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1.
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17 p, 1.2 MB |
Impact of Minimal Residual Disease on Progression-Free Survival Outcomes after Fixed-Duration Ibrutinib-Venetoclax Versus Chlorambucil-Obinutuzumab in the GLOW Study
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Munir, Talha (St James's Hospital) ;
Moreno, Carol (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Owen, Carolyn (Tom Baker Cancer Centre) ;
Follows, George (Addenbrookes Hospital (Cambridge, Regne Unit)) ;
Benjamini, Ohad (Sheba Medical Center) ;
Janssens, Ann (UZ Leuven Gasthuisberg) ;
Levin, Mark-David (Albert Schweitzer Hospital) ;
Osterborg, Anders (Karolinska University Hospital and Karolinska Institutet (Suecia)) ;
Robak, Tadeusz (Medical University of Lodz. Copernicus Memorial Hospital) ;
Simkovic, Martin (University Hospital Hradec Kralove (República Txeca)) ;
Stevens, Don (Norton Cancer Institute) ;
Voloshin, Sergey (Russian Scientific and Research Institute of Hematology and Transfusiology) ;
Vorobyev, Vladimir (S.P. Botkin Moscow City Clinical Hospital) ;
Yagci, Munci (Gazi Universitesi Tip Fakultesi) ;
Ysebaert, Loic (Institut Universitaire du Cancer Toulouse Oncopole) ;
Qi, Keqin (Janssen Research & Development) ;
Qi, Qianya (Janssen Research & Development) ;
Parisi, Lori (Janssen Research & Development) ;
Srinivasan, Srinivasan (Oncology Translational Research. Janssen Research & Development) ;
Schuier, Natasha (Janssen Research & Development) ;
Baeten, Kurt (Janssen Research & Development) ;
Howes, Angela (Janssen Research & Development) ;
Caces, Donne Bennett (Janssen Research & Development) ;
Niemann, Carsten U (Rigshospitalet Copenhagen University Hospital) ;
Kater, Arnon P. (Amsterdam Medical Centers. University of Amsterdam)
PURPOSEIn GLOW, fixed-duration ibrutinib + venetoclax showed superior progression-free survival (PFS) versus chlorambucil + obinutuzumab in older/comorbid patients with previously untreated chronic lymphocytic leukemia (CLL). [...]
2023 -  10.1200/JCO.22.02283
Journal of Clinical Oncology, Vol. 41 Núm. 21 (20 2023) , p. 3689-3699
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2.
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15 p, 1.6 MB |
A trans-omics assessment of gene-gene interaction in early-stage NSCLC
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Chen, Jiajin (Nanjing Medical University) ;
Song, Yunjie (Department of Biostatistics. Nanjing Medical University) ;
Li, Yi (Department of Biostatistics. University of Michigan) ;
Wei, Yongyue (Nanjing Medical University) ;
Shen, Sipeng (Department of Biostatistics. Nanjing Medical University) ;
Zhao, Yang (Department of Biostatistics. Nanjing Medical University) ;
You, Dongfang (Department of Biostatistics. Nanjing Medical University) ;
Su, Li (Harvard Medical School) ;
Bjaanæs, Maria Moksnes (Department of Cancer Genetics Oslo University Hospital) ;
Karlsson, Anna (Department of Clinical Sciences. Lund University) ;
Planck, Maria (Department of Clinical Sciences. Lund University) ;
Staaf, Johan (Department of Clinical Sciences. Lund University) ;
Helland, Åslaug (Institute of Clinical Medicine. University of Oslo) ;
Esteller, M (Universitat de Barcelona) ;
Shen, Hongbing (Nanjing Medical University) ;
Christiani, David C. (Harvard Medical School) ;
Zhang, Ruyang (Nanjing Medical University) ;
Chen, Feng (State Key Laboratory of Reproductive Medicine. Nanjing Medical University)
Epigenome-wide gene-gene (G × G) interactions associated with non-small-cell lung cancer (NSCLC) survival may provide insights into molecular mechanisms and therapeutic targets. Hence, we proposed a three-step analytic strategy to identify significant and robust G × G interactions that are relevant to NSCLC survival. [...]
2023 - 10.1002/1878-0261.13345
Molecular Oncology, Vol. 17 Núm. 1 (january 2023) , p. 173-187
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3.
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11 p, 771.0 KB |
Do GWAS-Identified Risk Variants for Chronic Lymphocytic Leukemia Influence Overall Patient Survival and Disease Progression?
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Cabrera Serrano, Antonio José (Instituto de Investigación Sanitaria de Granada) ;
Sánchez Maldonado, José Manuel (Instituto de Investigación Sanitaria de Granada) ;
ter Horst, Rob (CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences) ;
Macauda, Angelica (German Cancer Research Center) ;
García Martín, Paloma (Hospital Campus de la Salud (Granada)) ;
Benavente, Yolanda (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
Landi, Stefano (Department of Biology. University of Pisa) ;
Clay-Gilmour, Alyssa (Department of Epidemiology & Biostatistics. Arnold School of Public Health. University of South Carolina) ;
Niazi, Yasmeen (Hopp Children's Cancer Center) ;
Espinet, Blanca (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Rodriguez-Sevilla, Juan Jose (Department of Leukemia. The University of Texas MD Anderson Cancer Center) ;
Pérez, Eva María (Hospital Campus de la Salud) ;
Maffei, Rossana (University of Modena and Reggio Emilia) ;
Blanco, Gonzalo (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Giaccherini, Matteo (Department of Biology. University of Pisa) ;
Cerhan, James R. (Department of Quantitative Health Sciences. Mayo Clinic) ;
Marasca, Roberto (Department of Medical and Surgical Sciences. University of Modena and Reggio Emilia. AOU Policlinico) ;
Lopez Nevot, Miguel Angel (Hospital Universitario Virgen de las Nieves (Granada)) ;
Chen-Liang, Tzu Hua (Hospital Universitario Morales Meseguer (Múrcia)) ;
Thomsen, Hauke (MSB Medical School Berlin) ;
Gámez, Irene (Hematology Department. Morales Meseguer University Hospital) ;
Campa, Daniele (Department of Biology. University of Pisa) ;
Moreno Aguado, Víctor (Facultat de Medicina. Universitat de Barcelona) ;
de Sanjosé, Silvia (Universitat de Barcelona) ;
Marcos-Gragera, Rafael (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
García-Álvarez, María Flor (Instituto de Investigación Biomédica de Salamanca) ;
Dierssen-Sotos, Trinidad (Universidad de Cantabria) ;
Jerez, Andrés (Vall d'Hebron Institut d'Oncologia) ;
Butrym, Aleksandra (Department of Cancer Prevention and Therapy. Medical University of Wrocław) ;
Norman, Aaron D. (Department of Quantitative Health Sciences. Mayo Clinic) ;
Luppi, Mario (University of Modena and Reggio Emilia) ;
Slager, Susan L. (Mayo Clinic) ;
Hemminki, Kari (Charles University in Prague) ;
Li, Yang (Hannover Medical School) ;
Berndt, Sonja I. (National Institutes of Health (Estats Units d'Amèrica)) ;
Casabonne, Delphine (Universitat de Barcelona) ;
Alcoceba, Miguel (Instituto de Investigación Biomédica de Salamanca) ;
Puiggros, Anna (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Netea, Mihai G. (Department for Immunology & Metabolism. University of Bonn) ;
Försti, Asta (Hopp Children's Cancer Center) ;
Canzian, Federico (German Cancer Research Center) ;
Sainz, Juan (Department of Biochemistry and Molecular Biology. Universidad de Granada)
Chronic lymphocytic leukemia (CLL) is the most common leukemia among adults worldwide. Although genome-wide association studies (GWAS) have uncovered the germline genetic component underlying CLL susceptibility, the potential use of GWAS-identified risk variants to predict disease progression and patient survival remains unexplored. [...]
2023 - 10.3390/ijms24098005
International journal of molecular sciences, Vol. 24 Núm. 9 (may 2023) , p. 8005
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4.
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8 p, 715.4 KB |
Head and neck cancers survival in Europe, Taiwan, and Japan : results from RARECAREnet Asia based on a privacy-preserving federated infrastructure
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Botta, Laura (Department of Epidemiology and Data Science. Fondazione IRCCS Istituto Nazionale dei Tumori) ;
Matsuda, Tomohiro (Insititute of Cancer Control. National Cancer Center (Japò)) ;
Charvat, Hadrien (National Cancer Center (Japò)) ;
Chiang, Chung-Ju (Taiwan Cancer Registry Center) ;
Lee, Wen-Chung (Taiwan Cancer Registry Center) ;
van Gestel, Anna Jacoba (Department of Research & Development. Netherlands Comprehensive Cancer Organisation) ;
Martin, Frank (Department of Research & Development. Netherlands Comprehensive Cancer Organisation) ;
Geleijnse, Gijs (Department of Research & Development. Netherlands Comprehensive Cancer Organisation) ;
Cellamare, Mattheo (Department of Research & Development. Netherlands Comprehensive Cancer Organisation) ;
Bonfarnuzzo, Simone (Department of Epidemiology and Data Science. Fondazione IRCCS Istituto Nazionale dei Tumori) ;
Marcos-Gragera, Rafael (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Guevara, Marcela (Instituto de Investigación Sanitaria de Navarra) ;
Mousavi, Mohsen (East Switzerland Cancer Registry) ;
Craig, Stefano (Queen's University Belfast) ;
Rodrigues, Jessica (Porto Comprehensive Cancer Centre (Portugal)) ;
Rubió-Casadevall, Jordi (Institut de Recerca Biomèdica de Lleida) ;
Licitra, Lisa (Department of Oncology and Hemato-Oncology. University of Milan) ;
Cavalieri, Stephanie (Department of Oncology and Hemato-Oncology. University of Milan) ;
Resteghini, Carlo (Fondazione IRCCS Istituto Nazionale dei Tumori di Milano) ;
Gatta, Gemma (Fondazione IRCCS Istituto Nazionale dei Tumori di Milano) ;
Trama, Annalisa (Fondazione IRCCS Istituto Nazionale dei Tumori di Milano)
Background: The head and neck cancers (HNCs) incidence differs between Europe and East Asia. Our objective was to determine whether survival of HNC also differs between European and Asian countries. [...]
2023 - 10.3389/fonc.2023.1219111
Frontiers in Oncology, Vol. 13 (2023) , p. 1219111
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5.
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11 p, 1.1 MB |
Current real-life use of vasopressors and inotropes in cardiogenic shock - adrenaline use is associated with excess organ injury and mortality
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Tarvasmäki, Tuukka (Helsinki University Hospital (Finlàndia)) ;
Lassus, Johan (Helsinki University Hospital) ;
Varpula, Marjut (Helsinki) ;
Sionis, Alessandro (Institut d'Investigació Biomèdica Sant Pau) ;
Sund, Reijo (Helsinki) ;
Køber, Lars (Rigshospitalet) ;
Spinar, Jindrich (University Hospital Brno (República Txeca)) ;
Parissis, John (University General Hospital Attikon (Haidari, Grècia)) ;
Banaszewski, Marek (Institute of Cardiology) ;
Silva Cardoso, Jose (University of Porto) ;
Carubelli, Valentina (University and Civil Hospital of Brescia) ;
Di Somma, Salvatore (University of Rome Sapienza) ;
Mebazaa, Alexandre (Hopital Lariboisiere) ;
Harjola, Veli-Pekka (University of Helsinki) ;
Kober, Lars ;
Koniari, Katerina ;
Voumvourakis, Astrinos ;
Karavidas, Apostolos ;
Sans-Rosello, Jordi ;
Vila, Montserrat ;
Duran-Cambra, Albert ;
Metra, Marco ;
Bulgari, Michela ;
Lazzarini, Valentina ;
Parenica, Jiri ;
Stipal, Roman ;
Ludka, Ondrej ;
Palsuva, Marie ;
Ganovska, Eva ;
Kubena, Petr ;
Lindholm, Matias G. ;
Hassager, Christian ;
Bäcklund, Tom (Helsinki) ;
Jurkko, Raija (Helsinki) ;
Järvinen, Kristiina (Helsinki) ;
Nieminen, Tuomo (Helsinki) ;
Pulkki, Kari (Helsinki University Hospital (Finlàndia)) ;
Soininen, Leena (Helsinki) ;
Tierala, Ilkka (Helsinki) ;
Tolonen, Jukka (Helsinki) ;
Korva, Tuomas (Helsinki) ;
Pitkälä, Anne (Helsinki) ;
Marino, Rossella ;
Sousa, Alexandra ;
Sousa, Carla ;
Paiva, Mariana ;
Rangel, Inés ;
Almeida, Rui ;
Pinho, Teresa ;
Maciel, Maria Júlia ;
Stepinska, Janina ;
Skrobisz, Anna ;
Góral, Piotr ;
Universitat Autònoma de Barcelona
Vasopressors and inotropes remain a cornerstone in stabilization of the severely impaired hemodynamics and cardiac output in cardiogenic shock (CS). The aim of this study was to analyze current real-life use of these medications, and their impact on outcome and on changes in cardiac and renal biomarkers over time in CS. [...]
2016 - 10.1186/s13054-016-1387-1
Critical Care, Vol. 20 Núm. 1 (april 2016) , p. 208
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6.
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32 p, 5.0 MB |
Childhood and Adolescent Central Nervous System Tumours in Spain : Incidence and Survival over 20 Years: A Historical Baseline for Current Assessment
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Chirlaque, María D. (Universidad de Murcia. Departamento de Epidemiología) ;
Peris-Bonet, Rafael (Spanish Registry of Childhood Tumours. University of Valencia) ;
Sánchez, Antonia (Department of Epidemiology. Murcia Regional Health Authority) ;
Cruz, Ofelia (Hospital Sant Joan de Déu (Manresa)) ;
Marcos-Gragera, Rafael (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Gutiérrez-Ávila, Gonzalo (Castile-La Mancha Cancer Registry) ;
Quirós-García, José R. (Asturias Cancer Registry. Public Health Directorate) ;
Almela-Vich, Fernando (Valencian Regional Childhood Cancer Registry) ;
López de Munain, Arantza (Basque Country Cancer Registry) ;
Sánchez, María J. (Granada Bio-Health Research Institute) ;
Franch-Sureda, Paula (Mallorca Cancer Registry. Balearic Isles Health Research Institute) ;
Ardanaz, Eva (Navarre Health Research Institute) ;
Galceran, Jaume (Universitat Rovira i Virgili) ;
Martos, Carmen (Foundation for the Promotion of Health and Biomedical Research in the Valencian Region) ;
Salmerón, Diego (Universidad de Murcia. Department of Health and Social Sciences) ;
Gatta, Gemma (Fondazione IRCCS Istituto Nazionale dei Tumori di Milano) ;
Botta, Laura (Istituto Nazionale dei Tumori) ;
Cañete, Adela (Universitat de València)
Background: Central nervous system (CNS) neoplasms are highly frequent solid tumours in children and adolescents. While some studies have shown a rise in their incidence in Europe, others have not. Survival remains limited. [...]
2023 - 10.3390/cancers15245889
Cancers, Vol. 15 Núm. 24 (december 2023) , p. 5889
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7.
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8 p, 389.3 KB |
Impact of 3-monthly vitamin D supplementation plus exercise on survival after surgery for osteoporotic hip fracture in adult patients over 50 years : A pragmatic randomized, partially blinded, controlled trial
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Laiz, Ana (Institut d'Investigació Biomèdica Sant Pau) ;
Malouf Sierra, Jorge 1971- (Institut d'Investigació Biomèdica Sant Pau) ;
Marin, A. (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Longobardi, V. (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
de Caso, Julio (Institut d'Investigació Biomèdica Sant Pau) ;
Farrerons, J. (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Casademont i Pou, Jordi (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
To determine whether 3-monthly supplementation of an oral vitamin D widely used in Spain (calcifediol) plus daily exercise could influence survival at one and four years after surgery for osteoporotic hip fracture. [...]
2017 - 10.1007/s12603-016-0773-3
Journal of Nutrition, Health and Aging, Vol. 21 Núm. 4 (january 2017) , p. 413-420
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11 p, 338.4 KB |
Early Macrophage Infiltration and Sustained Inflammation in Kidneys From Deceased Donors Are Associated With Long-Term Renal Function
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Guillén-Gómez, E. (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Dasilva, I. (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Silva, Irene (Institut d'Investigació Biomèdica Sant Pau) ;
Arce, Yolanda (Institut d'Investigació Biomèdica Sant Pau) ;
Facundo, C. (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Ars, Elisabet (Institut d'Investigació Biomèdica Sant Pau) ;
Breda, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Ortiz, A. (IIS-Fundación Jiménez Díaz/UAM. REDinREN) ;
Guirado, Luis (Institut d'Investigació Biomèdica Sant Pau) ;
Ballarín, J.A. (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Díaz Encarnación, Montserrat Mercedes (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Kidney transplants from living donors (LDs) have a better outcome than those from deceased donors (DDs). Different factors have been suggested to justify the different outcome. In this study, we analyzed the infiltration and phenotype of monocytes/macrophages and the expression of inflammatory and fibrotic markers in renal biopsy specimens from 94 kidney recipients (60 DDs and 34 LDs) at baseline and 4 months after transplantation. [...]
2017 - 10.1111/ajt.13998
American Journal of Transplantation, Vol. 17 Núm. 3 (january 2017) , p. 733-743
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9.
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34 p, 1.3 MB |
Inhibitors of aldehyde dehydrogenases of the 1A subfamily as putative anticancer agents : Kinetic characterization and effect on human cancer cells
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Jiménez, Rafael (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Pequerul, Raquel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Amor Minguez, Adrián (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Lorenzo Rivera, Julia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Metwally, Kamel (Zagazig University. Department of Medicinal Chemistry) ;
Avilés, Francesc X (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Parés i Casasampera, Xavier (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Farrés, Jaume (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Aldehyde dehydrogenases (ALDHs) are enzymes catalyzing the NAD(P)+-dependent oxidation of aldehydes to their corresponding carboxylic acids. High ALDH activity has been related to some important features of cancer stem cells. [...]
2019 - 10.1016/j.cbi.2019.04.004
Chemico-Biological Interactions, Vol. 306 (2019) , p. 123-130
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10.
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14 p, 1.1 MB |
Long-Term Studies Assessing Outcomes of Ibrutinib Therapy in Patients With Del(11q) Chronic Lymphocytic Leukemia
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Kipps, Thomas J. (UC San Diego Moores Cancer Center) ;
Fraser, Graeme (McMaster University (Canadà)) ;
Coutre, Steven E (Stanford University School of Medicine) ;
Brown, Jennifer R. (Dana-Farber Cancer Institute (Boston, Estats Units d'Amèrica)) ;
Barrientos, Jacqueline C. (Northwell Health Cancer Institute) ;
Barr, Paul M. (University of Rochester) ;
Byrd, John C. (The Ohio State University Comprehensive Cancer Center) ;
O'Brien, Susan M. (University of California) ;
Dilhuydy, Marie-Sarah (Hôpital Haut-Lévêque) ;
Hillmen, Peter (University of Leeds) ;
Jaeger, Ulrich (Medical University of Vienna) ;
Moreno, Carol (Institut d'Investigació Biomèdica Sant Pau) ;
Cramer, Paula (University of Cologne) ;
Stilgenbauer, Stephan (University of Ulm) ;
Chanan-Khan, Asher A. (Mayo Clinic Cancer Center) ;
Mahler, Michelle (Janssen Research and Development) ;
Salman, Mariya (Janssen Research and Development) ;
Eckert, Karl (Pharmacyclics LLC. an AbbVie Company) ;
Solman, Isabelle G. (Pharmacyclics LLC. an AbbVie Company) ;
Balasubramanian, Sriram (Janssen Research and Development) ;
Cheng, Mei (Pharmacyclics LLC. an AbbVie Company) ;
Londhe, Anil (Janssen Research and Development) ;
Ninomoto, Joi (Pharmacyclics LLC. an AbbVie Company) ;
Howes, Angela (Janssen Research and Development) ;
James, Danelle F. (Pharmacyclics LLC. an AbbVie Company) ;
Hallek, Michael (University of Cologne) ;
Universitat Autònoma de Barcelona
Certain genomic features, such as del(11q), expression of unmutated immunoglobulin heavy-chain variable region (IGHV) gene, or complex karyotype, predict poorer outcomes to chemotherapy in patients with chronic lymphocytic leukemia (CLL). [...]
2019 - 10.1016/j.clml.2019.07.004
Clinical Lymphoma, Myeloma & Leukemia, Vol. 19 Núm. 11 (november 2019) , p. 715-722.e6
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