoan, Albert (Universitat Autònoma de Barcelona. Departament de Medicina) ; Navalpotro-Gómez, Irene (Institut Hospital del Mar d'Investigacions Mèdiques) ; García-Escobar, Greta (Institut Hospital del Mar d'Investigacions Mèdiques) ; Karikari, Thomas K. (University of Pittsburgh) ; Vanmechelen, Eugeen (ADx NeuroSciences (Ghent, Bèlgica)) ; Ashton, Nicholas J. (NIHR Biomedical Research Centre for Mental Health (Londres, Regne Unit)) ; Zetterberg, Henrik (University of Wisconsin School of Medicine and Public Health) ; Suárez-Calvet, Marc (Institut Hospital del Mar d'Investigacions Mèdiques) ; Paquet, Claire (Groupe Hospitalo Universitaire Assistance Publique Hôpitaux de Paris Nord Hôpital Lariboisière Fernand-Widal) ; Blennow, Kaj (Sahlgrenska University Hospital (Suècia))
Cerebrospinal fluid (CSF) p-tau235 is a novel biomarker highly specific of Alzheimer's disease (AD). However, CSF p-tau235 has only been studied in well-characterized research cohorts, which do not fully reflect the patient landscape found in clinical settings. [...]
2023 - 10.1186/s13195-023-01201-0
Alzheimer's research & therapy, Vol. 15 (march 2023)  
Detailed record - Creative Commons
3.
9 p, 3.7 MB Amyloid-beta peptide and tau protein crosstalk in Alzheimer's disease / Ramos Roda, Alejandro (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Serra-Mir, Gabriel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Montoliu-Gaya, Laia (University of Gothenburg) ; Tiessler, Lidia (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Villegas Hernández, Sandra (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Alzheimer's disease is a neurodegenerative disease that accounts for most of the 50-million dementia cases worldwide in 2018. A large amount of evidence supports the amyloid cascade hypothesis, which states that amyloid-beta accumulation triggers tau hyperphosphorylation and aggregation in form of neurofibrillary tangles, and these aggregates lead to inflammation, synaptic impairment, neuronal loss, and thus to cognitive decline and behavioral abnormalities. [...]
2022 - 10.4103/1673-5374.332127
Neural Regeneration Research, Vol. 17, Num. 8 (August 2022) , p. 1666-1674  
Detailed record - Creative Commons
4.
18 p, 8.6 MB Effects of an Aβ-antibody fragment on Aβ aggregation and astrocytic uptake are modulated by apolipoprotein E and J mimetic peptides / Montoliu-Gaya, Laia (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Mulder, Sandra D. (VU University Medical Center. Clinical Chemistry Department) ; Veerhuis, Robert (VU University Medical Center. Psychiatry Department) ; Villegas Hernández, Sandra (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Aβ-Immunotherapy has long been studied in the treatment of Alzheimer's disease (AD), but not how other molecules involved in the disease can affect antibody performance. We previously designed an antibody fragment, scFv-h3D6, and showed that it precludes Aβ-induced cytotoxicity by withdrawing Aβ oligomers from the amyloid pathway towards a non-toxic, worm-like pathway. [...]
2017 - 10.1371/journal.pone.0188191
PloS one, Vol. 12, Issue 11 (November 2017) , art. e0188191  
Detailed record - Creative Commons
5.
19 p, 18.6 MB Production of an anti-Aβ antibody fragment in Pichia pastoris and in vitro and in vivo validation of its therapeutic effect / Montoliu-Gaya, Laia (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Esquerda-Canals, Gisela (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Bronsoms, Sílvia (Universitat Autònoma de Barcelona. Servei de Proteòmica i Biologia Estructural) ; Villegas Hernández, Sandra (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
ScFv-h3D6 has been shown as an efficient therapy in the 3xTg-AD mouse model of Alzheimer's Disease. Because one of the major bottlenecks for the therapeutic uses of proteins produced in Escherichia coli is their potential contamination with endotoxins, LPS were extensively removed by a rather low-efficient, expensive, and time-consuming purification step. [...]
2017 - 10.1371/journal.pone.0181480
PloS one, Vol. 12 (August 2017) , art. e0181480  
Detailed record - Creative Commons
6.
23 p, 12.1 MB Both Amyloid-β Peptide and Tau Protein Are Affected by an Anti-Amyloid-β Antibody Fragment in Elderly 3xTg-AD Mice / Ramos Roda, Alejandro. (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Montoliu Gaya, Laia (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Serra-Mir, Gabriel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Villegas Hernández, Sandra (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Alzheimer's disease (AD) is the most common dementia worldwide. According to the amyloid hypothesis,the early accumulation of the Aβ-peptide triggers tau phosphorylation,synaptic dysfunction, and eventually neuronal death leading to cognitive impairment, as well as behavioral and psychological symptoms of dementia. [...]
2020 - 10.3390/ijms21186630
International journal of molecular sciences, Vol. 21, Núm. 18 (September 2020) , art. 6630  
Detailed record - Creative Commons

Research literature 1 records found  
1.
208 p, 7.3 MB Immunotherapy for Alzheimer disease : from antibody engineering to combined therapy with apolipoproteins / Montoliu Gaya, Laia ; Villegas Hernández, Sandra, dir. ; Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular
ScFv-h3D6 és un fragment variable de cadena lleugera, derivat de l'anticòs bapineuzumab, capaç d'evitar la citotoxicitat induïda pel pèptid Aβ, retirant els oligòmers de la via amiloide cap a una via d'agregació worm-like (WL). [...]
[Barcelona] : Universitat Autònoma de Barcelona, 2017.  
Detailed record - Creative Commons

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