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36 p, 4.7 MB |
METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer
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García-Vílchez, Raquel (Instituto de Investigación Biomédica de Salamanca) ;
Añazco-Guenkova, Ana M. (Instituto de Investigación Biomédica de Salamanca) ;
Dietmann, Sabine (Washington University School of Medicine in St. Lou) ;
López, Judith (Instituto de Investigación Biomédica de Salamanca) ;
Morón-Calvente, Virginia (Instituto de Investigación Biomédica de Salamanca) ;
D'Ambrosi, Silvia (CIC bioGUNE, Basque Research and Technology Alliance (BRTA)) ;
Nombela, Paz (Instituto de Investigación Biomédica de Salamanca) ;
Zamacola, Kepa (CIC bioGUNE, Basque Research and Technology Alliance (BRTA)) ;
Mendizabal, Isabel (CIC bioGUNE, Basque Research and Technology Alliance (BRTA)) ;
García-Longarte, Saioa (CIC bioGUNE, Basque Research and Technology Alliance (BRTA)) ;
Zabala-Letona, Amaia (Centro de Investigación Biomédica en Red de Cáncer) ;
Astobiza, Ianire (Centro de Investigación Biomédica en Red de Cáncer) ;
Fernández, Sonia (Centro de Investigación Biomédica en Red de Cáncer) ;
Paniagua, Alejandro (Universidad de Salamanca) ;
Miguel-López, Borja (Instituto de Investigación Biomédica de Salamanca) ;
Marchand, Virginie (Université de Lorraine, France) ;
Alonso-López, Diego (Universidad de Salamanca) ;
Merkel, Angelika (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
García-Tuñón, Ignacio (Universidad de Salamanca) ;
Ugalde-Olano, Aitziber (Hospital de Basurto (Bilbao, Biscaia)) ;
Loizaga-Iriarte, Ana (Hospital de Basurto (Bilbao, Biscaia)) ;
Lacasa-Viscasillas, Isabel (Hospital de Basurto (Bilbao, Biscaia)) ;
Unda, Miguel (Hospital de Basurto (Bilbao, Biscaia)) ;
Azkargorta, Mikel (Carlos III Networked Proteomics Platform (ProteoRed-ISCIII), Madrid) ;
Elortza, Félix (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Bárcena, Laura (CIC bioGUNE, Basque Research and Technology Alliance (BRTA)) ;
Gonzalez-Lopez, Monika (CIC bioGUNE, Basque Research and Technology Alliance (BRTA)) ;
Aransay, Ana M. (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Di Domenico, Tomás (Bioinformatics Unit, Spanish National Cancer Research Centre (CNIO)) ;
Sánchez-Martín, Manuel A. (Universidad de Salamanca) ;
De Las Rivas, Javier (Universidad de Salamanca) ;
Guil, S. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Motorin, Yuri (Université de Lorrain) ;
Helm, Mark (Johannes Gutenberg-University Mainz, Germany) ;
Pandolfi, Pier Paolo (University of Turin, Italy) ;
Carracedo, Arkaitz (Centro de Investigación Biomédica en Red de Cáncer) ;
Blanco, Sandra (Universidad de Salamanca)
Newly growing evidence highlights the essential role that epitranscriptomic marks play in the development of many cancers; however, little is known about the role and implications of altered epitranscriptome deposition in prostate cancer. [...]
2023 -  10.1186/s12943-023-01809-8
Molecular cancer, Vol. 22 Núm. 1 (july 2023)
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8 p, 535.7 KB |
Dovitinib in patients with gastrointestinal stromal tumour refractory and/or intolerant to imatinib
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Joensuu, Heikki (Helsinki University Hospital) ;
Blay, Jean-Yves (University Claude Bernard Lyon I) ;
Comandone, Alessandro (Gradenigo Hospital) ;
Martin-Broto, Javier (Hosp o Virgen del Rocío (Sevilla, Andalusia)) ;
Fumagalli, Elena (Fondazione IRCCS Istituto Nazionale Dei Tumori) ;
Grignani, Giovanni (Candiolo Cancer Institute. FPO - IRCCS) ;
Del Muro, Xavier Garcia (Hospital Universitari de Bellvitge) ;
Adenis, Antoine (Centre Oscar Lambret) ;
Valverde, Claudia (Hospital Universitari Vall d'Hebron) ;
López Pousa, Antonio (Institut d'Investigació Biomèdica Sant Pau) ;
Bouche, Olivier (University Hospital Robert Debre) ;
Italiano, Antoine (Comprehensive Cancer Centre. 2Institut Bergonie) ;
Bauer, Sebastian (University of Duisburg- Essen) ;
Barone, Carlo (University Hospital A. Gemelli) ;
Weiss, Claudia (Novartis Pharma GmbH) ;
Crippa, Stefania (Novartis Farma) ;
Camozzi, Maura (Novartis Farma) ;
Castellana, Ramon (Novartis Farmaceutica SA) ;
Le Cesne, Axel (Gustave Roussy) ;
Universitat Autònoma de Barcelona
This multicentre phase II trial (DOVIGIST) evaluated the antitumour activity of dovitinib as second-line treatment of patients with gastrointestinal stromal tumour (GIST) refractory to imatinib or who do not tolerate imatinib. [...]
2017 - 10.1038/bjc.2017.290
British Journal of Cancer, Vol. 117 Núm. 9 (2017) , p. 1278-1285
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11 p, 1018.7 KB |
Epidemiology of human papillomavirus-related oropharyngeal cancer in a classically low-burden region of southern Europe
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Mena, Marisa (Hospital Universitari de Bellvitge) ;
Frias-Gomez, Jon (Hospital Universitari de Bellvitge) ;
Taberna, Miren (Hospital Universitari de Bellvitge) ;
Quirós, Beatriz (Hospital Universitari de Bellvitge) ;
Marquez, Sandra (Hospital Universitari de Bellvitge) ;
Clavero, Omar (de Hospital Universitari de Bellvitge) ;
Baena, Antoni. (Hospital Universitari de Bellvitge) ;
Lloveras, Belén (Hospital del Mar (Barcelona, Catalunya)) ;
Alejo, María (Hospital General de l'Hospitalet) ;
León i Vintró, Xavier (Institut d'Investigació Biomèdica Sant Pau) ;
García, Jacinto Montero (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Mesía, Ricard (Institute Catala Oncologia) ;
Bermejo, Josep Oriol (Hospital Universitari de Bellvitge) ;
Bonfill Abella, Teresa (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Aguilà, Antón (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Guix, Marta (Hospital del Mar (Barcelona, Catalunya)) ;
Hijano, Rafael (Hospital del Mar (Barcelona, Catalunya)) ;
Pavón, Miguel Ángel (Hospital Universitari de Bellvitge) ;
Torres, Montserrat A. (Hospital Universitari de Bellvitge) ;
Tous, Sara (Hospital Universitari de Bellvitge) ;
Clèries, Ramón (Hospital Universitari de Bellvitge) ;
Alemany, Laia (Hospital Universitari de Bellvitge) ;
Universitat Autònoma de Barcelona
The incidence of human papillomavirus (HPV)-related oropharyngeal cancer is increasing in some regions. Nevertheless, the epidemiology of this disease has not been extensively investigated in southern Europe. [...]
2020 - 10.1038/s41598-020-70118-7
Scientific reports, Vol. 10 Núm. 1 (january 2020) , p. 13219
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12 p, 682.4 KB |
Peripheral Inflammatory Indexes Neutrophil/Lymphocyte Ratio (NLR) and Red Cell Distribution Width (RDW) as Prognostic Biomarkers in Advanced Solitary Fibrous Tumour (SFT) Treated with Pazopanib
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Hidalgo-Ríos, Samuel (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Carrillo García, Jaime (Hospital Universitario General de Villalba. Servicio de Oncología Médica) ;
Moura, David S. (Hospital Universitario General de Villalba. Servicio de Oncología Médica) ;
Stacchiotti, Silvia (Fondazione IRCCS Istituto Nazionale dei Tumori (Milà, Itàlia)) ;
López Pousa, Antonio (Institut d'Investigació Biomèdica Sant Pau) ;
Redondo, Andrés (Hospital Universitario La Paz. Servicio de Oncología Médica. Instituto de Investigación en Salud (IdiPAZ)) ;
Italiano, Antoine (Institut Bergonié. Department of Oncology) ;
Gutiérrez, Antonio (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Grignani, Giovanni (Candiolo Cancer Institute. FPO - IRCCS) ;
Hindi, Nadia (Hospital Universitario Fundación Jiménez Díaz. Servicio de Oncología Médica) ;
López-Guerrero, J.A (Laboratory of Molecular Biology. Fundación Instituto Valenciano de Oncología) ;
Garcia del Muro, Xavier (Institut d'Investigació Biomèdica de Bellvitge) ;
Martínez-Trufero, Javier (Hospital Universitario Miguel Servet. Servicio de Oncología Médica) ;
Palmerini, Emanuela (IRCCS Istituto Ortopedico Rizzoli (Bologna)) ;
Sebio, Ana (Institut d'Investigació Biomèdica Sant Pau) ;
Bernabeu, Daniel (Hospital Universitario La Paz. Sección de Radiología musculoesquelética) ;
Le Cesne, Axel (Gustave Roussy Cancer Campus. Department of Medical Oncology) ;
Casali, Paolo Giovanni (Fondazione IRCCS Istituto Nazionale dei Tumori. Adult Mesenchymal and Rare Tumor Unit. Department of Cancer Medicine) ;
Blay, Jean-Yves (Department of Medical Oncology. Centre Léon Bérard. Université Claude Bernard Lyon) ;
Cruz-Jurado, Josefina (Hospital Universitario de Canarias. Servicio de Oncología Médica) ;
Martín-Broto, Javier (Hospital Universitario Fundación Jiménez Díaz. Servicio de Oncología Médica)
Pazopanib was assessed prospectively in the GEIS-32 phase II study (NCT02066285) on advanced solitary fibrous tumour (SFT), resulting in a longer progression-free survival (PFS) and overall survival (OS) compared with historical controls treated with chemotherapy. [...]
2022 - 10.3390/cancers14174186
Cancers, Vol. 14 Núm. 17 (september 2022) , p. 4186
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19 p, 2.3 MB |
B Cells in Breast Cancer Pathology
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Li, Mengyuan (King's College London) ;
Quintana, Angela (Vall d'Hebron Institut d'Oncologia) ;
Alberts, Elena (The Francis Crick Institute) ;
Hung, Miu Shing (King's College London) ;
Boulat, Victoire (King's College London) ;
Martí, Mercè (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Grigoriadis, Anita (School of Cancer and Pharmaceutical Sciences) ;
Universitat Autònoma de Barcelona.
Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí"
B cells in the tumour microenvironment and lymph nodes have affirmed their role in breast cancer pathology. Multiplex imaging, single cell, and spatial transcriptomics of cancer patients' breast carcinomas and lymph nodes have illustrated the diversity and spatial context of B cells in this disease. [...]
2023 - 10.3390/cancers15051517
Cancers, Vol. 15, Issue 5 (February 2023) , art. 1517
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21 p, 858.2 KB |
Evaluation of the TCR Repertoire as a Predictive and Prognostic Biomarker in Cancer : diversity or Clonality?
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Aran, Andrea (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Garrigós Cubells, Laia (Centre Internacional de Càncer de Mama. Barcelona) ;
Curigliano, Giuseppe (University of Milan) ;
Cortés, Javier (University of Milano) ;
Martí, Mercè (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
T cells play a vital role in the anti-tumoural response, and the presence of tumour-infiltrating lymphocytes has shown to be directly correlated with a good prognosis in several cancer types. Nevertheless, some patients presenting tumour-infiltrating lymphocytes do not have favourable outcomes. [...]
2022 - 10.3390/cancers14071771
Cancers, Vol. 14 Núm. 7 (2022) , p. 1771
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10 p, 1.2 MB |
Anti-tumour necrosis factor discontinuation in inflammatory bowel disease patients in remission : study protocol of a prospective, multicentre, randomized clinical trial
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Chaparro, María (Universidad Autónoma de Madrid) ;
Donday, María G. (Universidad Autónoma de Madrid) ;
Barreiro de-Acosta, Manuel (Hospital Clínico Universitario (Santiago de Compostela, Galícia)) ;
Domènech, Eugeni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Esteve, Maria (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
García-Sánchez, Valle (Hospital Universitario Reina Sofía (Còrdova, Espanya)) ;
Nos, Pilar (Hospital Universitari i Politècnic La Fe (València)) ;
Panés, Julián (Hospital Clínic i Provincial de Barcelona) ;
Martínez, Concepción (Hospital Universitario de la Princesa (Madrid)) ;
P. Gisbert, Javier (Universidad Autónoma de Madrid)
Patients with inflammatory bowel disease who achieve remission with anti-tumour necrosis factor (anti-TNF) drugs may have treatment withdrawn due to safety concerns and cost considerations, but there is a lack of prospective, controlled data investigating this strategy. [...]
2019 - 10.1177/1756284819874202
Therapeutic Advances in Gastroenterology, Vol. 12 (september 2019)
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