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18 p, 3.4 MB |
Single-cell multi-omics analysis of COVID-19 patients with pre-existing autoimmune diseases shows aberrant immune responses to infection
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Barmada, Anis (Department of Medical Genetics. University of Cambridge) ;
Handfield, Louis-François (Wellcome Sanger Institute (Regne Unit)) ;
Godoy-Tena, Gerard (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
de la Calle-Fabregat, Carlos (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ciudad, Laura (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Arutyunyan, Anna (Wellcome Sanger Institute (Regne Unit)) ;
Andrés-León, Eduardo (Instituto de Parasitología y Biomedicina "López-Neyra") ;
Hoo, Regina (Wellcome Sanger Institute (Regne Unit)) ;
Porter, Tarryn (Wellcome Sanger Institute (Regne Unit)) ;
Oszlanczi, Agnes (Wellcome Sanger Institute (Regne Unit)) ;
Richardson, Laura (Wellcome Sanger Institute (Regne Unit)) ;
Calero-Nieto, Fernando (Department of Haematology and Wellcome & MRC Cambridge Stem Cell Institute. University of Cambridge) ;
Wilson, Nicola K. (Department of Haematology and Wellcome & MRC Cambridge Stem Cell Institute. University of Cambridge) ;
Marchese, Domenica (Centre de Regulació Genòmica) ;
Sancho-Serra, Carmen (Wellcome Sanger Institute. Wellcome Genome Campus) ;
Carrillo, Jorge (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Presas-Rodríguez, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ramo-Tello, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ruiz-Sanmartin, Adolfo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ferrer, Ricard (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ruiz-Rodriguez, Juan Carlos (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martínez Gallo, Mónica (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Munera-Campos, Mónica (Institut Germans Trias i Pujol) ;
Carrascosa, José Manuel (Institut Germans Trias i Pujol) ;
Göttgens, Berthold (Department of Haematology and Wellcome & MRC Cambridge Stem Cell Institute. University of Cambridge) ;
Heyn, Holger (Universitat Pompeu Fabra) ;
Prigmore, Elena (Wellcome Sanger Institute (Regne Unit)) ;
Casafont-Solé, Ivette (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Solanich, Xavier (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Sánchez-Cerrillo, Idelfonso (Department of Immunology. Hospital Universitario La Princesa) ;
González-Álvaro, Isidoro (Rheumatology Service. Hospital Universitario La Princesa) ;
Raimondo, Maria Gabriella (Deutsches Zentrum Immuntherapie. Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum Erlangen) ;
Ramming, Andreas (Deutsches Zentrum Immuntherapie. Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum Erlangen) ;
Martin, Javier (Instituto de Parasitología y Biomedicina "López-Neyra") ;
Martínez Cáceres, Eva María (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Ballestar, Esteban (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Vento-Tormo1, Roser (Wellcome Sanger Institute. Wellcome Genome Campus) ;
Rodríguez-Ubreva, Javier (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
In COVID-19, hyperinflammatory and dysregulated immune responses contribute to severity. Patients with pre-existing autoimmune conditions can therefore be at increased risk of severe COVID-19 and/or associated sequelae, yet SARS-CoV-2 infection in this group has been little studied. [...]
2024 -  10.1002/eji.202350633
European Journal of Immunology, Vol. 54 Núm. 1 (january 2024) , p. 2350633
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3.
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19 p, 7.0 MB |
Exposing and Overcoming Limitations of Clinical Laboratory Tests in COVID-19 by Adding Immunological Parameters; A Retrospective Cohort Analysis and Pilot Study
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Sánchez-Montalvá, Adrián (Hospital Universitari Vall d'Hebron) ;
Álvarez-Sierra, Daniel (Hospital Universitari Vall d'Hebron) ;
Martínez Gallo, Mónica (Hospital Universitari Vall d'Hebron) ;
Perurena-Prieto, Janire (Hospital Universitari Vall d'Hebron) ;
Arrese-Muñoz, Iria (Hospital Universitari Vall d'Hebron) ;
Ruiz-Rodriguez, Juan Carlos (Hospital Universitari Vall d'Hebron) ;
Espinosa-Pereiro, Juan (Hospital Universitari Vall d'Hebron) ;
Bosch-Nicolau, Pau (Hospital Universitari Vall d'Hebron) ;
Martínez Gómez, Xavier (Hospital Universitari Vall d'Hebron) ;
Antón, Andrés (Hospital Universitari Vall d'Hebron) ;
Martínez-Valle, Ferran (Hospital Universitari Vall d'Hebron) ;
Riveiro Barciela, Mar (Hospital Universitari Vall d'Hebron) ;
Blanco-Grau, Albert (Hospital Universitari Vall d'Hebron) ;
Rodríguez Frías, Francisco (Hospital Universitari Vall d'Hebron) ;
Castellano-Escuder, Pol (Universitat de Barcelona) ;
Poyatos Cantón, E (Hospital Universitari de Bellvitge) ;
Bas, Jordi (Hospital Universitari de Bellvitge) ;
Martínez Cáceres, Eva María (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Sánchez, Alex (Hospital Universitari Vall d'Hebron) ;
Zurera Egea, Coral (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Teniente Serra, Aina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Hernández-González, Manuel (Hospital Universitari Vall d'Hebron) ;
Pujol-Borrell, Ricardo (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
Two years since the onset of the COVID-19 pandemic no predictive algorithm has been generally adopted for clinical management and in most algorithms the contribution of laboratory variables is limited. [...]
2022 - 10.3389/fimmu.2022.902837
Frontiers in immunology, Vol. 13 (june 2022)
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4.
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16 p, 910.9 KB |
Characterization of a proteomic profile associated with organ dysfunction and mortality of sepsis and septic shock
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Ruiz-Sanmartín, Adolfo (Hospital Universitari Vall d'Hebron) ;
Ribas, Vicent (Centre Tecnològic de Catalunya) ;
Suñol, David (Centre Tecnològic de Catalunya) ;
Chiscano-Camón, Luis (Hospital Universitari Vall d'Hebron) ;
Palmada, Clara (Hospital Universitari Vall d'Hebron) ;
Bajaña, Iván (Hospital Universitari Vall d'Hebron) ;
Larrosa, María Nieves (Hospital Universitari Vall d'Hebron) ;
González-López, Juanjo 1975- (Hospital Universitari Vall d'Hebron) ;
Canela, Núria (Centre Tecnològic de Catalunya) ;
Ferrer, Ricard (Hospital Universitari Vall d'Hebron) ;
Ruiz-Rodriguez, Juan Carlos (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
The search for new biomarkers that allow an early diagnosis in sepsis and predict its evolution has become a necessity in medicine. The objective of this study is to identify, through omics techniques, potential protein biomarkers that are expressed in patients with sepsis and their relationship with organ dysfunction and mortality. [...]
2022 - 10.1371/journal.pone.0278708
PloS one, Vol. 17 (december 2022)
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5.
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16 p, 6.4 MB |
JAK2-STAT Epigenetically Regulates Tolerized Genes in Monocytes in the First Encounter With Gram-Negative Bacterial Endotoxins in Sepsis
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Morante-Palacios, Octavio (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Lorente-Sorolla, Clara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ciudad, Laura (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Calafell-Segura, Josep (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Garcia-Gomez, Antonio (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Català-Moll, Francesc (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ruiz-Sanmartín, Adolfo (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Martínez Gallo, Mónica (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ferrer, Ricard (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Ruiz-Rodriguez, Juan Carlos (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Álvarez-Errico, Damiana (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ballestar, Esteban (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Universitat Autònoma de Barcelona.
Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia
Microbial challenges, such as widespread bacterial infection in sepsis, induce endotoxin tolerance, a state of hyporesponsiveness to subsequent infections. The participation of DNA methylation in this process is poorly known. [...]
2021 - 10.3389/fimmu.2021.734652
Frontiers in immunology, Vol. 12 (november 2021) , p. 734652
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6.
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22 p, 5.6 MB |
Epigenetic and transcriptomic reprogramming in monocytes of severe COVID-19 patients reflects alterations in myeloid differentiation and the influence of inflammatory cytokines
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Godoy-Tena, Gerard (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Barmada, Anis (University of Cambridge. Department of Medical Genetics) ;
Morante-Palacios, Octavio (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
de la Calle-Fabregat, Carlos (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Martins-Ferreira, Ricardo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ferreté-Bonastre, Anna G. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ciudad, Laura (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ruiz-Sanmartín, Adolfo (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Martínez Gallo, Mónica (Hospital Universitari Vall d'Hebron) ;
Ferrer, Ricard (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Ruiz-Rodriguez, Juan Carlos (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Rodríguez-Ubreva, Javier (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Vento-Tormo, Roser (Wellcome Sanger Institute. Wellcome Genome Campus, Hinxton, UK) ;
Ballestar, Esteban (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
COVID-19 manifests with a wide spectrum of clinical phenotypes, ranging from asymptomatic and mild to severe and critical. Severe and critical COVID-19 patients are characterized by marked changes in the myeloid compartment, especially monocytes. [...]
2022 - 10.1186/s13073-022-01137-4
Genome Medicine, Vol. 14 (november 2022)
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4 p, 256.4 KB |
Hemadsorption as a Treatment Option for Multisystem Inflammatory Syndrome in Children Associated With COVID-19. A Case Report
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Ruiz-Rodríguez, Juan Carlos (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Chiscano-Camón, Luis (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Palmada, Clara (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ruiz-Sanmartin, Adolf (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
García-de-Acilu, Marina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Plata-Menchaca, Erika (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Perurena-Prieto, Janire (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Hernandez-Gonzalez, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pérez-Carrasco, Marcos (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Soler-Palacín, Pere (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ferrer, Ricard (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Multisystem Inflammatory Syndrome in Children (MIS-C) associated with COVID-19 is characterized by hypercytokinemia leading to overwhelming inflammation. We describe the use of a hemadsorption device as part of the supportive treatment for cytokine storm.
2021 - 10.3389/fimmu.2021.665824
Frontiers in immunology, Vol. 12 (june 2021)
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9 p, 8.2 MB |
Related Factors of Anemia in Critically Ill Patients : A Prospective Multicenter Study
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Juárez-Vela, Raúl (Universidad de La Rioja) ;
Andrés-Esteban, Eva María (Universidad Rey Juan Carlos) ;
Gea-Caballero, Vicente (Universidad Internacional de Madrid) ;
Sánchez-González, Juan Luis (Universidad de Salamanca) ;
Marcos Neira, Pilar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Serrano-Lázaro, Ainhoa (Hospital Clínic Universitari (València)) ;
Tirado-Anglés, Gabriel (Hospital Royo Villanova) ;
Ruiz-Rodriguez, Juan Carlos (Hospital Universitari Vall d'Hebron) ;
Durante, Ángela (Universidad de La Rioja) ;
Santolalla-Arnedo, Iván (Universidad de La Rioja) ;
García-Erce, José Antonio (Banco de sangre y tejidos, Pamplona) ;
Quintana Diaz, Manuel (Hospital Universitario La Paz (Madrid)) ;
Universitat Autònoma de Barcelona
Anemia is common in critically ill patients; almost 95% of patients admitted to intensive care units (ICUs) have hemoglobin levels below normal. Several causes may explain this phenomenon as well as the tendency to transfuse patients without adequate cause: due to a lack of adherence to protocols, lack of supervision, incomplete transfusion request forms, or a lack of knowledge about the indications, risks, and costs of transfusions. [...]
2022 - 10.3390/jcm11041031
Journal of clinical medicine, Vol. 11 (february 2022)
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9.
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10 p, 1.4 MB |
Epidemiology of sepsis in Catalonia : analysis of incidence and outcomes in a European setting
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Yébenes, Juan Carlos (Hospital de Mataró. Consorci Sanitari del Maresme) ;
Ruiz-Rodriguez, Juan Carlos (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ferrer, Ricard (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Cleries, Montserrat (Servei Català de la Salut) ;
Bosch, Anna (Servei Català de la Salut) ;
Lorencio, Carol (Hospital Universitari de Girona Doctor Josep Trueta) ;
Rodríguez, Alejandro (Hospital Universitari Joan XXIII de Tarragona) ;
Nuvials, Xavier (Institut de Recerca Biomèdica de Lleida) ;
Martin-Loeches, Ignacio (St James's University Hospital) ;
Artigas Raventós, Antoni (Universitat Autònoma de Barcelona) ;
Universitat Autònoma de Barcelona
Up-to-date identification of local trends in sepsis incidence and outcomes is of considerable public health importance. The aim of our study was to estimate annual incidence rates and in-hospital mortality trends for hospitalized patients with sepsis in a European setting, while avoiding selection bias in relation to different complexity hospitals. [...]
2017 - 10.1186/s13613-017-0241-1
Annals of Intensive Care, Vol. 7 (february 2017)
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7 p, 203.4 KB |
Cytokine Hemoadsorption as Rescue Therapy for Critically Ill Patients With SARS-CoV-2 Pneumonia With Severe Respiratory Failure and Hypercytokinemia
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Ruiz-Rodríguez, Juan Carlos (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Chiscano-Camón, Luis (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Ruiz-Sanmartin, Adolf (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Palmada, Clara (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Paola Plata-Menchaca, Erika (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Franco-Jarava, Clara (Hospital Universitari Vall d'Hebron) ;
Pérez-Carrasco, Marcos (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Hernández-González, Manuel (Hospital Universitari Vall d'Hebron) ;
Ferrer, Ricard (Universitat Autònoma de Barcelona. Departament de Medicina)
Introduction: A dysregulated inflammatory response, known as "cytokine storm", plays an important role in the pathophysiology of coronavirus 2019 disease (COVID-19). Identifying patients with a dysregulated inflammatory response and at high risk for severe respiratory failure, organ dysfunction, and death is clinically relevant, as they could benefit from the specific therapies, such as cytokine removal by hemoadsorption. [...]
2022 - 10.3389/fmed.2021.779038
Frontiers in Medicine, Vol. 8 (january 2022)
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