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5 p, 230.8 KB |
Cataract Surgery in Elderly Subjects with Heterozygous Familial Hypercholesterolemia in Prolonged Treatment with Statins
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Marco-Benedí, Victoria (Universidad de Zaragoza. Departamento de Medicina, Psiquiatría y Dermatología) ;
Laclaustra, Martín (Universidad de Zaragoza. Departamento de Medicina, Psiquiatría y Dermatología) ;
Sánchez-Hernández, Rosa M. (Hospital Universitario Insular de Gran Canaria) ;
Ortega, Emilio (Hospital Clínic i Provincial de Barcelona) ;
Pedro-Botet, Juan (Hospital del Mar (Barcelona, Catalunya)) ;
Puzo, Jose (Hospital San Jorge) ;
Civeira, Fernando (Universidad de Zaragoza. Departamento de Medicina, Psiquiatría y Dermatología) ;
Universitat Autònoma de Barcelona
Background: Cataracts are the main cause of blindness and represent one fifth of visual problems worldwide. It is still unknown whether prolonged statin treatment favors the development of cataracts. [...]
2021 -  10.3390/jcm10163494
Journal of clinical medicine, Vol. 10 (august 2021)
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29 p, 1.1 MB |
Elucidating the Effects of the Lipids Regulators Fibrates and Statins on the Health Status of Finfish Species : A Review
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Blonç, Manuel (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Lima, Jennifer (Universidade de São Paulo. Department of Physiology) ;
Balasch Alemany, Joan Carles (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Tort Bardolet, Lluís (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Gravato, Carlos (University of Lisbon. Faculty of Sciences) ;
Teles, Mariana (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Pharmaceuticals used to treat abnormal cholesterol levels in the blood are known as lipid regulators (fibrates and statins), and their use is in constant growth. Treatment plants are usually unable to efficiently remove these compounds from wastewater, where their degradation rate is considerably slow, making them an emerging concern for aquatic systems. [...]
2023 - 10.3390/ani13050792
Animals, Vol. 13 (february 2023)
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20 p, 189.2 KB |
LDL Cholesterol Reduction Variability with Different Types and Doses of Statins in Monotherapy or Combined with Ezetimibe. Results from the Spanish Arteriosclerosis Society Dyslipidaemia Registry
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Climent, Elisenda (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Bea Sanz, Ana Maria (Hospital Universitario Miguel Servet (Saragossa)) ;
Benaiges, David (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Brea-Hernando, Ángel (Hospital San Pedro, Logroño) ;
Pintó, Xavier (Hospital Universitari de Bellvitge) ;
Suarez Tembra, Manuel (Hospital San Rafael, A Coruña) ;
Perea, Verónica (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Plana, Núria (Hospital Universitari Sant Joan de Reus (Tarragona)) ;
Blanco Vaca, Francisco (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Pedro-Botet, Juan (Universitat Autònoma de Barcelona. Departament de Medicina)
Purpose: Low-density lipoprotein (LDL) cholesterol reduction by statin therapy is dose-dependent, varies among different statins, and has wide inter-individual variability. The present study aimed to compare mean LDL cholesterol reduction and its variability achieved with different doses of the three statins most frequently used in monotherapy or combined with ezetimibe in a real clinical setting. [...]
2022
Cardiovascular Drugs and Therapy, Vol. 36 Núm. 2 (2022) , p. 301-308
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8 p, 401.5 KB |
Impact of Medication Adherence on Mortality and Cardiovascular Morbidity : Protocol for a Population-Based Cohort Study
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Giner-Soriano, Maria (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Sotorra Figuerola, Gerard (Universitat Autònoma de Barcelona) ;
Cortés, Jordi (Universitat Autònoma de Barcelona) ;
Pera Pujadas, Helena (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Garcia-Sangenis, Ana (Universitat Autònoma de Barcelona) ;
Morros, Rosa (Institut Universitari d'Investigació en Atenció Primària Jordi Gol)
Cardiovascular disease (CVD) is a group of disorders of the heart and blood vessels, such as coronary heart disease (CHD), cerebrovascular disease, and peripheral artery disease. CVD is the leading threat to global health, whether measured by mortality, morbidity, or economic cost. [...]
2018 - 10.2196/resprot.8121
JMIR Research Protocols, Vol. 7, Issue 3 (March 2018) , art. e73
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11 p, 3.4 MB |
Low-dose statin treatment increases prostate cancer aggressiveness
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Caro-Maldonado, Alfredo (CIC bioGUNE, Bizkaia Technology Park, Derio, Spain) ;
Camacho, Laura (Biochemistry and Molecular Biology Department, University of the Basque Country, Bilbao, Spain) ;
Zabala-Letona, Amaia (Centro de Investigación Biomédica en Red de Cáncer) ;
Torrano, Verónica (Centro de Investigación Biomédica en Red de Cáncer) ;
Fernández Ruiz, Sonia (Centro de Investigación Biomédica en Red de Cáncer) ;
Zamacola-Bascaran, Kepa (CIC bioGUNE, Bizkaia Technology Park, Derio, Spain) ;
Arreal, Leire (CIC bioGUNE, Bizkaia Technology Park, Derio, Spain) ;
Valcárcel-Jiménez, Lorea (CIC bioGUNE, Bizkaia Technology Park, Derio, Spain) ;
Martín-Martín, Natalia (Centro de Investigación Biomédica en Red de Cáncer) ;
Flores, Juana M. (Department of Animal Medicine and Surgery, School of Veterinary Medicine, Complutense University of Madrid, Madrid, Spain) ;
Cortazar, Ana Rosa (CIC bioGUNE, Bizkaia Technology Park, Derio, Spain) ;
Zúñiga-García, Patricia (CIC bioGUNE, Bizkaia Technology Park, Derio, Spain) ;
Arruabarrena-Aristorena, Amaia (CIC bioGUNE, Bizkaia Technology Park, Derio, Spain) ;
Guillaumond, Fabienne (Université Aix-Marseille, Marseille, France) ;
Cabrera, Diana (CIC bioGUNE, Bizkaia Technology Park, Derio, Spain) ;
Falcón-Perez, Juan M. (IKERBASQUE, Basque foundation for science, Bilbao, Spain) ;
Aransay, Ana M. (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Gomez Muñoz, Antonio (Biochemistry and Molecular Biology Department, University of the Basque Country, Bilbao, Spain) ;
Olivan, M. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Morote Robles, Juan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Carracedo, Arkaitz (IKERBASQUE, Basque foundation for science, Bilbao, Spain) ;
Universitat Autònoma de Barcelona
Prostate cancer is diagnosed late in life, when co-morbidities are frequent. Among them, hypertension, hypercholesterolemia, diabetes or metabolic syndrome exhibit an elevated incidence. In turn, prostate cancer patients frequently undergo chronic pharmacological treatments that could alter disease initiation, progression and therapy response. [...]
2017 - 10.18632/oncotarget.22217
Oncotarget, Vol. 9 (october 2017) , p. 1494-1504
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8 p, 630.1 KB |
Consensus on the Statin of Choice in Patients with Impaired Glucose Metabolism : results of the DIANA Study
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Millán Núñez-Cortés, Jesús (Hospital General Universitario Gregorio Marañón) ;
Cases Amenós, Aleix (Hospital Clínic i Provincial de Barcelona) ;
Ascaso, Juan F (Hospital Clínic Universitari (València)) ;
Barrios, Vivencio (Hospital Universitario Ramón y Cajal (Madrid)) ;
Pascual Fuster, Vicente (Centro de Salud Palleter, Castellón, Spain) ;
Pedro-Botet Montoya, Juan Carles (Hospital del Mar (Barcelona, Catalunya)) ;
Pintó, Xavier (Hospital Universitari de Bellvitge) ;
Serrano Cumplido, Adalberto (Centro de Salud de Repélega (Portugalete, País Basc)) ;
Universitat Autònoma de Barcelona
Despite the recognized clinical benefit of statins on cardiovascular prevention, providing correct management of hypercholesterolaemia, possible adverse effects of their use cannot be disregarded. Previously published data shows that there is a risk of developing diabetes mellitus or experiencing changes in glucose metabolism in statin-treated patients. [...]
2016 - 10.1007/s40256-016-0197-9
American Journal of Cardiovascular Drugs, Vol. 17 (november 2016) , p. 135-142
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9 p, 695.8 KB |
Role of Serum Cholesterol and Statin Use in the Risk of Prostate Cancer Detection and Tumor Aggressiveness
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Morote Robles, Juan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Celma, Ana (Hospital Universitari Vall d'Hebron) ;
Planas, Jacques (Hospital Universitari Vall d'Hebron) ;
Placer, José (Hospital Universitari Vall d'Hebron) ;
de Torres, Inés (Hospital Universitari Vall d'Hebron) ;
Olivan, M. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Carles, Joan (Universitat Internacional de Catalunya. Departament de Ciències Bàsiques) ;
Reventós, Jaume (Institut d'Investigació Biomèdica de Bellvitge) ;
Doll, Andreas (Universitat Internacional de Catalunya. Departament de Ciències Bàsiques)
The aim of this study was to analyze the relationship between statin use along with serum cholesterol levels and prostate cancer (PCa) detection and aggressiveness. Statin users of three years or more and serum cholesterol levels (SC) were assessed in 2408 men scheduled for prostate biopsy. [...]
2014 - 10.3390/ijms150813615
International journal of molecular sciences, Vol. 15 (august 2014) , p. 13615-13623
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8 p, 611.0 KB |
Development of a Novel Heart Failure Risk Tool : The Barcelona Bio-Heart Failure Risk Calculator (BCN Bio-HF Calculator)
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Lupón, Josep (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
de Antonio Ferrer, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Vila, Joan (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Peñafiel, Judith (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Galán, Amparo (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Zamora, Elisabet (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Urrutia de Diego, Agustín (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bayés-Genís, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Background: A combination of clinical and routine laboratory data with biomarkers reflecting different pathophysiological pathways may help to refine risk stratification in heart failure (HF). A novel calculator (BCN Bio-HF calculator) incorporating N-terminal pro B-type natriuretic peptide (NT-proBNP, a marker of myocardial stretch), high-sensitivity cardiac troponin T (hs-cTnT, a marker of myocyte injury), and high-sensitivity soluble ST2 (ST2), (reflective of myocardial fibrosis and remodeling) was developed. [...]
2014 - 10.1371/journal.pone.0085466
PloS one, Vol. 9, Issue 1 (January 2014) , p.e85466
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