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1.
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14 p, 1.0 MB |
Effect of Combination Antibiotic Empirical Therapy on Mortality in Neutropenic Cancer Patients with Pseudomonas aeruginosa Pneumonia
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Albasanz-Puig, Adaia (Hospital Universitari de Bellvitge) ;
Durà-Miralles, Xavier (Hospital Universitari de Bellvitge) ;
Laporte-Amargós, Júlia (Hospital Universitari de Bellvitge) ;
Mussetti, Alberto (Hospital Universitari de Bellvitge) ;
Ruiz-Camps, Isabel (Hospital Universitari Vall d'Hebron) ;
Puerta-Alcalde, Pedro (Hospital Clínic i Provincial de Barcelona) ;
Abdala, Edson (Instituto do Câncer do Estado de São Paulo) ;
Oltolini, Chiara (IRCCS San Raffaele Scientific Institute (Milà, Itàlia)) ;
Akova, Murat (Hacettepe University School of Medicine) ;
Montejo, José Miguel (Hospital Universitario de Cruces (Barakaldo, País Basc)) ;
Mikulska, Malgorzata (University of Genoa (DISSAL) and Ospedale Policlinico San Martino) ;
Martín-Dávila, Pilar (Hospital Universitario Ramón y Cajal (Madrid)) ;
Herrera, Fabián (Centro de Educación Médica e Investigaciones Clínicas (CEMIC)) ;
Gasch Blasi, Oriol (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Drgona, Lubos (Comenius University and National Cancer Institute) ;
Morales, Hugo Manuel Paz (Hospital Erasto Gaertner) ;
Brunel, Anne-Sophie (Lausanne University Hospital) ;
García, Estefanía (Hospital Universitario Reina Sofía (Córdoba, Espanya)) ;
Isler, Burcu (Istanbul Education and Research Hospital) ;
Kern, Winfried V. (University of Freiburg Medical Center) ;
Retamar-Gentil, Pilar (Universidad de Sevilla) ;
Aguado, José María (Instituto de Investigación Hospital "12 de Octubre" (i + 12)) ;
Montero, Milagros (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Kanj, Souha S. (American University of Beirut Medical Center) ;
Sipahi, Oguz R. (Ege University) ;
Calik, Sebnem (University of Health Science Izmir Bozyaka Training and Research Hospital) ;
Márquez-Gómez, Ignacio (Hospital Regional Universitario de Málaga) ;
Marin, Jorge I. (Clínica Maraya (Pereira, Colòmbia)) ;
Gomes, Marisa Z. R. (Hospital Federal dos Servidores do Estado) ;
Hemmati, Philipp (Klinikum Ernst von Bergmann) ;
Araos, Rafael (Alemana Universidad del Desarrollo) ;
Peghin, Maddalena (University of Udine and Azienda Sanitaria Universitaria Integrata) ;
Del Pozo, Jose Luis (Clínica Universidad de Navarra) ;
Yáñez, Lucrecia (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ;
Tilley, Robert (University Hospitals Plymouth NHS Trust (Regne Unit)) ;
Manzur, Adriana (Hospital Rawson) ;
Novo, Andres (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Pallarès, Natàlia (Hospital Universitari de Bellvitge) ;
Bergas, Alba (Hospital Universitari de Bellvitge) ;
Carratalà, Jordi (Hospital Universitari de Bellvitge) ;
Gudiol, Carlota (Hospital Universitari de Bellvitge) ;
Universitat Autònoma de Barcelona
To assess the effect of combination antibiotic empirical therapy on 30-day case-fatality rate in neutropenic cancer patients with Pseudomonas aeruginosa (PA) bacteremic pneumonia. This was a multinational, retrospective cohort study of neutropenic onco-hematological patients with PA bloodstream infection (BSI) (2006-2018). [...]
2022 -  10.3390/microorganisms10040733
Microorganisms, Vol. 10 (march 2022)
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2.
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16 p, 1.0 MB |
Synthesis and evaluation of aromatic BDSF bioisosteres on biofilm formation and colistin sensitivity in pathogenic bacteria
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Gómez Camacho, Andromeda Celeste (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Horgan, Conor (University College Cork) ;
Yero, Daniel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Bravo, Marc (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Daura i Ribera, Xavier (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
O'Driscoll, Michelle (University College Cork) ;
Gibert, Isidre (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
O'Sullivan, Timothy (University College Cork)
The diffusible signal factor family (DSF) of molecules play an important role in regulating intercellular communication, or quorum sensing, in several disease-causing bacteria. These messenger molecules, which are comprised of cis-unsaturated fatty acids, are involved in the regulation of biofilm formation, antibiotic tolerance, virulence and the control of bacterial resistance. [...]
2023 - 10.1016/j.ejmech.2023.115819
European Journal of Medicinal Chemistry, Vol. 261 (December 2023) , art. 115819
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3.
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32 p, 518.6 KB |
Impact of pseudomonas aeruginosa infection on patients with chronic inflammatory airway diseases
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Garcia-Clemente, M. (Hospital Universitario Central de Asturias) ;
de la Rosa Carrillo, David (Institut d'Investigació Biomèdica Sant Pau) ;
Máiz, L. (Bronquiectasias e Infección Bronquial Crónica. Hospital Ramón y Cajal) ;
Girón, R. (Hospital Univesitario la Princesa) ;
Blanco, M. (Complejo Hospitalario Universitario de A Coruña) ;
Olveira, C. (Instituto de Investigación Biomédica de Málaga) ;
Cantón, Rafael (Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS)) ;
Martinez-García, M.A. (Instituto de Salud Carlos III) ;
Universitat Autònoma de Barcelona
Pseudomonas aeruginosa (P. aeruginosa) is a ubiquitous and opportunistic microorganism and is considered one of the most significant pathogens that produce chronic colonization and infection of the lower respiratory tract, especially in people with chronic inflammatory airway diseases such as asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), and bronchiectasis. [...]
2020 - 10.3390/jcm9123800
Journal of clinical medicine, Vol. 9 Núm. 12 (december 2020) , p. 1-32
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4.
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12 p, 4.4 MB |
A high-throughput microtiter plate screening assay to quantify and differentiate species in dual-species biofilms
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Campo Pérez, Víctor (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Alcàcer-Almansa, Júlia (Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística) ;
Julián Gómez, Esther (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Torrents, Eduard (Institut de Bioenginyeria de Catalunya)
Pathogenic bacteria form biofilms during infection, and polymicrobial biofilms are the most frequent manifestation. Biofilm attachment, maturation, and/or antibiotic sensitivity are mainly evaluated with microtiter plate assays, in which bacteria are stained to enable the quantification of the biomass by optical absorbance or fluorescence emission. [...]
2023 - 10.3390/microorganisms11092244
Microorganisms, Vol. 11, issue 9 (Sep. 2023) , art. 2244
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5.
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12 p, 295.7 KB |
Pseudomonas aeruginosa Bloodstream Infections in Patients with Cancer : Differences between Patients with Hematological Malignancies and Solid Tumors
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Royo-Cebrecos, Cristina (Hospital Nostra Senyora de Meritxell (Principat d'Andorra)) ;
Laporte-Amargós, Júlia (Hospital Universitari de Bellvitge) ;
Peña, Marta (Hospital Universitari de Bellvitge) ;
Ruiz-Camps, Isabel (Hospital Universitari Vall d'Hebron) ;
Puerta-Alcalde, Pedro (Hospital Clínic i Provincial de Barcelona) ;
Abdala, Edson (Univesity of São Paulo) ;
Oltolini, Chiara (IRCCS San Raffaele Scientific Institute (Milà, Itàlia)) ;
Akova, Murat (Hacettepe University School of Medicine) ;
Montejo, Miguel (Hospital Universitario de Cruces (Barakaldo, País Basc)) ;
Mikulska, Malgorzata (University of Genoa (DISSAL) and Ospedale Policlinico San Martino) ;
Martín-Dávila, Pilar (Hospital Universitario Ramón y Cajal (Madrid)) ;
Herrera, Fabian (Centro de Educación Médica e Investigaciones Clínicas) ;
Gasch Blasi, Oriol (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Drgona, Lubos (Comenius University and National Cancer Institute) ;
Morales, Hugo Manuel Paz (Hospital Erasto Gaertner) ;
Brunel, Anne-Sophie (Lausanne University Hospital) ;
García, Estefanía (Hospital Universitario Reina Sofía (Córdoba, Espanya)) ;
Isler, Burcu (Istanbul Education and Research Hospital) ;
Kern, Winfried V. (University of Freiburg Medical Center and Faculty of Medicine) ;
Palacios-Baena, Zaira R. (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
de la Calle, Guillermo Maestro (Instituto de Investigación Hospital "12 de Octubre" (i+12)) ;
Montero, María Milagro (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Kanj, Souha S. (American University of Beirut Medical Center) ;
Sipahi, Oguz R. (Ege University) ;
Calik, Sebnem (University of Health Science Izmir Bozyaka Training and Research Hospital) ;
Márquez-Gómez, Ignacio (Hospital Regional Universitario de Málaga) ;
Marin, Jorge I. (Clínica Maraya) ;
Gomes, Marisa Z. R. (Hospital Federal dos Servidores do Estado) ;
Hemmatti, Philipp (Charité University Medical School) ;
Araos, Rafael (Instituto de Ciencias e Innovación en Medicina) ;
Peghin, Maddalena (University of Udine and Azienda Sanitaria Universitaria Integrata in Udine) ;
Del Pozo, Jose Luis (Clínica Universitaria Navarra) ;
Yáñez, Lucrecia (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ;
Tilley, Robert (University Hospitals Plymouth NHS Trust (Regne Unit)) ;
Manzur, Adriana (Hospital Rawson) ;
Novo, Andrés (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Carratalà, Jordi (Hospital Universitari de Bellvitge) ;
Gudiol, Carlota (Hospital Universitari de Bellvitge) ;
Universitat Autònoma de Barcelona
To assess the clinical features and outcomes of Pseudomonas aeruginosa bloodstream infection (PA BSI) in neutropenic patients with hematological malignancies (HM) and with solid tumors (ST), and identify the risk factors for 30-day mortality. [...]
2022 - 10.3390/pathogens11101132
Pathogens, Vol. 11 (september 2022)
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6.
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9 p, 884.2 KB |
Comparison of Ceftolozane/Tazobactam Infusion Regimens in a Hollow-Fiber Infection Model against Extensively Drug-Resistant Isolates
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Montero, María Milagro (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Domene-Ochoa, Sandra (Institut Hospital del Mar d'Investigacions Mèdiques) ;
López-Causapé, Carla ;
López Montesinos, Inmaculada (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Luque, Sonia (Hospital del Mar (Barcelona, Catalunya)) ;
Sorlí, Luisa (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Campillo, Núria (Hospital del Mar (Barcelona, Catalunya)) ;
Padilla León, Eduardo ;
Prim, Núria ;
Ferrer Alapont, Lorena (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Grau, Santiago (Hospital del Mar (Barcelona, Catalunya)) ;
Oliver, Antonio ;
Horcajada, Juan Pablo (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Universitat Autònoma de Barcelona
The aim of this study was to compare the efficacy of intermittent (1-h), extended (4-h), and continuous ceftolozane-tazobactam (C/T) infusion against three extensively drug-resistant (XDR) sequence type (ST) 175 isolates with different susceptibilities to C/T (MIC = 2 to 16 mg/L) in a 7-day hollow-fiber infection model (HFIM). [...]
2022 - 10.1128/spectrum.00892-22
Microbiology Spectrum, Vol. 10 (june 2022)
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7.
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14 p, 1.9 MB |
Safety, efficacy, and pharmacokinetics of gremubamab (MEDI3902), an anti-Pseudomonas aeruginosa bispecific human monoclonal antibody, in P. aeruginosa-colonised, mechanically ventilated intensive care unit patients : a randomised controlled trial
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Chastre, Jean (Service de Médecine Intensive Réanimation. Institut de Cardiologie. Groupe Hospitalier Pitié-Salpêtrière. Assistance Publique-Hôpitaux de Paris. Sorbonne University) ;
François, Bruno (Réanimation Polyvalente and Inserm CIC 1435 & UMR 1092. CHU) ;
Bourgeois, Marc (AZ Sint-Jan Brugge-Oostende AV) ;
Komnos, Apostolos (General Hospital of Larissa) ;
Ferrer, Ricard (Hospital Universitari Vall d'Hebron) ;
Rahav, Galia (Chaim Sheba Medical Center. Sackler School of Medicine. Tel Aviv University) ;
De Schryver, Nicolas (Clinique Saint-Pierre) ;
Lepape, Alain (Hospices Civils de Lyon Hôpital Lyon Sud) ;
Koksal, Iftihar (Faculty of Medicine. Trabzon and Acibadem University Faculty of Medicine. Karadeniz Technical University) ;
Luyt, Charles-Edouard (Service de Médecine Intensive Réanimation. Institut de Cardiologie. Groupe Hospitalier Pitié-Salpêtrière. Assistance Publique-Hôpitaux de Paris. Sorbonne University) ;
Sánchez-García, Miguel (Hospital Clínico San Carlos. Unidad de Cuidados Intensivos) ;
Torres, Antoni (Hospital Clínic i Provincial de Barcelona. Servei de Pneumologia) ;
Eggimann, Philippe (Department of Locomotor Apparatus. Centre Hospitalier Universitaire Vaudois CHUV) ;
Koulenti, Despoina (2nd Critical Care Department. Attikon University Hospital. National and Kapodistrian. University of Athens) ;
Holland, Thomas L. (Duke Clinical Research Institute) ;
Ali, Omar (Clinical Research and Development. Vaccines and Immune Therapies. BioPharmaceuticals R&D. AstraZeneca Biopharmaceuticals) ;
Shoemaker, Kathryn (Respiratory and Immunology. BioPharmaceuticals R&D. AstraZeneca) ;
Ren, Pin (Respiratory and Immunology. BioPharmaceuticals R&D. AstraZeneca) ;
Sauser, Julien (Infection Control Program. Faculty of Medicine. Geneva University Hospitals) ;
Ruzin, Alexey (Clinical Research and Development. Vaccines and Immune Therapies. BioPharmaceuticals R&D. AstraZeneca Biopharmaceuticals) ;
Tabor, David E. (Clinical Research and Development. Vaccines and Immune Therapies. BioPharmaceuticals R&D. AstraZeneca Biopharmaceuticals) ;
Akhgar, Ahmad (Clinical Pharmacology and Quantitative Pharmacology. Clinical Pharmacology and Safety Sciences. BioPharmaceuticals R&D. AstraZeneca) ;
Wu, Yuling (Clinical Pharmacology and Quantitative Pharmacology. Clinical Pharmacology and Safety Sciences. BioPharmaceuticals R&D. AstraZeneca) ;
Jiang, Yu (Clinical Pharmacology and Quantitative Pharmacology. Clinical Pharmacology and Safety Sciences. BioPharmaceuticals R&D. AstraZeneca) ;
DiGiandomenico, Antonio (Clinical Research and Development. Vaccines and Immune Therapies. BioPharmaceuticals R&D. AstraZeneca Biopharmaceuticals) ;
Colbert, Susan (Oncology. US SM&M. AstraZeneca) ;
Vandamme, Drieke (Inserm CIC 1435. CHU) ;
Coenjaerts, Frank (University Medical Center Utrecht) ;
Malhotra-Kumar, Surbhi (University of Antwerp. Laboratory of Medical Microbiology) ;
Timbermont, Leen (University of Antwerp. Laboratory of Medical Microbiology) ;
Oliver, Antonio (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Barraud, Olivier (INSERM U1092. Centre Hospitalier Universitaire de Limoges. Université Limoges) ;
Bellamy, Terramika (Clinical Research and Development. Vaccines and Immune Therapies. BioPharmaceuticals R&D. AstraZeneca Biopharmaceuticals) ;
Bonten, Marc (Julius Center for Health Science and Primary Care. University Medical Center Utrecht. Utrecht University) ;
Goossens, Herman (Laboratory of Medical Microbiology. Vaccine and Infectious Disease Institute. University of Antwerp) ;
Reisner, Colin (DevPro Biopharma) ;
Esser, Mark T. (Clinical Research and Development. Vaccines and Immune Therapies. BioPharmaceuticals R&D. AstraZeneca Biopharmaceuticals) ;
Jafri, Hasan S. (Late-Stage Development. Respiratory and Immunology. BioPharmaceuticals R&D. AstraZeneca) ;
Joannidis, Michael ;
Klimscha, Walter ;
De Waele, Elisabeth ;
Devriendt, Jacques ;
Huberlant, Vincent ;
Depuydt, Pieter ;
Van Boxstael, Sam ;
Peric, Mladen ;
Kopic, Jasminka ;
Hanauer, Michal ;
Hruby, Tomas ;
Sramek, Vladimir ;
Svoboda, Petr ;
Vymazal, Tomas ;
Novacek, Martin ;
Annane, Djillali ;
Mira, Jean-Paul ;
Souweine, Bertrand ;
Dequin, Pierre-François ;
Meziani, Ferhat ;
Stephan, François ;
Nseir, Saad ;
Gibot, Sebastien ;
Schwebel, Carole ;
Plantefeve, Gaetan ;
Diehl, Jean-Luc ;
Richard, Christian ;
Lamer, Christian ;
Klouche, Kada ;
Jaber, Samir ;
Zakynthinos, Epaminondas ;
Filntisis, Georgios ;
Zakynthinos, Spyros ;
Koutsoukou, Antonia ;
Saroglou, Georgios ;
Nikolaou, Charikleia ;
Vlachogianni, Glykeria ;
Pnevmatikos, Ioannis ;
Mandragos, Konstantinos ;
Kremer, Ildiko ;
Rozgonyi, Zsolt Dezso ;
Marjanek, Zsuzsa ;
Martin-Loeches, Ignacio ;
Singer, Pierre ;
Van Heerden, Vernon ;
Carmeli, Yehuda ;
Povoa, Pedro ;
AlvarezSeoane, Antonio ;
Moura, Pedro ;
Gonzalez, Filipe ;
Ramirez, Paula ;
Torres Marti, Antonio ;
Ferrer Roca, Ricard ;
Oteiza, Lorena ;
Escudero, Dolores ;
Piacentini, Enrique ;
Vera-Artazcoz, Paula (Institut d'Investigació Biomèdica Sant Pau) ;
Tamayo, Luis ;
Gonzalez Gallego, Miguel Angel ;
Suberviola Canas, Borja ;
Figueira, Iglesias ;
Leon, Rafael ;
Korten, Volkan ;
Akova, Murat ;
Wyncoll, Duncan ;
Whitehouse, Tony ;
Hopkins, Phil ;
Sim, Malcolm ;
Golan, Yoav ;
Zervos, Marcus ;
Vazquez, Jose ;
Cherabuddi, Kartikeya ;
Smulian, George ;
Rouphael, Nadine ;
Welker, James ;
Sims, Mathew ;
Van Duin, David ;
McCarthy, Todd ;
Polk, Christopher
Background: Ventilator-associated pneumonia caused by Pseudomonas aeruginosa (PA) in hospitalised patients is associated with high mortality. The effectiveness of the bivalent, bispecific mAb MEDI3902 (gremubamab) in preventing PA nosocomial pneumonia was assessed in PA-colonised mechanically ventilated subjects. [...]
2022 - 10.1186/s13054-022-04204-9
Critical Care, Vol. 26 Núm. 1 (december 2022) , p. 355
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8.
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11 p, 3.7 MB |
Inhaled amikacin for pneumonia treatment and dissemination prevention : an experimental model of severe monolateral Pseudomonas aeruginosa pneumonia
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Motos, Ana (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Yang, Hua (Universitat de Barcelona) ;
Li Bassi, Gianluigi (Critical Care Research Group, The Prince Charles Hospital, University of Queensland, Queensland University of Technology, UnitingCare Hospitals, Wesley Medical Research, Brisbane, Australia) ;
Yang, Minlan (Universitat de Barcelona) ;
Meli, Andrea (Università degli Studi di Milano) ;
Battaglini, Denise (San Martino Policlinico Hospital) ;
Cabrera, Roberto (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Bobi, Joaquim (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Pagliara, Francesco (IRCCS for Oncology and Neurosciences. Anesthesia and Critical Care, San Martino Policlinico Hospital) ;
Frigola, Gerard (Hospital Clínic i Provincial de Barcelona) ;
Camprubí-Rimblas, Marta (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Fernández-Barat, Laia (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Rigol, Montserrat (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Ferrer-Segarra, Antoni (Parc de Salut MAR de Barcelona) ;
Kiarostami, Kasra (Universitat de Barcelona) ;
Martinez, Daniel (Hospital Clínic i Provincial de Barcelona) ;
Nicolau, David P. (Hartford Hospital) ;
Artigas Raventós, Antoni (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Pelosi, Paolo (Università degli Studi di Genova) ;
Vila, Jordi (Centro de Investigación Biomédica en Red de Enfermedades Infecciosas) ;
Torres, Antoni (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Universitat Autònoma de Barcelona
Pseudomonas aerugino sa pneumonia is commonly treated with systemic antibiotics to ensure adequate treatment of multidrug resistant (MDR) bacteria. However, intravenous (IV) antibiotics often achieve suboptimal pulmonary concentrations. [...]
2023 - 10.1186/s13054-023-04331-x
Critical Care, Vol. 27 (february 2023)
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9.
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16 p, 7.0 MB |
Synthesis and evaluation of novel furanones as biofilm inhibitors in opportunistic human pathogens
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Gómez Camacho, Andromeda Celeste (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Lyons, Thérèse (University College Cork. School of Pharmacy) ;
Mamat, Uwe (Leibniz Lung Center. Cellular Microbiology) ;
Yero, Daniel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Bravo, Marc (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Daura i Ribera, Xavier (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Elshafee, Osama (Leibniz Institute for Natural Product Research and Infection Biology. Department of Microbial Pathogenicity Mechanisms) ;
Brunke, Sascha (Leibniz Institute for Natural Product Research and Infection Biology. Department of Microbial Pathogenicity Mechanisms) ;
Gahan, Cormac G.M. (University College Cork. APC Microbiome Ireland) ;
O'Driscoll, Michelle (University College Cork. Analytical and Biological Chemistry Research Facility) ;
Gibert, Isidre (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
O'Sullivan, Timothy P. (University College Cork. Analytical and Biological Chemistry Research Facility)
Diseases caused by biofilm-forming pathogens are becoming increasingly prevalent and represent a major threat to human health. This trend has prompted a search for novel inhibitors of microbial biofilms which could, for example, be used to potentiate existing antibiotics. [...]
2022 - 10.1016/j.ejmech.2022.114678
European Journal of Medicinal Chemistry, Vol. 242 (November 2022) , art. 114678
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10.
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12 p, 1.0 MB |
An Immunochemical Approach to Detect the Quorum Sensing-Regulated Virulence Factor 2-Heptyl-4-Quinoline N-Oxide (HQNO) Produced by Clinical Isolates
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Montagut, Enrique J. (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Raya, Juan (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Martin-Gomez, M. Teresa (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Vilaplana, Lluïsa (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Rodriguez-Urretavizcaya, Barbara (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Marco, María Pilar (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina)
Understanding quorum sensing (QS) and its role in the development of pathogenesis may provide new avenues for diagnosing, surveillance, and treatment of infectious diseases. For this purpose, the availability of reliable and efficient analytical diagnostic tools suitable to specifically detect and quantify these essential QS small molecules and QS regulated virulence factors is crucial. [...]
2022 - 10.1128/spectrum.01073-21
Microbiology Spectrum, Vol. 10, Num. 4 (July 2022) , art. e01073-21
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