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Artículos, Encontrados 10 registros
Artículos Encontrados 10 registros  
1.
25 p, 2.2 MB In vivo experience with natural scaffolds for myocardial infarction : the times they are a-changin' / Perea-Gil, Isaac (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Prat-Vidal, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Bayés-Genís, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina)
Treating a myocardial infarction (MI), the most frequent cause of death worldwide, remains one of the most exciting medical challenges in the 21st century. Cardiac tissue engineering, a novel emerging treatment, involves the use of therapeutic cells supported by a scaffold for regenerating the infarcted area. [...]
2015 - 10.1186/s13287-015-0237-4
Stem cell research & therapy, Vol. 6 (december 2015)  
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2.
7 p, 1.6 MB Neoinnervation and neovascularization of acellular pericardial-derived scaffolds in myocardial infarcts / Gálvez-Montón, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Fernandez-Figueras, M. Teresa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Martí, Mercè (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ; Soler-Botija, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Roura, Santiago (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Perea-Gil, Isaac (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Prat-Vidal, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Llucià-Valldeperas, Aida (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Raya, Ángel (Institució Catalana de Recerca i Estudis Avançats) ; Bayés-Genís, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Universitat Autònoma de Barcelona. Departament de Medicina
Engineered bioimplants for cardiac repair require functional vascularization and innervation for proper integration with the surrounding myocardium. The aim of this work was to study nerve sprouting and neovascularization in an acellular pericardial-derived scaffold used as a myocardial bioimplant. [...]
2015 - 10.1186/s13287-015-0101-6
Stem cell research & therapy, Vol. 6 (may 2015)  
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3.
13 p, 4.9 MB Head-to-head comparison of two engineered cardiac grafts for myocardial repair : From scaffold characterization to pre-clinical testing / Perea-Gil, Isaac (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Gálvez-Montón, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Prat-Vidal, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Jorba, Ignasi (Universitat de Barcelona) ; Segú-Vergés, Cristina (Anaxomics Biotech) ; Roura, Santiago (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Soler-Botija, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Iborra Egea, Oriol (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Revuelta-López, Elena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Fernández, Marco A. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Farré, Ramon (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Navajas, Daniel (Universitat de Barcelona) ; Bayés-Genís, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina)
Cardiac tissue engineering, which combines cells and supportive scaffolds, is an emerging treatment for restoring cardiac function after myocardial infarction (MI), although, the optimal construct remains a challenge. [...]
2018 - 10.1038/s41598-018-25115-2
Scientific reports, Vol. 8 (april 2018)  
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4.
1 p, 662.5 KB Author Correction : Unravelling the effects of mechanical physiological conditioning on cardiac adipose tissue-derived progenitor cells in vitro and in silico / Llucià-Valldeperas, Aida (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Bragos, Ramon (Universitat Politècnica de Catalunya. Departament d'Enginyeria Electrònica) ; Soler-Botija, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Roura, Santiago (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Gálvez-Montón, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Prat-Vidal, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Perea-Gil, Isaac (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Bayés-Genís, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Universitat Autònoma de Barcelona
2018 - 10.1038/s41598-018-24808-y
Scientific reports, Vol. 8 (april 2018)  
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5.
12 p, 3.6 MB Electromechanical Conditioning of Adult Progenitor Cells Improves Recovery of Cardiac Function After Myocardial Infarction / Llucià-Valldeperas, Aida (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Soler Botija, Carolina (Institut Germans Trias i Pujol) ; Gálvez-Montón, Carolina (Institut Germans Trias i Pujol) ; Rudilla, F. (Institut Germans Trias i Pujol) ; Prat-Vidal, Cristina (Institut Germans Trias i Pujol) ; Perea Gil, Isaac (Institut Germans Trias i Pujol) ; Sanchez, Benjamin (Universitat Politècnica de Catalunya. Departament d'Enginyeria Electrònica) ; Bragos, Ramon (Universitat Politècnica de Catalunya. Departament d'Enginyeria Electrònica) ; Vunjak-Novakovic, Gordana (Columbia University. Biomedical Engineering and Medicine) ; Bayés-Genís, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina)
Cardiac cells are subjected to mechanical and electrical forces, which regulate gene expression and cellular function. Therefore, in vitro electromechanical stimuli could benefit further integration of therapeutic cells into the myocardium. [...]
2017 - 10.5966/sctm.2016-0079
Stem cells translational medicine, Vol. 6 (2017) , p. 970-981  
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6.
9 p, 3.9 MB Noninvasive Assessment of an Engineered Bioactive Graft in Myocardial Infarction: Impact on Cardiac Function and Scar Healing / Gálvez-Montón, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Bragos, Ramon (Universitat Politècnica de Catalunya. Departament d'Enginyeria Electrònica) ; Soler Botija, Carolina (Institut Germans Trias i Pujol) ; Díaz-Güemes, Idoia (Centro de Cirugía de Mínima Invasión Jesús Usón) ; Prat-Vidal, Cristina (Institut Germans Trias i Pujol) ; Crisóstomo, Verónica (Centro de Cirugía de Mínima Invasión Jesús Usón) ; Sánchez Margallo, Francisco M. (Centro de Cirugía de Mínima Invasión Jesús Usón) ; Llucià-Valldeperas, Aida (Institut Germans Trias i Pujol) ; Bogónez-Franco, Paco (Universitat Politècnica de Catalunya. Departament d'Enginyeria Electrònica) ; Perea Gil, Isaac (Institut Germans Trias i Pujol) ; Rudilla, F. (Institut Germans Trias i Pujol) ; Bayés-Genís, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina)
Cardiac tissue engineering, which combines cells and biomaterials, is promising for limiting the sequelae of myocardial infarction (MI). We assessed myocardial function and scar evolution after implanting an engineered bioactive impedance graft (EBIG) in a swine MI model. [...]
2017 - 10.5966/sctm.2016-0063
Stem cells translational medicine, Vol. 6 (2017) , p. 647-655  
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7.
13 p, 3.7 MB A Cell-Enriched Engineered Myocardial Graft Limits Infarct Size and Improves Cardiac Function / Perea-Gil, Isaac (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Prat-Vidal, Cristina (Institut Germans Trias i Pujol) ; Gálvez-Montón, Carolina (Institut Germans Trias i Pujol) ; Rudilla, F. (Centro de Medicina Regenerativa de Barcelona) ; Llucià-Valldeperas, Aida (Institut Germans Trias i Pujol) ; Soler-Botija, Carolina (Institut Germans Trias i Pujol) ; Iborra Egea, Oriol (Institut Germans Trias i Pujol) ; Díaz-Güemes, Idoia (Jesús Usón Minimally Invasive Surgery Centre, JUMISC, Cáceres, Spain) ; Crisóstomo, Verónica (Jesús Usón Minimally Invasive Surgery Centre, JUMISC, Cáceres, Spain) ; Sánchez-Margallo, Francisco M. (Jesús Usón Minimally Invasive Surgery Centre, JUMISC, Cáceres, Spain) ; Bayés-Genís, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina)
Myocardial infarction (MI) remains a dreadful disease around the world, causing irreversible sequelae that shorten life expectancy and reduce quality of life despite current treatment. Here, the authors engineered a cell-enriched myocardial graft, composed of a decellularized myocardial matrix refilled with adipose tissue-derived progenitor cells (EMG-ATDPC). [...]
2016 - 10.1016/j.jacbts.2016.06.005
JACC: Basic to Translational Science, Vol. 1 (august 2016) , p. 360-372  
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8.
12 p, 2.1 MB Unravelling the effects of mechanical physiological conditioning on cardiac adipose tissue-derived progenitor cells in vitro and in silico / Llucià-Valldeperas, Aida (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Bragos, Ramon (Universitat Politècnica de Catalunya. Departament d'Enginyeria Electrònica) ; Soler Botija, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Roura, Santiago (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Gálvez-Montón, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Prat-Vidal, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Perea Gil, Isaac (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Bayés-Genís, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Universitat Autònoma de Barcelona
Mechanical conditioning is incompletely characterized for stimulating therapeutic cells within the physiological range. We sought to unravel the mechanism of action underlying mechanical conditioning of adipose tissue-derived progenitor cells (ATDPCs), both in vitro and in silico. [...]
2018 - 10.1038/s41598-017-18799-5
Scientific reports, Vol. 8 (january 2018)  
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9.
9 p, 1.3 MB Mechanisms of action of sacubitril/valsartan on cardiac remodeling : a systems biology approach / Iborra Egea, Oriol (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Gálvez-Montón, Carolina (Institut Germans Trias i Pujol) ; Rudilla, F. (Institut Germans Trias i Pujol) ; Perea-Gil, Isaac (Institut Germans Trias i Pujol) ; Prat-Vidal, Cristina (Institut Germans Trias i Pujol) ; Soler-Botija, Carolina (Institut Germans Trias i Pujol) ; Bayés-Genís, Antoni (Institut Germans Trias i Pujol) ; Universitat Autònoma de Barcelona
Sacubitril/Valsartan, proved superiority over other conventional heart failure management treatments, but its mechanisms of action remains obscure. In this study, we sought to explore the mechanistic details for Sacubitril/Valsartan in heart failure and post-myocardial infarction remodeling, using an in silico, systems biology approach. [...]
2017 - 10.1038/s41540-017-0013-4
NPJ Systems Biology and Applications, Vol. 3 (april 2017)  
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10.
10 p, 723.5 KB Extracellular vesicles do not contribute to higher circulating levels of soluble 1 in idiopathic dilated cardiomyopathy / Rudilla, F. (Institut Germans Trias i Pujol) ; Gálvez-Montón, Carolina (Institut Germans Trias i Pujol) ; Gonzalo Calvo, David de (Institut d'Investigació Biomèdica Sant Pau) ; Valero, Ana Gámez (Institut Germans Trias i Pujol) ; Gastelurrutia, Paloma (Institut Germans Trias i Pujol) ; Revuelta López, Elena (Institut Germans Trias i Pujol) ; Prat-Vidal, Cristina (Institut Germans Trias i Pujol) ; Soler Botija, Carolina (Institut Germans Trias i Pujol) ; Llucià-Valldeperas, Aida (Institut Germans Trias i Pujol) ; Perea Gil, Isaac (Institut Germans Trias i Pujol) ; Iborra Egea, Oriol (Institut Germans Trias i Pujol) ; Borràs i Serres, Francesc Enric (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Lupón, Josep (Universitat Autònoma de Barcelona. Departament de Medicina) ; Llorente Cortés, Vicenta (Institut d'Investigació Biomèdica Sant Pau) ; Bayés-Genís, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina) ; Universitat Autònoma de Barcelona
Idiopathic dilated cardiomyopathy () is a frequent cause of heart transplantation. Potentially valuable blood markers are being sought, and low-density lipoprotein receptor-related protein 1 (1) has been linked to the underlying molecular basis of the disease. [...]
2017 - 10.1111/jcmm.13211
Journal of Cellular and Molecular Medicine, Vol. 21 (may 2017) , p. 3000-3009  
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