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2 p, 318.1 KB |
Dendritic cells from paediatric patients with type 1 diabetes show altered phagocytosis capacity correlating with disease evolution
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Rodríguez-Fernández, Silvia (Institut Germans Trias i Pujol) ;
Murillo, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Perna-Barrull, David (Institut Germans Trias i Pujol) ;
Villalba Felipe, Adrián (Institut Germans Trias i Pujol) ;
Maspoch, Daniel (Institut Català de Nanociència i Nanotecnologia) ;
Bel, Joan (Hospital Universitari Germans Trias i Pujol. Servei de Pediatria) ;
Vives-Pi, Marta (Institut Germans Trias i Pujol)
Autoimmunity against β-cells in type 1 diabetes (T1D) is prompted by defective immunological tolerance, an event in which dendritic cells (DCs) play a crucial role as orchestrators of the immune response. [...]
2019 -  10.1007/s00125-019-4946-6
Diabetologia, Vol. 62, supl. 1 (Set. 2019) , art. S224
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8 p, 1.3 MB |
Preclinical evaluation of antigen-specific nanotherapy based on phosphatidylserine-liposomes for type 1 diabetes
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Villalba Felipe, Adrián (Institut Germans Trias i Pujol) ;
Rodríguez-Fernández, Silvia (Institut Germans Trias i Pujol) ;
Ampudia, Rosa Maria (Institut Germans Trias i Pujol) ;
Cano-Sarabia, Mary (Institut Català de Nanociència i Nanotecnologia) ;
Perna-Barrull, David (Institut Germans Trias i Pujol) ;
Bertran-Cobo, Cesc (Institut Germans Trias i Pujol) ;
Ehrenberg, Clara (Institut Germans Trias i Pujol) ;
Maspoch, Daniel (Institut Català de Nanociència i Nanotecnologia) ;
Vives-Pi, Marta (Institut Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Type 1 diabetes (T1D) is an autoimmune disease caused by the destruction of insulin-producing cells. Due to the ability of apoptotic cells clearance to induce tolerance, we previously generated liposomes rich in phophatidylserine (PS) -a feature of apoptotic cells- loaded with insulin peptides to mimic apoptotic beta-cells. [...]
2020 - 10.1080/21691401.2019.1699812
Artificial Cells, Nanomedicine and Biotechnology, Vol. 48, issue 1 (2020) , p. 77-83
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14 p, 2.6 MB |
Repurposed analog of GLP-1 ameliorates hyperglycemia in type 1 diabetic mice through pancreatic cell reprogramming
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Villalba Felipe, Adrián (Institut Germans Trias i Pujol) ;
Rodríguez Fernández, Silvia (Institut Germans Trias i Pujol) ;
Perna Barrull, David (Institut Germans Trias i Pujol) ;
Ampudia, Rosa Maria (Institut Germans Trias i Pujol) ;
Gomez-Muñoz, Laia (Institut Germans Trias i Pujol) ;
Pujol-Autonell, Irma (Institut Germans Trias i Pujol) ;
Aguilera, Eva (Institut Germans Trias i Pujol) ;
Coma, Mireia (Anaxomics Biotech SL) ;
Cano-Sarabia, Mary (Institut Català de Nanociència i Nanotecnologia) ;
Vázquez, Federico (Institut Germans Trias i Pujol) ;
Verdaguer, Joan (Universitat de Lleida. Departament de Medicina Experimental) ;
Vives-Pi, Marta (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas)
Type 1 diabetes is an autoimmune disease caused by the destruction of the insulin-producing β-cells. An ideal immunotherapy should combine the blockade of the autoimmune response with the recovery of functional target cell mass. [...]
2020 - 10.3389/fendo.2020.00258
Frontiers in Endocrinology, Vol. 11 (May 2020) , art. 258
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13 p, 1.5 MB |
Impaired Phagocytosis in Dendritic Cells From Pediatric Patients With Type 1 Diabetes Does Not Hamper Their Tolerogenic Potential
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Rodríguez Fernández, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Murillo, Marta (Hospital Universitari Germans Trias i Pujol) ;
Villalba Felipe, Adrián (Hospital Universitari Germans Trias i Pujol) ;
Perna Barrull, David (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Cano-Sarabia, Mary (Institut Català de Nanociència i Nanotecnologia) ;
Gómez Muñoz, Laia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Aguilera, Eva (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Maspoch Comamala, Daniel (Institut Català de Nanociència i Nanotecnologia) ;
Vázquez, Federico (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bel, Joan (Hospital Universitari Germans Trias i Pujol) ;
Vives Pi, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Type 1 diabetes (T1D) is prompted by defective immunological tolerance, an event in which dendritic cells (DCs) are crucial as immune response orchestrators. In fact, they contribute to maintaining tolerance to self-antigens, but they can also prompt an immunogenic response against them, leading to autoimmunity. [...]
2019 - 10.3389/fimmu.2019.02811
Frontiers in immunology, Vol. 10 (November 2019) , art. 2811
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12 p, 2.5 MB |
Liposome-based immunotherapy against autoimmune diseases : Therapeutic effect on multiple sclerosis
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Pujol Autonell, Irma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Mansilla López, Maria José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rodríguez Fernández, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Cano-Sarabia, Mary (Institut Català de Nanociència i Nanotecnologia) ;
Navarro-Barriuso, Juan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ampudia, Rosa Maria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rius, Aleix (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
García Jimeno, Sonia (Institut Català de Nanociència i Nanotecnologia) ;
Perna Barrull, David (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez Cáceres, Eva María (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Maspoch Comamala, Daniel (Institut Català de Nanociència i Nanotecnologia) ;
Vives Pi, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Based on the ability of apoptosis to induce immunological tolerance, liposomes were generated mimicking apoptotic cells, and they arrest autoimmunity in Type 1 diabetes. Our aim was to validate the immunotherapy in other autoimmune disease: multiple sclerosis. [...]
2017 - 10.2217/nnm-2016-0410
Nanomedicine, Vol. 12, Issue 11 (June 2017) , p. 1231-1242
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17 p, 2.4 MB |
Phosphatidylserine-liposomes promote tolerogenic features on dendritic cells in human type 1 diabetes by apoptotic mimicry
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Rodriguez Fernandez, Silvia (Institut Germans Trias i Pujol) ;
Pujol Autonell, Irma (Institut Germans Trias i Pujol) ;
Brianso, Ferran (Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística) ;
Perna Barrull, David (Institut Germans Trias i Pujol) ;
Cano-Sarabia, Mary (Institut Català de Nanociència i Nanotecnologia) ;
García Jimeno, Sonia (Institut Català de Nanociència i Nanotecnologia) ;
Villalba Felipe, Adrián (Institut Germans Trias i Pujol) ;
Sanchez, Alex (Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística) ;
Aguilera, Eva (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Vazquez, Federico (Hospital Universitari Germans Trias i Pujol. Servei d'Endocrinologia) ;
Verdaguer, Joan (Universitat de Lleida. Departament de Medicina Experimental) ;
Maspoch Comamala, Daniel (Institució Catalana de Recerca i Estudis Avançats) ;
Vives-Pi, Marta (Institut Germans Trias i Pujol)
Type 1 diabetes (T1D) is a metabolic disease caused by the autoimmune destruction of insulin-producing β-cells. With its incidence increasing worldwide, to find a safe approach to permanently cease autoimmunity and allow β-cell recovery has become vital. [...]
2018 - 10.3389/fimmu.2018.00253
Frontiers in immunology, Vol. 9 (Feb. 2018) , art. 253
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22 p, 1.1 MB |
Type 1 diabetes prevention in NOD mice by targeting DPPIV/CD26 is associated with changes in CD8+T effector memory subset
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Alonso Pedrol, Núria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Julián, María Teresa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Carrascal, Jorge (Institut Germans Trias i Pujol) ;
Colobrán Oriol, Roger (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Pujol Autonell, Irma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rodriguez Fernandez, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Teniente Serra, Aina (Institut Germans Trias i Pujol) ;
Fernández Sanmartin, Marco Antonio (Institut Germans Trias i Pujol) ;
Miñarro Alonso, Antoni (Universitat de Barcelona. Departament d'Estadística) ;
Ruiz de Villa, María del Carmen (Universitat de Barcelona. Departament d'Estadística) ;
Vives Pi, Marta (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Puig Domingo, Manuel Luis (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
CD26 is a T cell activation marker consisting in a type II transmembrane glycoprotein with dipeptidyl peptidase IV (DPPIV) activity in its extracellular domain. It has been described that DPPIV inhibition delays the onset of type 1 diabetes and reverses the disease in non-obese diabetic (NOD) mice. [...]
2015 - 10.1371/journal.pone.0142186
PloS one, Vol. 10, Issue 11 (Novembre 2015) , p. e0142186
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19 p, 1.2 MB |
Use of autoantigen-loaded phosphatidylserine-liposomes to arrest autoimmunity in type 1 diabetes
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Pujol Autonell, Irma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Serracant Prat, Arnau (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Cano-Sarabia, Mary (Institut Català de Nanociència i Nanotecnologia) ;
Ampudia, Rosa Maria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rodriguez Fernandez, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Sànchez, Àlex (Sànchez Pla) (Universitat de Barcelona. Departament d'Estadística) ;
Izquierdo Castro, Cristina (Universitat de Barcelona. Departament de Fisiologia i Immunologia) ;
Stratmann, Thomas (Universitat de Barcelona. Departament de Fisiologia i Immunologia) ;
Puig Domingo, Manuel Luis (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Maspoch Comamala, Daniel (Institut Català de Nanociència i Nanotecnologia) ;
Verdaguer, Joan (Universitat de Lleida. Departament de Medicina Experimental) ;
Vives Pi, Marta (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Universitat Autònoma de Barcelona
INTRODUCTION: The development of new therapies to induce self-tolerance has been an important medical health challenge in type 1 diabetes. An ideal immunotherapy should inhibit the autoimmune attack, avoid systemic side effects and allow β-cell regeneration. [...]
2015 - 10.1371/journal.pone.0127057
PloS one, Vol. 19, Issue 6 (June 2015) , p. e0127057
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