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15 p, 9.2 MB |
Morphologically different hydroxyapatite nanoparticles exert differential genotoxic effects in Drosophila
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Güneş, Merve (Akdeniz University. Department of Biology) ;
Yalçın, Burçin (Akdeniz University. Department of Biology) ;
Burgazlı, Ayşen Yağmur (Akdeniz University. Department of Biology) ;
Tagorti, Ghada (Akdeniz University. Department of Biology) ;
Yavuz, Emre (Akdeniz University. Department of Chemistry) ;
Akarsu, Esin (Akdeniz University. Department of Chemistry) ;
Kaya, Nuray (Akdeniz University. Department of Biology) ;
Marcos Dauder, Ricardo (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Kaya, Bülent (Akdeniz University. Department of Biology)
Hydroxyapatite (HAP) occurs naturally in sedimentary and metamorphic rocks and constitutes the hard structures in many organisms. Since synthetic nano-sized HAP (HAP-NPs) are used in orthopedic applications and for heavy metal remediation in aquatic and terrestrial media, both environment and humans are exposed to them. [...]
2023 -  10.1016/j.scitotenv.2023.166556
Science of the total environment, Vol. 904 (December 2023) , art. 166556
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2.
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19 p, 4.4 MB |
Divergent patterns of meiotic double strand breaks and synapsis initiation dynamics suggest an evolutionary shift in the meiosis program between American and Australian marsupials
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Valero-Regalón, F. Javier (Universidad Autónoma de Madrid) ;
Solé, Mireia (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
López-Jiménez, Pablo (Universidad Autónoma de Madrid) ;
Valerio-de Arana, María (Universidad Autónoma de Madrid) ;
Martín-Ruiz, Marta (Universidad Autónoma de Madrid) ;
de la Fuente, Roberto (The Polish Academy of Sciences) ;
Marin Gual, Laia (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Renfree, Marilyn B. (The University of Melbourne) ;
Shaw, Geoff (The University of Melbourne) ;
Berríos, Soledad (Universidad de Chile) ;
Fernández-Donoso, Raúl (Universidad de Chile) ;
Waters, Paul D. (University of New South Wales) ;
Ruiz-Herrera Moreno, Aurora (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Gómez, Rocío (Universidad Autónoma de Madrid) ;
Page, Jesús (Universidad Autónoma de Madrid)
In eutherian mammals, hundreds of programmed DNA double-strand breaks (DSBs) are generated at the onset of meiosis. The DNA damage response is then triggered. Although the dynamics of this response is well studied in eutherian mammals, recent findings have revealed different patterns of DNA damage signaling and repair in marsupial mammals. [...]
2023 - 10.3389/fcell.2023.1147610
Frontiers in Cell and Developmental Biology, Vol. 11 (April 2023) , art. 1147610
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3.
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4.
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12 p, 2.1 MB |
Enabling full-scale grain boundary mitigation in polycrystalline perovskite solids
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Zhao, Lichen (Peking University. State Key Laboratory for Artificial Microstructure and Mesoscopic Physics) ;
Tang, PengYi (Institut Català de Nanociència i Nanotecnologia) ;
Luo, Deying (Peking University. State Key Laboratory for Artificial Microstructure and Mesoscopic Physics) ;
Dar, Ibrahim (University of Cambridge. Department of Physics) ;
Eickemeyer, Felix (École Polytechnique Fédérale de Lausanne. Laboratory of Photonics and Interfaces) ;
Arora, Neha (University of Cambridge. Department of Physics) ;
Hu, Qin (University of Massachusetts. Polymer Science and Engineering Department) ;
Luo, Jingshan (École Polytechnique Fédérale de Lausanne. Laboratory of Photonics and Interfaces) ;
Liu, Yuhang (École Polytechnique Fédérale de Lausanne. Laboratory of Photonics and Interfaces) ;
Zakeeruddin, Shaik Mohammed (École Polytechnique Fédérale de Lausanne. Laboratory of Photonics and Interfaces) ;
Hagfeldt, Anders (École Polytechnique Fédérale de Lausanne. Laboratory of Photomolecular Science) ;
Arbiol i Cobos, Jordi (Institut Català de Nanociència i Nanotecnologia) ;
Huang, Wei (Nanjing Tech University. Key Laboratory of Flexible Electronics & Institute of Advanced Materials) ;
Gong, Qihuang (Peking University. State Key Laboratory for Artificial Microstructure and Mesoscopic Physics) ;
Russell, Thomas (University of Massachusetts. Polymer Science and Engineering Department) ;
Friend, Richard Henry (University of Cambridge. Department of Physics) ;
Grätzel, Michael (École Polytechnique Fédérale de Lausanne. Laboratory of Photonics and Interfaces) ;
Zhu, Rui (Peking University. State Key Laboratory for Artificial Microstructure and Mesoscopic Physics)
There exists a considerable density of interaggregate grain boundaries (GBs) and intra-aggregate GBs in polycrystalline perovskites. Mitigation of intra-aggregate GBs is equally notable to that of interaggregate GBs as intra-aggregate GBs can also cause detrimental effects on the photovoltaic performances of perovskite solar cells (PSCs). [...]
2022 - 10.1126/sciadv.abo3733
Science advances, Vol. 8, issue 35 (Sep. 2022) , art. eabo3733
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5.
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23 p, 2.1 MB |
Deviations from Mendelian Inheritance on Bovine X-Chromosome Revealing Recombination, Sex-of-Offspring Effects and Fertility-Related Candidate Genes
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Id-Lahoucine, Samir (University of Guelph. Department of Animal Biosciences) ;
Casellas Vidal, Joaquim (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments) ;
Fonseca, Pablo A. S. (University of Guelph. Department of Animal Biosciences) ;
Suárez-Vega, Aroa (University of Guelph. Department of Animal Biosciences) ;
Schenkel, Flavio S. (University of Guelph. Department of Animal Biosciences) ;
Cánovas, Angela (University of Guelph. Department of Animal Biosciences)
Transmission ratio distortion (TRD), or significant deviations from Mendelian inheritance, is a well-studied phenomenon on autosomal chromosomes, but has not yet received attention on sex chromosomes. [...]
2022 - 10.3390/genes13122322
Genes, Vol. 13 (december 2022)
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6.
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15 p, 3.8 MB |
Meiotic chromosome dynamics and double strand break formation in reptiles
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Marin Gual, Laia (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
González Rodelas, Laura (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
M. Garcias, Maria (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Kratochvíl, Lukáš (Charles University. Department of Ecology) ;
Valenzuela, Nicole (Iowa State University. Department of Ecology) ;
Georges, Arthur (University of Canberra) ;
Waters, Paul D. (UNSW. Faculty of Science) ;
Ruiz-Herrera Moreno, Aurora (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
During meiotic prophase I, tightly regulated processes take place, from pairing and synapsis of homologous chromosomes to recombination, which are essential for the generation of genetically variable haploid gametes. [...]
2022 - 10.3389/fcell.2022.1009776
Frontiers in Cell and Developmental Biology, Vol. 10 (october 2022)
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7.
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18 p, 1.9 MB |
The use of genome wide association methods to investigate pathogenicity, population structure and serovar in Haemophilus parasuis
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Howell, Kate J. (University of Cambridge. Department of Veterinary Medicine) ;
Weinert, Lucy A. (University of Cambridge. Department of Veterinary Medicine) ;
Chaudhuri, Roy R. (University of Sheffield. Department of Molecular Biology and Biotechnology) ;
Luan, Shi-Lu (University of Cambridge. Department of Veterinary Medicine) ;
Peters, Sarah E. (University of Cambridge. Department of Veterinary Medicine) ;
Corander, Jukka (University of Helsinki. Department of Mathematics and Statistics) ;
Harris, David (Wellcome Trust Sanger Institute (Regne Unit)) ;
Angen, Øystein (Norwegian Veterinary Institute) ;
Aragon, Virginia (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
Bensaid, Albert (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
Williamson, Susanna M. (Animal Health and Veterinary Laboratories Agency) ;
Parkhill, Julian (Wellcome Trust Sanger Institute (Regne Unit)) ;
Langford, Paul R. (Imperial College London. Department of Medicine, Section of Paediatrics) ;
Rycroft, Andrew N. (The Royal Veterinary College) ;
Wren, Brendan W. (London School of Hygiene & Tropical Medicine. Faculty of Infectious & Tropical Diseases) ;
Holden, Matthew T. G. (University of St. Andrews. School of Medicine) ;
Tucker, Alexander W. (University of Cambridge. Department of Veterinary Medicine) ;
Maskell, Duncan J.. (University of Cambridge. Department of Veterinary Medicine)
Haemophilus parasuis is the etiologic agent of Glässer's disease in pigs and causes devastating losses to the farming industry. Whilst some hyper-virulent isolates have been described, the relationship between genetics and disease outcome has been only partially established. [...]
2014 - 10.1186/1471-2164-15-1179
BMC genomics, Vol. 15 (december 2014)
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16 p, 1.2 MB |
A RAD51 assay feasible in routine tumor samples calls inhibitor response beyond BRCA mutation
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Castroviejo-Bermejo, Marta (Vall d'Hebron Institut d'Oncologia) ;
Cruz Zambrano, Cristina (Universitat Autònoma de Barcelona) ;
Llop-Guevara, Alba (Vall d'Hebron Institut d'Oncologia) ;
Gutiérrez-Enríquez, Sara (Vall d'Hebron Institut d'Oncologia) ;
Ducy, Mandy (CHUL. Genomics Center) ;
Ibrahim, Yasir Hussein (Vall d'Hebron Institut d'Oncologia) ;
Gris-Oliver, Albert (Vall d'Hebron Institut d'Oncologia) ;
Pellegrino, Benedetta (University Hospital of Parma) ;
Bruna, Alejandra (University of Cambridge) ;
Guzmán, Marta (Vall d'Hebron Institut d'Oncologia) ;
Rodríguez, Olga (Vall d'Hebron Institut d'Oncologia) ;
Grueso, Judit (Vall d'Hebron Institut d'Oncologia) ;
Bonache, Sandra (Vall d'Hebron Institut d'Oncologia) ;
Moles-Fernández, Alejandro (Vall d'Hebron Institut d'Oncologia) ;
Villacampa Javierre, Guillermo (Vall d'Hebron Institut d'Oncologia) ;
Viaplana, Cristina (Vall d'Hebron Institut d'Oncologia) ;
Gómez, Patricia (Vall d'Hebron Institut d'Oncologia) ;
Vidal, Marc (Vall d'Hebron Institut d'Oncologia) ;
Peg, Vicente (Instituto de Salud Carlos III) ;
Serres-Créixams, Xavier (Hospital Universitari Vall d'Hebron) ;
Dellaire, Graham (Dalhousie University) ;
Simard, Jacques (CHUL. Genomics Center) ;
Nuciforo, Paolo (Vall d'Hebron Institut d'Oncologia) ;
Rubio, Isabel T. (Hospital Universitari Vall d'Hebron) ;
Dientsmann, Rodrigo (Vall d'Hebron Institut d'Oncologia) ;
Barrett, J. Carl (AstraZeneca) ;
Caldas, Carlos (Cancer Research UK (CRUK) Cambridge Cancer Centre) ;
Baselga Torres, Josep 1959-2021 (Memorial Sloan Kettering Cancer Center) ;
Saura, Cristina (Vall d'Hebron Institut d'Oncologia) ;
Cortés, Javier (Vall d'Hebron Institut d'Oncologia) ;
Déas, Olivier (XenTech) ;
Jonkers, Jos (The Netherlands Cancer Institute (Amsterdam, Països Baixos)) ;
Masson, Jean-Yves (Laval University Cancer Research Center) ;
Cairo, Stefano (XenTech) ;
Judde, Jean-Gabriel (XenTech) ;
O'Connor, Mark J.. (AstraZeneca) ;
Diez, Orland (Vall d'Hebron Institut d'Oncologia) ;
Balmaña Gelpí, Judith (Vall d'Hebron Institut d'Oncologia) ;
Serra, Violeta (Instituto de Salud Carlos III) ;
Universitat Autònoma de Barcelona
Poly(-ribose) polymerase () inhibitors (i) are effective in cancers with defective homologous recombination repair (), including 1/2-related cancers. A test to identify additional -deficient tumors will help to extend their use in new indications. [...]
2018 - 10.15252/emmm.201809172
EMBO Molecular Medicine, Vol. 10 (october 2018)
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9.
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14 p, 2.3 MB |
TALEN mediated gene editing in a mouse model of Fanconi anemia
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Pino-Barrio, Maria José (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Giménez, Yari (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Villanueva, Mariela (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Hildenbeutel, Marcus (University of Freiburg. Center for Chronic Immunodeficiency - Medical Center) ;
Sánchez-Dominguez, Rebeca (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Rodriguez-Perales, Sandra (Centro Nacional de Investigaciones Oncológicas. Grupo de Citogenética Molecular) ;
Pujol i Calvet, M. Roser (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Surrallés i Calonge, Jordi (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Río, Paula (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Cathomen, Toni (University of Freiburg. Center for Chronic Immunodeficiency - Medical Center) ;
Mussolino, Claudio (University of Freiburg. Center for Chronic Immunodeficiency - Medical Center) ;
Bueren, Juan (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Navarro Ordóñez, Susanna (Centro de Investigación Biomédica en Red de Enfermedades Raras)
The promising ability to genetically modify hematopoietic stem and progenitor cells by precise gene editing remains challenging due to their sensitivity to in vitro manipulations and poor efficiencies of homologous recombination. [...]
2020 - 10.1038/s41598-020-63971-z
Scientific reports, Vol. 10 (April 2020) , art. 6997
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10.
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13 p, 4.7 MB |
Unraveling the cellular origin and clinical prognostic markers of infant B-cell acute lymphoblastic leukemia using genome-wide analysis
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Agraz-Doblás, Antonio (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bueno, Clara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Rogers, R. B. (Department of Medicine. University of Cambridge. Cambridge Biomedical Campus) ;
Roy, A. (Department of Paediatrics. University of Oxford) ;
Schneider, P. (Princess Maxima Center for Pediatric Oncology) ;
Bardini, Michela (Università degli Studi di Milano-Bicocca) ;
Ballerini, Paola (Pediatric Hematology. A. Trousseau Hospital) ;
Cazzaniga, Giovanni (Centro Ricerca Tettamanti. Department of Pediatrics. University of Milano Bicocca. Fondazione MBBM) ;
Moreno, T. (Instituto de Biomedicina y Biotecnología de Cantabria. Universidad de Cantabria-CSIC) ;
Revilla, C. (Instituto de Biomedicina y Biotecnología de Cantabria. Universidad de Cantabria-CSIC) ;
Gut, Marta (Universitat Pompeu Fabra) ;
Valsecchi, M. G. (Interfant Trial Data Center. University of Milano-Bicocca) ;
Roberts, I. (MRC Molecular Haematology Unit. MRC Weatherall Institute of Molecular Medicine. University of Oxford) ;
Pieters, R. (Princess Maxima Center for Pediatric Oncology) ;
De Lorenzo, P. (Interfant Trial Data Center. University of Milano-Bicocca) ;
Varela, Ignacio (Instituto de Biomedicina y Biotecnología de Cantabria. Universidad de Cantabria-CSIC) ;
Menéndez Bujan, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Stam, R. W. (Princess Maxima Center for Pediatric Oncology) ;
Universitat Autònoma de Barcelona
Bcell acute lymphoblastic leukemia is the commonest childhood cancer. In infants, B-cell acute lymphoblastic leukemia remains fatal, especially in patients with t(4;11), present in ~80% of cases. The pathogenesis of t(4;11)/KMT2A-AFF1 (MLL-AF4) infant B-cell acute lymphoblastic leukemia remains difficult to model, and the pathogenic contribution in cancer of the reciprocal fusions resulting from derivative translocated-chromosomes remains obscure. [...]
2019 - 10.3324/haematol.2018.206375
Haematologica, Vol. 104 Núm. 6 (2019) , p. 1176-1188
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