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17 p, 921.2 KB |
Real-World Validation of Molecular International Prognostic Scoring System for Myelodysplastic Syndromes
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Sauta, Elisabetta (Humanitas Clinical and Research Center (Itàlia)) ;
Robin, Marie (Department of Hematology and Bone Marrow Transplantation. Hôpital Saint-Louis (França)) ;
Bersanelli, Mateo (Department of Biomedical Sciences. Humanitas University) ;
Travaglino, Erica (IRCCS Humanitas Clinical and Research Center (Milà, Itàlia)) ;
Meggendorfer, Manje (Mll Munich Leukemia Laboratory) ;
Zhao, Lin-Pierre (Department of Hematology and Bone Marrow Transplantation. Hôpital Saint-Louis (França)) ;
Caballero Berrocal, Juan Carlos (Hematology Department. Hospital Universitario de Salamanca) ;
Sala, Claudia (Experimental. Diagnostic and Specialty Medicine. Dimes) ;
Maggioni, Giulia (IRCCS Humanitas Clinical and Research Center (Milà, Itàlia)) ;
Bernardi, Massimo (University Vita-Salute San Raffaele (Itàlia)) ;
Di Grazia, Carmen (Irccs Ospedale Policlinico San Martino) ;
Vago, Luca (University Vita-Salute San Raffaele (Itàlia)) ;
Rivoli, Giulia (Irccs Ospedale Policlinico San Martino) ;
Borin, Lorenza (Ospedale San Gerardo) ;
D'Amico, Saverio (IRCCS Humanitas Clinical and Research Center (Milà, Itàlia)) ;
Tentori, Cristina Astrid (IRCCS Humanitas Clinical and Research Center (Milà, Itàlia)) ;
Ubezio, Marta (IRCCS Humanitas Clinical and Research Center (Milà, Itàlia)) ;
Campagna, Alessia (IRCCS Humanitas Clinical and Research Center (Milà, Itàlia)) ;
Russo, Antonio (IRCCS Humanitas Clinical and Research Center (Milà, Itàlia)) ;
Mannina, Daniele (IRCCS Humanitas Clinical and Research Center (Milà, Itàlia)) ;
Lanino, Luca (IRCCS Humanitas Clinical and Research Center (Milà, Itàlia)) ;
Chiusolo, Patrizia (Università Cattolica Del Sacro Cuore) ;
Giaccone, Luisa (Department of Molecular Biotechnology and Health Sciences. University of Turin) ;
Voso, Maria Teresa (Tor Vergata University) ;
Riva, Maria (Asst Grande Ospedale Metropolitano Niguarda) ;
Oliva, Esther Natalie (Grande Ospedale Metropolitano Bianchi Melacrino Morelli) ;
Zampini, Matteo (IRCCS Humanitas Clinical and Research Center (Milà, Itàlia)) ;
Riva, Elena (IRCCS Humanitas Clinical and Research Center (Milà, Itàlia)) ;
Nibourel, Olivier (Chu Lille) ;
Bicchieri, Marinela (IRCCS Humanitas Clinical and Research Center (Milà, Itàlia)) ;
Bolli, Niccolo (Department of Oncology and Hemato-Oncology. University of Milan) ;
Rambaldi, Alessandro (Azienda Ospedaliera Papa Giovanni Xxiii) ;
Passamonti, Francesco (Department of Medicine and Surgery. University of Insubria) ;
Savevski, Victor (IRCCS Humanitas Clinical and Research Center (Milà, Itàlia)) ;
Santoro, Armando (Department of Biomedical Sciences. Humanitas University) ;
Germing, Ulrich (Department of Hematology. Heinrich-Heine-University. University Clinic) ;
Kordasti, Shahram (Hematology Department. DISCLIMO-Università Politecnica Delle Marche) ;
Santini, Valeria (University of Florence) ;
Diez-Campelo, María (Hospital Universitario de Salamanca) ;
Sanz, Guillermo (Hospital Universitari i Politècnic La Fe (València)) ;
Sole, F (Institut de Recerca Contra la Leucèmia Josep Carreras) ;
Kern, Wolfgang (Mll Munich Leukemia Laboratory) ;
Platzbecker, Uwe (University Hospital Leipzig) ;
Arenillas, Leonor (Department of Hematology and Bone Marrow Transplantation. Hôpital Saint-Louis) ;
Fenaux, Pierre (Department of Hematology and Bone Marrow Transplantation. Hôpital Saint-Louis) ;
Haferlach, Torsten (Mll Munich Leukemia Laboratory) ;
Castellani, Gastone (Experimental. Diagnostic and Specialty Medicine. Dimes) ;
Della Porta, Matteo Giovanni (Department of Biomedical Sciences. Humanitas University)
PURPOSEMyelodysplastic syndromes (MDS) are heterogeneous myeloid neoplasms in which a risk-adapted treatment strategy is needed. Recently, a new clinical-molecular prognostic model, the Molecular International Prognostic Scoring System (IPSS-M) was proposed to improve the prediction of clinical outcome of the currently available tool (Revised International Prognostic Scoring System [IPSS-R]). [...]
2023 -  10.1200/JCO.22.01784
Journal of Clinical Oncology, Vol. 41 Núm. 15 (20 2023) , p. 2827-2842
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26 p, 1.8 MB |
Molecular and Clinicopathologic Characterization of Intravenous Leiomyomatosis
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Ordulu, Zehra (Massachusetts General Hospital (Boston)) ;
Chai, Hongyan (Department of Genetics, Yale University School of Medicine; New Haven, CT) ;
Peng, Gang (Department of Biostatistics, Yale School of Public Health, New Haven, CT) ;
McDonald, Anna G. (Department of Pathology, Wake Forest Baptist Medical Center, Winston Salem, NC) ;
De Nictolis, Michele (Department of Pathology, San Salvatore Hospital, Pesaro, Italy) ;
Garcia-Fernandez, Eugenia (Hospital Universitario La Paz (Madrid)) ;
Hardisson, David (Hospital Universitario La Paz (Madrid)) ;
Prat, Jaime (Institut d'Investigació Biomèdica Sant Pau) ;
Li, Peining (Department of Genetics, Yale University School of Medicine; New Haven, CT) ;
Hui, Pei (Department of Pathology, Yale University School of Medicine; New Haven, CT) ;
Oliva, Esther (Massachusetts General Hospital (Boston)) ;
Buza, Natalia (Department of Pathology, Yale University School of Medicine; New Haven, CT)
Intravenous leiomyomatosis (IVL) is an unusual uterine smooth muscle proliferation that can be associated with aggressive clinical behavior despite a histologically benign appearance. It has some overlapping molecular characteristics with both uterine leiomyoma and leiomyosarcoma based on limited genetic data. [...]
2020 - 10.1038/s41379-020-0546-8
Modern Pathology, Vol. 33 (april 2020) , p. 1844-1860
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22 p, 1.6 MB |
Primitive Neuroectodermal Tumors of the Female Genital Tract: A Morphologic, Immunohistochemical and Molecular Study of 19 Cases
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Chiang, Sarah (Memorial Sloan Kettering Cancer Center) ;
Snuderl, Matija (Department of Pathology, New York University Langone Medical Center) ;
Kojiro-Sanada, Sakiko (Department of Pathology, Kurume University School of Medicine) ;
Quer, Ariadna (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Daya, Dean (Department of Pathology, McMaster University, Juravinski Hospital) ;
Hayashi, Tohru (Department of Pathology, Junwakai Memorial Hospital) ;
Bosincu, Luisanna (Department of Pathology, University of Sassar) ;
Ogawa, Fumihiro (Department of Diagnostic Pathology, Sainokuni Higashiomiya Medical Center) ;
Rosenberg, Andrew E. (Department of Pathology, Miller School of Medicine, University of Miami) ;
Horn, Lars-Christian (Division of Gynecologic, Breast and Perinatal Pathology, University Hospital Leipzig) ;
Wang, Lu (Memorial Sloan Kettering Cancer Center) ;
Iafrate, John (Harvard Medical School) ;
Oliva, Esther (Harvard Medical School) ;
Universitat Autònoma de Barcelona
Primary primitive neuroectodermal tumor (PNET) of the female genital tract is rare, and its proper classification remains unclear. The clinical, histologic, and immunophenotypic features as well as EWSR1 rearrangement status of 19 gynecologic PNETs, including 10 ovarian, 8 uterine, and 1 vulvar tumors, are herein reported. [...]
2017 - 10.1097/PAS.0000000000000831
American Journal Of Surgical Pathology, Vol. 41 Núm. 6 (772 2017) , p. 761
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12 p, 3.2 MB |
Dual loss of the SWI/SNF complex ATPases SMARCA4/BRG1 and SMARCA2/BRM is highly sensitive and specific for small cell carcinoma of the ovary, hypercalcaemic type
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Karnezis, Anthony N. (University of British Columbia. Department of Pathology and Laboratory Medicine) ;
Wang, Yemin (University of British Columbia. Department of Pathology and Laboratory Medicine) ;
Ramos, Pilar (Translational Genomics Research Institute) ;
Hendricks, William P. D. (Translational Genomics Research Institute) ;
Oliva, Esther (Massachusetts General Hospital (Boston)) ;
D'Angelo, Emanuela (Institut d'Investigació Biomèdica Sant Pau) ;
Prat, Jaime (Institut d'Investigació Biomèdica Sant Pau) ;
Nucci, Marisa R. (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ;
Nielsen, Torsten O. (University of British Columbia. Department of Pathology and Laboratory Medicine) ;
Chow, Christine (University of British Columbia. Genetic Pathology Evaluation Centre) ;
Leung, Samuel (University of British Columbia. Genetic Pathology Evaluation Centre) ;
Kommoss, Friedrich (Synlab MVZ Pathologie) ;
Kommoss, Stefan (University Hospital of Tübingen (Alemanya)) ;
Silva, Annacarolina (Harvard Medical School. The James Homer Wright Pathology Laboratories) ;
Ronnett, Brigitte M. (The Johns Hopkins Hospital. Department of Pathology) ;
Rabban, Joseph T. (University of California San Francisco. Department of Anatomic Pathology) ;
Bowtell, David D. (Peter MacCallum Cancer Centre) ;
Weissman, Bernard E. (University of North Carolina. Department of Pathology and Laboratory Medicine) ;
Trent, Jeffrey M. (Translational Genomics Research Institute) ;
Gilks, C. Blake (University of British Columbia. Department of Pathology and Laboratory Medicine) ;
Huntsman, David G. (University of British Columbia. Department of Pathology and Laboratory Medicine) ;
Universitat Autònoma de Barcelona
Small cell carcinoma of the ovary, hypercalcaemic type () is a lethal and sometimes familial ovarian tumour of young women and children. We and others recently discovered that over 90% of harbour inactivating mutations in the chromatin remodelling gene with concomitant loss of its encoded protein (), one of two mutually exclusive of the / chromatin remodelling complex. [...]
2015 - 10.1002/path.4633
The Journal of Pathology, Vol. 238, Issue 3 (december 2015) , p. 389-400
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