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16 p, 3.6 MB |
The population genomic legacy of the second plague pandemic
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Gopalakrishnan, Shyam (University of Copenhagen. The GLOBE Institute) ;
Ebenesersdóttir, S. Sunna (University of Iceland. Department of Anthropology) ;
Lundstrøm, Inge K.C. (University of Copenhagen. The GLOBE Institute) ;
Turner-Walker, Gordon (National Yunlin University of Science & Technology (Taiwan)) ;
Moore, Kristjan H.S. (deCODE Genetics (Reykjavík, Islàndia)) ;
Luisi, Pierre (Universidad Nacional de Córdoba (Argentina)) ;
Margaryan, Ashot (University of Copenhagen. The GLOBE Institute) ;
Martin, Michael D. (Norwegian University of Science and Technology. NTNU University Museum) ;
Ellegaard, Martin Rene (Norwegian University of Science and Technology. NTNU University Museum) ;
Magnússon, Ólafur þ. (deCODE Genetics (Reykjavík, Islàndia)) ;
Sigurðsson, Ásgeir (deCODE Genetics (Reykjavík, Islàndia)) ;
Snorradóttir, Steinunn (deCODE Genetics (Reykjavík, Islàndia)) ;
Magnúsdóttir, Droplaug N. (deCODE Genetics (Reykjavík, Islàndia)) ;
Laffoon, Jason E. (Leiden University. Department of Archaeological Sciences) ;
van Dorp, Lucy (University College London. Department of Genetics, Evolution and Environment) ;
Liu, Xiaodong (University of Copenhagen. Department of Biology) ;
Moltke, Ida (University of Copenhagen. Department of Biology) ;
Ávila-Arcos, Maria C (Universidad Nacional Autónoma de México. Laboratorio Internacional de Investigación sobre el Genoma Humano) ;
Schraiber, Joshua G. (Illumina Inc. Illumina Artificial Intelligence Laboratory (USA)) ;
Rasmussen, Simon (University of Copenhagen. Novo Nordisk Foundation Center for Protein Research) ;
Juan, David (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ;
Gelabert, Pere (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ;
de-Dios, Toni (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ;
Fotakis, Anna K. (University of Copenhagen. The GLOBE Institute) ;
Iraeta-Orbegozo, Miren (University of Copenhagen. The GLOBE Institute) ;
Vågene, Åshild J. (Max Planck Institute for the Science of Human History) ;
Denham, Sean Dexter (University of Stavanger. Museum of Archaeology) ;
Christophersen, Axel (Norwegian University of Science and Technology. NTNU University Museum) ;
Stenøien, Hans K. (Norwegian University of Science and Technology. NTNU University Museum) ;
Garrett Vieira, Filipe (University of Copenhagen. The GLOBE Institute) ;
Liu, Shanlin (China National GeneBank) ;
Günther, Torsten (Evolutionsbiologisk Centrum EBC (Sweden)) ;
Kivisild, Toomas (University of Tartu. Institute of Genomics) ;
Moseng, Ole Georg (University of South-Eastern Norway. Department of Business, History and Social Sciences) ;
Skar, Birgitte (Norwegian University of Science and Technology. NTNU University Museum) ;
Cheung, Christina (Muséum National d'Histoire Naturelle (París, França)) ;
Sandoval-Velasco, Marcela (University of Copenhagen. The GLOBE Institute) ;
Wales, Nathan (University of York. Department of Archaeology) ;
Schroeder, Hannes (University of Copenhagen. The GLOBE Institute) ;
Campos, Paula F. (Universidade do Porto. Centro Interdisciplinar de Investigação Marinha e Ambiental) ;
Guðmundsdóttir, Valdís B. (University of Iceland. Department of Anthropology) ;
Sicheritz-Ponten, Thomas (AIMST University (Malàisia). Centre of Excellence for Omics-Driven Computational Biodiscovery) ;
Petersen, Bent (AIMST University (Malàisia). Centre of Excellence for Omics-Driven Computational Biodiscovery) ;
Halgunset, Jostein (Biobank1 (Norway)) ;
Gilbert, Edmund (School of Pharmacy and Biomolecular Sciences (Ireland)) ;
Cavalleri, Gianpiero L. (FutureNeuro SFI Research Centre (Ireland)) ;
Hovig, Eivind (University of Oslo. Center for Bioinformatics) ;
Kockum, Ingrid (Karolinska Institutet (Estocolm, Suècia). Department of Clinical Neuroscience) ;
Olsson, Tomas (Karolinska Institutet (Estocolm, Suècia). Department of Clinical Neuroscience) ;
Alfredsson, Lars (Karolinska Institutet (Estocolm, Suècia)) ;
Hansen, Thomas F. (Copenhagen Mental Health Services. Institute of Biological Psychiatry) ;
Werge, Thomas (Copenhagen Mental Health Services. Institute of Biological Psychiatry) ;
Willerslev, Eske (University of Cambridge. Department of Zoology) ;
Balloux, François (University College London. Department of Genetics, Evolution and Environment) ;
Marques-Bonet, Tomas 1975- (Institut Català de Paleontologia Miquel Crusafont) ;
Lalueza-Fox, Carles (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ;
Nielsen, Rasmus (University of California. Department of Integrative Biology) ;
Stefánsson, Kári (deCODE Genetics (Reykjavík, Islàndia)) ;
Helgason, Agnar (deCODE Genetics (Reykjavík, Islàndia)) ;
Gilbert, M. Thomas P. (Norwegian University of Science and Technology. University Museum)
Human populations have been shaped by catastrophes that may have left long-lasting signatures in their genomes. One notable example is the second plague pandemic that entered Europe in ca. 1,347 CE and repeatedly returned for over 300 years, with typical village and town mortality estimated at 10%-40%. [...]
2022 -  10.1016/j.cub.2022.09.023
Current Biology, Vol. 32 (November 2022) , p. 1-9/e1-e6
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16 p, 3.3 MB |
Prediction of combination therapies based on topological modeling of the immune signaling network in multiple sclerosis
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Bernardo-Faura, Martí (Centre de Recerca en Agrigenòmica) ;
Rinas, Melanie (Rwth Aachen University. Joint Research Center for Computational Biomedicine) ;
Wirbel, Jakob (Rwth Aachen University. Joint Research Center for Computational Biomedicine) ;
Pertsovskaya, Inna (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Pliaka, Vicky (School of Mechanical Engineering, National Technical University of Athens) ;
Messinis, Dimitris E. (ProtATonce) ;
Vila, Gemma (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Sakellaropoulos, Theodore (National Technical University of Athens) ;
Faigle, Wolfgang (University of Zurich) ;
Stridh, Pernilla (Karolinska Institutet (Estocolm, Suècia). Department of Clinical Neuroscience) ;
Behrens, Janina R. (Charité University Medicine Berlin. NeuroCure Clinical Research Center and Department of Neurology) ;
Olsson, Tomas (Karolinska Institutet (Estocolm, Suècia). Department of Clinical Neuroscience) ;
Martin, Roland (University Hospital Zurich (Suïssa)) ;
Paul, Friedemann (Charité University Medicine Berlin. NeuroCure Clinical Research Center and Department of Neurology) ;
Alexopoulos, Leonidas G. (ProtATonce) ;
Villoslada, Pablo (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Saez-Rodriguez, Julio (Heidelberg University Hospital (Alemanya))
Multiple sclerosis (MS) is a major health problem, leading to a significant disability and patient suffering. Although chronic activation of the immune system is a hallmark of the disease, its pathogenesis is poorly understood, while current treatments only ameliorate the disease and may produce severe side effects. [...]
2021 - 10.1186/s13073-021-00925-8
Genome Medicine, Vol. 13 (July 2021) , art. 117
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21 p, 2.1 MB |
Natural Polymorphisms in Tap2 Influence Negative Selection and CD4:CD8 Lineage Commitment in the Rat
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Tuncel, Jonatan (Karolinska Institutet (Estocolm, Suècia). Department of Medical Biochemistry and Biophysics) ;
Haag, Sabrina (Karolinska Institutet (Estocolm, Suècia). Department of Medical Biochemistry and Biophysics) ;
Yau, Anthony C. (Karolinska Institutet (Estocolm, Suècia). Department of Medical Biochemistry and Biophysics) ;
Norin, Ulrika (Karolinska Institutet (Estocolm, Suècia). Department of Medical Biochemistry and Biophysics) ;
Baud, Amelie (Wellcome Trust Centre for Human Genetics (Oxford, Regne Unit)) ;
Lönnblom, Erik (Karolinska Institutet (Estocolm, Suècia). Department of Medical Biochemistry and Biophysics) ;
Maratou, Klio (Imperial College London) ;
Ytterberg, A. Jimmy (Karolinska University Hospital and Karolinska Institutet (Suècia)) ;
Ekman, Diana (Karolinska Institutet (Estocolm, Suècia). Department of Medical Biochemistry and Biophysics) ;
Thordardottir, Soley (Karolinska Institutet (Estocolm, Suècia). Department of Medical Biochemistry and Biophysics) ;
Johannesson, Martina (Karolinska Institutet (Estocolm, Suècia). Department of Medical Biochemistry and Biophysics) ;
Gillett, Alan (Karolinska University Hospital and Karolinska Institutet (Suècia)) ;
Stridh, Pernilla (Karolinska University Hospital and Karolinska Institutet (Suècia)) ;
Jagodic, Maja (Karolinska University Hospital and Karolinska Institutet (Suècia)) ;
Olsson, Tomas (Karolinska University Hospital and Karolinska Institutet (Suècia)) ;
Fernández-Teruel, Alberto (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Zubarev, Roman (Karolinska Institutet (Estocolm, Suècia). Department of Medical Biochemistry and Biophysics) ;
Mott, Richard (Wellcome Trust Centre for Human Genetics (Oxford, Regne Unit)) ;
Aitman, Timothy J. (Imperial College London) ;
Flint, Jonathan (Wellcome Trust Centre for Human Genetics (Oxford, Regne Unit)) ;
Holmdahl, Rikard (Karolinska Institutet (Estocolm, Suècia). Department of Medical Biochemistry and Biophysics) ;
EURATRANS Consortium
Genetic variation in the major histocompatibility complex (MHC) affects CD4∶CD8 lineage commitment and MHC expression. However, the contribution of specific genes in this gene-dense region has not yet been resolved. [...]
2014 - 10.1371/journal.pgen.1004151
PLoS Genetics, Vol. 10 Issue 2 (February 2014) , p. e1004151
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