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9 p, 1.3 MB Molecular basis of ligand dissociation in beta-adrenergic receptors / Gonzalez, Angel (Universitat Autònoma de Barcelona. Laboratori de Medicina Computacional) ; Pérez-Acle, Tomás (Universidad de Chile. Center for Mathematical Modeling) ; Pardo Carrasco, Leonardo (Universitat Autònoma de Barcelona. Laboratori de Medicina Computacional) ; Deupi, Xavier (Paul Scherrer Institut (Suïssa))
The important and diverse biological functions of β-adrenergic receptors (βARs) have promoted the search for compounds to stimulate or inhibit their activity. In this regard, unraveling the molecular basis of ligand binding/unbinding events is essential to understand the pharmacological properties of these G protein-coupled receptors. [...]
2011 - 10.1371/journal.pone.0023815
PloS one, Vol. 6, Issue 9 (September 2011) , p. e23815  
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