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Artículos, Encontrados 2 registros
Artículos Encontrados 2 registros  
1.
812.9 KB ​Comparative genomics of Balto, a famous historic dog, captures lost diversity of 1920s sled dogs / Moon, Katherine L. (University of California. Department of Ecology and Evolutionary Biology) ; Huson, Heather J. (Cornell University College of Agriculture and Life Sciences. Department of Animal Sciences) ; Morrill, Kathleen (University of Massachusetts Medical School. Bioinformatics and Integrative Biology) ; Wang, Ming-Shan (University of California. Howard Hughes Medical Institute) ; Li, Xue (Broad Institute of MIT and Harvard) ; Srikanth, Krishnamoorthy (Cornell University College of Agriculture and Life Sciences. Department of Animal Sciences) ; Lindblad-Toh, Kerstin (Uppsala University. Department of Medical Biochemistry & Microbiology) ; Svenson, Gavin J. (Cleveland Museum of Natural History) ; Karlsson, Elinor K. (University of Massachusetts Medical School. Bioinformatics and Integrative Biology) ; Shapiro, Beth (University of California. Department of Ecology and Evolutionary Biology)
We reconstruct the phenotype of Balto, the heroic sled dog renowned for transporting diphtheria antitoxin to Nome, Alaska in 1925, using evolutionary constraint estimates from the Zoonomia alignment of 240 mammals and 682 genomes from dogs and wolves of the 21st century. [...]
2023 - 10.1126/science.abn5887
Science, Vol. 380 Num. 6643 (April 2023) , art. eabn5887  
2.
28 p, 5.4 MB BarkBase : Epigenomic Annotation of Canine Genomes / Megquier, Kate (Vertebrate Genomics, Broad Institute of MIT and Harvard, Cambridge.) ; Genereux, Diane P. (Broad Institute of MIT and Harvard) ; Hekman, Jessica (Broad Institute of MIT and Harvard) ; Swofford, Ross (Broad Institute of MIT and Harvard) ; Turner-Maier, Jason (Broad Institute of MIT and Harvard) ; Johnson, Jeremy (Broad Institute of MIT and Harvard) ; Alonso, Jacob (Broad Institute of MIT and Harvard) ; Li, Xue (University of Massachusetts Medical School. Bioinformatics and Integrative Biology) ; Morrill, Kathleen (University of Massachusetts Medical School. Bioinformatics and Integrative Biology) ; Anguish, Lynne J. (Cornell University. Baker Institute for Animal Health) ; Koltookian, Michele (Broad Institute of MIT and Harvard) ; Logan, Brittney (University of Massachusetts Medical School. Bioinformatics and Integrative Biology) ; Sharp, Claire R. (Murdoch University. School of Veterinary and Life Sciences) ; Ferrer i Caubet, Lluís (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ; Lindblad-Toh, Kerstin (Uppsala University. Department of Medical Biochemistry & Microbiology) ; Meyers-Wallen, Vicki N. (Cornell University. Baker Institute for Animal Health) ; Hoffman, Andrew (Tufts University. Cummings School of Veterinary Medicine) ; Karlsson, Elinor K. (University of Massachusetts Medical School. Program in Molecular Medicine)
Dogs are an unparalleled natural model for investigating the genetics of health and disease, particularly for complex diseases like cancer. Comprehensive genomic annotation of regulatory elements active in healthy canine tissues is crucial both for identifying candidate causal variants and for designing functional studies needed to translate genetic associations into disease insight. [...]
2019 - 10.3390/genes10060433
Genes, Vol. 10 (june 2019)  

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1 Morrill, K.
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