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Articles, 12 records found
Articles 12 records found  1 - 10next  jump to record:
1.
12 p, 1.2 MB Plasma biomarkers for amyloid, tau, and cytokines in Down syndrome and sporadic Alzheimer's disease / Startin, Carla M. (LonDownS Consortium (London Down Syndrome Consortium)) ; Ashton, Nicholas J. (University of Gothenburg) ; Hamburg, Sarah (LonDownS Consortium (London Down Syndrome Consortium)) ; Hithersay, Rosalyn (LonDownS Consortium (London Down Syndrome Consortium)) ; Wiseman, Frances K. (University College London) ; Mok, Kin Y. (Hong Kong University of Science and Technology) ; Hardy, John (University College London) ; Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ; Lovestone, Simon (University of Oxford) ; Parnetti, Lucilla (University of Perugia) ; Zetterberg, Henrik (UCL Institute of Neurology (Regne Unit)) ; Hye, Abdul (Maudsley NHS Foundation) ; Fisher, Elisabeth ; Nizetic, Dean ; Tybulewicz, Victor ; Karmiloff-Smith, Anette ; Al-Janabi, Tamara ; Zhang, David ; Strydom, André (LonDownS Consortium (London Down Syndrome Consortium)) ; Universitat Autònoma de Barcelona
Down syndrome (DS), caused by chromosome 21 trisomy, is associated with an ultra-high risk of dementia due to Alzheimer's disease (AD), driven by amyloid precursor protein (APP) gene triplication. Understanding relevant molecular differences between those with DS, those with sporadic AD (sAD) without DS, and controls will aid in understanding AD development in DS. [...]
2019 - 10.1186/s13195-019-0477-0
Alzheimer's research & therapy, Vol. 11 Núm. 1 (21 2019) , p. 26  
2.
12 p, 2.0 MB A multicentre validation study of the diagnostic value of plasma neurofilament light / Ashton, Nicholas J. (NIHR Biomedical Research Centre for Mental Health (Londres, Regne Unit)) ; Janelidze, Shorena (Clinical Memory Research Unit. Department of Clinical Sciences Malmö. Lund University) ; Al Khleifat, Ahmad (Department of Basic and Clinical Neuroscience. Maurice Wohl Clinical Neuroscience Institute. King's College London) ; Leuzy, Antoine (Clinical Memory Research Unit. Department of Clinical Sciences Malmö. Lund University) ; van der Ende, Emma L. (Alzheimer Center Rotterdam and Dept. of Neurology. Erasmus University Medical Center) ; Karikari, Thomas K (Department of Psychiatry and Neurochemistry. Institute of Neuroscience & Physiology. The Sahlgrenska Academy at the University of Gothenburg) ; Benedet, AndreaL. (Montreal Neurological Institute) ; Pascoal, Tharick A. (Montreal Neurological Institute) ; Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ; Parnetti, Lucilla (Laboratory of Clinical Neurochemistry. Neurology Clinic. University of Perugia) ; Galimberti, Daniela (University of Milan) ; Bonanni, Laura (Department of Neuroscience. Imaging and Clinical Sciences. University G.d'Annunzio of Chieti-Pescara) ; Pilotto, Andrea (Parkinson's Disease Rehabilitation Centre. FERB ONLUS) ; Padovani, Alessandro (Neurology Unit. Department of Clinical and Experimental Sciences. University of Brescia) ; Lycke, Jan (Sahlgrenska University Hospital (Suècia)) ; Novakova, Lenka (Sahlgrenska University Hospital (Suècia)) ; Axelsson, Markus (Sahlgrenska University Hospital (Suècia)) ; Velayudhan, Latha (Department of Health Sciences. University of Leicester) ; Rabinovici, Gil D. (Department of Radiology & Biomedical Imaging. University of California) ; Miller, Bruce L. (University of California San Francisco. Memory and Aging Center) ; Pariante, Carmine M (Stress. Psychiatry and Immunology Lab & Perinatal Psychiatry. Maurice Wohl Clinical Neuroscience Institute. King's College London) ; Nikkheslat, Naghmeh (King's College London (Regne Unit)) ; Resnick, Susan M. (Brain Aging and Behavior Section. Laboratory of Behavioral Neuroscience. National Institute on Aging. National Institutes of Health) ; Thambisetty, Madhav (Clinical and Translational Neuroscience Section. Laboratory of Behavioral Neuroscience. National Institute on Aging. National Institutes of Health) ; Schöll, Michael (Department of Neurodegenerative Disease. Queen Square Institute of Neurology. University College London) ; Fernández-Eulate, Gorka (Department of Neurology. Donostia University Hospital. Osakidetza) ; Gil-Bea, Francisco J. (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; López de Munain, Adolfo (Universidad del País Vasco. Departamento de Neurociencias) ; Al-Chalabi, Ammar (King's College Hospital NHS Foundation Trust) ; Rosa-Neto, Pedro (Montreal Neurological Institute) ; Strydom, Andre (London Down Syndrome Consortium (LonDowns)) ; Svenningsson, Per (Karolinska Institutet (Estocolm, Suècia). Department of Clinical Neuroscience) ; Stomrud, Erik (Skåne University Hospital (Suècia)) ; Santillo, Alexander (Lund University. Department of Clinical Sciences Malmö) ; Aarsland, Dag (Stavanger University Hospital) ; van Swieten, John C. (Erasmus University Medical Center) ; Palmqvist, Sebastian (Lund University. Skåne University Hospital) ; Zetterberg, Henrik (University College London. UK Dementia Research Institute) ; Blennow, Kaj (Sahlgrenska University Hospital (Suècia)) ; Hye, Abdul (Stavanger University Hospital) ; Hansson, Oskar (Skåne University Hospital (Suècia))
Increased cerebrospinal fluid neurofilament light (NfL) is a recognized biomarker for neurodegeneration that can also be assessed in blood. Here, we investigate plasma NfL as a marker of neurodegeneration in 13 neurodegenerative disorders, Down syndrome, depression and cognitively unimpaired controls from two multicenter cohorts: King's College London (n = 805) and the Swedish BioFINDER study (n = 1,464). [...]
2021 - 10.1038/s41467-021-23620-z
Nature communications, Vol. 12 Núm. 1 (january 2021) , p. 3400  
3.
11 p, 712.3 KB Comparison of covid-19 and non-covid-19 pneumonia in down syndrome / Real de Asua, Diego (Instituto de Investigación Hospital Universitario de la Princesa) ; Mayer, Miguel Angel (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ; Del Carmen Ortega, María (Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12)) ; Borrel, Jose M. (Down España Huesca) ; de Jesús Bermejo, Teresa (Unidad de Neuropediatría. Instituto Hispalense de Pediatría) ; González-lamuño, Domingo (Instituto de Investigación Sanitaria Valdecilla (Santander, Cantàbria)) ; Manso, Coral (Down España) ; Moldenhauer, Fernando (Instituto de Investigación Hospital Universitario de la Princesa) ; Carmona Iragui, María (Institut d'Investigació Biomèdica Sant Pau) ; Hüls, Anke (Department of Epidemiology and Gangarosa. Department of Environmental Health. Rollins School of Public Health. Emory University) ; Sherman, Stephanie L. (Department of Human Genetics. School of Medicine. Emory University) ; Strydom, Andre (The London Down Syndrome (LonDownS) Consortium. London. United Kingdom and South London and the Maudsley NHS Foundation Trust) ; De La Torre, Rafael (Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición) ; Dierssen, Mara (Biomedical Research Networking Center for Rare Diseases (CIBERER)) ; Universitat Autònoma de Barcelona
Whether the increased risk for coronavirus disease 2019 (COVID-19) hospitalization and death observed in Down syndrome (DS) are disease specific or also occur in individuals with DS and non-COVID-19 pneumonias is unknown. [...]
2021 - 10.3390/jcm10163748
Journal of clinical medicine, Vol. 10 Núm. 16 (february 2021) , p. 3748  
4.
9 p, 938.4 KB Conducting clinical trials in persons with Down syndrome : summary from the NIH INCLUDE Down syndrome clinical trials readiness working group / Baumer, Nicole (Boston Children's Hospital (Boston, Estats Units d'Amèrica)) ; Becker, Mara L. (Duke University School of Medicine) ; Capone, George (The Johns Hopkins School of Medicine) ; Egan, Kathleen (Parent/Advocate, Virginia, USA) ; Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ; Handen, Benjamin L. (University of Pittsburgh) ; Head, Elizabeth (University of California) ; Hendrix, James E. (LuMind IDSC Foundation, Burlington, USA) ; Litovsky, Ruth Y. (University of Wisconsin) ; Strydom, Andre (King's College London) ; Tapia, Ignacio E. (University of Pennsylvania) ; Rafii, Michael S. (University of Southern California) ; Universitat Autònoma de Barcelona
The recent National Institute of Health (NIH) INCLUDE (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE) initiative has bolstered capacity for the current increase in clinical trials involving individuals with Down syndrome (DS). [...]
2022 - 10.1186/s11689-022-09435-z
Journal of Neurodevelopmental Disorders, Vol. 14 (march 2022)  
5.
20 p, 1.6 MB Immune Dysregulation and the Increased Risk of Complications and Mortality Following Respiratory Tract Infections in Adults With Down Syndrome / Illouz, Tomer (Bar-Ilan University) ; Biragyn, Arya (National Institute on Aging, National Institute of Health, Baltimore) ; Iulita, M. Florencia (Institut d'Investigació Biomèdica Sant Pau) ; Flores-Aguilar, Lisi (McGill University) ; Dierssen, Mara (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; De Toma, Ilario (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Antonarakis, Stylianos E. (iGE3 Institute of Genetics and Genomics of Geneva) ; Yu, Eugene (State University of New York at Buffalo) ; Herault, Yann (Université de Strasbourg) ; Potier, Marie-Claude (Paris Brain Institute (ICM)) ; Botté, Alexandra (Paris Brain Institute (ICM)) ; Roper, Randall (Indiana University-Purdue University Indianapolis) ; Sredni, Benjamin (Bar-Ilan University) ; London, Jacqueline (Université de Paris) ; Mobley, William (University of California, San Diego) ; Strydom, Andre (South London and Maudsley NHS Foundation Trust) ; Okun, Eitan (Bar-Ilan University) ; Universitat Autònoma de Barcelona
The risk of severe outcomes following respiratory tract infections is significantly increased in individuals over 60 years, especially in those with chronic medical conditions, i. e. , hypertension, diabetes, cardiovascular disease, dementia, chronic respiratory disease, and cancer. [...]
2021 - 10.3389/fimmu.2021.621440
Frontiers in immunology, Vol. 12 (june 2021)  
6.
2 p, 347.5 KB Correction to : Specific Susceptibility to COVID-19 in Adults with Down Syndrome / Illouz, Tomer (Bar-Ilan University) ; Biragyn, Arya (NIA. Laboratory of Molecular Biology and Immunology) ; Frenkel-Morgenstern, Milana (Bar-Ilan University) ; Weissberg, Orly (Bar-Ilan University) ; Gorohovski, Alessandro (Bar-Ilan University) ; Merzon, Eugene (Tel Aviv University) ; Green, Ilan (Tel Aviv University) ; Iulita, M. Florencia (Institut d'Investigació Biomèdica Sant Pau) ; Flores-Aguilar, Lisi (McGill University) ; Dierssen, Mara (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; De Toma, Ilario (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Lifshitz, Hefziba (Bar-Ilan University) ; Antonarakis, Stylianos E. (iGE3 Institute of Genetics and Genomics of Geneva) ; Yu, Eugene (State University of New York At Buffalo) ; Herault, Yann (Université de Strasbourg) ; Potier, Marie-Claude (Sorbonne Université) ; Botté, Alexandra (Sorbonne Université) ; Roper, Randall (Indiana University-Purdue University Indianapolis) ; Sredni, Benjamin (Bar-Ilan University) ; Sarid, Ronit (Sorbonne Université) ; London, Jacqueline (Université de Paris) ; Mobley, William (University of California) ; Strydom, Andre (South London and Maudsley NHS Foundation Trust) ; Okun, Eitan (Bar-Ilan University) ; Universitat Autònoma de Barcelona
2021 - 10.1007/s12017-021-08695-7
Neuromolecular Medicine, may 2021, p. 1-2  
7.
11 p, 935.0 KB Specific Susceptibility to COVID-19 in Adults with Down Syndrome / Illouz, Tomer (Bar-Ilan University. The Paul Feder Laboratory On Alzheimer's Disease Research) ; Biragyn, Arya (NIA. Laboratory of Molecular Biology and Immunology) ; Frenkel-Morgenstern, Milana (Bar-Ilan University. Cancer Genomics and BioComputing of Complex Diseases Lab, Azrieli Faculty of Medicine) ; Weissberg, Orly (Bar-Ilan University. Cancer Genomics and BioComputing of Complex Diseases Lab, Azrieli Faculty of Medicine) ; Gorohovski, Alessandro (Bar-Ilan University. Cancer Genomics and BioComputing of Complex Diseases Lab, Azrieli Faculty of Medicine) ; Merzon, Eugene (Tel Aviv University. Leumit Health Services, Department of Family Medicine, Sackler School of Medicine) ; Green, Ilan (Tel Aviv University. Leumit Health Services, Department of Family Medicine, Sackler School of Medicine) ; Iulita, M. Florencia (Institut d'Investigació Biomèdica Sant Pau) ; Flores-Aguilar, Lisi (McGill University. Department of Anatomy and Cell Biology) ; del Mar Dierssen Sotos, Maria (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; De Toma, Ilario (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Lifshitz, Hefziba (Bar-Ilan University. School of Education) ; Antonarakis, Stylianos E. (iGE3 Institute of Genetics and Genomics of Geneva, 1211 Geneva, Switzerland) ; Yu, Eugene (State University of New York At Buffalo. Genetics, Genomics and Bioinformatics Program) ; Herault, Yann (IGBMC-UMR. Université de Strasbourg, CNRS, INSERM, Institut de Génétique Biologie Moléculaire Et Cellulaire) ; Potier, Marie-Claude (Sorbonne Université, Hôpital de La Pitié-Salpêtrière. Paris Brain Institute (ICM), CNRS UMR7225, INSERM U1127) ; Botté, Alexandra (Sorbonne Université, Hôpital de La Pitié-Salpêtrière. Paris Brain Institute (ICM), CNRS UMR7225, INSERM U1127) ; Roper, Randall (Indiana University-Purdue University Indianapolis. Department of Biology) ; Sredni, Benjamin (Bar-Ilan University. The Mina and Everard Goodman Faculty of Life Sciences) ; Sarid, Ronit (Bar-Ilan University. The Mina and Everard Goodman Faculty of Life Sciences) ; London, Jacqueline (CNRS. Université de Paris, BFA, UMR 8251) ; Mobley, William (University of California. Department of Neurosciences) ; Strydom, Andre (South London and Maudsley NHS Foundation Trust) ; Okun, Eitan (Bar-Ilan University. The Mina and Everard Goodman Faculty of Life Sciences) ; Universitat Autònoma de Barcelona
The current SARS-CoV-2 outbreak, which causes COVID-19, is particularly devastating for individuals with chronic medical conditions, in particular those with Down Syndrome (DS) who often exhibit a higher prevalence of respiratory tract infections, immune dysregulation and potential complications. [...]
2021 - 10.1007/s12017-021-08651-5
Neuromolecular Medicine, march 2021, p. 1-11  
8.
13 p, 1.5 MB Medical vulnerability of individuals with Down syndrome to severe COVID-19-data from the Trisomy 21 Research Society and the UK ISARIC4C survey / Hüls, Anke (Department of Epidemiology and Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA) ; Costa, Alberto C. S. (Departments of Pediatrics and of Psychiatry, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA) ; Dierssen, Mara (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Baksh, R. Asaad (The London Down Syndrome (LonDownS) Consortium, London, United Kingdom) ; Bargagna, Stefania (Fondazione Stella Maris IRCCS, Pisa, Italy) ; Baumer, Nicole (Harvard Medical School) ; Brandão, Ana Claudia (Hospital Israelita Albert Einstein (Sao Paolo, Brasil)) ; Carfi, Angelo (Policlinico Universitario Agostino Gemelli IRCCS (Roma, Itàlia)) ; Carmona Iragui, María (Institut d'Investigació Biomèdica Sant Pau) ; Chicoine, Brian (Advocate Medical Group Adult Down Syndrome Center, Park Ridge, IL, USA) ; Ghosh, Sujay (Cytogenetics and Genomics Reserach Unit. Department of Zoology, University of Calcutta.Kolkata. West Bengal, India) ; Lakhanpaul, Monica (Whttington NHS Trust, London, United Kingdom; Down Syndrome Medical Interest Group, London, United Kingdom) ; Manso, Coral (CM: DOWN ESPAÑA, Madrid, Spain) ; Mayer, Miguel-Angel (Institut Hospital del Mar d'Investigacions Mèdiques) ; Ortega, Maria del Carmen (Hospital Universitario 12 de Octubre (Madrid)) ; de Asua, Diego Real (Instituto de Investigación Hospital Universitario de la Princesa) ; Rebillat, Anne-Sophie (Institut Jérôme Lejeune, Paris, France) ; Russell, Lauren Ashley (Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA) ; Sgandurra, Giuseppina (Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy) ; Valentini, Diletta (Bambino Gesù Children's Hospital) ; Sherman, Stephanie L. (Department of Human Genetics, School of Medicine, Emory University, Atlanta, Georgia, USA) ; Strydom, Andre (South London and the Maudsley NHS Foundation Trust) ; Universitat Autònoma de Barcelona
Health conditions, immune dysfunction, and premature aging associated with trisomy 21 (Down syndrome, DS) may impact the clinical course of COVID-19. The T21RS COVID-19 Initiative launched an international survey for clinicians or caregivers on patients with COVID-19 and DS. [...]
2021 - 10.1016/j.eclinm.2021.100769
EClinicalMedicine, february 2021  
9.
8 p, 395.8 KB Neurodevelopmental risk copy number variants in adults with intellectual disabilities and comorbid psychiatric disorders / Thygesen, Johan H. (University College London) ; Wolfe, Kate (University College London) ; McQuillin, Andrew (University College London) ; Viñas-Jornet, Marina (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ; Baena Díez, Neus (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ; Brison, Nathalie (University Hospitals Leuven (Bèlgica)) ; D'Haenens, Greet (Bierbeek. St Camillus Psychiatric Hospital) ; Esteba-Castillo, Susanna (Institut Assistència Sanitària (IAS)) ; Gabau, Elisabeth (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ; Ribas-Vidal, Núria (Institut Assistència Sanitària (IAS)) ; Ruiz, Anna (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ; Vermeesch, Joris (University Hospitals Leuven (Bèlgica)) ; Weyts, Eddy (Bierbeek. St Camillus Psychiatric Hospital) ; Novell, Ramon (Institut Assistència Sanitària (IAS)) ; Buggenhout, Griet Van (Leuven. University Hospitals Leuven. Department of Human Genetics, Centre for Human Genetics) ; Strydom, André (University College London) ; Bass, Nicholas (University College London) ; Guitart, Míriam (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ; Vogels, Annick (University Hospitals Leuven (Bèlgica)) ; Universitat Autònoma de Barcelona
Copy number variants (CNVs) are established risk factors for neurodevelopmental disorders. To date the study of CNVs in psychiatric illness has focused on single disorder populations. The role of CNVs in individuals with intellectual disabilities and psychiatric comorbidities are less well characterised. [...]
2018 - 10.1192/bjp.2017.65
The British Journal of Psychiatry, Vol. 212 (may 2018) , p. 287-294  
10.
16 p, 930.6 KB Assessing general cognitive and adaptive abilities in adults with Down syndrome : a systematic review / Hamburg, Sarah (The London Down Syndrome Consortium (LonDownS), London, UK) ; Lowe, Bryony (Loughborough University. Department of Psychology) ; Startin, Carla Marie (The London Down Syndrome Consortium (LonDownS), London, UK) ; Padilla, Concepción (Department of Psychiatry, Herchel Smith Building for Brain & Mind Sciences, Forvie Site, Robinson Way, Cambridge, CB2 0SZ UK) ; Coppus, Antonia (Radboud University Medical Center. Department of Primary and Community Care) ; Silverman, Wayne (University of California. Department of Pediatrics) ; Fortea, Juan (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Zaman, Shahid (Department of Psychiatry, Herchel Smith Building for Brain & Mind Sciences, Forvie Site, Robinson Way, Cambridge, CB2 0SZ UK) ; Head, Elizabeth (University of Kentucky. Sanders-Brown Center on Aging) ; Handen, Benjamin L. (University of Pittsburgh School of Medicine. Department of Psychiatry) ; Lott, Ira (University of California. Departments of Pediatrics and Neurology) ; Song, Weihong (The University of British Columbia. Townsend Family Laboratories, Department of Psychiatry) ; Strydom, André (The London Down Syndrome Consortium (LonDownS), London, UK)
NOUAB.
Measures of general cognitive and adaptive ability in adults with Down syndrome (DS) used by previous studies vary substantially. This review summarises the different ability measures used previously, focusing on tests of intelligence quotient (IQ) and adaptive behaviour (AB), and where possible examines floor effects and differences between DS subpopulations. [...]

2019 - 10.1186/s11689-019-9279-8
Journal of Neurodevelopmental Disorders, Vol. 11 (august 2019)  

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13 Strydom, Andre
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