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10 p, 2.6 MB |
Epigenetic Profiling and Response to CD19 Chimeric Antigen Receptor T-Cell Therapy in B-Cell Malignancies
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García-Prieto, Carlos A (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Villanueva, Lorea (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bueno-Costa, Alberto (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Davalos, Veronica (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
González-Navarro, Europa Azucena (Department of Immunology. Hospital Clinic) ;
Juan, Manuel (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Urbano-Ispizua, Álvaro (Department of Hematology. University of Barcelona) ;
Delgado, Julia (Centro de Investigación Biomedica en Red de Cancer) ;
Ortiz-Maldonado, Valetín (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Del Bufalo, Francesca (Department of Paediatric Haematology and Oncology. Bambino Gesù Children's Hospital) ;
Locatelli, Franco (Sapienza University of Rome) ;
Quintarelli, Concetta (Department of Clinical Medicine and Surgery. University of Naples Federico II) ;
Sinibaldi, Matilde (Department of Paediatric Haematology and Oncology. Bambino Gesù Children's Hospital) ;
Soler, Marta (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Castro De Moura, Manuel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ferrer, Gerardo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Urdinguio, Rocío G. (Universidad de Oviedo) ;
Fernandez, A.F. (Universidad de Oviedo) ;
Fraga, Mario F. (Universidad de Oviedo) ;
Bar, Diana (The Edmond and Lily Safra Children's Hospital) ;
Meir, Agustín (The Edmond and Lily Safra Children's Hospital) ;
Itzhaki, Orit (Ella Lemelbaum Institute for Immuno Oncology) ;
Besser, MichalJ. (Tel Aviv University) ;
Avigdor, Abraham (Sheba Medical Center) ;
Jacoby, Elad (Tel Aviv University) ;
Esteller, Manel (Universitat de Barcelona. Departament de Ciències Fisiològiques)
Background: Chimeric antigen receptor (CAR) T cells directed against CD19 (CART19) are effective in B-cell malignancies, but little is known about the molecular factors predicting clinical outcome of CART19 therapy. [...]
2022 -  10.1093/jnci/djab194
Journal of the National Cancer Institute, Vol. 114 Núm. 3 (january 2022) , p. 436-445
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26 p, 2.6 MB |
Taste and smell : a unifying chemosensory theory
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Mollo, Ernesto (Consiglio Nazionale delle Ricerche. Istituto di Chimica Biomolecolare) ;
Boero, Ferdinando (Università degli Studi di Napoli Federico II. Dipartimento di Biologia) ;
Peñuelas, Josep (Centre de Recerca Ecològica i d'Aplicacions Forestals) ;
Fontana, Angelo (Consiglio Nazionale delle Ricerche. Istituto di Chimica Biomolecolare) ;
Garson, Mary J. (University of Queensland. School of Chemistry and Molecular Biosciences) ;
Roussis, Vassilios (National and Kapodistrian University of Athens. Department of Pharmacy) ;
Cerrano, Carlo (Polytechnic University of Marche. Dipartimento di Scienze della Vita e dell'Ambiente) ;
Polese, Gianluca (Università degli Studi di Napoli Federico II. Dipartimento di Biologia) ;
Cattaneo, Alberto Maria (Swedish University of Agricultural Sciences. Department of Plant Protection Biology) ;
Mudianta, I Wayan (Universitas Pendidikan Ganesha. Department of Analytical Chemistry) ;
Genta-Jouve, Gregory (Centre national de la recherche scientifique. Université de Guyane. Laboratory of Ecology, Evolution, Interactions of Amazonian System) ;
Taglialatela-Scafati, Orazio (Università degli Studi di Napoli Federico II. Dipartimento di Farmacia) ;
Appendino, Giovanni (Università degli Studi del Piemonte Orientale "Amedeo Avogadro". Dipartimento di Scienze Farmaceutiche) ;
Amodeo, Pietro (Consiglio Nazionale delle Ricerche. Istituto di Chimica Biomolecolare) ;
Ghiselin, Michael T. (California Academy of Sciences. Department of Invertebrate Zoology)
Since antiquity, the sense of smell (olfaction) is considered as a distance sense, just like sight and hear-ing. Conversely, the sense of taste (gustation) is thought to operate by direct contact, similarly to touch. [...]
2022 - 10.1086/720097
The Quarterly Review of Biology, Vol. 97, issue 2 (June 2022) , 69-94
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33 p, 1.2 MB |
Metabotropic Glutamate Receptor 2 and Dopamine Receptor 2 Gene Expression Predict Sensorimotor Gating Response in the Genetically Heterogeneous NIH-HS Rat Strain
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Østerbøg, Tina Becher (Research Laboratory for Stereology and Neuroscience. Bispebjerg and Frederiksberg Hospitals. Copenhagen) ;
On, Doan Minh (Department of Physiology and Biophysics. Virginia Commonwealth University School of Medicine) ;
Oliveras, Ignasi (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Río-Álamos, Cristobal (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Sánchez González, Ana (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Tapias-Espinosa, Carles (Departamento de Psiquiatría y Medicina Legal.) ;
Tobeña, Adolf 1950- (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Gonzalez-Maeso, Javier (Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine) ;
Fernández-Teruel, Alberto (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Aznar, Susana (Bispebjerg and Frederiksberg Hospitals (Copenhagen, Dinamarca))
Disruption of sensorimotor gating causes "flooding" of irrelevant sensory input and is considered a congenital trait in several neurodevelopmental disorders. Prepulse inhibition of acoustic startle response (PPI) is the operational measurement and has a high translational validity. [...]
2020 - 10.1007/s12035-019-01829-w
Molecular neurobiology, Vol. 57 Núm. 3 (March 2020) , p. 1516-1528
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13 p, 2.2 MB |
High circulating SDF-1and MCP-1 levels and genetic variations in CXCL12, CCL2 and CCR5 : Prognostic signature of immune recovery status in treated HIV-positive patients
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Yeregui, Elena (Institut d'Investigació Sanitària Pere Virgili) ;
Viladés, Consuelo (Institut d'Investigació Sanitària Pere Virgili) ;
Domingo, Pere (Institut d'Investigació Biomèdica Sant Pau) ;
Ceausu, Andra (Universitat Rovira i Virgili) ;
Pacheco, Yolanda María (Universidad de Sevilla) ;
Veloso, Sergi (Universitat Rovira i Virgili) ;
Inciarte, Alexy (Hospital Clínic i Provincial de Barcelona) ;
Vidal-González, Judit (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Peraire, Maria (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Perpiñán, Carles (CAP Sant Pere) ;
Falcó, Vicenç (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Masip, Jenifer (Universitat Rovira i Virgili) ;
Alba Elvira, Veronica (Universitat Rovira i Virgili) ;
Vargas Laguna, Montserrat (Universitat Rovira i Virgili) ;
Martí, Anna (Universitat Rovira i Virgili) ;
Reverté Calvet, Laia (Universitat Rovira i Virgili) ;
Mallolas Masferrer, Josep (Hospital Clínic i Provincial de Barcelona) ;
Vidal, Francesc (Universitat Rovira i Virgili) ;
Peraire, Joaquim (Universitat Rovira i Virgili) ;
Rull, Anna (Universitat Rovira i Virgili) ;
Universitat Autònoma de Barcelona
The underlying mechanisms of incomplete immune reconstitution in treated HIV-positive patients are very complex and may be multifactorial, but perturbation of chemokine secretion could play a key role in CD4 T-cell turnover. [...]
2020 - 10.1016/j.ebiom.2020.103077
EBioMedicine, Vol. 62 (december 2020) , p. 103077
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14 p, 3.9 MB |
Deletion or Inhibition of NOD1 Favors Plaque Stability and Attenuates Atherothrombosis in Advanced Atherogenesis †
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González-Ramos, S. (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Fernández-García, V. (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Recalde, M. (Instituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM)) ;
Rodríguez, Cristina (Institut d'Investigació Biomèdica Sant Pau) ;
Martínez-González, José (Institut d'Investigació Biomèdica Sant Pau) ;
Andrés, Vicente (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Martín-Sanz, P. (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Boscá, Lisardo (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Universitat Autònoma de Barcelona
Atherothrombosis, the main cause of acute coronary syndromes (ACS), is characterized by the rupture of the atherosclerotic plaque followed by the formation of thrombi. Fatal plaque rupture sites show large necrotic cores combined with high levels of inflammation and thin layers of collagen. [...]
2020 - 10.3390/cells9092067
Cells, Vol. 9 Núm. 9 (october 2020) , p. 632
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11 p, 421.8 KB |
Health-Related Quality of Life Outcomes in Patients with Resected Epidermal Growth Factor Receptor-Mutated Non-Small Cell Lung Cancer Who Received Adjuvant Osimertinib in the Phase III ADAURA Trial
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Majem, Margarita (Institut d'Investigació Biomèdica Sant Pau) ;
Goldman, Jonathan W. (David Geffen School of Medicine. University of California Los Angeles) ;
John, Thomas (Department of Medical Oncology. Austin Health) ;
Grohe, Christian (Klinik fur € Pneumologie-Evangelische Lungenklinik Berlin Buch) ;
Laktionov, Konstantin (N.N. Blokhin National Medical Research Center of Oncology (Rússia)) ;
Kim, Sang-We (Department of Oncology. Asan Medical Center) ;
Kato, Terufumi (Depart-ment of Thoracic Oncology. Kanagawa Cancer Center) ;
Vu, Huu Vinh (Department of Thoracic Surgery. Choray Hospital) ;
Lu, Shun (Lung Cancer Center. Shanghai Chest Hospital. Shanghai Jiao Tong University) ;
Li, Shanqing (Department of Thoracic Surgery. Peking Union Medical College Hospital. Chinese Academy of Medical Sciences) ;
Lee, Kye Young (Pre-cision Medicine Lung Cancer Center. Konkuk University Medical Center) ;
Akewanlop, Charuwan (Division of Medical Oncology. Faculty of Medicine. Siriraj Hospital) ;
Yu, Chong-Jen (Department of Internal Medicine. National Taiwan University Hospital Hsinchu Branch. National Taiwan University College of Medicine) ;
De Marinis, Filippo (Thoracic Oncology Division. European Institute of Oncology (IEO). IRCCS) ;
Bonanno, Laura (Medical Oncology 2. Istituto Oncologico Veneto (IOV). IRCCS) ;
Domine, Manuel (Hospital Universitario Fundacion Jimenez Díaz. Servicio de Oncología) ;
Shepherd, Frances A. (Department of Medical Oncology and Hematology. University Health Network. Princess Margaret Cancer Center. the University of Toronto) ;
Atagi, Shinji (Department of Thoracic Oncology. National Hospital Organization Kinki-Chuo Chest Medical Center) ;
Zeng, Lingmin (Late Oncology Statistics. AstraZeneca) ;
Kulkarni, Dakshayini (Late Oncology R&D. AstraZeneca) ;
Medic, Nenad (AstraZeneca Oncology Business Unit. Academy House) ;
Tsuboi, Masahiro (Department of Thoracic Surgery and Oncology. National Cancer Center Hospital East) ;
Herbst, Roy S. (Medical Oncology. Yale School of Medicine. Yale Cancer Center) ;
Wu, Yi-Long (Guangdong Lung Cancer Institute)
Purpose: In the phase III ADAURA trial, adjuvant treatment with osimertinib versus placebo, with/without prior adjuvant chemotherapy, resulted in a statistically significant and clinically meaningful disease-free survival benefit in completely resected stage IB-IIIA EGFR-mutated (EGFRm) non-small cell lung cancer (NSCLC). [...]
2022 - 10.1158/1078-0432.CCR-21-3530
Clinical Cancer Research, Vol. 28 Núm. 11 (january 2022) , p. 2286-2296
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12 p, 3.0 MB |
Epitope characterization of a monoclonal antibody that selectively recognizes allotypes
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Falco, Michela (IRCCS Istituto Giannina Gaslini) ;
Meazza, Raffaella (IRCCS Ospedale Policlinico San Martino) ;
Alicata, Claudia (IRCCS Ospedale Pediatrico Bambino Gesù) ;
Canevali, Paolo (IRCCS Ospedale Policlinico San Martino) ;
Muntasell i Castellví, Aura 1972- (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Bottino, Cristina (DIMES, University of Genoa) ;
Moretta, Lorenzo (IRCCS Ospedale Pediatrico Bambino Gesù) ;
Pende, Daniela (IRCCS Ospedale Policlinico San Martino) ;
Lopez-Botet, Miguel (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Universitat Autònoma de Barcelona
Killer immunoglobulin-like receptor (KIR) genes code for a family of inhibitory and activating receptors, finely tuning NK cell function. Numerous studies reported the relevance of KIR allelic polymorphism on KIR expression, ligand affinity, and strength in signal transduction. [...]
2022 - 10.1111/tan.14630
Hla, Vol. 100 (june 2022) , p. 107-118
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