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1.
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21 p, 4.0 MB |
MacroH2As regulate enhancer-promoter contacts affecting enhancer activity and sensitivity to inflammatory cytokines
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Corujo, David (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Malinverni, Roberto (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Carrillo-Reixach, Juan (Institut Germans Trias i Pujol) ;
Meers, Oliver (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Garcia-Jaraquemada, Arce (Institut Germans Trias i Pujol) ;
Le Pannérer, Marguerite Marie (Universitat Pompeu Fabra) ;
Valero, Vanesa (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Pérez, Ainoha (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Del Río-Álvarez, Álvaro (Institut Germans Trias i Pujol) ;
Royo, Laura (Institut Germans Trias i Pujol) ;
Pérez-González, Beatriz (Universitat Pompeu Fabra. Departament de Medicina i Ciències de la Vida) ;
Raurell Vila, Helena (Universitat Pompeu Fabra. Departament de Medicina i Ciències de la Vida) ;
Acemel, Rafael D. (Universidad Pablo de Olavide) ;
Santos-Pereira, José M. (Universidad Pablo de Olavide) ;
Garrido-Pontnou, Marta (Hospital Universitari Vall d'Hebron) ;
Gómez-Skarmeta, José Luís (Centro Andaluz de Biología del Desarrollo (CABD). CSIC-Universidad Pablo de Olavide) ;
Pasquali, Lorenzo (Universitat Pompeu Fabra. Departament de Medicina i Ciències de la Vida) ;
Manyé, Josep (Institut Germans Trias i Pujol) ;
Armengol, Carolina (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ;
Buschbeck, Marcus (Institut Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
MacroH2A histone variants have a function in gene regulation that is poorly understood at the molecular level. We report that macroH2A1. 2 and macroH2A2 modulate the transcriptional ground state of cancer cells and how they respond to inflammatory cytokines. [...]
2022 -  10.1016/j.celrep.2022.110988
Cell reports, Vol. 39 Núm. 12 (6 2022) , p. 110988
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17 p, 5.7 MB |
An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells
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Colli, M. L. (ULB Center for Diabetes Research. Medical Faculty. Université Libre de Bruxelles) ;
Ramos-Rodríguez, M. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Nakayasu, E. S. (Biological Sciences Division. Pacific Northwest National Laboratory) ;
Alvelos, M. I. (ULB Center for Diabetes Research. Medical Faculty. Université Libre de Bruxelles) ;
Lopes, M. (ULB Center for Diabetes Research. Medical Faculty. Université Libre de Bruxelles) ;
Hill, J. L. E. (Institute of Biomedical & Clinical Science. University of Exeter Medical School) ;
Turatsinze, J. V. (ULB Center for Diabetes Research. Medical Faculty. Université Libre de Bruxelles) ;
Coomans de Brachène, A. (ULB Center for Diabetes Research. Medical Faculty. Université Libre de Bruxelles) ;
Russell, M. A. (Institute of Biomedical & Clinical Science. University of Exeter Medical School) ;
Raurell Vila, Helena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Castela, A. (ULB Center for Diabetes Research. Medical Faculty. Université Libre de Bruxelles) ;
Juan-Mateu, J. (ULB Center for Diabetes Research. Medical Faculty. Université Libre de Bruxelles) ;
Webb-Robertson, B. J. M. (Biological Sciences Division. Pacific Northwest National Laboratory) ;
Krogvold, L. (Oslo University Hospital (Oslo, Noruega)) ;
Dahl-Jorgensen, K. (Oslo University Hospital (Oslo, Noruega)) ;
Marselli, L. (Department of Clinical and Experimental Medicine. Islet Cell Laboratory. University of Pisa) ;
Marchetti, P. (Department of Clinical and Experimental Medicine. Islet Cell Laboratory. University of Pisa) ;
Richardson, S. J. (Institute of Biomedical & Clinical Science. University of Exeter Medical School) ;
Morgan, N. G. (Institute of Biomedical & Clinical Science. University of Exeter Medical School) ;
Metz, T. O. (Biological Sciences Division. Pacific Northwest National Laboratory) ;
Pasquali, Lorenzo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Eizirik, D. L. (Indiana Biosciences Research Institute) ;
Universitat Autònoma de Barcelona
Interferon-α (IFNα), a type I interferon, is expressed in the islets of type 1 diabetic individuals, and its expression and signaling are regulated by T1D genetic risk variants and viral infections associated with T1D. [...]
2020 - 10.1038/s41467-020-16327-0
Nature communications, Vol. 11 Núm. 1 (january 2020) , p. 2584
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3.
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5 p, 786.3 KB |
B-cell leukemia transdifferentiation to macrophage involves reconfiguration of DNA methylation for long-range regulation
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Bueno-Costa, Alberto (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Piñeyro, David (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Soler, Marta (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Javierre, B. M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Raurell Vila, Helena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Subirana-Granés, Marc (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pasquali, Lorenzo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Martinez-Climent, J. A. (Centro de Investigación Biomédica en Red de Cáncer) ;
Esteller, M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Universitat Autònoma de Barcelona
2020 - 10.1038/s41375-019-0643-1
Leukemia, Vol. 34 Núm. 4 (april 2020) , p. 1158-1162
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4.
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13 p, 3.4 MB |
Human Pancreatic ß Cell lncRNAs Control Cell-Specific Regulatory Networks
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Akerman, Ildem (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Tu, Zhidong (Department of Genetics and Genomic Science, Icahn School of Medicine at Mount Sinai) ;
Beucher, Anthony (Imperial College London) ;
Rolando, Delphine M. Y. (Imperial College London) ;
Sauty-Colace, Claire (Institut du cerveau et de la moelle. Hôpital Pitié-Salpêtrière) ;
Benazra, Marion (Institut du cerveau et de la moelle. Hôpital Pitié-Salpêtrière) ;
Nakic, Nikolina (Imperial College London) ;
Yang, Jialiang (Department of Genetics and Genomic Science, Icahn School of Medicine at Mount Sinai) ;
Wang, Huan (Department of Genetics and Genomic Science, Icahn School of Medicine at Mount Sinai) ;
Pasquali, Lorenzo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Moran, Ignasi (Imperial College London) ;
Garcia Hurtado, Javier (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Castro, Natalia (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Gonzalez Franco, Roser (Imperial College London) ;
Stewart, Andrew F. (Icahn School of Medicine at Mount Sinai (Nova York, Estats Units d'Amèrica). Diabetes, Obesity, and Metabolism Institute) ;
Bonner, Caroline (European Genomic Institute for Diabetes) ;
Piemonti, Lorenzo (Diabetes Research Institute (HSR-DRI), San Raffaele Scientific Institute) ;
Berney, Thierry (Cell Isolation and Transplantation Center, University of Geneva) ;
Groop, Leif (Department of Clinical Sciences, Lund University Diabetes Centre) ;
Kerr-Conte, Julie (European Genomic Institute for Diabetes) ;
Pattou, Francois (European Genomic Institute for Diabetes) ;
Argmann, Carmen (Department of Genetics and Genomic Science, Icahn School of Medicine at Mount Sinai) ;
Schadt, Eric (Department of Genetics and Genomic Science, Icahn School of Medicine at Mount Sinai) ;
Ravassard, Phillipe (Institut du cerveau et de la moelle. Hôpital Pitié-Salpêtrière) ;
Ferrer, Jorge (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Universitat Autònoma de Barcelona
Recent studies have uncovered thousands of long non-coding RNAs (lncRNAs) in human pancreatic ß cells. ß cell lncRNAs are often cell type specific and exhibit dynamic regulation during differentiation or upon changing glucose concentrations. [...]
2017 - 10.1016/j.cmet.2016.11.016
Cell metabolism, Vol. 25 (february 2017) , p. 400-411
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5.
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8 p, 1.6 MB |
The Pancreatic Islet Regulome Browser
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Mularoni, Loris (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Ramos-Rodríguez, Mireia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pasquali, Lorenzo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
The pancreatic islet is a highly specialized tissue embedded in the exocrine pancreas whose primary function is that of controlling glucose homeostasis. Thus, understanding the transcriptional control of islet-cell may help to puzzle out the pathogenesis of glucose metabolism disorders. [...]
2017
Frontiers in Genetic, Vol. 8 (2017) , p. 1
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