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Clinical, virological and biochemical evidence supporting the association of HIV-1 reverse transcriptase polymorphism R284K and thymidine analogue resistance mutations M41L, L210W and T215Y in patients failing tenofovir/emtricitabine therapy / Betancor, Gilberto (Centro de Biología Molecular Severo Ochoa) ; Garriga, César (Centro Nacional de Epidemiología (Espanya)) ; Puertas, Maria C.. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Nevot Banús, Maria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Anta, Lourdes (Hospital Carlos III (Madrid)) ; Blanco, José L. (Hospital Clínic i Provincial de Barcelona) ; Pérez Elías, M. Jesús (Hospital Universitario Ramón y Cajal (Madrid)) ; Mendoza, Carmen de (Hospital Carlos III (Madrid)) ; Martínez, Miguel A. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Menéndez-Arias, Luis (Centro de Biología Molecular Severo Ochoa) ; Spanish AIDS Research Network (ResRIS)
Background: Thymidine analogue resistance mutations (TAMs) selected under treatment with nucleoside analogues generate two distinct genotypic profiles in the HIV-1 reverse transcriptase (RT): (i) TAM1: M41L, L210W and T215Y, and (ii) TAM2: D67N, K70R and K219E/Q, and sometimes T215F. [...]
2012 - DOI (Digital Object Identifier)

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