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18 p, 288.5 KB |
Translational research opportunities regarding homologous recombination in ovarian cancer
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Romeo Marín, Margarita (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pardo, J.C. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez Cardús, Anna (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez Balibrea, Eva (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Quiroga, Vanesa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez Román, Sergio (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Solé, Francesc (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Margelí, Mireia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Mesía, Ricard (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Homologous recombination (HR) is a DNA repair pathway that is deficient in 50% of high-grade serous ovarian carcinomas (HGSOC). Deficient HR (DHR) constitutes a therapeutic opportunity for these patients, thanks to poly (ADP-ribose) polymerases (PARP) inhibitors (PARPi; olaparib, niraparib, and rucaparib are already commercialized). [...]
2018 -  10.3390/ijms19103249
International journal of molecular sciences, Vol. 19 Núm. 10 (19 2018) , p. 3249
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13 p, 2.3 MB |
The NER-related gene GTF2H5 predicts survival in high-grade serous ovarian cancer patients
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Gayarre, Javier (Human Genetics Group, Spanish National Cancer Research Center (CNIO)) ;
Kamieniak, Marta M. (Human Genetics Group, Spanish National Cancer Research Center (CNIO)) ;
Cazorla-Jiménez, Alicia (Department of Pathology, Fundación Jiménez Díaz-IDC Salud) ;
Muñoz-Repeto, Ivan (Human Genetics Group, Spanish National Cancer Research Center (CNIO)) ;
Borrego, Salud (Biomedical Network Research Centre on Rare Diseases (CIBERER)) ;
García-Donas, Jesús (Medical Oncology Service, Oncologic Center Clara Campal) ;
Hernando, Susana (Department of Oncology, Fundación Hospital Alcorcón) ;
Robles-Díaz, Luis (Familial Cancer Unit and Medical Oncology Department, Hospital 12 de Octubre) ;
García-Bueno, José M. (Department of Oncology, Hospital General de Albacete) ;
Ramón y Cajal, Teresa (Institut d'Investigació Biomèdica Sant Pau) ;
Hernández-Agudo, Elena (Breast Cancer Clinical Research Unit, Spanish National Cancer Research Center (CNIO)) ;
Heredia Soto, Victoria (Pathology and Translational Oncology Research Laboratories, Hospital La Paz Institute for Health Research (IdiPAZ)) ;
Márquez-Rodas, Ivan (Medical Oncology Service, Instituto de Investigación Sanitaria Gregorio Marañón, Universidad Complutense) ;
Echarri, María José (Medical Oncology Service, Hospital Severo Ochoa) ;
Lacambra-Calvet, Carmen (Department of Internal Medicine, Hospital Severo Ochoa) ;
Sáez, Raquel (Laboratory of Genetics, Hospital Donostia) ;
Cusidó, Maite (Department of Obstetrics and Gynecology, Hospital Universitario Quirón-Dexeus) ;
Redondo, Andrés (Department of Medical Oncology, Hospital La Paz IdiPAZ, Madrid) ;
Paz-Ares, Luis (Medical Oncology Service, Hospital 12 de Octubre) ;
Hardisson, David (Pathology Research Laboratory, Department of Pathology, Hospital La Paz IdiPAZ, and Facultad de Medicina, Universidad Autónoma de Madrid) ;
Mendiola, Marta (Pathology and Translational Oncology Research Laboratories, Hospital La Paz Institute for Health Research (IdiPAZ)) ;
Palacios, José (Department of Pathology, Hospital Universitario Ramón y Cajal) ;
Benítez, Javier (Biomedical Network Research Centre on Rare Diseases (CIBERER)) ;
García, María José (Biomedical Network Research Centre on Rare Diseases (CIBERER)) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
We aimed to evaluate the prognostic and predictive value of the nucleotide excision repair-related gene GTF2H5, which is localized at the 6q24. 2-26 deletion previously reported by our group to predict longer survival of high-grade serous ovarian cancer patients. [...]
2015 - 10.3802/jgo.2016.27.e7
Journal of Gynecologic Oncology, Vol. 27 (november 2015)
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7 p, 662.6 KB |
Random-start GnRH antagonist for emergency fertility preservation : a self-controlled trial
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Checa, Miguel Angel (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetricia i Ginecologia i Medicina Preventiva) ;
Brassesco, Mario (Centro de Infertilidad y Reproducción Humana) ;
Sastre, Margalida (Parc de Salut Mar. Departament d'Obstetrícia i Ginecologia) ;
Gómez, Manuel (Centro de Infertilidad y Reproducción Humana) ;
Herrero García, Julio (Centro de Reproducción Asistida Sagrada Familia, Clínica Sagrada Familia) ;
Marque, Laura (Centro de Reproducción Asistida Sagrada Familia, Clínica Sagrada Familia) ;
Brassesco, Arturo (Centro de Infertilidad y Reproducción Humana) ;
Espinós, Juan José (Centro de Reproducción Asistida Sagrada Familia, Clínica Sagrada Familia)
The aim of this study is to evaluate the feasibility and safety of random-start controlled ovarian hyperstimulation (COH) for emergency fertility preservation, regardless of the phase of the menstrual cycle. [...]
2015 - 10.2147/IJWH.S66743
International Journal of Women's Health, Vol. 7 (february 2015) , p. 219-225
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15 p, 3.0 MB |
Epigenetic inactivation of the extracellular matrix metallopeptidase ADAMTS19 gene and the metastatic spread in colorectal cancer
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Alonso, Sergio (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ;
González, Beatriz (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ;
Ruiz-Larroya, Tatiana (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ;
Durán Domínguez, Mercedes (Instituto de Biología y Genética Molecular (Valladolid)) ;
Kato, Takaharu (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ;
Matsunaga, Akihiro (Sanford Burnham Prebys Medical Discovery Institute (Califòrnia)) ;
Suzuki, Koichi (Jichi Medical University (Japó)) ;
Strongin, Alex Y. (Sanford Burnham Prebys Medical Discovery Institute (Califòrnia)) ;
Giménez Bonafé, Pepita (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ;
Perucho, Manuel (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer)
BACKGROUND: ADAMTS19 encodes a member of the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin motifs) protein family with emerging roles in carcinogenesis and metastasis. ADAMTS shares several distinct protein modules including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. [...]
2015 - 10.1186/s13148-015-0158-1
Clinical Epigenetics, Vol. 7, No. 124 (December 2015)
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