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16 p, 2.8 MB |
SIRT1 regulates DNA damage signaling through the PP4 phosphatase complex
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Rasti, George (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Becker, Maximilian (Institut d'Investigació Biomèdica de Bellvitge) ;
Vazquez, Berta N. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Espinosa-Alcantud, Maria (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Fernández-Duran, Irene (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Gámez-García, Andrés (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ianni, Alessandro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Gonzalez, Jessica (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bosch-Presegu, Laia (Institut d'Investigació Biomèdica de Bellvitge) ;
Marazuela-Duque, Anna (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Guitart-Solanes, Anna (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Segura-Bayona, Sandra (Institute for Research in Biomedicine (IRB Barcelona)) ;
Bech-Serra, Joan Josep (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Scher, Michael (University of Medicine and Dentistry of New Jersey, USA) ;
Serrano, Lourdes (The City University of New York, USA) ;
Shankavaram, Uma (National Cancer Institute, Bethesda, USA) ;
Erdjument-Bromage, Hediye (University School of Medicine, New York) ;
Tempst, Paul (Memorial Sloan-Kettering Cancer Center, New York) ;
Reinberg, Danny (New York University School of Medicine) ;
Olivella, Mireia (Universitat de Vic. Universitat Central de Catalunya) ;
Stracker, Travis H. (Institute for Research in Biomedicine (IRB Barcelona)) ;
De La Torre, Carolina (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Vaquero, Alejandro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
The Sirtuin family of NAD+-dependent enzymes plays an important role in maintaining genome stability upon stress. Several mammalian Sirtuins have been linked directly or indirectly to the regulation of DNA damage during replication through Homologous recombination (HR). [...]
2023 -  10.1093/nar/gkad504
Nucleic acids research, Vol. 51 Núm. 13 (july 2023) , p. 6754-6769
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20 p, 11.4 MB |
Disruption of the HLA-E/NKG2X axis is associated with uncontrolled HIV infections
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Romero-Martín, Luis (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Duran-Castells, Clara (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Olivella, Mireia (Universitat de Vic - Universitat Central de Catalunya) ;
Rosás-Umbert, Miriam (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ruiz Riol, Marta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Sanchez, Jorge (Impacta) ;
Hartigan-O'Connor, Dennis (University of California) ;
Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Olvera, Alex (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Universitat Autònoma de Barcelona
The contribution of the HLA-E/NKG2X axis in NK-mediated control of HIV infection remains unclear. We have studied the relationship between HLA-E expression and phenotypical as well as functional characteristics of NK cells, in the context of chronic HIV infection and in an in vitro model of acute infection. [...]
2022 - 10.3389/fimmu.2022.1027855
Frontiers in immunology, Vol. 13 (november 2022)
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6 p, 1.4 MB |
TMalphaDB and TMbetaDB : web servers to study the structural role of sequence motifs in α-helix and β-barrel domains of membrane proteins
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Perea, Marc (Universitat Autònoma de Barcelona. Laboratori de Medicina Computacional) ;
Lugtenburg, Ivar (Universitat Autònoma de Barcelona. Laboratori de Medicina Computacional) ;
Mayol, Eduardo (Universitat Autònoma de Barcelona. Laboratori de Medicina Computacional) ;
Cordomí Montoya, Arnau (Universitat Autònoma de Barcelona. Laboratori de Medicina Computacional) ;
Deupi, Xavier (Condensed Matter Theory Group and Laboratory of Biomolecular Research, Paul Scherrer Institut, Villigen PSI, Switzeland) ;
Pardo Carrasco, Leonardo (Universitat Autònoma de Barcelona. Laboratori de Medicina Computacional) ;
Olivella, Mireia (Universitat de Vic. Departament de Biologia de Sistemes)
Membrane proteins represent over 25 % of human protein genes and account for more than 60 % of drug targets due to their accessibility from the extracellular environment. The increasing number of available crystal structures of these proteins in the Protein Data Bank permits an initial estimation of their structural properties. [...]
2015 - 10.1186/s12859-015-0699-5
BMC bioinformatics, Vol. 16, Num. 1 (august 2015)
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14 p, 6.5 MB |
GPCR-SAS : A web application for statistical analyses on G protein-coupled receptors sequences
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Gómez-Tamayo, José Carlos (Universitat Autònoma de Barcelona) ;
Olivella, Mireia (Universitat de Vic) ;
Ríos, Santiago (Universitat Autònoma de Barcelona) ;
Hoogstraat, Marlous (The Netherlands Cancer Institute (Amsterdam)) ;
Gonzalez, Angel (Universitat Autònoma de Barcelona) ;
Mayol, Eduardo (Universitat Autònoma de Barcelona) ;
Deupi, Xavier (Laboratory of Biomolecular Research and Condensed Matter Theory Group (Suïssa)) ;
Campillo Grau, María Mercedes (Universitat Autònoma de Barcelona) ;
Cordomí Montoya, Arnau (Universitat Autònoma de Barcelona)
G protein-coupled receptors (GPCRs) are one of the largest protein families in mammals. They mediate signal transduction across cell membranes and are important targets for the pharmaceutical industry. [...]
2018 - 10.1371/journal.pone.0199843
PloS one, Vol. 13 (july 2018)
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6 p, 167.4 KB |
TMSNP : a web server to predict pathogenesis of missense mutations in the transmembrane region of membrane proteins
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García Recio, Ädrian (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública) ;
Gómez-Tamayo, José Carlos (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Reina, Iker (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública) ;
Campillo Grau, María Mercedes (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública) ;
Cordomí Montoya, Arnau (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública) ;
Olivella, Mireia (Universitat de Vic. Facultat de Ciències i Tecnologia)
The massive amount of data generated from genome sequencing brings tons of newly identified mutations, whose pathogenic/non-pathogenic effects need to be evaluated. This has given rise to several mutation predictor tools that, in general, do not consider the specificities of the various protein groups. [...]
2021 - 10.1093/nargab/lqab008
NAR Genomics and Bioinformatics, Vol. 3 (february 2021)
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17 p, 1.6 MB |
SirT7 auto-ADP-ribosylation regulates glucose starvation response through mH2A1
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Simonet, Nicolas G.. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Thackray, J. K. (Department of Genetics. Human Genetics Institute of New Jersey. Rutgers University) ;
Vazquez Prat, Berta Nieves (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ianni, A. (Max Planck Institute for Heart and Lung Research. Department of Cardiac Development and Remodelling) ;
Espinosa-Alcantud, María Dolores (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Morales-Sanfrutos, J. (Universitat Pompeu Fabra) ;
Hurtado-Bagès, Sarah. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Sabidó, Eduard (Universitat Pompeu Fabra) ;
Buschbeck, Marcus (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Tischfield, J. (Department of Genetics. Human Genetics Institute of New Jersey. Rutgers University) ;
De La Torre Gómez, Gisela Carolina (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Esteller, M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Braun, T. (Max Planck Institute for Heart and Lung Research. Department of Cardiac Development and Remodelling) ;
Olivella, Mireia (Universitat de Vic. Facultat de Ciències i Tecnologia) ;
Serrano, L. (Department of Science. BMCC. City University of New York (CUNY)) ;
Vaquero, Alejandro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Universitat Autònoma de Barcelona
Sirtuins are key players of metabolic stress response. Originally described as deacetylases, some sirtuins also exhibit poorly understood mono-adenosine 5'-diphosphate (ADP)-ribosyltransferase (mADPRT) activity. [...]
2020 - 10.1126/sciadv.aaz2590
Science advances, Vol. 6 Núm. 30 (july 2020) , p. aaz2590
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6 p, 1.6 MB |
HomolWat : a web server tool to incorporate 'homologous' water molecules into GPCR structures
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Mayol, Eduardo (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública) ;
García Recio, Ädrian (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública) ;
Tiemann, Johanna K. S. (Medical University Leipzig. Institute of Medical Physics and Biophysics) ;
Hildebrand, Peter W. (Medical University Leipzig. Institute of Medical Physics and Biophysics) ;
Guixà González, Ramon (Paul Scherrer Institute. Laboratory of Biomolecular Research) ;
Olivella, Mireia (Universitat de Vic - Universitat Central de Catalunya. Departament de Biociències) ;
Cordomí Montoya, Arnau (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública)
Internal water molecules play an essential role in the structure and function of membrane proteins including G protein-coupled receptors (GPCRs). However, technical limitations severely influence the number and certainty of observed water molecules in 3D structures. [...]
2020 - 10.1093/nar/gkaa440
Nucleic acids research, Vol. 48 (june 2020) , p. W54-W59
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