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28 p, 707.9 KB |
Ver para pensar : la construcción visual de las enfermedades "raras"
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Rodríguez Sánchez, Juan Antonio (Universidad de Salamanca) ;
Ruiz Somavilla, María José (Universidad de Málaga)
A partir del concepto de dominios escópicos se estudian las visualidades hegemónicas (científica y social) que han intervenido en la construcción de la categoría "enfermedades raras". Para ello se han investigado, entre 1940 y 2015, los tratados médicos -por su papel en la creación del concepto icónico de enfermedad y su transmisión mediante su uso pedagógico- y la prensa diaria, por la difusión social de las imágenes generadas. [...]
Study of hegemonic visualities (scientific and social) that have intervened in the construction of the "rare disease" category is based on the concept of scopic domains. Accordingly, medical treatises published between 1940 and 2015 were examined due to their pedagogic role in creating the iconic concept of disease and its transmission, and the daily press was studied for their role in social diffusion of the images obtained. [...]
2022 -  10.30827/dynamis.v42i2.27718
Dynamis : Acta Hispanica ad Medicinae Scientiarumque. Historiam Illustrandam, Vol. 42 Núm. 2 (2022) , p. 473-499 (Dossier)
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21 p, 985.0 KB |
Role of Moonlighting Proteins in Disease : Analyzing the Contribution of Canonical and Moonlighting Functions in Disease Progression
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Huerta Casado, Mario (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Franco Serrano, Luis (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Amela Abellan, Isaac (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Pérez-Pons, Josep A (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Piñol Ribas, Jaume (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Mozo-Villarias, Angel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Querol Murillo, Enrique (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Cedano Rodríguez, Juan Antonio (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
The term moonlighting proteins refers to those proteins that present alternative functions performed by a single polypeptide chain acquired throughout evolution (called canonical and moonlighting, respectively). [...]
2023 - 10.3390/cells12020235
Cells, Vol. 12, Issue 2 (January 2023) , art. 235
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13 p, 1.9 MB |
Pathogen Moonlighting Proteins : From Ancestral Key Metabolic Enzymes to Virulence Factors
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Franco Serrano, Luis (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Sánchez-Redondo, David (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Nájar-García, Araceli (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Hernández, Sergio (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Amela Abellan, Isaac (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Pérez-Pons, Josep A (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Piñol Ribas, Jaume (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Mozo-Villarias, Angel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Cedano Rodríguez, Juan Antonio (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Querol Murillo, Enrique (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Moonlighting and multitasking proteins refer to proteins with two or more functions performed by a single polypeptide chain. An amazing example of the Gain of Function (GoF) phenomenon of these proteins is that 25% of the moonlighting functions of our Multitasking Proteins Database (MultitaskProtDB-II) are related to pathogen virulence activity. [...]
2021 - 10.3390/microorganisms9061300
Microorganisms, Vol. 9, Issue 6 (June 2021) , art. 1300
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18 p, 6.6 MB |
A multilayered post-GWAS assessment on genetic susceptibility to pancreatic cancer
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López de Maturana, Evangelina (Centro de Investigación Biomédica en Red de Cáncer) ;
Rodríguez, Juan Antonio (Centre de Regulació Genòmica) ;
Alonso, Lola (Centro de Investigación Biomédica en Red de Cáncer) ;
Lao, Oscar (Centre de Regulació Genòmica) ;
Molina-Montes, Esther (Centro de Investigación Biomédica en Red de Cáncer) ;
Martín-Antoniano, Isabel Adoración (Centro de Investigación Biomédica en Red de Cáncer) ;
Gómez-Rubio, Paulina (Centro de Investigación Biomédica en Red de Cáncer) ;
Lawlor, Rita (University and Hospital Trust of Verona. ARC-Net Centre for Applied Research on Cancer and Department of Pathology and Diagnostics) ;
Carrato, Alfredo (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ;
Hidalgo, Manuel (Weill Cornell Medicine) ;
Iglesias, Mar (Parc de Salut MAR de Barcelona) ;
Molero, Xavier (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Löhr, Matthias (Gastrocentrum, Karolinska Institutet and University Hospital) ;
Michalski, Christopher (Martin-Luther-University Halle-WittenberHalle (Saale). Department of Visceral, Vascular and Endocrine Surgery) ;
Perea, José (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ;
O'Rorke, Michael (The University of Iowa. College of Public Health) ;
Barberà, Victor Manuel (Hospital General Universitario de Elche) ;
Tardón, Adonina (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
Farré, Antoni (Institut d'Investigació Biomèdica Sant Pau) ;
Muñoz-Bellvís, Luís (Instituto de Investigación Biomédica de Salamanca) ;
Crnogorac-Jurcevic, Tanja (Queen Mary University of London. Barts Cancer Institute, Centre for Molecular Oncology) ;
Domínguez-Muñoz, Enrique (Complejo Hospitalario Universitario de Santiago de Compostela) ;
Gress, Thomas (University Hospital of Giessen and Marburg (Alemanya)) ;
Greenhalf, William (University of Liverpool. Department of Molecular and Clinical Cancer Medicine) ;
Sharp, Linda (Newcastle University, Institute of Health & Society) ;
Arnes, Luís (Columbia University Medical Center. Department of Systems Biology) ;
Cecchini, Lluís (Parc de Salut MAR de Barcelona) ;
Balsells, Joaquim (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Costello, Eithne (University of Liverpool. Department of Molecular and Clinical Cancer Medicine) ;
Ilzarbe, Lucas (Parc de Salut MAR de Barcelona) ;
Kleeff, Jörg (Martin-Luther-University Halle-WittenberHalle (Saale). Department of Visceral, Vascular and Endocrine Surgery) ;
Kong, Bo (Technical University of Munich. Department of Surgery) ;
Márquez, Mirari (Centro de Investigación Biomédica en Red de Cáncer) ;
Mora Brugués, Josefina (Institut d'Investigació Biomèdica Sant Pau) ;
O'Driscoll, Damian (University College Cork. National Cancer Registry Ireland and HRB Clinical Research Facility) ;
Scarpa, Aldo (University and Hospital Trust of Verona. ARC-Net Centre for Applied Research on Cancer and Department of Pathology and Diagnostics) ;
Ye, Weimin (Karolinska Institutet (Estocolm, Suècia). Department of Medical Epidemiology and Biostatistics) ;
Yu, Jingru (Karolinska Institutet (Estocolm, Suècia). Department of Medical Epidemiology and Biostatistics) ;
García-Closas, Montserrat (Centro Nacional de Investigaciones Oncológicas) ;
Kogevinas, M.. (Hospital del Mar (Barcelona, Catalunya)) ;
Rothman, Nathaniel (Centro Nacional de Investigaciones Oncológicas) ;
Silverman, Debra T. (Centro Nacional de Investigaciones Oncológicas) ;
Albanes, Demetrius (Centro Nacional de Investigaciones Oncológicas) ;
Arslan, Alan A. (New York University School of Medicine. Department of Population Health) ;
Beane-Freeman, Laura (Centro Nacional de Investigaciones Oncológicas) ;
Bracci, Paige M. (University of California. Department of Epidemiology and Biostatistics) ;
Brennan, Paul (International Agency for Research on Cancer (IARC)) ;
Bueno-de-Mesquita, Bas (National Institute for Public Health and the Environment (RIVM). Deparment for Determinants of Chronic Diseases (DCD)) ;
Buring, Julie (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ;
Canzian, Federico (German Cancer Research Center (DKFZ. Genomic Epidemiology Group) ;
Du, Margaret (Memorial Sloan Kettering Cancer Center) ;
Gallinger, Steven (Sinai Health System. Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute) ;
Gaziano, J. Michael (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ;
Goodman, Phyllis J. (SWOG Statistical Center, Fred Hutchinson Cancer Research Center) ;
Gunter, Marc (International Agency for Research on Cancer (IARC)) ;
LeMarchand, Loic (University of Hawaii Cancer Center. Cancer Epidemiology Program) ;
Li, Donghui (University of Texas MD Anderson Cancer Center) ;
Neale, Rachael E. (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia). Population Health Department) ;
Peters, Ulrika (Fred Hutchinson Cancer Research Center. Division of Public Health Sciences) ;
Petersen, Gloria M. (Mayo Clinic College of Medicine. Department of Health Sciences Research) ;
Risch, Harvey A. (Yale School of Public Health. Department of Chronic Disease Epidemiology) ;
Sánchez, Maria José (Universidad de Granada) ;
Shu, Xiao-Ou (Vanderbilt University School of Medicine. Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center) ;
Thornquist, Mark D. (Fred Hutchinson Cancer Research Center. Division of Public Health Sciences) ;
Visvanathan, Kala (Mayo Clinic College of Medicine. Department of Health Sciences Research) ;
Zheng, Wei (Vanderbilt University School of Medicine. Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center) ;
Chanock, Stephen (Centro Nacional de Investigaciones Oncológicas) ;
Easton, Douglas F (University of Cambridge. Centre for Cancer Genetic Epidemiology) ;
Wolpin, Brian M. (Dana-Farber Cancer Institute (Boston, Estats Units d'Amèrica)) ;
Stolzenberg-Solomon, Rachael Z. (Centro Nacional de Investigaciones Oncológicas) ;
Klein, Alison P. (Johns Hopkins School of Medicine. Department of Oncology, Sidney Kimmel Comprehensive Cancer Center) ;
Amundadottir, Laufey T. (National Cancer Institute (Bethesda, Estats Units d'Amèrica)) ;
Marti-Renom, Marc A. (Universitat Pompeu Fabra. Centre de Regulació Genòmica (CRG-UPF)) ;
Real, Francisco X (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ;
Malats, Núria (Centro de Investigación Biomédica en Red de Cáncer)
Pancreatic cancer (PC) is a complex disease in which both non-genetic and genetic factors interplay. To date, 40 GWAS hits have been associated with PC risk in individuals of European descent, explaining 4. [...]
2021 - 10.1186/s13073-020-00816-4
Genome Medicine, Vol. 13 (february 2021)
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10 p, 2.5 MB |
Multifunctional Proteins : Involvement in Human Diseases and Targets of Current Drugs
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Franco Serrano, Luis (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Huerta Casado, Mario (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Hernández, Sergio (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Cedano Rodríguez, Juan Antonio (Universidad de la República Regional Norte-Salto. Laboratorio de Inmunología) ;
Pérez-Pons, Josep A (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Piñol Ribas, Jaume (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Mozo-Villarias, Angel (Universitat de Lleida. Departament de Medicina Experimental) ;
Amela Abellan, Isaac (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Querol Murillo, Enrique (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Multifunctionality or multitasking is the capability of some proteins to execute two or more biochemical functions. The objective of this work is to explore the relationship between multifunctional proteins, human diseases and drug targeting. [...]
2018 - 10.1007/s10930-018-9790-x
The Protein Journal, Vol. 37, Issue 5 (October 2018) , p. 444-453
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6 p, 665.3 KB |
Can bioinformatics help in the identification of moonlighting proteins?
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Hernández, Sergio (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Calvo, Alejandra (Universidad de la República Regional Norte-Salto. Laboratorio de Inmunología) ;
Ferragut, Gabriela (Universidad de la República Regional Norte-Salto. Laboratorio de Inmunología) ;
Franco Serrano, Luis (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Hermoso, Antoni (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Amela Abellan, Isaac (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Gómez, Antonio (Institut d'Investigació Biomèdica de Bellvitge) ;
Querol Murillo, Enrique (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Cedano Rodríguez, Juan Antonio (Universidad de la República Regional Norte-Salto. Laboratorio de Inmunología)
Protein multitasking or moonlighting is the capability of certain proteins to execute two or more unique biological functions. This ability to perform moonlighting functions helps us to understand one of the ways used by cells to perform many complex functions with a limited number of genes. [...]
2014 - 10.1042/BST20140241
Biochemical Society Transactions, Vol. 42, issue 6 (Dec. 2014) , p. 1692-1697
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