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8 p, 509.9 KB |
Psoriasis and mental health workshop report : Exploring the links between psychosocial factors, psoriasis, neuroinflammation and cardiovascular disease risk
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Kleyn, C.E. (Manchester Academic Health Science Centre) ;
Talbot, P.S. (University of Manchester) ;
Mehta, N.N. (National Institutes of Health (Bethesda, Estats Units d'Amèrica)) ;
Sampogna, F. (IDI-IRCCS) ;
Bundy, C. (Cardiff University) ;
Ashcroft, D.M. (University of Manchester) ;
Kimball, A.B. (Beth Israel Deaconess Medical Center) ;
van de Kerkhof, P. (International Psoriasis Council) ;
Griffiths, C.E.M. (NIHR Manchester Biomedical Research Centre) ;
Valenzuela, F. (University of Chile and Probity Medical Research) ;
van der Walt, J.M. (International Psoriasis Council) ;
Aberra, T. (National Institutes of Health (Bethesda, Estats Units d'Amèrica)) ;
Puig-Verdié, Lluís (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Psoriasis is a systemic, relapsing, inflammatory disease associated with serious comorbidities including mood problems and/or unhealthy lifestyle behaviours. Cutaneous and systemic abnormalities in innate and acquired immunity play a role in its pathogenesis. [...]
2020 -  10.2340/00015555-3375
Acta dermato-venereologica, Vol. 100 Núm. 1 (january 2020) , p. adv00020
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19 p, 2.3 MB |
Vascular Endothelial Growth Factor as a Potential Biomarker of Neuroinflammation and Frontal Cognitive Impairment in Patients with Alcohol Use Disorder
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Requena-Ocaña, Nerea (Universidad Complutense de Madrid. Departamento de Psicobiología) ;
Flores-Lopez, María (Hospital Regional Universitario de Málaga) ;
Papaseit, Esther (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
García-Marchena, Nuria (Institut Germans Trias i Pujol) ;
Ruiz, Juan Jesús (Centro Provincial de Drogodependencias (CPD) de Málaga) ;
Ortega-Pinazo, Jesús (Hospital Regional Universitario de Málaga) ;
Serrano, Antonia (Hospital Regional Universitario de Málaga) ;
Pavón-Morón, Francisco Javier (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Farre, Magi (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Suarez, Juan (Department of Anatomy, Legal Medicine and History of Science, School of Medicine, University of Malaga) ;
Rodríguez de Fonseca, Fernando (Hospital Regional Universitario de Málaga) ;
Araos, Pedro (Universidad de Málaga. Departamento de Psicobiología y Metodología de las Ciencias del Comportamiento)
(1) Background: Alcohol Use Disorder (AUD) is associated with functional disruption of several brain structures that may trigger cognitive dysfunction. One of the mechanisms of alcohol-associated cognitive impairment has been proposed to arise from its direct impact on the immune system, which culminates in the release of cytokines and chemokines which can eventually reach the brain. [...]
2022 - 10.3390/biomedicines10050947
Biomedicines, Vol. 10 (april 2022)
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33 p, 8.1 MB |
Efficacy of Vafidemstat in Experimental Autoimmune Encephalomyelitis Highlights the KDM1A/RCOR1/HDAC Epigenetic Axis in Multiple Sclerosis
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Cavalcanti, Fernando (Oryzon Genomics S.A) ;
Gonzalez-Rey, Elena (Instituto de Parasitología y Biomedicina "López-Neyra") ;
Delgado, Mario (Instituto de Parasitología y Biomedicina "López-Neyra") ;
Falo, Clara P. (Instituto de Parasitología y Biomedicina "López-Neyra") ;
Mestre, Leyre (Instituto Cajal (Consejo Superior de Investigaciones Científicas)) ;
Guaza, Carmen (Instituto Cajal (Consejo Superior de Investigaciones Científicas)) ;
O'Valle, Francisco (Univeridad de Granada. Departamento de Patologia) ;
Lufino, Michele M. P. (Oryzon Genomics S.A) ;
Xaus, Jordi (Oryzon Genomics S.A) ;
Mascaró, Cristina (Oryzon Genomics S.A) ;
Lunardi, Serena (Oryzon Genomics S.A) ;
Sacilotto, Natalia (Oryzon Genomics S.A) ;
Dessanti, Paola (Oryzon Genomics S.A) ;
Rotllant, David (Oryzon Genomics S.A) ;
Navarro, X. (Xavier) (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Herrando-Grabulosa, Mireia (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Buesa, Carlos (Oryzon Genomics S.A) ;
Maes, Tamara (Oryzon Genomics S.A)
Lysine specific demethylase 1 (LSD1; also known as KDM1A), is an epigenetic modulator that modifies the histone methylation status. KDM1A forms a part of protein complexes that regulate the expression of genes involved in the onset and progression of diseases such as cancer, central nervous system (CNS) disorders, viral infections, and others. [...]
2022 - 10.3390/pharmaceutics14071420
Pharmaceutics, Vol. 14 Núm. 7 (2022) , p. 1420
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12 p, 801.4 KB |
Different Inflammatory Signatures in Alzheimer's Disease and Frontotemporal Dementia Cerebrospinal Fluid
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Boström, Gustaf (Department of Public Health and Caring Sciences. Geriatrics. Uppsala University) ;
Freyhult, Eva (Department of Medical Sciences. Science for Life Laboratory. National Bioinformatics Infrastructure Sweden. Uppsala University) ;
Virhammar, Johan (Department of Neuroscience. Neurology. Uppsala University Hospital) ;
Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ;
Tumani, Hayrettin (Department of Neurology. Ulm University Hospital) ;
Otto, Markus (Department of Neurology. Ulm University Hospital) ;
Brundin, Rose-Marie (Department of Public Health and Caring Sciences. Geriatrics. Uppsala University) ;
Kilander, Lena (Department of Public Health and Caring Sciences. Geriatrics. Uppsala University) ;
Löwenmark, Malin (Department of Public Health and Caring Sciences. Geriatrics. Uppsala University) ;
Giedraitis, Vilmantas (Department of Public Health and Caring Sciences. Geriatrics. Uppsala University) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Von Arnim, Christine A.F. (Department of Geriatric Medicine. University Medical Center Göttingen. Georg-August-University) ;
Kultima, Kim (Department of Medical Sciences. Clinical Chemistry. Uppsala University) ;
Ingelsson, Martin (Department of Public Health and Caring Sciences. Geriatrics. Uppsala University)
Background: Neuroinflammatory processes are common in neurodegenerative diseases such as Alzheimer's disease (AD) and frontotemporal dementia (FTD), but current knowledge is limited as to whether cerebrospinal fluid (CSF) levels of neuroinflammatory proteins are altered in these diseases. [...]
2021 - 10.3233/jad-201565
Journal of Alzheimer's disease, Vol. 81 Núm. 2 (2021) , p. 629-640
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13 p, 8.3 MB |
Microglial response promotes neurodegeneration in the Ndufs4 KO mouse model of Leigh syndrome
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Aguilar Ludwig, Kevin (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Comes, Gemma (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Canal Capdevila, Carla (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Quintana Romero, Albert (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Sanz, Elisenda (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Hidalgo Pareja, Juan (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Leigh syndrome is a mitochondrial disease characterized by neurodegeneration, neuroinflammation, and early death. Mice lacking NDUFS4, a mitochondrial complex I subunit (Ndufs4 KO mice), have been established as a good animal model for studying human pathology associated with Leigh syndrome. [...]
2022 - 10.1002/glia.24234
GLIA, Vol. 70, Issue 11 (November 2022) , p. 2032-2044
2 documents
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13 p, 1.6 MB |
Cognitive and brain cytokine profile of non-demented individuals with cerebral amyloid-beta deposition
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Flores-Aguilar, Lisi (McGill University) ;
Iulita, M. Florencia (Institut d'Investigació Biomèdica Sant Pau) ;
Orciani, Chiara (McGill University) ;
Tanna, Neil (McGill University) ;
Yang, Jingyun (Rush University Medical Center) ;
Bennett, David A. (Rush University Medical Center) ;
Cuello, A. C. (Oxford University) ;
Universitat Autònoma de Barcelona
Brain inflammation has been increasingly associated with early amyloid accumulation in Alzheimer's disease models; however, evidence of its occurrence in humans remains scarce. To elucidate whether amyloid deposition is associated with neuroinflammation and cognitive deficits, we studied brain inflammatory cytokine expression and cognitive decline in non-demented elderly individuals with and without cerebral amyloid-beta deposition. [...]
2021 - 10.1186/s12974-021-02169-0
Journal of neuroinflammation, Vol. 18 (july 2021)
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11 p, 14.5 MB |
Fragment C Domain of Tetanus Toxin Mitigates Methamphetamine Neurotoxicity and Its Motor Consequences in Mice
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Mendieta, Liliana (Instituto Cajal, Consejo Superior de Investigaciones Científicas, CSIC) ;
Granado, Noelia (Instituto Cajal, Consejo Superior de Investigaciones Científicas, CSIC) ;
Aguilera, José (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Tizabi, Yousef (Instituto Cajal, Consejo Superior de Investigaciones Científicas, CSIC) ;
Moratalla, Rosario (Instituto Cajal, Consejo Superior de Investigaciones Científicas, CSIC) ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular
The C-terminal domain of the heavy chain of tetanus toxin (Hc-TeTx) is a nontoxic peptide with demonstrated in vitro and in vivo neuroprotective effects against striatal dopaminergic damage induced by 1-methyl-4-phenylpyridinium and 6-hydoxydopamine, suggesting its possible therapeutic potential in Parkinson's disease. [...]
2016 - 10.1093/ijnp/pyw021
International journal of neuropsychopharmacology, Vol. 19 (march 2016)
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25 p, 17.1 MB |
Differential Roles of TREM2+ Microglia in Anterograde and Retrograde Axonal Injury Models
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Manich, Gemma (Universitat Autònoma de Barcelona. Departament de Ciències Morfològiques) ;
Gómez-López, Ariadna Regina (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Almolda Ardid, Beatriz (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Villacampa, Nàdia (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Recasens, Mireia (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Shrivastava, Kalpana (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
González, Berta (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Castellano López, Bernardo (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Microglia are the main immune cells of the central nervous system (CNS), and they are devoted to the active surveillance of the CNS during homeostasis and disease. In the last years, the microglial receptor Triggering Receptor Expressed on Myeloid cells-2 (TREM2) has been defined to mediate several microglial functions, including phagocytosis, survival, proliferation, and migration, and to be a key regulator of a new common microglial signature induced under neurodegenerative conditions and aging, also known as disease-associated microglia (DAM). [...]
2020 - 10.3389/fncel.2020.567404
Frontiers in cellular neuroscience, Vol. 14 (november 2020)
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18 p, 4.4 MB |
Interleukin-6 Derived from the Central Nervous System May Influence the Pathogenesis of Experimental Autoimmune Encephalomyelitis in a Cell-Dependent Manner
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Sanchis, Paula (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Fernandez-Gayol, Olaya (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Comes, Gemma (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Escrig, Anna (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Giralt, Mercedes (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Palmiter, Richard D. (Department of Biochemistry, Genome Sciences, and Howard Hughes Medical Institute, University of Washington) ;
Hidalgo Pareja, Juan (Universitat Autònoma de Barcelona. Institut de Neurociències)
BACKGROUND: Interleukin-6 (IL-6) is a pleiotropic and multifunctional cytokine that plays a critical role in induction of experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis (MS). [...]
2020 - 10.3390/cells9020330
Cells, Vol. 9 Núm. 2 (2 2020)
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