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1.
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15 p, 739.8 KB |
Advances in diagnostic tools for respiratory tract infections : from tuberculosis to COVID-19 - changing paradigms?
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Stojanovic, Zoran (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gonçalves-Carvalho, Filipe (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Marín, Alicia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Abad Capa, Jorge (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Domínguez, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Latorre, Irene (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Lacoma, Alicia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat i Aymerich, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Respiratory tract infections (RTIs) are one of the most common reasons for seeking healthcare, but are amongst the most challenging diseases in terms of clinical decision-making. Proper and timely diagnosis is critical in order to optimise management and prevent further emergence of antimicrobial resistance by misuse or overuse of antibiotics. [...]
2022 -  10.1183/23120541.00113-2022
ERJ Open Research, Vol. 8 (september 2022)
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2.
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9 p, 1.2 MB |
BCG vaccination to reduce the impact of COVID-19 in healthcare workers : Protocol for a randomised controlled trial (BRACE trial)
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Pittet, Laure F (The Royal Children's Hospital Melbourne) ;
Messina, Nicole L (The University of Melbourne) ;
Gardiner, Kaya (Murdoch Children's Research Institute) ;
Orsini, Francesca (Murdoch Children's Research Institute) ;
Abruzzo, Veronica (Murdoch Children's Research Institute) ;
Bannister, Samantha (The Royal Children's Hospital Melbourne) ;
Bonten, Marc (Julius Center for Health Sciences and Primary Care) ;
Campbell, John L (University of Exeter Medical School) ;
Croda, Julio (Yale School of Public Health) ;
Dalcolmo, Margareth (Pontifical Catholic University of Rio de Janeiro) ;
Elia, Sonja (The Royal Children's Hospital Melbourne) ;
Germano, Susie (Murdoch Children's Research Institute) ;
Goodall, Casey (Murdoch Children's Research Institute) ;
Gwee, Amanda (The Royal Children's Hospital Melbourne) ;
Jamieson, Tenaya (Murdoch Children's Research Institute) ;
Jardim, Bruno (Fundação de Medicina Tropical Doutor Heitor Vieira Dourado) ;
Kollmann, Tobias R (Telethon Kids Institute) ;
Guimarães Lacerda, Marcus Vinícius (Fundação Oswaldo Cruz (Brasil)) ;
Lee, Katherine J (Murdoch Children's Research Institute) ;
Legge, Donna (Royal Children's Hospital Melbourne) ;
Lucas, Michaela (The University of Western Australia) ;
Lynn, David J (Flinders University) ;
McDonald, Ellie (Murdoch Children's Research Institute) ;
Manning, Laurens (Fiona Stanley Hospital (Perth, Austràlia)) ;
Munns, Craig F (The University of Sydney) ;
Perrett, Kirsten P (Murdoch Children's Research Institute) ;
Prat i Aymerich, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Richmond, Peter (The University of Western Australia) ;
Shann, Frank (The Royal Children's Hospital Melbourne) ;
Sudbury, Eva (Murdoch Children's Research Institute) ;
Villanueva, Paola (The University of Melbourne) ;
Wood, Nicholas J (National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases) ;
Lieschke, Katherine (Murdoch Children's Research Institute) ;
Subbarao, Kanta (The Peter Doherty Institute for Infection and Immunity) ;
Davidson, Andrew (Murdoch Children's Research Institute) ;
Curtis, Nigel (The Royal Children's Hospital Melbourne) ;
Universitat Autònoma de Barcelona
BCG vaccination modulates immune responses to unrelated pathogens. This off-target effect could reduce the impact of emerging pathogens. As a readily available, inexpensive intervention that has a well-established safety profile, BCG is a good candidate for protecting healthcare workers (HCWs) and other vulnerable groups against COVID-19. [...]
2021 - 10.1136/bmjopen-2021-052101
BMJ open, Vol. 11 (october 2021)
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3.
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12 p, 1.4 MB |
Study of CD27, CD38, HLA-DR and Ki-67 immune profiles for the characterization of active tuberculosis, latent infection and end of treatment
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Díaz-Fernández, Sergio (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Villar-Hernández, Raquel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Stojanovic, Zoran (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Fernández, Marco A (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
De Souza Galvão, Maria Luiza (Hospital Universitari Vall d'Hebron) ;
Tolosa, Guillermo (Universidad de la Frontera) ;
Sánchez-Montalva, Adrián (Hospital Universitari Vall d'Hebron) ;
Abad Capa, Jorge (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Jiménez-Fuentes, María Ángeles (Hospital Universitari Vall d'Hebron) ;
Safont Gonzalez, Guillem (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Romero i Andrada, Iris (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Sabrià, Josefina (Hospital de Sant Joan Despí Moisès Broggi) ;
Prat i Aymerich, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Domínguez, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Latorre, Irene (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Current blood-based diagnostic tools for TB are insufficient to properly characterize the distinct stages of TB, from the latent infection (LTBI) to its active form (aTB); nor can they assess treatment efficacy. [...]
2022 - 10.3389/fmicb.2022.885312
Frontiers in microbiology, Vol. 13 (july 2022)
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4.
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12 p, 2.7 MB |
Factors influencing scar formation following Bacille Calmette-Guérin (BCG) vaccination
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Villanueva, Paola (Department of General Medicine, Royal Children's Hospital Melbourne (Austràlia)) ;
Crawford, Nigel W. (Immunisation Service, Royal Children's Hospital Melbourne) ;
Croda, Mariana Garcia (Universidade Federal do Mato Grosso do Sul (Brasil)) ;
Collopy, Simone (Department of Pediatrics, Universidade Estadual do Rio de Janeiro) ;
Jardim, Bruno Araújo (Fundação de Medicina Tropical Dr. Heitor Vieira Dourado (Brasil)) ;
de Almeida Pinto Jardim, Tyane (Fundação de Medicina Tropical Dr. Heitor Vieira Dourado (Brasil)) ;
Manning, Laurens (Fiona Stanley Hospital (Austràlia)) ;
Lucas, Michaela (QE2 Medical Centre (Austràlia)) ;
Marshall, Helen (The University of Adelaide and Department of Paediatrics (Austràlia)) ;
Prat i Aymerich, Cristina (Institut Germans Trias i Pujol) ;
Sawka, Alice (Royal Adelaide Hospital (Austràlia)) ;
Sharma, Ketaki (The Children's Hospital at Westmead (Austràlia)) ;
Troeman, Darren (University Medical Center Utrecht) ;
Wadia, Ushma (Wesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids Institute (Austràlia)) ;
Warris, Adilia (Great Ormond Street Hospital, London, UK) ;
Wood, Nicholas (University of Sydney) ;
Messina, Nicole L. (Infection and Immunity, Murdoch Children's Research Institute, (Austràlia)) ;
Curtis, Nigel (The Royal Children's Hospital Melbourne) ;
Pittet, Laure F. (University of Geneva) ;
Universitat Autònoma de Barcelona
The prevalence of scar formation following Bacille Calmette-Guérin (BCG) vaccination varies globally. The beneficial off-target effects of BCG are proposed to be stronger amongst children who develop a BCG scar. [...]
2023 - 10.1016/j.heliyon.2023.e15821
Heliyon, Vol. 9 (april 2023)
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5.
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11 p, 1.5 MB |
Gut to lung translocation and antibiotic mediated selection shape the dynamics of Pseudomonas aeruginosa in an ICU patient
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Wheatley, Rachel M. (University of Oxford, Department of Biology) ;
Caballero, Julio Diaz (University of Oxford, Department of Biology) ;
van der Schalk, Thomas E. (University of Antwerp. Laboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, Faculty of Medicine, Wilrijk, Belgium) ;
De Winter, Fien H. R. (University of Antwerp. Molecular Pathology Group, Laboratory of Cell Biology and Histology, Faculty of Medicine, Wilrijk, Belgium) ;
Shaw, Liam P. (University of Oxford, Department of Biology) ;
Kapel, Natalia (University of Oxford, Department of Biology) ;
Recanatini, Claudia (University Medical Center Utrecht, Utrecht University. Julius Center for Health Sciences and Primary Care, Utrecht) ;
Timbermont, Leen (University of Antwerp. Laboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, Faculty of Medicine, Wilrijk, Belgium) ;
Kluytmans, Jan (University Medical Center Utrecht, Utrecht University. Julius Center for Health Sciences and Primary Care, Utrecht) ;
Esser, Mark (Microbial Sciences, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA) ;
Lacoma, Alicia (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Prat i Aymerich, Cristina (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Oliver, Antonio (Institut d'Investigació Sanitària Illes Balears, Hospital Universitari Son Espases) ;
Kumar-Singh, Samir (University of Antwerp. Molecular Pathology Group, Laboratory of Cell Biology and Histology, Faculty of Medicine, Wilrijk, Belgium) ;
Malhotra-Kumar, Surbhi (University of Antwerp. Laboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, Faculty of Medicine, Wilrijk, Belgium) ;
Craig MacLean, R. (University of Oxford, Department of Biology)
Bacteria have the potential to translocate between sites in the human body, but the dynamics and consequences of within-host bacterial migration remain poorly understood. Here we investigate the link between gut and lung Pseudomonas aeruginosa populations in an intensively sampled ICU patient using a combination of genomics, isolate phenotyping, host immunity profiling, and clinical data. [...]
2022 - 10.1038/s41467-022-34101-2
Nature communications, Vol. 13 (november 2022)
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6.
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12 p, 1.6 MB |
Direct Quantitative Immunochemical Analysis of Autoinducer Peptide IV for Diagnosing and Stratifying Staphylococcus aureus Infections
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Montagut, Enrique-J. (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Acosta, Gerardo (Institut de Química Avançada de Catalunya) ;
Albericio, Fernando (University of KwaZulu-Natal) ;
Royo, Miriam (Institut de Química Avançada de Catalunya) ;
Godoy-Tena, Gerard (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Lacoma, Alicia (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Prat i Aymerich, Cristina (University Medical Center Utrecht, Utrecht University) ;
Salvador, Juan-Pablo (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Marco, María Pilar (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina)
An immunochemical strategy to detect and quantify AIP-IV, the quorum sensing (QS) signaling molecule produced by Staphylococcus aureus agr type IV, is reported here for the first time. Theoretical calculations and molecular modeling studies have assisted on the design and synthesis of a suitable peptide hapten (AIPIVS), allowing to obtain high avidity and specific antibodies toward this peptide despite its low molecular weight. [...]
2022 - 10.1021/acsinfecdis.1c00670
ACS infectious diseases, Vol. 8 (02 2022) , p. 645-656
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7.
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15 p, 2.0 MB |
Strain-specific interspecies interactions between co-isolated pairs of Staphylococcus aureus and Pseudomonas aeruginosa from patients with tracheobronchitis or bronchial colonization
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Gomes Fernandes, Meissiner (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gómez Camacho, Andromeda Celeste (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Bravo, Marc (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Huedo Moreno, Pol (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Coves, Xavier (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Prat i Aymerich, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gibert, Isidre (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Lacoma, Alicia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Yero, Daniel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Dual species interactions in co-isolated pairs of Staphylococcus aureus and Pseudomonas aeruginosa from patients with tracheobronchitis or bronchial colonization were examined. The genetic and phenotypic diversity between the isolates was high making the interactions detected strain-specific. [...]
2022 - 10.1038/s41598-022-07018-5
Scientific reports, Vol. 12 (March 2022) , art. 3374
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8.
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9 p, 3.2 MB |
Exploring the evolution and epidemiology of European CC1-MRSA-IV : tracking a multidrug-resistant community-associated meticillin-resistant Staphylococcus aureus clone
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Earls, Megan R. (University of Dublin) ;
Steinig, Eike J. (Australian Institute of Tropical Health and Medicine) ;
Monecke, Stefan (InfectoGnostics Research Campus Jena) ;
Samaniego Castruita, José Alfredo (Copenhagen University Hospital) ;
Simbeck, Alexandra (University Hospital Regensburg) ;
Schneider-Brachert, Wulf (University Hospital Regensburg) ;
Vremerǎ, Teodora (University of Medicine and Pharmacy "Grigore T Popa") ;
Dorneanu, Olivia S. (University of Medicine and Pharmacy "Grigore T Popa") ;
Loncaric, Igor (University of Veterinary Medicine Vienna) ;
Bes, Michèle (Institut des Agents Infectieux) ;
Lacoma, Alicia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat i Aymerich, Cristina (University Medical Center Utrecht) ;
Wernery, Ulrich (Central Veterinary Research Laboratory) ;
Armengol-Porta, Marc (Dresden Municipal Hospital) ;
Blomfeldt, Anita (Akershus University Hospital) ;
Duchene, Sebastian (University of Melbourne) ;
Bartels, Mette D. (Copenhagen University Hospital) ;
Ehricht, Ralf (Friedrich-Schiller University) ;
Coleman, David C. (University of Dublin) ;
Universitat Autònoma de Barcelona
This study investigated the evolution and epidemiology of the community-associated and multidrug-resistant clone European CC1-MRSA-IV. Whole-genome sequences were obtained for 194 European CC1-MRSA-IV isolates (189 of human and 5 of animal origin) from 12 countries, and 10 meticillin-susceptible precursors (from North-Eastern Romania; all of human origin) of the clone. [...]
2021 - 10.1099/mgen.0.000601
Microbial Genomics, Vol. 7 (july 2021)
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9.
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11 p, 1.7 MB |
Urine NMR-based TB metabolic fingerprinting for the diagnosis of TB in children
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Comella-del-Barrio, Patricia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Izquierdo-Garcia, José Luis (Basque Research and Technology Alliance) ;
Gautier, Jacqueline (Hôpital Saint-Damien (Haití)) ;
Doresca, Mariette Jean Coute (Hôpital Saint-Damien (Haití)) ;
Campos-Olivas, Ramón (Centro Nacional de Investigaciones Oncológicas (Madrid)) ;
Santiveri, Clara M. (Centro Nacional de Investigaciones Oncológicas (Madrid)) ;
Muriel-Moreno, Beatriz (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat i Aymerich, Cristina (University Medical Center Utrecht) ;
Abellana, Rosa (Universitat de Barcelona. Facultat de Medicina i Ciències de la Salut) ;
Pérez-Porcuna, Tomás M. (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Cuevas, Luis E.. (Liverpool School of Tropical Medicine. Department of Clinical Sciences) ;
Ruiz-Cabello, Jesús (IKERBASQUE, Basque Foundation for Science) ;
Domínguez, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Tuberculosis (TB) is a major cause of morbidity and mortality in children, and early diagnosis and treatment are crucial to reduce long-term morbidity and mortality. In this study, we explore whether urine nuclear magnetic resonance (NMR)-based metabolomics could be used to identify differences in the metabolic response of children with different diagnostic certainty of TB. [...]
2021 - 10.1038/s41598-021-91545-0
Scientific reports, Vol. 11 (june 2021)
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10.
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13 p, 1.6 MB |
Immunogenicity of 60 novel latency-related antigens of Mycobacterium tuberculosis
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Serra-Vidal, Mᵃdel Mar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Latorre, Irene (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Franken, Kees L. C. M. (Department of Immunohematology and Blood Transfusion/Department of Infectious Diseases, Leiden University Medical Center) ;
Díaz, Jéssica (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
De Souza Galvão, Maria Luiza (Hospital Universitari Vall d'Hebron) ;
Casas, Irma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Maldonado, José (Serveis Clínics (Barcelona)) ;
Milà, Celia (Hospital Universitari Vall d'Hebron) ;
Solsona, Jordi (Hospital Universitari Vall d'Hebron) ;
Jimenez-Fuentes, M. Ángeles (Hospital Universitari Vall d'Hebron) ;
Altet, Neus (Hospital Universitari Vall d'Hebron) ;
Lacoma, Alicia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ruiz-Manzano, Juan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ausina, Vicente (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat i Aymerich, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ottenhoff, Tom H. M. (Department of Immunohematology and Blood Transfusion/Department of Infectious Diseases, Leiden University Medical Center) ;
Domínguez, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
The aim of our work here was to evaluate the immunogenicity of 60 mycobacterial antigens, some of which have not been previously assessed, notably a novel series of in vivo -expressed Mycobacterium tuberculosis (IVE-TB) antigens. [...]
2014 - 10.3389/fmicb.2014.00517
Frontiers in microbiology, Vol. 5 (october 2014)
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